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서정미 ( Jeongmi Seo ) 사단법인 아시아문화학술원 2021 인문사회 21 Vol.12 No.5
본 연구는 선행연구들에 대한 문헌고찰법을 통해 북한의 군사문화 형성과정에 대한 분석을 하였다. 이를 통해, 북한의 사회문화에 대한 이해를 시도하였다. 북한은 수령 한 사람을 제외한 모든 북한 사람이 ‘조직’에 소속되는 사회적 특성을 지니고 있기 때문에 군사문화를 이해하는 것은 곧 사회문화를 이해하는 방법이기도 하다. 연구 결과 북한에서는 2013년의 ‘경제ㆍ핵무력 병진노선’을 2018년에 ‘경제건설 총력집중노선’으로 전환하면서 군사문화와 궤를 같이하는 사회문화의 변화가 있었다. 최근 코로나19의 확산 이후에는 위기를 극복하기 위해 주민에 대한 통제 강화의 수단으로 군사문화를 강조하는 경향을 보이고 있다. 향후 북한과 교류를 확대하는 과정에서 북한의 군사문화에 대한 지속적인 연구를 통해 사회문화에 대한 이해가 가능할 것이다. 다만 본 연구에서는 제한적인 연구방법론만을 사용하였다는 한계가 있어, 향후에는 보다 더 다양한 연구방법론적 접근을 통한 체계적인 연구가 필요할 것이다. This study analyzed the process of forming North Korea’s military culture through literature review methods for previous studies. Through this, we attempted to understand North Korea’s social culture. Understanding military culture is also a way to understand social culture because North Korea has social characteristics that all North Koreans except the recipient belong to the “organization.” As a result of the study, in North Korea, there was a change in social culture in line with military culture as the “economic and nuclear force transformation route” in 2013 was converted to the “concentrated economic construction route” in 2018. After the recent spread of COVID-19, there is a tendency to emphasize military culture as a means of strengthening control over residents to overcome the crisis. In the process of expanding exchanges with North Korea in the future, it will be possible to understand social culture through continuous research on North Korea’s military culture. However, since this study has a limitation in using only limited research methodology, systematic research through more diverse research methodological approaches will be needed in the future.
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The role of mucosal barriers in human gut health
Kangseok Seo,Jeongmi Seo,Jiyoun Yeun,Haebin Choi,Young-In Kim,장선영 대한약학회 2021 Archives of Pharmacal Research Vol.44 No.4
The intestinal mucosa is continuously exposedto a large number of commensal or pathogenic microbiotaand foreign food antigens. The intestinal epithelium formsa dynamic physicochemical barrier to maintain immunehomeostasis. To effi ciently absorb nutrients from food, theepithelium in the small intestine has thin, permeable layersspread over a vast surface area. Epithelial cells are renewedfrom the crypt toward the villi, accompanying epithelial celldeath and shedding, to control bacterial colonization. Tightjunction and adherens junction proteins provide epithelialcell–cell integrity. Microbial signals are recognized by epithelialcells via toll-like receptors. Environmental signalsfrom short-chain fatty acids derived from commensal microbiotametabolites, aryl hydrocarbon receptors, and hypoxiainducedfactors fortify gut barrier function. Here we summarizerecent fi ndings regarding various environmental factorsfor gut barrier function. Further, we discuss the role of gutbarriers in the pathogenesis of human intestinal disease andthe challenges of therapeutic strategies targeting gut barrierrestoration.
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Park, Jeongmi,Cho, Su Yeon,Youn, Young-Sang,Lee, Jeongmook,Kim, Jong-Yun,Park, Seo-Hyeon,Bae, Sang-Eun,Kuk, Seoung Woo,Park, Jeong-Yong,Rhee, Choong Kyun,Lim, Sang Ho Elsevier 2019 Journal of Nuclear Materials Vol.527 No.-
<P><B>Abstract</B></P> <P>We characterized the lattice parameter and phase transformation behaviors of six uranium-based metallic fuels in the temperature range 303–1173 K using <I>in situ</I> high-temperature X-ray diffraction (HT-XRD). In all of the fuels, α-U crystal structure almost vanished at 1023 K while UO<SUB>2</SUB> crystal structure started forming at 843 K. Pawley refinement of HT-XRD data revealed anisotropic lattice thermal expansion with increases along the <I>a</I>- and <I>c</I>-axes upon annealing in all the metallic fuels. Furthermore, we confirmed that rare-earth elements (Nd, Ce, Pr, and La) contained in the U–10Zr metallic fuel hardly influenced the thermal behavior of the lattice parameters.</P>
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Kwon, Ok-Seon,Kwon, Soo-Jung,Kim, Jin Sang,Lee, Gunbong,Maeng, Han-Joo,Lee, Jeongmi,Hwang, Gwi Seo,Cha, Hyuk-Jin,Chun, Kwang-Hoon The Korean Society of Applied Pharmacology 2018 Biomolecules & Therapeutics(구 응용약물학회지) Vol.26 No.3
Melanin is a pigment produced from tyrosine in melanocytes. Although melanin has a protective role against UVB radiation-induced damage, it is also associated with the development of melanoma and darker skin tone. Tyrosinase is a key enzyme in melanin synthesis, which regulates the rate-limiting step during conversion of tyrosine into DOPA and dopaquinone. To develop effective RNA interference therapeutics, we designed a melanin siRNA pool by applying multiple prediction programs to reduce human tyrosinase levels. First, 272 siRNAs passed the target accessibility evaluation using the RNAxs program. Then we selected 34 siRNA sequences with ${\Delta}G{\geq}-34.6kcal/mol$, i-Score value ${\geq}65$, and siRNA scales score ${\leq}30$. siRNAs were designed as 19-bp RNA duplexes with an asymmetric 3' overhang at the 3' end of the antisense strand. We tested if these siRNAs effectively reduced tyrosinase gene expression using qRT-PCR and found that 17 siRNA sequences were more effective than commercially available siRNA. Three siRNAs further tested showed an effective visual color change in MNT-1 human cells without cytotoxic effects, indicating these sequences are anti-melanogenic. Our study revealed that human tyrosinase siRNAs could be efficiently designed using multiple prediction algorithms.
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( Ok-seon Kwon ),( Soo-jung Kwon ),( Jin Sang Kim ),( Gunbong Lee ),( Han-joo Maeng ),( Jeongmi Lee ),( Gwi Seo Hwang ),( Hyuk-jin Cha ),( Kwang-hoon Chun ) 한국응용약물학회 2018 Biomolecules & Therapeutics(구 응용약물학회지) Vol.26 No.3
Melanin is a pigment produced from tyrosine in melanocytes. Although melanin has a protective role against UVB radiationinduced damage, it is also associated with the development of melanoma and darker skin tone. Tyrosinase is a key enzyme in melanin synthesis, which regulates the rate-limiting step during conversion of tyrosine into DOPA and dopaquinone. To develop effective RNA interference therapeutics, we designed a melanin siRNA pool by applying multiple prediction programs to reduce human tyrosinase levels. First, 272 siRNAs passed the target accessibility evaluation using the RNAxs program. Then we selected 34 siRNA sequences with ΔG ≥-34.6 kcal/mol, i-Score value ≥65, and siRNA scales score ≤30. siRNAs were designed as 19-bp RNA duplexes with an asymmetric 3’ overhang at the 3’ end of the antisense strand. We tested if these siRNAs effectively reduced tyrosinase gene expression using qRT-PCR and found that 17 siRNA sequences were more effective than commercially available siRNA. Three siRNAs further tested showed an effective visual color change in MNT-1 human cells without cytotoxic effects, indicating these sequences are anti-melanogenic. Our study revealed that human tyrosinase siRNAs could be efficiently designed using multiple prediction algorithms.
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