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방울토마토중 Dichlofluanid 및 Iprodione의 생산단계별 잔류농약 경시변화
최규일,성기용,정태균,이주환,허장현,고광용,이규승 한국환경농학회 2002 한국환경농학회지 Vol.21 No.4
방울토마토의 생산단계에서의 잔류허용기준 설정과 수확후 저장기간중 경시변화 및 세척에 의한 잔류농약의 감소양상을 파악하였다. 해당약제를 안전사용기준의 기준량 및 배량을 각각 시설재배 포장에서 살포후 10일간 잔류양상을 조사하였고, 실온 및 냉장조건 하에서의 저장실험 및 세척에 따른 전류농약의 잔소량을 파악하여 생산단계부터, 출하, 저장, 소비단계까지의 잔류량을 예측할 수 있는 모델개발을 위한 자료로 이용하고자 연구를 수행하였다. Dichlofluanid와 iprodione은 포장조건에서 반감일수가 기준량 2.2, 3.3일 이었으며, 배량은 3.5, 5.4일로 나타났다. 저장조건하에서의 약제별 반감기는 포장조건보다 잔류량의 감소속도가 느린 것으로 나타나 반감일수가 증가하였고, 세척방법에 의한 잔류농약의 감소량을 조사한 결과 세제 사용시의 평균제거율은 dichlofluanid는 73.7%, iprodione은 64.3%로 나타났고, tap-water 사용시에는 dichlofluanid 73.5%, iprodione 63.5%로 나타났다. 이러한 결과는 작물의 생산단계에서 구한 합리적인 희귀식을 이용하여 잔류농약의 경시변화를 파악하고, 저장 및 세척과정을 거쳐 최종 소비단계에서의 잔류농약의 수준을 평가할 수 있었다. We studied the residual patterns of two fungicides, dichlofluanid and iprodione, in cherry tomato greenhouse after applying with the recommended and double dose. Also, the degradation patterns during storage periods of up to ten days were compared between at room temperature (20℃) and at cold temperature (4℃). Removal rates of fungicides by washing with tap-water and detergent solution (0.1%, 0.2%) were measured. Half-lives of dichlofluanid and iprodione in greenhouse cherrytomato were 2.2~3.5 and 3.3~5.4 days, respectively. During the storage period, the residues were dissipated more slow. Removal rates were 62.8~80.3% by tap-water, 60.4~83.1% by 0.1% detergent solution, and 65.3~77.6% by 0.2% detergent solution. So, we can predict of terminal residues from cultivation period to marketing, storage and consuming.
최장균(Jang Gyun Choi),윤석암(Suk Am Yoon),강병복(Byeong Bog Gang),이정일(Zeng.Ri Lee),조경재(Kyeng Jai Cho),차인수(In Su Cha) 전력전자학회 2002 전력전자학술대회 논문집 Vol.- No.-
In electrical machinery and apparatus, the most important problem is protect of machinery and apparatus m due to transient phenomena and overload on operation.<br/> Particularly by advanced technology of late, there is demand for low cost of equipments and hi percentage of use of equipments.<br/> Therefore, protection of machinery and apparatus in condition of overload is more valued considering that all efficiency increase is passed by operating all machinery and apparatus in condition of heavyload In tills paper, the suggested system is added overload interrupt system using CT m condition of overload.
Analysis of Process Parameters to Improve On-Chip Linewidth Variation
Jang, Yun-Kyeong,Lee, Doo-Youl,Lee, Sung-Woo,Lee, Eun-Mi,Choi, Soo-Han,Kang, Yool,Yeo, Gi-Sung,Woo, Sang-Gyun,Cho, Han-Ku,Park, Jong-Rak The Institute of Electronics and Information Engin 2004 Journal of semiconductor technology and science Vol.4 No.2
The influencing factors on the OPC (optical proximity correction) results are quantitatively analyzed using OPCed L/S patterns. ${\sigma}$ values of proximity variations are measured to be 9.3 nm and 15.2 nm for PR-A and PR-B, respectively. The effect of post exposure bake condition is assessed. 16.2 nm and 13.8 nm of variations are observed. Proximity variations of 11.6 nm and 15.2 nm are measured by changing the illumination condition. In order not to seriously deteriorate the OPC, these factors should be fixed after the OPC rules are extracted. Proximity variations of 11.4, 13.9, and 15.2 nm are observed for the mask mean-to-targets of 0, 2 and 4 nm, respectively. The decrease the OPC grid size from 1 nm to 0.5 nm enhances the correction resolution and the OCV is reduced from 14.6 nm to 11.4 nm. The enhancement amount of proximity variations are 9.2 nm corresponding to 39% improvement. The critical dimension (CD) uniformity improvement for adopting the small grid size is confirmed by measuring the CD uniformity on real SRAM pattern. CD uniformities are measured 9.9 nm and 8.7 nm for grid size of 1 nm and 0.5 nm, respectively. 22% improvement of the CD uniformity is achieved. The decrease of OPC grid size is shown to improve not only the proximity correction, but also the uniformity.
Antinociceptive Effect of Cyperi rhizoma and Corydalis tuber Extracts on Neuropathic Pain in Rats
Choi, Jae-Gyun,Kang, Suk-Yun,Kim, Jae-Min,Roh, Dae-Hyun,Yoon, Seo-Yeon,Park, Jin Bong,Lee, Jang-Hern,Kim, Hyun-Woo The Korean Society of Pharmacology 2012 The Korean Journal of Physiology & Pharmacology Vol.16 No.6
In this study, we examined the antinociceptive effect of Cyperi rhizoma (CR) and Corydalis tuber (CT) extracts using a chronic constriction injury-induced neuropathic pain rat model. After the ligation of sciatic nerve, neuropathic pain behavior such as mechanical allodynia and thermal hyperalgesia were rapidly induced and maintained for 1 month. Repeated treatment of CR or CT (per oral, 10 or 30 mg/kg, twice a day) was performed either in induction (day 0~5) or maintenance (day 14~19) period of neuropathic pain state. Treatment of CR or CT at doses of 30 mg/kg in the induction and maintenance periods significantly decreased the nerve injury-induced mechanical allodynia. In addition, CR and CT at doses of 10 or 30 mg/kg alleviated thermal heat hyperalgesia when they were treated in the maintenance period. Finally, CR or CT (30 mg/kg) treated during the induction period remarkably reduced the nerve injury-induced phosphorylation of NMDA receptor NR1 subunit (pNR1) in the spinal dorsal horn. Results of this study suggest that extracts from CR and CT may be useful to alleviate neuropathic pain.
First Imported Case of Zika Virus Infection into Korea
Jang, Hee-Chang,Park, Wan Beom,Kim, Uh Jin,Chun, June Young,Choi, Su-Jin,Choe, Pyoeng Gyun,Jung, Sook-In,Jee, Youngmee,Kim, Nam-Joong,Choi, Eun Hwa,Oh, Myoung-don The Korean Academy of Medical Sciences 2016 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.31 No.7
<P>Since Zika virus has been spreading rapidly in the Americas from 2015, the outbreak of Zika virus infection becomes a global health emergency because it can cause neurological complications and adverse fetal outcome including microcephaly. Here, we report clinical manifestations and virus isolation findings from a case of Zika virus infection imported from Brazil. The patient, 43-year-old Korean man, developed fever, myalgia, eyeball pain, and maculopapular rash, but not neurological manifestations. Zika virus was isolated from his semen, and reverse-transcriptase PCR was positive for the virus in the blood, urine, and saliva on the 7th day of the illness but was negative on the 21st day. He recovered spontaneously without any neurological complications. He is the first case of Zika virus infection in Korea imported from Brazil.</P>
Jang, Jiryeon,Rath, Oliver,Schueler, Julia,Sung, Hyun Hwan,Jeon, Hwang Gyun,Jeong, Byong Chang,Seo, Seong Il,Jeon, Seong Soo,Lee, Hyun Moo,Choi, Han-Yong,Kwon, Ghee-Young,Park, Woong Yang,Lee, Jeeyun Neoplasia Press 2017 Translational oncology Vol.10 No.3
<P><I>PURPOSE:</I> Although targeting angiogenesis with tyrosine kinase inhibitors (TKIs) has become standard of care in the treatment of clear cell renal cell carcinoma (RCC), resistance mechanism are not fully understood, and there is a need to develop new therapeutic options overcoming them. <I>METHODS AND MATERIALS:</I> To develop a preclinical model that predicts clinical activity of novel agents in 19 RCC patients, we established patient-derived cell (PDC) and xenograft (PDX) models derived from malignant effusions or surgical specimen. RESULTS: Successful PDCs, defined as cells that maintained growth following two passages, were established in 5 of 15 malignant effusions and 1 of 4 surgical specimens. One PDC, clinically refractory to TKIs, was implanted and engrafted in mice, resulting in a comparable histology to the primary tumor. The PDC-PDX model also showed similar genomic features when tested using targeted sequencing of cancer-related genes. When we examined the drug effects of the PDX model, the tumor cells showed resistance to TKIs and everolimus <I>in vitro</I>. <I>CONCLUSION:</I> The results suggest that the PDC-PDX preclinical model we developed using malignant effusions can be a useful preclinical model to interrogate sensitivity to targeted agents based on genomic alterations.</P>
FAULT DETECTION COVERAGE QUANTIFICATION OF AUTOMATIC TEST FUNCTIONS OF DIGITAL I&C SYSTEM IN NPPS
Choi, Jong-Gyun,Lee, Seung-Jun,Kang, Hyun-Gook,Hur, Seop,Lee, Young-Jun,Jang, Seung-Cheol Korean Nuclear Society 2012 Nuclear Engineering and Technology Vol.44 No.4
Analog instrument and control systems in nuclear power plants have recently been replaced with digital systems for safer and more efficient operation. Digital instrument and control systems have adopted various fault-tolerant techniques that help the system correctly and safely perform the specific required functions regardless of the presence of faults. Each fault-tolerant technique has a different inspection period, from real-time monitoring to monthly testing. The range covered by each faulttolerant technique is also different. The digital instrument and control system, therefore, adopts multiple barriers consisting of various fault-tolerant techniques to increase the total fault detection coverage. Even though these fault-tolerant techniques are adopted to ensure and improve the safety of a system, their effects on the system safety have not yet been properly considered in most probabilistic safety analysis models. Therefore, it is necessary to develop an evaluation method that can describe these features of digital instrument and control systems. Several issues must be considered in the fault coverage estimation of a digital instrument and control system, and two of these are addressed in this work. The first is to quantify the fault coverage of each fault-tolerant technique implemented in the system, and the second is to exclude the duplicated effect of fault-tolerant techniques implemented simultaneously at each level of the system's hierarchy, as a fault occurring in a system might be detected by one or more fault-tolerant techniques. For this work, a fault injection experiment was used to obtain the exact relations between faults and multiple barriers of faulttolerant techniques. This experiment was applied to a bistable processor of a reactor protection system.