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- 저자 : Jeon Byeong seok (검색결과 156 건)
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3차 의료기관 응급실로 내원한 안면부 열상 환자에 대한 임상적 고찰
김양원,안성훈,류석용,김홍용,전병민,김기태 대한응급의학회 2001 대한응급의학회지 Vol.12 No.2
Background: Facial laceration is a common clinical problem in the emergency room that is frequently associated with other craniofacial injuries. It elicits an emotional response from the patient because of the underlying concern of permanent scar and secondary facial disfigurement, so they demand prompt and adequate treatment. The aim of this study is to analyze the incidence, etiology, depth, and site of facial lacerations to provide basic data for further understanding. Method: This study reviewed 1,043 facial-laceration patients treated in the emergency room at Pusan Paik Hospital between March 1999 and February 2000. This retrospective study was done by reviewing and analyzing the sex and age distributions, the monthly and daily distributions, the causes of injury, the types of injury, the sites of injury, the lengths of the lacerations, and associated injuries. Results: The sex ratio of men to wemen was 2.4:1, and the 0~10 age group was at the top of the age distribution. The number of patients was the highest on sundays and during March. About 9.2% of the patients visited the emergency room between 10:00 P.M. and 11:00 P.M. Falls(38.1%) were the most common cause of facial laceration, and deep laceration(51.8%) was the most common type of facial laceration. The most common laceration site was the forehead, followed by the chin and the nose. The most common associated craniofacial injury was facial bone fracture(39%), Facial-lacerations were sutured by plastic surgeons(80%), emergency physicians(10%), and oromaxillofacial surgeons(10%). We found statistical significance in the types and lengths of lacerations between men and women, among age groups(p<0.05). Conclusion: Facial laceration is one of the most common craniofacial injuries in the emergency room. By now, most lacerations have been repaired by plastic surgeons, But, the causes of lacerations are diverse and many patients are admitted due to the associated injuries. Therefore, emergency physicians should participate more aggressively in the care of facial-laceration patients to improve the outcome of the patients.
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( Byeong Ho Jeong ),( Kyeongman Jeon ),( Hye Yun Park ),( Su Young Kim ),( Hee Jae Huh ),( Chang Seok Ki ),( Nam Yong Lee ),( Sung Jae Shin ),( Won Jung Koh ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Although intermittent, three-times-weekly, therapy is recommended for initial treatment for the non-cavitary nodular bronchiectatic Mycobacterium avium complex (MAC) lung disease, supporting data are limited. This study is conducted to evaluate the clinical effi cacy of intermittent therapy compared with daily therapy for the nodular bronchiectatic MAC lung disease. Methods: A retrospective cohort study of 217 patients with treatment-naive non-cavitary nodular bronchiectatic MAC lung disease. These patients received daily (n = 99) or intermittent therapy (n = 118) which included clarithromycin or azithromycin, rifampin, and ethambutol. Results: Modifi cation of initial antibiotic therapy occurred more frequently in daily therapy group than in intermittent therapy group (46% vs. 21%, P < 0.001). In particular, ethambutol was more frequently discontinued in daily therapy group than in intermittent therapy group (24% vs. 1%, P < 0.001). However, rates of symptomatic improvement, radiographic improvement, and sputum culture conversion were not different between two groups (daily therapy vs. intermittent therapy; 75% vs. 82%, P = 0.181; 68% vs. 73%, P = 0.402; 76% vs. 67%, P = 0.154; respectively). In addition, adjusted proportion of sputum culture conversion rates was similar between daily therapy group (71.3%, 95% confidence interval [CI] 59.1-81.1%) and intermittent therapy group (73.6%, 95% CI 62.9-82.2%, P = 0.785). Conclusions: These results suggested that intermittent three-times-weekly therapy with macrolide, rifampin, and ethambutol is a reasonable initial treatment regimen to patients with non-cavitary nodular bronchiectatic MAC lung disease.
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Endothelium-dependent Contraction of Aorta in One-kidney, One-clip Goldblatt Hypertensive Rat
Jeon, Byeong-Hwa,Lee, Kug-Hee,Kim, Hoe-Suk,Kim, Se-Hoon,Chang, Seok-Jong The Korean Physiological Society 1996 대한생리학회지 Vol.30 No.2
The mechanism of impaired endothelium-dependent relaxation in the aorta of one-kidney, one clip Goldblatt hypertensive (1K,1C-GBH) rats was investigated. 8 week-old Wistar-Kyoto (WKY) rats were made hypertensive by left renal artery stenosis with contralateral nephrectomy. Endothelium-dependent relaxation was significantly reduced in 1K,1C-GBH rats as compared with WKY rats. However, the relaxation by sodium nitroprusside in 1K,1C-GBH rats was not reduced as compared with WKY rats. The impairment of endothelium-dependent relaxation in 1K,1C-GBH rats was partially restored by the pretreatment of indomethacin or SQ29548. When the nitric oxide production was inhibited by L-nitroarginine methyl ester, acetylcholine (ACh) induced a endothelium-dependent contraction that was greater in 1K,1C-GBH rats than in WKY rats. Endothelium-dependent contraction by ACh was completely abolished by indomethacin or SQ29548. However, imidazole, tranylcypromine and superoxide dismutase did not affect the endothelium-dependent contraction in 1K,1C-GBH rats. These results suggest that impaired endothelium-dependent relaxation in the 1K,1C-GBH rats might be due to the simultaneous release of EDCF, and that prostaglandin B2 may be involved as a mediator of endothelium-dependent contraction.
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Seok Kim,Jaehoon Jung,Hwajin Kim,Rok Won Heo,Chin-ok Yi,Jung Eun Lee,Byeong Tak Jeon,Won-Ho Kim,Jong Ryeal Hahm,Gu Seob Roh 대한생리학회-대한약리학회 2014 The Korean Journal of Physiology & Pharmacology Vol.18 No.4
Exendin-4 (Ex-4), a glucagon-like peptide-1 receptor (GLP-1R) agonist, has been known to reverse hepatic steatosis in ob/ob mice. Although many studies have evaluated molecular targets of Ex-4, its mechanism of action on hepatic steatosis and fibrosis has not fully been determined. In the liver, glucose transporter 4 (GLUT4) is mainly expressed in hepatocytes, endothelial cells and hepatic stellate cells (HSCs). In the present study, the effects of Ex-4 on GLUT4 expression were determined in the liver of ob/ob mice. Ob/ob mice were treated with Ex-4 for 10 weeks. Serum metabolic parameters, hepatic triglyceride levels, and liver tissues were evaluated for hepatic steatosis. The weights of the whole body and liver in ob/ob mice were reduced by long-term Ex-4 treatment. Serum metabolic parameters, hepatic steatosis, and hepatic fibrosis in ob/ob mice were reduced by Ex-4. Particularly, Ex-4 improved hepatic steatosis by enhancing GLUT4 via GLP-1R activation in ob/ob mice. Ex-4 treatment also inhibited hepatic fibrosis by decreasing expression of connective tissue growth factor in HSCs of ob/ob mice. Our data suggest that GLP-1 agonists exert a protective effect on hepatic steatosis and fibrosis in obesity and type 2 diabetes.
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( Byeong Ho Jeong ),( Su Young Kim ),( Kyeong Man Jeon ),( Hee Jae Huh ),( Chang Seok Ki ),( Nam Yong Lee ),( Sung Jae Shin ),( Won Jung Ko ) 대한결핵 및 호흡기학회 2014 Tuberculosis and Respiratory Diseases Vol.76 No.1
We report the first Korean case of lung diseases caused by Mycobacterium abscessus subsp. bolletii in a previously healthy male, except for a previous history of pulmonary tuberculosis and bronchiectasis. All serial isolates are identified as M. abscessus subsp. bolletii by multi-locus sequence analysis based on the hsp65, rpoB, and 16S rRNA fragments. At the genetic level, the isolate has the erm(41) gene with a T28 sequevar, associated with clarithromycin resistance, and no rrl mutation. The isolate is resistant to clarithromycin. Although the symptoms and radiographic findings have improved after combination of antibiotics, the follow-up sputum cultures are persistently positive.
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고혈압백서 대동맥에서 Ca에 의한 수축에 미치는 Na/Ca교환기전의 영향
전병화,김국성,박경숙,김주석,김세훈,장석종 충남대학교 의과대학 지역사회의학연구소 1999 충남의대잡지 Vol.26 No.1
We investigated the contraction by sodium-calcium(Na-Ca) exchanges in the aortic strips of spontaneously hypertensive rats(SHR) and Wistar-Kyoto (WKY) rats. Resting tension of aortic strips in SHR was decreased by the removal of extracellular Ca and those were recovered by the addition of Ca. However, resting tone of aortic strips in WKY was not changed by Ca removal or Ca addition. Ca-induced contraction after exposure to Ca-free solution was suppressed by verapamil 10^-6M to 90% or more. In the presence of verapamil 10^-5M, phentolamine 10^-6M, caffeine 5mM and atropine 10^-6M, the reduction of extracellular sodium concentration([Na]o) from normal(158 mM) to 0 mM(replaced by choline chloride) caused the contraction(Ca entry by Na-Ca exchange). The amplitude of contraction was more greater in SHR than in WKY rats. In the presence of verapamil 10^-5M, phentolamine 10^-6M, caffeine 5mM and atropine 10^-6M, aortic strips were not contracted by Naand Ca-free solution, but was contracted by the addition of Ca. In the presence of verapamil 10^-5M and phentolamine 10^-6M and ouabain 10^-5M, Ca did not induce contraction after exposure to Ca-free Tyrode ' s solution, but in the presence of verapamil 10^-5M and phentolamine 10^-6M and monensin 10^-5M a sodium ionophore, Ca induced a little contraction in the aortic strips of SHR. These observations suggest that Na-Ca exchange does not contribute the development of Ca-induced contraction after exposure to Ca-free Tyrode ' s Solution in the presence of normal extracellular Na concentration. However, Na/Ca exchange in vascular smooth muscle is increased in SHR and may be involved in the mechanism for hypertension in SHR.
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( Byeong Ho Jeong ),( Kyeong Man Jeon ),( Hye Yun Park ),( Su Young Kim ),( Hee Jae Huh ),( Chang Seok Ki ),( Nam Yong Lee ),( Sung Jae Shin ),( Won Jung Koh ) 대한결핵 및 호흡기학회 2014 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.118 No.-
Background: Although intermittent, three-times-weekly, therapy is recommended for initial treatment for the non-cavitary nodular bronchiectatic Mycobacterium avium complex (MAC) lung disease, supporting data are limited. This study is conducted to evaluate the clinical efficacy of intermittent therapy compared with daily therapy for the nodular bronchiectatic MAC lung disease. Methods: A retrospective cohort study of 217 patients with treatment-naive non-cavitary nodular bronchiectatic MAC lung disease. These patients received daily (n = 99) or intermittent therapy (n = 118) which included clarithromycin or azithromycin, rifampin, and ethambutol. Results: Modification of initial antibiotic therapy occurred more frequently in daily therapy group than in intermittent therapy group (46% vs. 21%, P < 0.001). In particular, ethambutol was more frequently discontinued in daily therapy group than in intermittent therapy group (24% vs. 1%, P < 0.001). However, rates of symptomatic improvement, radiographic improvement, and sputum culture conversion were not different between two groups (daily therapy vs. intermittent therapy; 75% vs. 82%, P = 0.181; 68% vs. 73%, P = 0.402; 76% vs. 67%, P = 0.154; respectively). In addition, adjusted proportion of sputum culture conversion rates was similar between daily therapy group (71.3%, 95% confidence interval [CI] 59.1-81.1%) and intermittent therapy group (73.6%, 95% CI 62.9-82.2%, P = 0.785). Conclusions: These results suggested that intermittent three-times-weekly therapy with macrolide, rifampin, and ethambutol is a reasonableinitial treatment regimen to patients with non-cavitary nodular bronchiectatic MAC lung disease.
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Jeon Byeong Jun,Kang Ji Eun,Do Kim Jeong,Kim Beom Seok 한국응용생명화학회 2023 Applied Biological Chemistry (Appl Biol Chem) Vol.66 No.-
A natural product library consisting of the culture extracts of 814 actinomycete strains was screened for antifungal compounds that disrupt the cell integrity of plant pathogenic fungi using an adenylate kinase (AK) assay system. The culture extract of Streptomyces xanthocidicus strain S3 exhibited high AK activity against various plant pathogens. The active ingredients, AT-1 and AT-2, were isolated from the culture extract using a series of chromatographic procedures. Based on MS, UV, and NMR spectrometric analyses, the structures of AT-1 and AT-2 were determined as the pentaene macrolides, AB023a and takanawaene C. AB023a and takanawaene C displayed broad-spectrum antifungal activity against Aspergillus oryzae, Botrytis cinerea, Colletotrichum coccodes, C. gloeosporioides, C. orbiculare, Cylindrocarpon destructans, and Fusarium oxysporum f. sp. lycopersici, showing minimum inhibitory concentrations of 1–32 μg/mL. Treatment of AB023a and takanawaene C successfully inhibited anthracnose development on pepper plants in a concentration-dependent manner without phytotoxicity. The disease control efficacy of both compounds was comparable to that of the commercial fungicide chlorothalonil. Collectively, these results suggest that the polyene macrolides produced by S. xanthocidicus strain S3 can be used as natural fungicides for plant disease control.
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Effect of Blood Pressure on the Endothelium-Dependent Contraction in Rat Aorta
Jeon. Byeong-Hwa,Kim. Hoe-Suk,Kim. Se-Hoon,Chang. Seok-Jong 대한생리학회 1996 대한생리학회지 Vol.30 No.1
To investigate the mechanisms of increased endothelium-dependent contraction by acetylcholine in hypertensive rats, the relationship between endothelium-dependent contraction by acetylcholine and blood pressure was studied in spontaneously hypertensive rats (SHR), one-kidney, one clip Goldblatt hypertension (1K,1C-GBH) rats, and Wistar-Kyoto rats (WKY). SHR were treated orally with enalapril or nicardipine in order to prevent development of hypertension or suppress the developed hypertension. 1K,1C-GBH rats were made by renal artery stenosis with contralateral nephrectomy in 8 week-WKY. 1. Endothelium-dependent contractions by acetylcholine (10<sup>-6</sup> ~ 10<sup>-5</sup> M) in SHR were significantly greater than those in WKY. 2. Chronic treatment with enalapril or nicardipine reduced the endothelium-dependent contraction in SHR 3. The degree of reduction of endothelium-dependent contraction was greater in SHR which was prevented from developing hypertension than in SHR of which high blood pressure was suppressed. 4. In aortic rings from 1K,1C-GBH rats, endothelium-dependent contractions by acetylcholine were augmented as compared with WKY. 5. There is good relationship between the value of blood pressure and magnitude of endothelium-dependent contraction. Thus, it is suggested that increased endothelium-dependent contraction in hypertensive rats may he due to the high blood pressure and endothelium-dependent contraction may not be a cause of the initiation of hypertension in SHR.
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