Quantification of Intratumoral Metabolic Macroheterogeneity on 18F-FDG PET/CT and Its Prognostic Significance in Pathologic N0 Squamous Cell Lung Carcinoma

Kim, Do-Hoon,Jung, Ji-hoon,Son, Seung Hyun,Kim, Choon-Young,Jeong, Shin Young,Lee, Sang-Woo,Lee, Jaetae,Ahn, Byeong-Cheol Wolters Kluwer Health, Inc. All rights reserved. 2016 Clinical nuclear medicine Vol.41 No.2

<P>Purpose: This study aimed to develop a novel quantification method for intratumoral metabolic macroheterogeneity (IMMH) on F-18-FDG PET/CT and evaluate its prognostic significance in pathologic N0 (pN0) squamous cell lung carcinoma (SQCLC) patients. Patients and Methods: A total of 83 patients who underwent pretreatment F-18-FDG PET/CT and were diagnosed with pN0 SQCLC after curative surgery were examined. Patients with tumor measuring greater than 2 cm were included. Metabolic parameters (SUVmax, metabolic tumor volume, and total lesion glycolysis) for the primary lesions were calculated on the F-18-FDG PET/CT, and IMMH was quantified as the macroheterogeneity factor (MHF), defined as surface/spherical surface area having volume of the primary tumor multiplied by the sphericity. Heterogeneity of the primary tumor was also visually assessed (visual heterogeneity score) and compared with MHF. Univariate and multivariate analyses for recurrence were performed using the Cox proportional hazards regression. Results: Recurrence was observed in 27 (32.5%) of 83 patients during follow-up period (37.6 +/- 25.5 months). Significant correlations were observed between the visual heterogeneity score and the MHF (R = 0.534, P < 0.001). Macroheterogeneity factor was significantly higher in patients who experienced recurrence (median, 1.073 vs 1.016; P = 0.004). Univariate analysis showed that MHF was only significant prognostic factor for recurrence (P = 0.019), and multivariate analysis after adjusting for age, sex, tumor size, histologic grade, and pathologic T stage, high MHF exhibited an association with increased risk of recurrence. Conclusions: New quantification method for IMMH on F-18-FDG PET/CT was developed, and the heterogeneity parameter MHF was well correlated with visual heterogeneity. Macroheterogeneity factor on pretreatment F-18-FDG PET/CT was the sole prognostic factor predicting recurrence in pN0 SQCLC patients.</P>

Identification of a novel nonsynonymous mutation of EYA1 disrupting splice site in a Korean patient with BOR syndrome

Kim, Hui Ram,Song, Mee Hyun,Kim, Min-A,Kim, Ye-Ri,Lee, Kyu-Yup,Sonn, Jong Kyung,Lee, Jaetae,Choi, Jae Young,Kim, Un-Kyung Springer-Verlag 2014 MOLECULAR BIOLOGY REPORTS Vol.41 No.7

Brazilin Isolated from Caesalpinia sappan suppresses nuclear envelope reassembly by inhibiting barrier-to-autointegration factor phosphorylation.

Kim, Seong-Hoon,Lyu, Ha-Na,Kim, Ye Seul,Jeon, Yong Hyun,Kim, Wanil,Kim, Sangjune,Lim, Jong-Kwan,Lee, Ho Won,Baek, Nam-In,Choi, Kwan-Yong,Lee, Jaetae,Kim, Kyong-Tai American Society for Pharmacology and Experimental 2015 The Journal of Pharmacology and Experimental Thera Vol.352 No.1

<P>To date, many anticancer drugs have been developed by directly or indirectly targeting microtubules, which are involved in cell division. Although this approach has yielded many anticancer drugs, these drugs produce undesirable side effects. An alternative strategy is needed, and targeting mitotic exit may be one alternative approach. Localization of phosphorylated barrier-to-autointegration factor (BAF) to the chromosomal core region is essential for nuclear envelope compartment relocalization. In this study, we isolated brazilin from Caesalpinia sappan Leguminosae and demonstrated that it inhibited BAF phosphorylation in vitro and in vivo. Moreover, we demonstrated direct binding between brazilin and BAF. The inhibition of BAF phosphorylation induced abnormal nuclear envelope reassembly and cell death, indicating that perturbation of nuclear envelope reassembly could be a novel approach to anticancer therapy. We propose that brazilin isolated from C. sappan may be a new anticancer drug candidate that induces cell death by inhibiting vaccinia-related kinase 1-mediated BAF phosphorylation.</P>

손해사정회사 종업원의 직장만족 결정요인 연구

Kim, Jaetae,Yoo, kyungjin,Choi, Youngjin,Kim, Jongwon 한국재난정보학회 2015 한국재난정보학회 논문집 Vol.11 No.2

태풍 등 재난발생 시에 손해액을 평가하는 손해사정회사 종업원들의 직장만족은 손해평가업무에 영향을 미치며 종국적으로는 피해자의 보상만족에 영향에 미치게 된다. 따라서 종업원의 직장만족은 재난피해자의 보상만족에 영향을 미치는 요인 중 하나이다. 본 연구는 손해사정회사 종업원의 직장만족 결정요인에 대한 실증연구로 연구결과는 종업원들의 심리차원의 요인, 조직차원의 요인 및 개인차원의 요인이 종업원들의 직장만족에 통계적으로 유의하게 영향을 미치는 것으로 나타났다. 그중에서 심리차원의 요인이 가장 크게 영향을 미치고, 다음으로 조직차원의 요인과 개인차원의 요인이 비슷한 크기로 영향을 미치는 것으로 나타났다. 인지차원의 요인은 종업원의 직장만족에 통계적으로 유의하지 않은 것으로 나타났다. 손해사정회사들은 종업원직장만족의 향상을 위하여 이러한 연구결과를 활용할 수 있을 것이다. Employee's workplace satisfaction of claim adjusting company, who assesses the loss of catastrophe, have a direct influence on the loss evaluation job. Eventually their satisfaction would affect the compensation satisfaction of victims, therefore it is one of important factors for victims's compensation satisfaction. This paper analyzes empirically the determinants of employee's satisfaction to their firm for a claim adjusting company. As a result of the empirical research, it is found that the statistically significant determinant are the psychological factor, the organizational factor, and the individual factor. Among the significant factors, the psychological factor has the biggest positive factor. And the organizational factor and the individual factor is next with similar positive measurement. But the cognitive factor is not statistically significant. A claim adjusting company may use the research result for the improvement of employee's workplace satisfaction.

Prognostic Significance of Intratumoral Metabolic Heterogeneity on 18F-FDG PET/CT in Pathological N0 Non–Small Cell Lung Cancer

Kim, Do-Hoon,Jung, Ji-hoon,Son, Seung Hyun,Kim, Choon-Young,Hong, Chae Moon,Oh, Jong-Ryool,Jeong, Shin Young,Lee, Sang-Woo,Lee, Jaetae,Ahn, Byeong-Cheol Lippincott 2015 Clinical nuclear medicine Vol.40 No.9

PURPOSE: The aim of the study was to evaluate the prognostic significance of intratumoral metabolic heterogeneity on pretreatment F-FDG PET/CT in patients with lung cancer who were pathologically N0 (pN0) after curative surgical resection. METHODS: We examined 119 patients (M/F = 79/40; mean age, 64.6 ± 9.0 years) who had undergone pretreatment F-FDG PET/CT and were diagnosed as pN0 after curative surgery for adenocarcinoma (ADC; n = 67) or squamous cell carcinoma (SQCC; n = 52). Heterogeneity factor (HF) and other metabolic parameters (SUVmax, metabolic tumor volume [MTV] and total lesion glycolysis [TLG]) for the primary lesions were measured, and the results were analyzed for recurrence. The HF, defined as the derivative of the volume-threshold function from 20% to 80%, was computed for primary lesions. Univariate and multivariate analyses for recurrence were performed using the Kaplan-Meier method and using the Cox proportional hazards model. RESULTS: SUVmax, MTV, TLG, and HF were statistically different between patients with ADC and SQCC. Forty-one (34.5%) of 119 patients experienced recurrence (ADC, 25/67 = 37.3% vs. SQCC, 16/52 = 30.8%). Results of univariate analysis indicate that SUVmax, MTV, TLG, and HF in ADC and TLG and HF in SQCC were predictors for recurrence. After adjusting for sex, age, and histological grade in multivariate analysis, high SUVmax, MTV, TLG, and HF in ADC exhibited an association with increased risk of recurrence. CONCLUSIONS: Metabolic parameters and heterogeneity of primary tumor on pretreatment F-FDG PET/CT can predict recurrence in pN0 NSCLC patients of ADC type who have undergone curative surgery but not in patients of SQCC type.

Prediction for Recurrence Using F-18 FDG PET/CT in Pathologic N0 Lung Adenocarcinoma After Curative Surgery

Kim, Do-Hoon,Son, Seung Hyun,Kim, Choon-Young,Hong, Chae Moon,Oh, Jong-Ryool,Song, Bong-Il,Kim, Hae Won,Jeong, Shin Young,Lee, Sang-Woo,Lee, Jaetae,Ahn, Byeong-Cheol Springer - Society of Surgical Oncology 2014 Annals of Surgical Oncology Vol.21 No.2

손해사정회사 종업원의 직장만족 결정요인 연구

Jaetae Kim,kyungjin Yoo,Youngjin Choi,Jongwon Kim 한국재난정보학회 2015 한국재난정보학회 논문집 Vol.11 No.2

태풍 등 재난발생 시에 손해액을 평가하는 손해사정회사 종업원들의 직장만족은 손해평가 업무에 영향을 미치며 종국적으로는 피해자의 보상만족에 영향에 미치게 된다. 따라서 종 업원의 직장만족은 재난피해자의 보상만족에 영향을 미치는 요인 중 하나이다. 본 연구는 손해사정회사 종업원의 직장만족 결정요인에 대한 실증연구로 연구결과는 종 업원들의 심리차원의 요인, 조직차원의 요인 및 개인차원의 요인이 종업원들의 직장만족에 통계적으로 유의하게 영향을 미치는 것으로 나타났다. 그중에서 심리차원의 요인이 가장 크게 영향을 미치고, 다음으로 조직차원의 요인과 개인차원의 요인이 비슷한 크기로 영향 을 미치는 것으로 나타났다. 인지차원의 요인은 종업원의 직장만족에 통계적으로 유의하지 않은 것으로 나타났다. 손해사정회사들은 종업원직장만족의 향상을 위하여 이러한 연구결 과를 활용할 수 있을 것이다. Employee’s workplace satisfaction of claim adjusting company, who assesses the loss of catastrophe, have a direct influence on the loss evaluation job. Eventually their satisfaction would affect the compensation satisfaction of victims, therefore it is one of important factors for victims’s compensation satisfaction. This paper analyzes empirically the determinants of employee‘s satisfaction to their firm for a claim adjusting company. As a result of the empirical research, it is found that the statistically significant determinant are the psychological factor, the organizational factor, and the individual factor. Among the significant factors, the psychological factor has the biggest positive factor. And the organizational factor and the individual factor is next with similar positive measurement. But the cognitive factor is not statistically significant. A claim adjusting company may use the research result for the improvement of employee’s workplace satisfaction.

Difference of clinical and radiological characteristics according to radioiodine avidity in pulmonary metastases of differentiated thyroid cancer.

Kim, Do-Hoon,Jung, Ji-Hoon,Son, Seung Hyun,Kim, Choon-Young,Hong, Chae Moon,Jeong, Shin Young,Lee, Sang-Woo,Lee, Jaetae,Ahn, Byeong-Cheol 大韓核醫學會 2014 핵의학 분자영상 Vol.48 No.1

<P>To evaluate differences in clinical, radiological and laboratory findings between pulmonary metastasis with and without radioiodine avidity in thyroidectomized differentiated thyroid cancer (DTC) patients with pulmonary metastasis who underwent high-dose I-131 treatment.</P>

부동산 중개사무소 서비스가 고객그룹별 신뢰에 미치는 영향 연구

김재태(Jaetae Kim),설영미(Yeongmi Seul),김종원(Jongwon Kim) 한국콘텐츠학회 2014 한국콘텐츠학회논문지 Vol.14 No.12

본 연구는 부동산 중개소가 제공하는 서비스요인인 물리적시설, 고객지향성, 정보제공, 유대 등 4개 요인이 고객의 부동산 중개소 대한 신뢰에 미치는 영향을 연구하였다. 연구결과는 연구대상 전체 고객집단, 남녀별 그룹 및 연령대별 그룹 등 총 7개 고객 그룹 모두에서 부동산 중개소가 제공하는 유대 서비스 요인이 고객에 부동산 중개소에 가지는 신뢰에 통계적으로 유의하게 영향을 미치고 그 영향도가 가장 큰 것으로 나타났다. 기타 서비스 요인은 고객유형별로 차이를 보였다. 이렇게 유대가 부동산 중개소에 대한 신뢰에 중요하게 영향을 미치는 이유는 부동산의 매매 또는 임대가 거래금액규모가 크고, 고객의 자산에 매우 중요하며, 법적으로 복잡하고 어려운 사항이 관련되고, 그리고 거래의 영향이 장기에 미침으로 인하여 의사결정이 어려워서 고객은 여러 서비스 요인 중 유대를 바탕으로 부동산 중개소를 찾고 있기 때문으로 생각된다. 따라서 부동산 중개소는 고객의 신뢰를 확보하기 위여 유대를 강화할 수 있는 친절과 예의, 편안함 향상 등 유대중심의 고객 마케팅을 중점적으로 추진하고, 기타 서비스요인은 고객그룹유형에 따라 적절하게 보완적으로 추진하는 것이 바람직할 것으로 생각된다. This research analyzes the effect of the service factors(bonds with customers, customer orientation, information, and physical environment) referred to the licensed real estate agent on the customer trust by costumer patterns based on the sex and ages. This study is based on metropolitan customers, who have had the experiences on real estate transaction through the licensed real estate agent over the past three years, by questionnaire. We found that the bonds between customers and licensed real estate agent has statistically significant and big influence on the all groups of costumer pattern such as the entire customer group, men and women groups, and thirties to sixties age groups(4 groups). And the other service factors have various significant depending on the customer patterns. According to the result of this paper, for more efficient customer marketing, the licensed real estate agent may focus on the ties with customer to the all kinds of customer group, and use the other service factors depending on the customer group patterns.

A Study on the Decision Factors and Satisfaction of SMEs

Yongsang PARK(Yongsang PARK),Jaetae KIM(Jaetae KIM) 국제융합경영학회 2023 융합경영연구 Vol.11 No.3

Purpose: The purpose of this study is to identify the determinants of store occupancy based on the rental characteristics of small and medium-sized enterprises (SMEs) renting buildings across the country, and to analyze the satisfaction level after opening. Research design, data and methodology: The study conducted an empirical survey through questionnaires targeting individual business owners, corporate representatives, and executives and employees nationwide, including Seoul, Gyeonggi, and other metropolitan areas and provincial cities. Results: In this study, the most important factor that SMEs consider when deciding whether to rent a commercial building or office is financial characteristics, followed by management characteristics, location characteristics, building characteristics, and facility characteristics. In addition, management characteristics were found to have the greatest impact on rental satisfaction of SMEs, followed by financial characteristics, building characteristics, and location characteristics in order. Conclusions: Since the lessor cannot immediately improve the location characteristics or building characteristics, in order to increase the rental satisfaction of small and medium-sized businesses in a relatively short period of time, it is necessary to improve managerial characteristics such as prompt civil complaint handling and clean management of the building. In addition, it is analyzed that if the factors that can reduce the burden on the tenants are found in advance and reflected in the financial characteristics, the satisfaction of the tenants can be increased.