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제갈덕주(Deok Ju Jegal) 언어과학회 2014 언어과학연구 Vol.0 No.69
The Purpose of this study is to examine the general structure of polysemy and facets. Polysemous words are understood that one lexeme has many sememe. But in recent years, A study about facets and multi-faceted words have been conducted by Cruse(1995), Lim Ji-Ryong(2011) etc. Lim Ji-Ryong(2011) argues that Korean words consist of 3 types. They are monosemous, polysemous, and faceted words. In this paper, I will also accept such an opinion. But I don`t agree that facets are a kind of a word type. I think that polysemy and facets are a kind of characters on a word. So In Jegal Deok-Ju(2013), I have argued that. And In this paper, I will examine the structure where polysemy and facts coexist. To achieve this, this study will be based on Ogden·Richards(1923).
Jegal, J. H.,Choi, G. H.,Lee, H. J.,Kim, K. D.,Lee, S. C. THE POLYMER SOCIETY OF KOREA 2016 Macromolecular Research Vol.24 No.1
<P>We describe a novel approach for surface engineering of titanium (Ti) with polymer nanoparticles that can sustainably release an osteogenic compound, simvastatin (SV). The SV-loaded nanoparticles (SV-GC-CA) were prepared by self-assembly of 5 beta-cholanic acid-conjugated glycol chitosan (GC-CA) in the presence of SV. Dynamic light scattering (DLS) and transmission electron microscopy (TEM) analyses showed that the SV-GC-CA nanoparticles had a hydrodynamic diameter of 371.4 nm with a spherical shape. The surface engineering of Ti was performed by pre-treatment of Ti surface with polydopamine (PD) coatings, followed by immobilization of the SV-GC-CA nanoparticles. The immobilization of the SV-GC-CA nanoparticles onto PD-treated Ti surfaces could be achieved by a simple dipping method in an aqueous solution. The successful immobilization of the SV-GC-CA nanoparticles onto Ti surfaces was confirmed by field-emission scanning electron microscopy (FE-SEM), and the density of immobilized nanoparticles could be controlled. SV was sustainably released for up to 20 days, and the release rate was dependent on the loading amount of SV. The Ti substrate functionalized with SV-releasing nanoparticles significantly promoted alkaline phosphatase (ALP) activity of osteoblast-like cells (MC3T3-E1). The surface engineering approach described in this work has an applicability for various medical devices to generate surfaces with improved osteogenic potentials.</P>
The Utility of a Three-Dimensional Approach with T-Shaped Osteotomy in Osseous Genioplasty
Jegal, Jung Jae,Kang, Seok Joo,Kim, Jin Woo,Sun, Hook Korean Society of Plastic and Reconstructive Surge 2013 Archives of Plastic Surgery Vol.40 No.4
Background Facial beauty depends on the form, proportion, and position of various units of the face. In terms of the frontal view and facial profile, the chin is the most prominent aesthetic element of the lower third of the face. Many methods have been implemented to obtain good proportions of the lower face. In this study, we applied the T-shaped genioplasty method to correcting chin deformities. Methods All of the procedures in 9 cases were performed under general anesthesia. For genioplasty, a horizontal cutting line and 1 or 2 vertical cutting lines were drawn 5 mm below the mental foramen. Osteotomed bone segments of the chin were used for horizontal widening using bone grafts or for horizontal shortening. Likewise, they were used as bone grafts for vertical lengthening or vertical shortening. The bone segments were approximated in the midline and held in place using miniplates. Results The postoperative appearance of the 9 cases showed that the lower third of the face had been naturally changed. At the same time, vertical lengthening or shortening, and horizontal widening or shortening could be implemented during the operation. Satisfactory results were obtained based on reviews of the patients' preoperative and postoperative photographs. The patients were also satisfied with the outcomes. Conclusions Using T-shaped genioplasty, we efficiently adjusted the shape and position of the chin to obtain good proportions of the lower face and change its contour to obtain an aesthetically appealing oval face in accordance with East Asians' aesthetic preferences.
Tyrosinase inhibitory flavonoid from <i>Juniperus communis</i> fruits
Jegal, Jonghwan,Park, Sang-a,Chung, KiWung,Chung, Hae Young,Lee, Jaewon,Jeong, Eun Ju,Kim, Ki Hyun,Yang, Min Hye Informa UK (TaylorFrancis) 2016 Bioscience, biotechnology, and biochemistry Vol.80 No.12
<P>The fruits of Juniperus communis have been traditionally used in the treatment of skin diseases. In our preliminary experiment, the MeOH extract of J. communis effectively suppressed mushroom tyrosinase activity. Three monoflavonoids and five biflavonoids were isolated from J. communis by bioassay-guided isolation and their inhibitory effect against tyrosinase was evaluated. According to the results of all isolates, hypolaetin 7-O--xylopyranoside isolated from J. communis exhibited most potent effect of decreasing mushroom tyrosinase activity with an IC50 value of 45.15M. Further study provided direct experimental evidence for hypolaetin 7-O--D-xylopyranoside-attenuated tyrosinase activity in -MSH-stimulated B16F10 murine melanoma cell. Hypolaetin 7-O--D-xylopyranoside from the EtOAc fraction of J. communis was also effective at suppressing -MSH-induced melanin synthesis. This is the first report of the enzyme tyrosinase inhibition by J. communis and its constituent. Therapeutic attempts with J. communis and its active component, hypolaetin 7-O--D-xylopyranoside, might be useful in treating melanin pigmentary disorders.</P>
Jegal, K.H.,Park, S.M.,Cho, S.S.,Byun, S.H.,Ku, S.K.,Kim, S.C.,Ki, S.H.,Cho, I.J. Elsevier Biomedical Press 2017 Biochimica et biophysica acta, Molecular cell rese Vol.1864 No.7
Endoplasmic reticulum (ER) stress is characterized by an accumulation of misfolded proteins, and ER stress reduction is essential for maintaining tissue homeostasis. However, the molecular mechanisms that protect cells from ER stress are not completely understood. The present study investigated the role of sestrin 2 (SESN2) on ER stress and sought to elucidate the mechanism responsible for the hepatoprotective effect of SESN2 in vitro and in vivo. Treatment with tunicamycin (Tm) increased SESN2 protein and mRNA levels and reporter gene activity. Activating transcription factor 6 (ATF6) bound to unfolded protein response elements of SESN2 promoter, transactivated SESN2, and increased SESN2 protein expression. In addition, dominant negative mutant of ATF6α and siRNA against ATF6α blocked the ER stress-mediated SESN2 induction, whereas chemical inhibition of PERK or IRE1 did not affect SESN2 induction by Tm. Ectopic expression of SESN2 in HepG2 cells inhibited CHOP and GRP78 expressions by Tm. Moreover, SESN2 decreased the phosphorylations of JNK and p38 and PARP cleavage, and blocked the cytotoxic effect of excessive ER stress. In a Tm-induced liver injury model, adenoviral delivery of SESN2 in mice decreased serum ALT, AST and LDH activities and the mRNA levels of CHOP and GRP78 in hepatic tissues. Moreover, SESN2 reduced numbers of degenerating hepatocytes, and inhibited caspase 3 and PARP cleavages. These results suggest ATF6 is essential for ER stress-mediated SESN2 induction, and that SESN2 acts as a feedback regulator to protect liver from excess ER stress.