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THE PARTICLE SIZE EFFECT ON COMBUSTION BEHAVIOR OF CELLULOSE INSULATION
Choi,Jeong-Hwa,Kim,Hong,Ryu,Kyong-Ok 한국화재소방학회 1997 한국화재소방학회 학술대회 논문집 Vol.1997 No.-
The combustion of cellulose insulation treated with Borax, Boric acid and Aluminum Sulfate as combustion retardants is examined by candle type combustion tester. The cellulose fibers in cellulose insulation are classified by diameter as less than 0.2mm, 0.2mm-0.5mm, 0.5mm-2mm and more than 2mm. The burning behavior of cellulose insulation are studied by LOI (Limit Oxygen Index: Beginning point of smoldering), L- point (Lower point of combustion transition from smoldering- flaming to flaming combustion), LOI, L-point and H-point rise with the increasing particle size of cellulose fibers because thermal decomposition rate of cellulose fiber decreases. The phenomena of combustion transition from smoldering to flaming combustion are determined by the generating rate of combustible gas and the formation rate of combustible gas mixture within the zone of cellulose fiber heated.
Choi, Hyunmo,Jeong, Suyeong,Kim, Dong Su,Na, Hyung Jin,Ryu, Jong Sang,Lee, Seung Sik,Nam, Hong Gil,Lim, Pyung Ok,Woo, Hye Ryun Blackwell Publishing Ltd 2014 Physiologia plantarum Vol.150 No.2
<P>Phytochromes are red (R)/far-red (FR) photoreceptors that are central to the regulation of plant growth and development. Although it is well known that photoactivated phytochromes are translocated into the nucleus where they interact with a variety of nuclear proteins and ultimately regulate genome-wide transcription, the mechanisms by which these photoreceptors function are not completely understood. In an effort to enhance our understanding of phytochrome-mediated light signaling networks, we attempted to identify novel proteins interacting with phytochrome B (phyB). Using affinity purification in ArabidopsisphyB overexpressor, coupled with mass spectrometry analysis, 16 proteins that interact with phyB in vivo were identified. Interactions between phyB and six putative phyB-interacting proteins were confirmed by bimolecular fluorescence complementation (BiFC) analysis. Involvement of these proteins in phyB-mediated signaling pathways was also revealed by physiological analysis of the mutants defective in each phyB-interacting protein. We further characterized the athb23 mutant impaired in the homeobox protein 23 (ATHB23) gene. The athb23 mutant displayed altered hypocotyl growth under R light, as well as defects in phyB-dependent seed germination and phyB-mediated cotyledon expansion. Taken together, these results suggest that the ATHB23 transcription factor is a novel component of the phyB-mediated R light signaling pathway.</P>
Choi, Ki-Choon,Hwang, Jung-Min,Bang, Sung-Jun,Son, Young-Ok,Kim, Beom-Tae,Kim, Dong-Hern,Lee, Seung-Ah,Chae, Minseon,Kim, Da Hye,Lee, Jeong-Chae Informa Healthcare USA, Inc. 2013 PHARMACEUTICAL BIOLOGY Vol.51 No.8
<P><I>Context</I>: Recently, there has been renewed interest in barley (<I>Hordeum vulgare</I> L. Poaceae) as a functional food and for its medicinal properties.</P><P><I>Objective</I>: This study examines the anti-inflammatory potential of the active fractions of barley and the mechanisms involved.</P><P><I>Materials and methods</I>: The macrophages were exposed to 100 μg/mL of each of the barley extracts in the presence of 1 μg/mL lipopolysaccharide (LPS) and after 24 or 48 h of incubation, cells or culture supernatants were analyzed by various assays. The anti-inflammatory potential of barley fractions was also investigated using the LPS-injected septic mouse model. The active constituents in the fractions were identified using gas chromatography-mass spectrometry (GC-MS).</P><P><I>Results</I>: The active fractions, named F<SUB>4</SUB>, F<SUB>7</SUB>, F<SUB>9</SUB> and F<SUB>12</SUB>, inhibited almost completely the LPS-induced production of nitric oxide (NO) and inducible NO synthase. Pre-treatment with these fractions at 100 μg/mL diminished the tumor necrosis factor-α (TNF-α) levels to 19.8, 3.5, 1.2 and 1.7 ng/mL, respectively, compared to LPS treatment alone (41.5 ng/mL). These fractions at 100 μg/mL also suppressed apparently the secretion of interleukin (IL)-6 and IL-1β and the DNA-binding activity of nuclear factor-κB in LPS-stimulated cells. Mice injected intraperitoneally with LPS (30 mg/kg BW) showed 20% survival at 48 h after injection, whereas oral administration of the fractions improved the survival rates to 80%. GC-MS analysis revealed the presence of the derivatives of benzoic and cinnamic acids and fatty acids in the fractions.</P><P><I>Discussion and conclusion</I>: The aerial parts of barley are useful as functional food to prevent acute inflammatory responses.</P>
Ok, Seong-Ho,Lee, Soo Hee,Kwon, Seong-Chun,Choi, Mun Hwan,Shin, Il-Woo,Kang, Sebin,Park, Miyeong,Hong, Jeong-Min,Sohn, Ju-Tae MDPI AG 2017 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.18 No.2
<P>The goal of this in vitro study was to examine the effect of a lipid emulsion on toxic-dose bupivacaine-induced vasodilation in a model of tyrosine phosphatase inhibitor sodium orthovanadate-induced contraction in endothelium-denuded rat aortae and to elucidate the associated cellular mechanism. The effect of a lipid emulsion on vasodilation induced by a toxic dose of a local anesthetic during sodium orthovanadate-induced contraction was examined. In addition, the effects of various inhibitors, either bupivacaine alone or a lipid emulsion plus bupivacaine, on protein kinase phosphorylation induced by sodium orthovanadate in rat aortic vascular smooth muscle cells was examined. A lipid emulsion reversed the vasodilation induced by bupivacaine during sodium orthovanadate-induced contraction. The lipid emulsion attenuated the bupivacaine-mediated inhibition of the sodium orthovanadate-induced phosphorylation of protein tyrosine, c-Jun NH<SUB>2</SUB>-terminal kinase (JNK), myosin phosphatase target subunit 1 (MYPT1), phospholipase C (PLC) γ-1 and extracellular signal-regulated kinase (ERK). These results suggest that a lipid emulsion reverses toxic-dose bupivacaine-induced vasodilation during sodium orthovanadate-induced contraction via the activation of a pathway involving either tyrosine kinase, JNK, Rho-kinase and MYPT1 or tyrosine kinase, PLC γ-1 and ERK, and this reversal is associated with the lipid solubility of the local anesthetic and the induction of calcium sensitization.</P>
Choi, Yeon Jeong,Han, Yonggyu,Ok, Myoung‐,Ahn,Kim, Dong‐,Won WILEY‐VCH Verlag 2011 Macromolecular chemistry and physics Vol.212 No.23
<P><B>Abstract</B></P><P>Poly(propylene carbonate) (PPC) is synthesized from the copolymerization of CO<SUB>2</SUB> and propylene oxide. Novel nanocomposite gel polymer electrolytes (GPEs) are prepared by utilizing PPC, organic solvents containing a redox couple, and aluminum oxide nanoparticles for application in dye‐sensitized solar cells (DSSCs). The quasi‐solid‐state DSSC assembled with optimized nanocomposite GPEs exhibits a relatively high conversion efficiency of 6.16% at 100 mW cm<SUP>−2</SUP> and better stability than DSSC with liquid electrolyte.</P>
Choi, Jae Hyun,Han, Hye-Suk,Lee, Ho-chang,Lee, Ok-Jun,Kim, Jeong Tae,Lim, Sung-Nam,Lee, Ki Hyeong,Kim, Seung Taik S. Karger Verlag für Medizin und Naturwissens 2011 Onkologie Vol.34 No.11
<P><I>Background: </I>Trastuzumab, a humanized monoclonal antibody directed against human epidermal growth factor receptor 2 (HER2), has been shown to be active against metastatic gastric cancers that overexpress HER2. <I>Case Report: </I>A 47-year-old man presented with a headache and visual disturbance. He was subsequently found to have an intracranial hemorrhage. Laboratory testing showed severe thrombocytopenia, and a bone marrow biopsy revealed aggregates of malignant tumor cells. Endoscopic biopsy of an ulcerative lesion of the gastric antrum confirmed signet ring cell carcinoma based on the results of H&E staining. Immunohistochemistry of the tumor cells revealed HER2 overexpression with an intensity of 3+, and silver in situ hybridization showed HER2 gene amplification. The patient was treated with trastuzumab because of the presence of severe thrombocytopenia. After 2 months of trastuzumab therapy, gastric wall thickening and ascites were diminished and thrombocytopenia was markedly improved. Trastuzumab was continued for an additional 3 months. <I>Conclusion: </I>This is the first report of a positive response to trastuzumab in a patient with HER2-overexpressing metastatic gastric cancer that was accompanied by bone marrow involvement and severe thrombocytopenia. This finding is of considerable relevance for difficult cases of metastatic gastric cancer that preclude the administration of aggressive antineoplastic regimens.</P><P>Copyright © 2011 S. Karger AG, Basel</P>