제1형 Trichorhinophalangeal 증후군

손효성,오창근,김문범,이재봉,장호선,권경술 대한피부과학회 2003 대한피부과학회지 Vol.41 No.6

Trichorhinophalangeal syndrome(TRPS) typeⅠis characterized by sparse and slow-growing hairs, pear-shaped nose, elongated philtrum, thin upper lip, and bone deformities, especially, cone-shaped epiphyses of the phalanges. The syndrome is inherited in an autosomal dominant manner. We report a case of TRPS typeⅠ with alopecia like male pattern baldness and Perthes-like changes on the right hip joint. (Korean J Dermatol 2003;41(6) : 801~804)

RCGKA를 이용한 최적 퍼지 예측 시스템 설계

방영근,심재선,이철희 江原大學校 産業技術硏究所 2009 産業技術硏究 Vol.29 No.B

In the case of traditional binary encoding technique, it takes long time to converge the optimal solutions and brings about complexity of the systems due to encoding and decoding procedures. However, the ROGAs (real-coded genetic algorithms) do not require these procedures, and the k-means clustering algorithm can avoid global searching space. Thus, this paper proposes a new approach by using their advantages. The proposed method constructs the multiple predictors using the optimal differences that can reveal the patterns better and properties concealed in non- stationary time series where the k-means clustering algorithm is used for data classification to each predictor, then selects the best predictor. After selecting the best predictor, the cluster centers of the predictor are tuned finely via RCGKA in secondary tuning procedure. Therefore, performance of the predictor can be more enhanced. Finally, we verifies the prediction performance of the proposed system via simulating typical time series examples.

가압유동층연소로에서 국내무연탄의 황산화물 배출특성

한근희,송용식,류정인,손재익,진경태 한국화학공학회 2003 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.41 No.1

본 연구는 가압유동충연소로에서 국내 무연탄을 연소함에 있어서 SO_2 배출농도에 대하여 고찰하였다. Bench scale PFBC에서 석탁을 연소하는 동안에 탈황제로 식회석을 사용하였으며, 배가스의 배출특성을 조사함에 있어서 SO_2의 제어에 주안점을 두었다. 석탁은 강원도 태백지역에서 채탄된 무연탄이고, 석회석은 강원도 삼척지역에서 얻은 것이다. 실험장치는 층 직경 0.17m, freeboard 직경 0.25m이고, 총 높이가 5m로 이루어졌다. 실험은 운전압력(1-6 atm), 운전온도(850-950℃), 과잉공기(10-30%), Ca/S 몰비(0.8-4.8)의 조건으로 수행하였다. 결과적으로 최대 탈황율을 보인 층(bed)온도는 1, 2 기압일 때 850℃, 4 기압일때 900℃, 6 기압일 때 950℃로 나타났다. 또 탈황율은 모든 실험조건에서 운전압력, Ca/s 몰비, 과잉공기가 증가함에 따라 증가하였다. 국내무연탄의 가압유동충연소시 안정적인 SO_2의 배출을 위하여 각각의 운전압력에서 적정한 Ca/S 몰비는 2 기압 이하일때 Ca/S≥4.8, 4기압일 때 Ca/S=4.8, 6 기압 이상일때 Ca/S≤4.8를 보였다. This study was to investigate the SO_2 emission with Korean anthracite in a PFBC (Pressurized Fluidized Bed Combustor). This work focuses on the control of SO_2, one of the severe air pollutants in flue gas, emission characteristics by injecting sorbent during the combustion of coal in a bench scale PFBC. The coal and limestone used in this work were Taeback anthracite and Samchuck limestone, respectively, in Korea. The effects of operation parameters such as pressure (1-6 atm), bed temperature (850-950℃), excess air ratio(10-30%), and Ca/S mole(0.8-4.8) on desulfurization was investigated in PFBC(0.17m of bed diamether, 0.25m of freeboard diameter and 5.0m height). The bed temperature showing maximum sulfur capture increased from 850℃ at 1 and 2 atm. to 950℃ at 6 atm. with 10% of excess air ratio. Sulfur capture increased as excess air ratio increased at all experimental condition. Both the sulfur capture and the temperature showing maximum sulfur capture increased as operation pressure increased. It was recognized that Ca/S mole ratio higher than 4.8 was needed below 2 atm. and lower Ca/S mole ratio than 4.8 was needed at 4 and 6 atm. for the stable SO_2 emission in combustion of Korean anthracite.

THE EFFECT OF PRIMING ETCHED DENTIN WITH SOLVENT ON THE MICROTENSILE BOND STRENGTH OF HYDROPHOBIC DENTIN ADHESIVE

박은숙,배지현,김종순,김재훈,이인복,김창근,손호현,조병훈 대한치과보존학회 2009 Restorative Dentistry & Endodontics Vol.34 No.1

장기적인 상아질 접착의 내구성 악화는 접착층과 혼성층의 친수성 부위에서의 가수분해에 의해 일어나는 것으로 보고 되고 있다. 본 연구의 가설은 콜라겐 망상체를 유기용매로 프라이밍하면 콜라겐 조직을 붕괴시키지 않고 수분을 밀어내고 소수성 단량체와 유기용매로 이루어진 접착제가 침투하여 접착강도를 얻을 수 있다는 것이다. 두 소수성 단량체인 Bisphenol-A-glycidylmethacrylate (Bis-GMA)와 triethyleneglycol dimethacrylate (TEGDMA)를 아세톤, 에탄올 또는 메탄올에 용해시켜 세 가지의 실험용 접착제를 준비하였다. 산 부식과 수세과정 후에, 접착제를 습윤 상아질 표면(습윤 접착)이나 동일한 용매로 프라이밍 된 상아질 표면(용매 프라이밍 접착)에 적용하였다. 48시간 후와 1개월 후, 및 10.000회의 열순환 후에 미세인장결합강도를 측정하였다 접착계면은 주사전자현미경을 이용하여 관찰하였다. 접착방법에 무관하게 대부분의 시편의 접착계면예서 잘 발달된 혼성층을 관찰할 수 있었고 가장 높은 평균 미세인장결합강도는 에탄올을 포함하는 접착제의 48시간 후 시편에서 관찰되었다. 용매를 이용하여 프라이밍하는 접착 방법에서는 에탄올이나 메탄올을 포함하는 접착제에서 열순환 후에 미세인장접착강도가 증가하는 경향을 보였다. 그러나 습윤 접착의 경우에는 시효처리 후 미세인장결합강도의 증가가 관찰되지 않았다. 본 연구에서 에탄올을 이용한 상아질 프라이밍으로 우수한 접착력을 얻을 수 있었고. 열순환 후 접착력이 더욱 증가하였다 Deterioration of long-term dentin adhesion durability is thought to occur by hydrolytic degradation within hydrophilic domains of the adhesive and hybrid layers. This study investigated the hypothesis that priming the collagen network with an organic solvent displacc water without collapse and thereby obtain good bond strength with an adhesive made of hydrophobic monomers and organic solvents. Three experimentaladhesives were prepared by dissolving two hydrophobic monomers bisphenol-A-glycidylmethacrylate (Bis-GMA) and triethyleneglycol dimethacrylate (TEGDMA), into acetone, ethanol or methanol. After an entching and rinsing procedure, the adhesives were applied onto either wet dentin surfaces (wet bonding) or dentin .surfaces primed with the same solvent (solvent-primed bonding). Microtensile bond strength (MTBS) was measured at 48 hrs, 1 month and after 10,000 times of thermocycles. The bonded interfaces were evaluated using a scanning electron microscope (SEM) Regardless of bonding protocols, weIl-developed hybrid layers were observed at the bonded interface in most specimens. The highest mean MTBS was observed in the adhesive containing ethanol at 48 hrs. With solvent-primed bonding increased MTBS tendencies were seen with thermocycling in the adhesives containing ethanol or methanol. However in the case of wet bonding, no increase in MTBS was observed with aging.

Molecular marker evaluated for heat tolerance in wheat

Jae-Han Son,Kyeung-Hoon Kim,Chon-Sik Kang,Young-Keun Cheong,Jong-Chul Park,Kyong-Ho Kim,Yang-Kil Kim,Young-Jin Oh,Jong-Ho Park,Tae-Hwa Song,Jae-Seong Choi,Bo-Kyeong Kim 한국육종학회 2015 한국육종학회 심포지엄 Vol.2015 No.07

High temperature is one of major environmental stress. Some of molecular markers related heat stress or tolerance have been reported by many researchers. Heat tolerance managing is difficult through the phenotypic selection, so marker assistant selection (MAS) using molecular markers like as RAPD, SSR ect. was tried to selection of useful traits for heat tolerance. Fourteen SSR markers reported by previous research were selected for this research. These markers were linked to important traits including grain filling duration, HIS (Heat susceptibility index) grain filling duration. In this study, we tried to evaluate 14 SSR markers for MAS using 31 useful wheat resources including 24 crossing line from Turkey and six Korean wheat cultivars using 14 SSR markers. The average of the number of alleles and PIC values in this study were 6.14 and 0.63, respectively. Two major clades and six sub clades were grouped by phylogenetic tree using UPGMA program. Six Korean wheat cultivars were distinct from other Turkey resources in the phylogenetic dendrogram. From the results, we expected that these markers were able to adapt to screening wheat genotyping for heat tolerance.

A MODIFIED NIEMENTOWSKI REACTION FOR THE SYNTHESIS OF 4-HYDROXYQUINOLINE AND ITS REALTED COMPOUNDS

Son, Jae Keun,Kim, Seung Ill,Jahng, Yurngdong 영남대학교 약품개발연구소 2002 영남대학교 약품개발연구소 연구업적집 Vol.11 No.-

The iminoketene generated from anthranilic acid and thionyl chloride reacted with ketones to afford 4-hydroxyquinoline derivatives in good yields.

SYNTHESIS OF NEW FRIEDLA¨NDER SYNTHON AND ITS APPLICATION TOWARDS THE CONSTRUCTION OF PYRIDO[3,2-c]ACRIDINES

Son, Jong Keun,Son, Jae Keun,Jahng, Yorngdong 영남대학교 약품개발연구소 2002 영남대학교 약품개발연구소 연구업적집 Vol.11 No.-

A new Friedlander synthon, 4-aminoacridine-3-carbaldehyde was prepared in 4 steps from 3-methylacridine in 38% overall yield, which was readily condensed with acetylaromatics to yield 2-arypyrido[3,2-c]-acridines.

Development of Molecular Marker for Korean Wheat Cultivar Identification using AFLP Technique

Jae-Han Son,Kyeong-Hoon Kim,Sanghyun Shin,Young-Keun Cheong,Hag-Sin Kim,Induk Choi,Young-Jin Kim,Choon-Ki Lee,Kwang-Geun Park,Chon-Sik Kang 한국육종학회 2014 한국육종학회 심포지엄 Vol.2014 No.07

Amplified fragment length polymorphism (AFLP) is one of molecular marker technique based on DNA and is extremely useful in detection of high polymorphism between closely related genotypes like Korean wheat cultivars. Six Korean wheat cultivar specific marker sets have been developed from inter simple sequence repeat (ISSR) analysis and we can identify the 13 Koran wheat cultivars form other cultivars using six that (Son et al., 2013). We used four combinations of primer sets in our AFLP analysis for developing additional cultivar specific markers in Korean wheat. Twenty-one of the AFLP bands were isolated from ACG/M-CAC primer combination and 19 bands were isolated from E-AGC/M-CTG primer combination, respectively. We used forty bands to design sequence characterized amplified region (SCAR) primer pairs for Korean wheat cultivar identification. Only one of 40 amplified primer pairs, C2, were able to use for wheat cultivar identification. The DNA band of 215bp length was amplified by C2 primer pairs in ten cultivars, Eunpa, Olgeuru, Gobun, Saeol, Milsung, Sinmichal, Jokyung, Sugang, Goso, and Joah. Then C2 primer was applied to these primer sets as newly SCAR marker, six cultivars are identifying from other cultivars, additionally. Finally, to use the C2 and six primer sets, 19 Korean wheat cultivars are identified.

전신진동자극이 20대 여성의 정적균형과 동적균형에 미치는 영향

전재근(Jae-Keun Jeon),김재웅(Jae-Woong Kim),손경현(Kyung-Hyun Son),오세민(Se-Min O),정종호(Jong-Ho Jung),유병국(Byung-Kook Yoo) 한국엔터테인먼트산업학회 2015 한국엔터테인먼트산업학회논문지 Vol.9 No.1

본 연구에서는 안정지지면 위의 스쿼트자세와 전신진동기구 위에서의 스쿼트 자세가 정적?동적 균형 능력에 어떠한 영향을 미치는지 알아보기 위하여 H 대학교에 재학 중인 20대 여성 24명을 대상으로 두 군으로 나누어 안정지지면 운동과 전신진동자극 운동을 10분간 실시하였고, 운동 전·후의 정적·동적 균형 능력을 Good Balance system을 통해 측정한 결과 운동 전ㆍ후 비교군과 실험군의 동적 균형 능력은 모두 통계적으로 유의한 차이를 보였고, 군 간 동적 균형 능력 비교에서도 통계적으로 유의한 차이를 보였다(p<0.05). 이와 같은 결과는 전신진동기기에서의 스쿼트 자게가 동적균형능력에 더 효과적이라고 판단된다. 따라서 동적균형능력의 개선을 위하여 전신진동자극이 임상적 목적으로 활용되기를 기대한다. Purpose: The purpose of this study examines the effects of whole-body vibration stimulator on the static balance and dynamic balance with stable support surface or vibrator in the deep squat position. Methods: 24 healthy women in their 20"s participated in the study, and various variable as the indicator of the static balance and dynamic balance were measured by good balance system before and after exercise which is deep squat positioning on the stable support surface or vibrator. Results: The following result of the study was drawn up; 1) In exercise using deep squat positioning on the stable support surface or vibrator, all of the value of good balance system for dynamic balance ability after doing exercise of control group and experimental group showed significant statistical difference from before doing exercise. 2) In exercise using deep squat positioning on the stable support surface or vibrator, the value of good balance system for dynamic balance ability showed significant statistical difference that the experimental group is more than control group Conclusion: Therefore, the results of this study demonstrate that the application of deep squat positioning on the stable support surface or vibrator has positive effects for dynamic balance ability.

차나무의 품종, 부위, 채취시기에 따른 향기생성 효소의 활성과 향기배당체의 함량

정재천(Jae-Cheon Jeong),최정연(Jeong-Youn Choi),최문희(Moon-Hui Choi),손영란(Young-Lan Son),조정용(Jeong-Yong Cho),김선재(Seon-Jae Kim),문제학(Jae-Hak Moon),박근형(Keun-Hyung Park),마승진(Seung-Jin Ma) 한국차학회 2012 한국차학회지 Vol.18 No.4

Enzymatic activities and amounts of aromatic precursors, which are related with aroma formation in fermanted tea, were indirectly measured in vanious cultivars (Korean native cultivar, Taicha No.12, Yabukita), harvest time (May, July, September), and parts (aged leaves, young leaves, stem) by means of crude enzyme assay. Enzyme activities related to aroma formation in stems and young leaves were higher than those in aged leaves. Activities in parts harvested in September and July were higher than in those harvested in May. Total amounts of aromatic precursors were higher in young leaves than those in aged leaves from each cultivar. Amounts of precursors of geraniol and methyl salicylate were much higher in each part of Taicha No.12 than those of Yabukita, although much greater amounts of benzyl alcohol and 2-phenylethanol were liberated from Yabukita.