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박형진,이현승,Chan Seo,Jeuk Min,지문기,김영배,Subin Choi,Doo-Young Kim,Jung Dong Kim,정도현,Wonjae Lee,백만정 대한화학회 2020 Bulletin of the Korean Chemical Society Vol.41 No.3
Tranexamic acid (TA) as a synthetic derivative of lysine is a potent antifibrinolytic drug used to reduce bleeding during surgeries including dental extraction. The efficacy of TA administration in ovarian cancer and melasma has also been reported in a previous study. In this study, the mass spectral data set of TA as ethoxycarbonyl-tert-butyldimethylsilyl derivatives was newly constructed by gas chromatography-tandem mass spectrometry in multiple reaction-monitoring mode. This analytical method was validated with good linearity (r?>?0.9988), limit of detection (LOD, 0.22?ng/mL), limit of quantification (LOQ, 0.72?ng/mL), relative standard deviation (1.3 to 4.8%), and relative error (?6.8 to 3.5%) under optimal conditions. The LOD and LOQ were assessed to be lower than other reported methods. Therefore, the present method will be useful for monitoring of TA in the pharmacological and cosmetic fields.