Salicylamide의 腸管吸收에 관한 硏究

李琬夏,智雄吉,咸光洙 成均館大學校 1982 論文集 Vol.31 No.-

The absorption of salicylamide from the everted intestine of a rabbit in combination with ephedrine, and salicylamide alone and chlropheniramine, was examined. This examination was taken to method of cannulated everted sac technique and used to the Crane and Wilson appartus. The results were as follows: 1. The absorption of salicylamide in the everted intestine were incresed by the compound of ephedrine. 2. Also, the compound of chlorpheniramine was increased to the absorption of salicylamide. 3. Moreover, the compounds of chlorpheniramine and ephedrine were increased to the absorption of salicylamide. 4. In the region of intestine, the absorption of salicylamide showed most increased absorption in the middle region of intestine. 5. The intestinal transfer rate of salicylamide was 2.29 and the intestinal transfer rate of salicylamide of compound with chlorpheniramine and ephedrine was 3.42.

공격성 비호지킨 림프종의 예후인자로서의 혈청 LDH

어완규,이지현,김종철 고신대학교 의학부 2004 高神大學校 醫學部 論文集 Vol.19 No.1

Introduction: The purpose of this study was to find prognostic factors influencing overall survival in patients with aggressive non-Hodgkin's lymphoma. Methods: Eighty eight patients, all diagnosed with aggressive lymphoma and treated with conventional chemotherapy, were registered in the section of hematology/medical oncology. Gospel Hospital. Busan. Korea. We analyzed the response rate and survival time by the pre-treatment several variables including age, serum LDH, performance state, number of extranodal site, stage, B-symptom, bone marrow involvement, international prognostic index (IPI), and serum beta2-microglobulin (B2M) to identify the prognostic variables in the patients. Results: The median age was 53 years. Forty-five (56.9%) patients achieved complete response, and 26 (32.9%) achieved partial response to conventional chemotherapy. Of the variables serum LDH, performance status, extranodal involvement, stage, IPI, and serum B2M were predictive of complete response (P=0.000, 0.005, 0.022, 0.002, 0.000, 0.035, respectively). Estimated overall survival at 5 years was 56.5%. By univariate analysis, 6 variables significantly influenced overall survival: serum LDH, performance status, stage, serum B2M, IPI, and response to chemotherapy (P=0.0005, 0.0022, 0.0022, 0.0161, 0.0131, 0.0000, respectively). By multivariate analysis only serum LDH was the significant variable(P=0.001). Conclusion: Serum LDH appears to be a useful marker for predicting survival in patients with aggressive non-Hodgkin's lymphoma treated with conventional chemotherapy.

Thiamine 誘導體의 摘出腸管에의 吸收에 관하여

李琬夏,柳柄泰,智雄吉,朴大圭 成均館大學校 1980 論文集 Vol.27 No.-

Thiamine-HCI, Thiamine Propyl Disulfide (TPD) and Thiamine Tetrahydrofur furyl Disulfide (TTFD) were studied to stability in artifcial gastric juice and artificial pancreatic juice. And in the in vitro isolated intestine of rabbit, absorption rate of this compounds were examined. The results were as follows. 1. The stability of this compounds in artificial gastric juice and artificial panereatic juice were stable. 2. In the in vitro isolated intestine of rabbit, absorption rate of TPD was increased than that of thiamine-HCI about 20% after 120 minutes. And absorption rate of TTFD was much the same in the case of thiamine-HCI.

무손실 공진기를 이용한 병렬형 능동전력필터의 Digital 제어

박지호,김동완,배종일,우정인 동아대학교 정보기술연구소 2000 情報通信硏究所論文誌 Vol.8 No.1

In this paper, a new simple control method for active power filter which can realized the complete compensation of the harmonic currents is proposed. In the proposed scheme, a compensating current reference generator employing lossless resonator implemented by a DSP(Digital Signal Processor) is introduced. Deadbeat control is employed to control the active power filter. The switching pulse width based SVM(Space Vector Modulation) is adopted so that the current of active power filter is been exactly equal to its reference at the next sampling instant. To compensate the computation delay of digital controller, the prediction of current is achieved by the current observer with deadbeat response.

대장통과시간 측정용 방사선 비투과성 표지자인 KolomarkTM의 국내 개발

김지은,이풍렬,김영호,성인경,심상군,김재준,고광철,최규완,임효근,서수원 대한소화관운동학회 1999 Journal of Neurogastroenterology and Motility (JNM Vol.5 No.2

Indoprofen 및 Indoprofen Lysinate와 Human Serum Albumin의 結合에 관한 硏究

李琬夏,柳柄泰,智雄吉,金東吉 成均館大學校 科學技術硏究所 1984 論文集 Vol.35 No.1

Indoprofen, 4- (1, 3-dihydro-1-oxo-2H-isoindol-2-yl)-α-methylbenzene acetic acid, has many advantages over the other antiinflammatory drugs, such as salicylates, naproxen. Although indoprofen is widely used as an antiinflammatory agent, it shows poor solubility in water. In order to inhance water solubility, indoprofen was made as lysine salt. The purpose of this study was to inspect the binding of the 1-anilinonaphthalene-8-sulfonatc(ANS) to human serum albumin (HSA) and to be to comparative studies on indoprofen lysinate and indoprofen in aspect of the binding to HSA and the number of binding sites was obtained using a fluorescent probe technique. The numbers of binding sites for indoprofen and indoprofen lysinate appear to be 3.35, 3.4, respectively and the association constants were found as follows; HSA-Indoprofen. ; K_b1 = 6.62 × 10 exp(5), K_b2 = 5.44 × 10 exp(4) HSA-Indoprofen lysinate ; K_b1 = 2.32 × 10 exp(5), K_b2 = 5.03 × 10 exp(4)

파라메타 변동에 강인한 유도전동기의 센서리스 벡터제어

우정인,김동완,김춘삼,박지호 東亞大學校 大學院 1999 大學院論文集 Vol.24 No.-

본 논문에서는 파라메타의 변동에 기인한 유도전동기의 성능저하를 개선하기 위한 강인한 센서리스 벡터제어를 제안한다. 동일차원 상태관측기를 구성하여 고정자전류와 회전자자속을 추정하고, 추정된 고정자전류와 회전자자속을 이용하여 속도 동정기를 구성한 후 회전자의 속도를 추정하여 Deadbeat 전류제어를 수행한다. 또한, 회전자속도의 추정에서 고정자전류 오차는 가변극배치 동일차원 상태관측기에 의해서 보상되며, 회전자자속 오차는 고정자전류를 입력으로 하고 회전자자속을 출력으로 하는 모델을 설정하여 이 모델에 파라메타 변동에 강인한 슬라이딩 관측기로 구성된 회전자자속 관측기를 부가한다. 이 회전자자속 관측기에서 회전자자속의 지령치와 추정값 사이의 오차를 보상하므로써 속도 동정기에 강인성을 부여하고, 정확한 Deadbeat 전류제어의 상태예측을 수행한다.

비열처리형 쾌삭 알루미늄 합금의 조직과 절삭성에 관한 연구

韓允熙,金元哲,池泰求 弘益大學校 1989 弘大論叢 Vol.21 No.2

In order develop the free cutting alloys of Al-Cu-Mn-Fe-Sn-Bi-Pb and Al-Mg-Si groups. Various studies were carried out by changing the mold temperature(I/M alloy). We confirmed the possibility of manufacturing a free cutting Aluminium alloy by mechanical alloying method(P/M alloy) and the results shown below were obtained. 1. Microstructure of I/M alloys are highly dependent on the cooling velosity of melt and agitating the molten metal. Therefore, it is necessary that melts should be rapidly solidified and agitated. 2. The machinability and chip-treatability of rapidly solidified alloys by melt-agitated(I/M alloy) and mechanical alloying products(P/M alloy) were improved most. 3. Serve working of M/A products(P/M) produced a very fine grain size and substructural strengthening(high dislocation density and fine sub-grain size). The dispersoid particles, and Intermetallic compound(Mg??Si, Al??Mn, Al??Cu etc) were spherical and much finer than those obtained by conventional casting.

세팔로스포린 3′-퀴놀론의 물리화학적 성질, 안정성 및 체내약물동태

나성범,공재양,김완주,지웅길 충남대학교 약학대학 의약품개발연구소 1993 藥學論文集 Vol.9 No.-

A cephalosporin with an aminothiazolylmethoxyimino-type side chain at the 7 position and bicyclic quinolone dithicarbamate at the 3' position was synthesized. It has broad and potent antivacterial activity in vitro. The antibacterial spectrum reflects contributions of both the cephalosporin moiety and the quinolone moiety. Thus, this compound was named DACD implying a dual-action cephalosporin derivative. In this paper, the physicochemical properties (lipid-water partition, pKa), stability and pharmacokinetics of DACD were determined and compared with cefotaxime 3'-norfloxacin dithiocarbamate (CENO). Stability tests were studied in pH 1.20, 6.80 and 8.00 buffers and in the presence of AB type human plasma, rat liver homogenate and its β-lactamase. The pharmacokinetic paramaters of DACD were evaluated in mice after a single intravenous dose of 40 ㎎/㎏. The results are as follows. The lipid-water partition coefficient of DACD was higher than that of CENO. The calculated pKa values of CENO and DACD, were 6.82±0.03, 7.53±0.21, respectively. In the hydrolysis test, half-lives (t^1/2) of CENO and DACD was 66.0 hr and 80.0 hr in pH 6.80 buffer, 190 hr and 91.4 hr in pH 8.00 buffer. CENO and DACD were rapidly hydrolyzed in human plasma and in rat liver homogenate. Half-lives (t_1/2) of CENO and DACD were 1.29 hr and 1.15 hr in human plasma, 0.62 hr and 0.71 hr rat liver homogenate. In β-lactamase stability test, CENO and DACD were very stable to the β-lactamase obtained from three different strains. Half-life (t_1/2) and areas under the curve (AUC) in mice were 2.33 hr and 15.97 (㎎·h/I), respectively.

세팔로스포린 3′-퀴놀론의 합성 및 항균작용

나성범,정명희,김완주,지웅길 충남대학교 약학대학 의약품개발연구소 1993 藥學論文集 Vol.9 No.-

To a suspension of 1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-{3,7-diazabicyclo[3.3.0]oct-1(5)-en-3-yl}-4-oxo-3-quinoline carboxylic acid(C1) in sodium hydroxide solution and water is added dropwise with stirring carbon disulfide. [6R][6α, 7β(Z)]]-7-[[[(2-Amino-4-thiazoly)methoxyimino]-acetyl]amino]-3-[[[[7-(3-carboxy-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-7-guinolonyl)-3,7-diazabicyclo[3.3.0 ]act-1(5)-en-3-yl]thioxomethyl]thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-carboxylic acid (DACD) was synthesized from 1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-[7-(mercapto)thioxomethyl-{3,7-diazabicyclo[3.3.0]oct-1(5)-en-3-yl}]-4-oxo-3-quinoline carboxylic acid disodium salt(C2) and cefotaxime. The in vitro activity of novel dual-action cephalosporin, DACD, was compared with the in vitro activities of CENO(cefotaxime 3'-norfloxacin dithiocarbamate), cefotaxime, and norfloxacin against a variety of bacterial species. In vitro activity of DACD was superior to that of norfloxacin against Streptococcus pyogenes. Against Gram-positive and Gram-negative bacteria, its activity was almost equal to that of CENO.