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- 저자 : Jeong Seongtae (검색결과 12 건)
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Suyoeng Cho,Jeong-Il Choi,Seongtae Jeong 조선대학교 의학연구원 2020 Medical Bilogical Science and Engineering Vol.3 No.2
Subclavian artery injury during central venous catheterization appears to be reported less than in actual cases. We report management of incidental subclavian artery catheterization in a 65-year-old man who has limited neck motion, undergoing emergency spine hematoma removal surgery. Despite the use of ultrasonography for central venous catheterization via right internal jugular vein, incidental subclavian artery injury has not been prevented. The management of incidental arterial injury during central venous catheterization is discussed, and a review of the literature is provided. To prevent injury to the right subclavian artery during right IJV catheterization, the location of adjacent blood vessels should be ascertained and not damaged. It is important to note that the damage can also occur due to ultrasonography. When right subclavian artery injury is suspected, the catheter should not be removed. Early detection of injury and early intervention may reduce morbidity and mortality.
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Jin Baoyuan,Kim Hyehyun,Jeong Seongtae 조선대학교 의학연구원 2023 Medical Bilogical Science and Engineering Vol.6 No.1
Traumatic brain injury (TBI) leads to a cascade of neuroinflammation and subsequent long-term cognitive deficits. Alpha melanocyte stimulating hormone (a-MSH) is a neuropeptide that protects against TBI. In this study, we aimed to evaluate the effect of a-MSH on TBI induced brain inflammation. a-MSH improved rotarod latencies during the first 3 days and water maze latencies over 29-32 days. Here, a-MSH-treated mice had significantly lower tumor necrosis factor-alpha (TNF-a) concentrations in the cortex at 30 min and 1 h. The mitogen-activated protein kinase (MAPK) isoforms JNK, ERK, and p38 decreased following administration of a-MSH. The inhibitor of nuclear factor-kB (IkB) kinase (IKK)/Nuclear factor-kB (NFkB) signaling system is a key regulator of inflammation. Phosphorylation of IKK/NFkB increased after TBI but decreased significantly in response to a-MSH. Strongly immunoreactive microglia increased and were observed throughout the hippocampus in the TBI model, whereas a-MSH-treated mice showed less activation. TNF-a concentrations tended to decrease in the hippocampus. These data indicate that a-MSH might attenuate inflammation in a TBI mouse model.
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Yin, Mei,Kim, Yeo-Ok,Choi, Jeong-Il,Jeong, Seongtae,Yang, Si-Ho,Bae, Hong-Beom,Yoon, Myung-Ha The Korean Pain Society 2020 The Korean Journal of Pain Vol.33 No.4
Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a major side effect of anti-cancer drugs. Neurotensin receptors (NTSRs) are widely distributed within the pain circuits in the central nervous system. The purpose of this study was to determine the role of NTSR1 by examining the effects of an NTSR1 agonist in rats with CIPN and investigate the contribution of spinal serotonin receptors to the antinociceptive effect. Methods: Sprague-Dawley rats (weight 150-180 g) were used in this study. CIPN was induced by injecting cisplatin (2 mg/kg) once a day for 4 days. Intrathecal catheters were placed into the subarachnoid space of the CIPN rats. The antiallodynic effects of intrathecally or intraperitoneally administered PD 149163, an NTSR1 agonist, were evaluated. Furthermore, the levels of serotonin in the spinal cord were measured by high-performance liquid chromatography. Results: Intrathecal or intraperitoneal PD 149163 increased the paw withdrawal threshold in CIPN rats. Intrathecal administration of the NTSR1 antagonist SR 48692 suppressed the antinociceptive effect of PD 149163 given via the intrathecal route, but not the antinociceptive effect of intraperitoneally administered PD 149163. Intrathecal administration of dihydroergocristine, a serotonin receptor antagonist, suppressed the antinociceptive effect of intrathecally administered, but not intraperitoneally administered, PD 149163. Injecting cisplatin diminished the serotonin level in the spinal cord, but intrathecal or intraperitoneal administration of PD 149163 did not affect this reduction. Conclusions: NTSR1 played a critical role in modulating CIPN-related pain. Therefore, NTSR1 agonists may be useful therapeutic agents to treat CIPN. In addition, spinal serotonin receptors may be indirectly involved in the effect of NTSR1 agonist.
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Jung Seung Eun,Kim Sang Woo,Jeong Seongtae,Moon Hanbyeol,Choi Won Seok,Lim Soyeon,Lee Seahyoung,Hwang Ki-Chul,Choi Jung-Won 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-
Myocardial infarction (MI) damage induces various types of cell death, and persistent ischemia causes cardiac contractile decline. An effective therapeutic strategy is needed to reduce myocardial cell death and induce cardiac recovery. Therefore, studies on molecular and genetic biomarkers of MI, such as microRNAs (miRs), have recently been increasing and attracting attention due to the ideal characteristics of miRs. The aim of the present study was to discover novel causative factors of MI using multiomics-based functional experiments. Through proteomic, MALDI-TOF-MS, RNA sequencing, and network analyses of myocardial infarcted rat hearts and in vitro functional analyses of myocardial cells, we found that cytochrome c oxidase subunit 5a (Cox5a) expression is noticeably decreased in myocardial infarcted rat hearts and myocardial cells under hypoxic conditions, regulates other identified proteins and is closely related to hypoxia-induced cell death. Moreover, using in silico and in vitro analyses, we found that miR-26a-5p and miR-26b-5p (miR-26a/b-5p) may directly modulate Cox5a, which regulates hypoxia-related cell death. The results of this study elucidate the direct molecular mechanisms linking miR-26a/b-5p and Cox5a in cell death induced by oxygen tension, which may contribute to the identification of new therapeutic targets to modulate cardiac function under physiological and pathological conditions.
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Sugammadex reversal of large subcutaneous injection of rocuronium in an obese patient
Dae-Hoon Kim,Sung Min Kim,Joungmin Kim,Seongtae Jeong 조선대학교 의학연구원 2020 Medical Bilogical Science and Engineering Vol.3 No.1
In obese patients, correct insertion of the intravenous line and early identification of subcutaneous injection may be difficult. We report management of accidental subcutaneous rocuronium administration in a 38-year-old, obese Korean woman undergoing elective breast cancer surgery. The perioperative management of the patient is discussed, and a review of the literature is provided. Little information is available regarding the absorption of medications outside of the typical route of administration. The accidental subcutaneous infiltration of neuromuscular blocking agents may lead to pulmonary complications. Early identification of subcutaneous infiltration is important and open discussion with many treatment team members is critical. Careful monitoring including neuromuscular monitoring in the post-anesthesia care unit is essential.
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Yang, Jihoon,Lee, Hyung Gon,Cho, Suyeong,Kim, Woong Mo,Jeong, Seongtae,Bae, Hong-Beom,Yoon, Myung Ha,Choi, Jeong Il Elsevier 2019 Neuroscience Letters Vol.690 No.-
<P><B>Abstract</B></P> <P>Macrophage-inducible C-type lectin (Mincle), a pattern recognition receptor, is a critical component of the innate immune system that is involved in the pathogenesis of chronic pain. Previous studies have reported the expression of Mincle in neuronal and glial cells of the brain, but its expression and role in pain processing at the spinal level remain to be determined. The current study was performed to identify Mincle in the spinal cord and to investigate the effect of Mincle activation on spinal sensitization.</P> <P>Most Mincle immunoreactivity was localized within the grey matter and the dorsal and ventral horns of the lumbar spinal cord in naïve rats. A single intrathecal (i.t.) injection of trehalose-6,6-dibehenate (TDB), a Mincle ligand, induced mechanical allodynia. Immunoreactivity to Mincle and Iba-1 in the spinal cord significantly increased after i.t. injection of TDB. Mechanical allodynia was attenuated by daily i.t. injection of minocycline. However, double immunofluorescence revealed that Mincle co-localizes with NeuN (neurons), but not with Iba-1 (microglia) or GFAP (astrocytes).</P> <P>In conclusion, we found that Mincle was present in spinal cord neurons, but not microglia or astrocytes, and may play a role in microglia-induced spinal sensitization.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Mincle is expressed in the dorsal and ventral horns of the lumbar spinal cord in rat. </LI> <LI> Mincle is present in neuron, but not microglia or astrocyte in the lumbar spinal cord. </LI> <LI> Intrathecal injection of Mincle ligand, trehalose dibehenate induces mechanical allodynia. </LI> <LI> Microglia is activated by intrathecal injection of Mincle ligand. </LI> <LI> Intrathecal minocycline reduces the allodynic response induced by Mincle activation. </LI> </UL> </P>
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Sugammadex reversal of large subcutaneous injection of rocuronium in an obese patient
Dae-Hoon Kim,Sung Min Kim,Joungmin Kim,Seongtae Jeong 조선대학교 의학연구원 2020 Medical Bilogical Science and Engineering Vol.1 No.1
In obese patients, correct insertion of the intravenous line and early identification of subcutaneous injection may be difficult. We report management of accidental subcutaneous rocuronium administration in a 38-year-old, obese Korean woman undergoing elective breast cancer surgery. The perioperative management of the patient is discussed, and a review of the literature is provided. Little information is available regarding the absorption of medications outside of the typical route of administration. The accidental subcutaneous infiltration of neuromuscular blocking agents may lead to pulmonary complications. Early identification of subcutaneous infiltration is important and open discussion with many treatment team members is critical. Careful monitoring including neuromuscular monitoring in the post-anesthesia care unit is essential.
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이홍석 ( Hongseok Lee ),전현정 ( Hyenchung Chun ),박진기 ( Jinki Park ),정회정 ( Hoejeong Jeong ),이성태 ( Seongtae Lee ),정미혜 ( Mihye Jeong ) 한국농공학회 2023 한국농공학회 학술대회초록집 Vol.2023 No.0
Among the fundamental problems of soybean cultivation, damage from selective and non-selective herbicides used in conventional agriculture continues to occur. In particular, damage from herbicides and nutrients during early growth is difficult to classify even through visual inspection by experts, so analysis is being conducted in a laboratory environment. As such, analysis in a laboratory environment has a delayed response time and requires a lot of manpower. To solve this problem, we developed a technology to detect herbicide damage using hyperspectral imaging. To diagnose damage, Daechan beans were treated with the most commonly used herbicides, foliar treatments, bentazone and glufosinate, and soil treatments, Linuron and Alachlor. Germination of the soil treatment agent began 10 days after soil treatment, and analysis was performed based on when the cotyledons were fully unfolded. Reneuron showed the highest classification accuracy when using 785nm and 890nm wavelengths, and Alachlor showed the highest classification accuracy when using 788nm and 944nm wavelengths. For Reneuron, the classification accuracy is 88.49% (1x), 89.51% (2x), 90.31% (4x), 99.99% (8x), and 100% (16x), and for Alachlor, the classification accuracy is 63.41% (1x). They were 82.82% (2x), 95.06% (4x), 96.62% (8x), and 96.71% (16x). The foliage treatment agent was applied during the third leaf stage of the crop growth season, and images were measured and analyzed for 10 days. Glufosinate showed the highest classification accuracy when using 1387nm and 1563nm wavelengths, and bentazone showed the highest classification accuracy when using 1408nm and 1493nm wavelengths. For glufosinate, the classification accuracy was measured at 77.97% (1x), 93.52% (2x), 93.70% (4x), 96.70% (8x), and 97.53% (16x), and for bentazone, the classification accuracy was 87.06% (1x), 94.04% (2x), 93.72% (4x), 93.02% (8x), and 93.64% (16x).
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