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Templated and template-free fabrication strategies for zero-dimensional hollow MOF superstructures
Kim, Hyehyun,Lah, Myoung Soo The Royal Society of Chemistry 2017 Dalton transactions Vol.46 No.19
<▼1><P>Fabrication strategies for hollow MOF superstructures are classified based on the existence of external templates and the types and properties of templates, and their advantages and disadvantages are reviewed.</P></▼1><▼2><P>Various fabrication strategies for hollow metal–organic framework (MOF) superstructures are reviewed and classified using various types of external templates and their properties. Hollow MOF superstructures have also been prepared without external templates, wherein unstable intermediates obtained during reactions convert to the final hollow MOF superstructures. Many hollow MOF superstructures have been fabricated using hard templates. After the core–shell core@MOF structure was prepared using a hard template, the core was selectively etched to generate a hollow MOF superstructure. Another approach for generating hollow superstructures is to use a solid reactant as a sacrificial template; this method requires no additional etching process. Soft templates such as discontinuous liquid/emulsion droplets and gas bubbles in a continuous soft phase have also been employed to prepare hollow MOF superstructures.</P></▼2>
Kim, Hyehyun,Mondal, Sudip,Bharathiraja, Subramaniyan,Manivasagan, Panchanathan,Moorthy, Madhappan Santha,Oh, Junghwan Elsevier 2018 CERAMICS INTERNATIONAL Vol.44 No.6
<P><B>Abstract</B></P> <P>The synthesis and fabrication of multifunctional nanostructures with enhanced biocompatibility are the most important characteristics for biomedical research. The goal of our present research is to study the optimum zinc (Zn)-loading on pure hydroxyapatite (HAp) bioceramics and its potential advantages in biomedical application. In this study, different mole concentrations (1, 2, 5mol%) of Zn doped HAp (Zn-HAp) nanoparticles were synthesized through a facile co-precipitation technique using zinc nitrate as a source for Zn metal. The synthesized Zn-HAp nanoparticles were critically characterized for their structural and morphological changes by different spectroscopy and electron microscopy analysis. The potential advances of Zn-HAp nanoparticles in biological application was studied by using MG-63 cell line, drug model experiment and scaffold cell attachment, proliferation study. The cell cytotoxicity test (MTT assay and trypan blue) was first conducted to confirm the nontoxic characteristics of Zn-HAp with enhanced MG-63 cell proliferation activity. The drug loading experiment of Zn-HAp nanoparticles was then confirmed with 1mol% Zn-HAp (which had the maximum drug loading efficiency with pH responsive drug interaction). Furthermore, the optimized 1mol% Zn-HAp constructed biomimetic scaffold shows excellent cell attachment and proliferation behavior with MG-63 cells. The result suggests that the biomimetic 1mol% Zn-HAp scaffolds may be of enormous potential in bone repair and regeneration. This research distinguishes from other research by showing an advanced analysis of the Zn-HAp and its enhanced physicochemical properties for tissue engineering and pH responsive drug delivery application.</P>
Anti-inflammatory activity of 6-O-phospho-7-hydroxycoumarin in LPS-induced RAW 264.7 cells
Hyehyun Hong,Tae-Jin Park,Sungchan Jang,Min-Seon Kim,Jin-Soo Park,Won-Jae Chi,Seung-Young Kim 한국응용생명화학회 2022 Journal of Applied Biological Chemistry (J. Appl. Vol.65 No.1
Esculetin (also known as 6, 7-dihydroxycoumarin) a type of coumarin, has been exhibited anti-inflammatory and antiaging effects. Biorenovation is the microbe-mediated enhancement of biological efficacies and structurally diversified compounds relative to their substrate compounds. The production of different kinds of esculetin derivatives using Bacillus sp. JD3-7 and their effects on lipopolysaccharide (LPS)-triggered inflammatory response in RAW 26.7 cells were assessed. One of the biorenovation products, identified as esculetin 6-O-phosphate (ESP), at concentrations of 1.25, 2.5, and 5 μM inhibited the LPSstimulated production of inflammation markers of nitric oxide synthase 2 and cyclooxygenase 2 as well as their respective enzymatic reaction products of nitric oxide and prostaglandin E2 in the order of increasing concentrations (1.25, 2.5, and 5 μM). Additionally, ESP treatment suppressed the LPS-stimulated secretion of pro-inflammatory cytokines of interleukin (IL)-1β, IL-6, and tumor necrosis factor- α. Furthermore, these antiinflammatory effect of ESP was associated with the downregulation of mitogen-activated protein kinase signaling, that is, extracellular signal-regulated kinase, c-Jun NH2-terminal kinase, and p38 mitogen-activated protein kinase signaling pathways. This study would therefore provide interesting insights into the biorenovationassisted generation of a novel anti-inflammatory compound. ESP may be used to develop treatments for inflammatory disorders.
Kim, Hyehyun,Oh, Minhak,Kim, Dongwook,Park, Jeongin,Seong, Junmo,Kwak, Sang Kyu,Lah, Myoung Soo The Royal Society of Chemistry 2015 Chemical communications Vol.51 No.17
<P>Single crystalline hollow metal–organic frameworks (MOFs) with cavity dimensions on the order of several micrometers and hundreds of micrometers were prepared using a metal–organic polyhedron single crystal as a sacrificial hard template. The hollow nature of the MOF crystal was confirmed by scanning electron microscopy of the crystal sliced using a focused ion beam.</P> <P>Graphic Abstract</P><P>Single crystalline hollow MOFs with cavity dimensions on the order of several micrometers and hundreds of micrometers were prepared using a metal–organic polyhedron single crystal as a sacrificial hard template. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c4cc10051d'> </P>
Kim, Hyehyun,Mondal, Sudip,Jang, Bian,Manivasagan, Panchanathan,Moorthy, Madhappan Santha,Oh, Junghwan Elsevier 2018 Ceramics international Vol.44 No.16
<P><B>Abstract</B></P> <P>An innovative biomimetic approach has been employed for the synthesis of human and environmental friendly nanomaterials for biomedical application. The aim of this research is to study the structural analysis of biomimetic-synthesized gold (Au) and silver (Ag) nanoparticles loaded on pristine hydroxyapatite (HAp) and their potential advances in biomedical applications. The synthesized metal–hydroxyapatite nanoparticles’ structural and morphological characteristics were studied using X-ray diffraction (XRD), different spectroscopies (UV–vis, DRS, FTIR, zeta potential), BET surface area and pore size analyzer and electron microscopy (FE-TEM, FE-SEM). Biological activity was established using osteoblast-like MG-63 cell line and antibacterial tests with <I>Escherichia coli</I> (<I>E. coli</I>), which is one of the most common bacteria in the human body. Cell cytotoxicity test (MTT assay and fluorescence imaging with AO/PI staining) was conducted with MG-63 cells to study the toxicity of Au-HAp, Ag-HAp, and Au-Ag-HAp (bimetallic) nanoparticles. Antimicrobial studies have shown that all Ag-HAp nanoparticles have excellent in vitro antibacterial activity with <I>E. coli</I>. The present research investigates the structural stability and biocompatibility of Au-HAp, Ag-HAp, and Au-Ag-HAp nanoparticles, which may be the best materials to repair bone infection (osteomyelitis) and could be useful as a potential scaffold material to prevent postoperative infections.</P>
가야금을 이용한 오디오-비주얼 인터랙티브 설치작품 표현 연구 : <풍류 (風流): 침향무>를 중심으로
김혜현(Kim Hyehyun),박승호(Park Seungho) 한국디지털디자인학회 2008 디지털디자인학연구 Vol.8 No.2
오늘날 다양한 멀티미디어 환경에 둘러싸여 있는 우리에게 오디오 비주얼(Audio-Visual)의 개념은 전혀 새롭거나 낯설지 않은 개념이지만 시각과 청각의 교류는 인간 정신에 매우 강력한 영향을 끼칠 수 있다는 점에서 매우 중요하다. 시간을 거슬러 올라가 우리에게 디지털 기술이나 매체가 없었던 고대부터 아리스토텔레스와 피타고라스를 포함한 사상가들과 철학자들이 세상에 대한 우리의 다감각적인 경험을 설명할 수 있는 통합법칙에 대해서 탐색해왔으며 예술 분야에서 많은 사람들이 시청각적인 표현에 관한 시도와 연구를 하였다. 이러한 흐름은 현재까지도 이어져 최근 미디어 아트 분야에서 이미지와 사운드를 연결한 시청각적인 표현의 작품을 찾아 볼 수 있다. 본 연구에서는 오랫동안 분리되어 발전되어온 시각 예술과 청각예술을 디지털 기술을 이용하여 연결시키고 통합하는 시도를 해보고자 한다. 한국의 전통악기인 가야금에 초점을 맞춰서 오랜 시간의 연습을 통해 익힌 숙련된 기술로 연주해야 하는 악기인터페이스를 쉽고 새로운 인터페이스로 변형하여 연주와 감상의 간격을 좁히고 연주와 그림 그리기를 연결하였다. 사용자는 이 작품에서 기존의 가야금 인터페이스에서 만들어지는 음악과는 다른 음악을 만들며 본인이 동시에 만들어 내는 음악과 그림을 감상하는 새로운 연주 체험을 한다. 시간이 지나면 사라지는 소리를 시각화하기 위해 사운드와 어울리는 붓 획을 제작하여 매치시킴으로써 연주 후에 소리의 자취라고 할 수 있는 한 폭의 한국화가 남는 미디어 아트 작품을 제작하였다. Today the Audio-Visual concept is not unfamiliar or new to us because we are surrounded with the multimedia environment. Yet the interaction between auditory sense and the sense of sight can affect to the human spirit very powerfully. Since ancient times there were no digital technologies and digital medias thinkers and philosophers such as Aristotle and Socrates have searched for unifying principles that could explain our multisensory experiences of the world and in the field of arts there were many attempts and researches done by artists about the audio-visual expression. In this study I attempted to unify and combine visual arts to audio arts using digital technology. I focused on the Gayaguem and modify the musical instrument interface which usually requires a skill for play. It allows people to play easily and enjoy the new music playing experiment using a more simple musical interface. People make music with Gayaguem sound source but the music they play is different from the music played with original Gayaguem. My goal in this paper is to make a media art work that can make music and painting at the same time. In my work eight strokes made with brush are matched with loop sounds properly to visualize the music.