척수 손상 환자에서의 Euthyroid Sick Syndrome -증례 보고-

서정환,고명환,김근수,김연희 大韓再活醫學會 1998 Annals of Rehabilitation Medicine Vol.22 No.2

재조합 BMP-7 유전자가 전달된 HEK 293 세포에 의한 누드 마우스에서의 뼈형성

정수연,장원태,장연실,안면환,김재룡,송인환 영남대학교 의과대학 2003 Yeungnam University Journal of Medicine Vol.20 No.2

To induce bone formation at ectopic site by tissue engineering and gene therapy, we transplanted collagen sponges containing rhBMP-7 transduced HEK 293 cells in the hypodermis of nude mice. Bone formation was investigated by histological and electron microscopic method at 3, 6, and 9 weeks after transplantation. At 9 weeks after transplantation, eosinophilic bony tissue was observed in the implanted collagen sponge and was confirmed as bone tissue by Von Kossa stain. In the transmission electron microscopic observation, the cells in newly formed bone tissue had eccentrically located nucleus and well developed rough endoplasmic reticulum (rER). Therefore, the cells were evaluated as osteoblasts. Those results suggest that it is possible to form a bone tissue in the ectopic site by transplantation of rhBMP-7 transduced HEK 293 cells. This will be contributed to push more advanced gene therapy for bone formation. However, the HEK 293 cell is unable to apply to the clinical gene therapy. Therefore it is worth to find more compatible cells for clinical application. In addition, collagen sponge is considered as an excellent scaffold and/or carrier for gene therapy and a good biomaterial for tissue engineering.

척수손상 환자에서 골 대사의 생화학적 변화

김상수,서정환,김완호,김연희 大韓再活醫學會 1997 Annals of Rehabilitation Medicine Vol.21 No.6

보툴리눔 독소 주사 효과의 정량적 분석을위한 복합근활동전위 측정

서정환,김상수,김남균,이주홍 大韓再活醫學會 1998 Annals of Rehabilitation Medicine Vol.22 No.6

관상동맥질환 환자에서 스텐트 시술 후 재협착에 관한 연구

강진환,권영주,박상호,한대희,이상철,김명구,변정득,최병조,심규혁,온영근,현민수,김성구 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background and aims : In the coronary artery disease, a rate of restenosis was much decreased by placement of coronary stent than when percutaneous transluminal coronary angioplasty has been applied, but there are still important clinical problems of restenosis. There has been many progressive studies about various factors contributed to this restenosis. So, we studied a relation between restenosis after placement of coronary stent in the coronary artery disease and many clinical factors, characteristics of stenotic lesion and procedural factors, and also assessed the restenosis rate of various coronary stents. Methods : Total 58 lesions(46 cases of patients ; man 30, woman 16) were evaluated, which has been performed a follow-up coronary angiography after 6 months (mean 188 days) since coronary stent had been placed. Various stents were implanted and assessed a relation between restenosis and many factors. Results : Of 58 lesions were target stenotic studies, there were 22 of restenotic lesions(37.9%), and the restenosis rate wes statistically significant difference in the relation with diabetes mellitus(p<0.05), group of acute myocardial infarction(p<0.05) among clinical diagnosis of ischemic heart disease(stable angina, unstable angina and acute myocardial infarction) in clinical factors and with high dilation pressure of stent(p<0.05) in procedural factors. When the rate of restenosis was evaluated among implanted stents, it was lowest in the Multilink^(®) stent and highest in the Nir Royal^(®) stent(60%). Conclusion : In this study of restenosis and various factors after placement of stents in the coronary artety disease, factors such as diabetes mellitus, group of acute myocardial infarction and a dilation pressure of stent were significant related with restenosis and the restenosis rate of Multilink^(®) stent was lowest and the highest restenosis rate was of Nir Royal^(®) stent.

뇌졸중 노인을 돌보는 주간호제공자의 부담감과 예측요인 : 한방병원 입원 노인을 중심으로

유수정,김신미,이윤정,박연환 노인간호학회 2004 노인간호학회지 Vol.6 No.1

Purpose : The purpose of this study was to investigate factors influencing burden in primary caregivers caring for an elderly person who has had a stroke. Method : A convenience sample of 124 primary caregivers of elderly people with a stroke admitted to an oriental medicine hospital participated in this study. Interviews were done with a standardized questionnaire including Caregiver Burden Scale (Chang, 1995). Result: Average burden score was 93.19, indicating a moderate to severe level of burden. Time-dependent burden had the highest score of the sub-domains. For general characteristics, the factors significantly influencing caregiver burden were gender and age of the elderly person, age and educational level of the caregiver, whether living together or not, and the presence of another caregiver. Multiple regression analyses demonstrated that level of ADL of the elderly person, relationship between the elderly person and the caregiver prior to the stroke, caregivers' relation to the elderly person and primary income were significant factors in explaining variance in overall burden. Conclusion : Recognition of high levels of caregiver burden and factors influencing burden will allow us to develop different nursing strategies to decrease caregiver burden in those caring for an elderly person with a stroke.

하악 무치악 인공치아매식술시 하치조신경 전위술

최의환,하정완,김수관,정태영,김수흥 대한악안면성형재건외과학회 2001 Maxillofacial Plastic Reconstructive Surgery Vol.23 No.3

Modified surgical technique for transposition of the inferior alveolar nerve followed by immediate placement of endosseous implants in mandibles with moderate to severe atrophy are presented. Five transpositions of the inferior alveolar nerve together with the installation of 10 implants were performed in four patients. The mean postoperative follow-up time was 17 months, with a range of 8 to 20 months. All implants with functioning pontics remained stable, with no mobility or symptoms of pain and infection during the follow-up period. Neurosensory evaluation was performed using the two-point discrimination test. Two patients had objective neurosensory dysfunction at postoperative, but all the nerve function were reported as normal by the patients 4 months postoperatively.

허혈성 심질환에서 염증지표에 관한 연구

번정득,권영주,박상호,한대희,이상철,강진환,김명구,심규혁,최병조,온영근,현민수,김성구 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background : Atherosclerosis is the chief underlying cause of ischemic heart disease and there is increasing evidence that inflammation is an important determinant of the development of atherosclerosis. We assessed the levels of inflammatory markers in patients with ischemic heart disease and normal group who has normal coronary angiograms. Materials and Methods : Coronary angiography was performed in 142 patients. 107 patients of ischemic heart disease(stable angina pectoris 58, unstable angina pectoris 30, Acute myocardial infarction 19) and 38 normal control subjects. We assessed the level of inflammatory markers, such as CRP, ESR, fibrinogen and leukocyte. Results : CRP, ESR and fibrinogen values of the patients with stable angina pectoris and unstable angina pectoris were higher than that of normal control group, but there were no statistical significance. Leukocyte value of the patients with unstable angina pectoris(9003.3±701.5/mm^(3)) was significantly higher than that of the patients with stable angina pectoris(6685.5±245.8/mm^(3)) and normal control subjects(6394.3±235.1/mm^(3)). CRP, ESR and fibrinogen values of the patients with acute myocardial infarction were also higher than that of normal control subjects. CRP was 3.88±2.05 mg/dL in acute mocardial infarction group, and 0.29±0.15 mg/dL in normal control subject group(p<0.05). Fibrinogen was 541.6±45.1 mg/dL in acute myocardial infarction group, 321.4±25.6 mg/dL in normal control subject group(p<0.05). Leukocyte was 10942.1±737.6/mm^(3) in acute myocardial infarction group, 6394.3±235.1/mm^(3) in normal control subject group(p<0.05). Conclusions : This study demonstrate that CRP, fibrinogen and leukocyte values of acute myocardial infarction group were significantly higher than that of control group and stable, unstable argina pectoris group. Leucokyte values were significantly elevated in unstable angina group, but CRP values were not in unstable angina group.

치질에 흡수된 불소가 미세경도와 불소함량에 미치는 영향

이수종,정진호,반일환 조선대학교 구강생물학연구소 2003 Oral Biology Research (Oral Biol Res) Vol.27 No.1

The Purpose of this study was to evaluate the influence of fluoride uptake on microhardness and fluoride contents of tooth structure, Forty extracted human teeth were used, which were prepared proximal cavities. Experimental teeth were divided into five groups. Group 1: Prime & Bond NT and 2100 : Group 2 : Prime & Bond NT and F2000 : Group 3 : Scotchbond Multi-Purpose and 2100 : Group 4 : Scothcbond Multi-purpose and F2000 : Group 5 : Fuji Ⅱ LC. The cavities were filled with dentin adhesives and restorative materials. Teeth were coated 2 times with nail varnish. and immersed in a polypropylene tube. Tubes were stored in water bath at 37±0.5℃. After four weeks, the tooth was bisected longitudinally and the microhardness of the dentin and enamel were determined by indentation (at 30.100㎛ depth). The other halves were analyzed for fluoride by an EPMA-WDX device (at30, 100, 200㎛ depth). The results were as follows : 1. There was no correlation between the microhardness and amount of uptaken fluoride in the all groups. 2. There was no significant statistical difference in the amount of uptaken fluoride of the all groups in enamel without regard for groups and depth(p>0.05). 3. In the Group 2 and 5, EPMA-WDX result showed higher fluoride uptake of the. each depths in dentin(p<0.05). 4. At 30㎛ depth in dentin, EPMA-WDX result showed that group 2 had higher fluoride uptake than group 1 and 3 and group 5 had than the other groups. In conclusion, fluoride uptake increased by fluoride releasing materials. But, it was influenced by dentin bonding agents and surface conditions. Therefore, further study about relation between dentin bonding agent, surface coating, and fluoride uptake is necessary.

배드민턴 드롭샷 동작의 운동학적 분석

오정환,최수남,정익수 한국운동역학회 2005 한국운동역학회지 Vol.15 No.1

C. H. OH, S. N. CHOI, I. S. JEONG. Kinematic Analysis of the Badminton Drop-shot Motion. Korean Journal of Sport Biomechartics, Vol. 15, No. 1, pp. 221-235, 2005. The purpose of this study was to analyse badminton players' drop-shots, in order to make players understand the principles of drop-shot motion in badminton. Three dimensional analysis was used to measure movements such as the time required per section, the change of center of gravity, joint angle and speed, and joint speed. The results of this study revealed as follows: (1) top players are faster than amateurs in the total time required per section; (2) top players moved more in the x-axis and z-axis, while amateurs moved more in the y-axis; (3) the inclination of amateurs was greater than that of top players in all phases; (4) amateurs showed larger angle on the shoulder joints than top players in the first phase, while top players showed larger angle on the shoulder joint than amateurs in the second and third phase. Amateurs' angle was larger on angle joint in the first phase than top players' ones, while top players' angle was larger in the third phase than amateurs; (5) the speed of racket head of top players was faster than that of amateurs; and the velocity of the center of gravity of amateurs was greater than that of the top players. The findings of this study were that gravity decreases during impact and then the velocity increases to perform the follow-through and making the swing fast by increasing the speed of the racket head is most important.