대기오염물질의 통계적 확산모델에 관한 연구

정태섭,유재연 全北大學校 附設 都市및環境硏究所 1997 都市 및 環境硏究 Vol.12 No.1

Under natural condition, the accuracy of measured and predicted value of regular distribution plume model was not good. This study proposed the Multi-Layer Gaussian Dispersion Model which is based on plume rise model and Surface-corrected Gaussian Model, and is able to predict the concentration when meteorologic condition is change. And studied merit and utilization of Multi-Layer Gaussian Dispersion Model. The results was as follows ; 1. Multi-Layer Gaussian Dispersion Model showed the trustful concentration distribution by means of mass flux up to atmospheric boundary or earth surface in change of spatial meteorologic condition. 2. Multi-Layer Gaussian Dispersion Model was simulated in short time relatively, because this model was based on regular distribution plume model. 3. The consideration of earth configuration was relatively simple, because the concentration was simulated by mass flux in boundary condition. 4. Therefore, if this model is more expanded by what is consider the change of meteorology in spatial and according to time, this model is applied immediately in urgency.

전북지역 강수의 주요 이온성분 분석과 발원지 평가

유재연,정태섭 全北大學校 附設 都市및環境硏究所 2000 都市 및 環境硏究 Vol.15 No.1

This study was conducted to investigate the trajectory analysis and chemical characteristics of precipitation at Namwon, Imsil, Kunsan, Buan, Chonju and Changsu from the period between January and August 1999. Samples were analyzed for anions and cations. And in order to understand the characteristics of rainfall during observation, backward trajectory analysis was carried by using HYSPLIT_4(Hybrid Single-Particle Lagrangian Integrated Trajectory) model(Version 4) and factor analysis was conducted from each sources. It showed the major source of pollutants in precipitation were from the natural such as sea, soil. But it was explained from the first component that the major source of China was from the anthropogenic of using fossil fuels. And it was explained from the third component that the major source of Japan was from the anthropogenic of vehicle and industry. The result of factor anaylsis is correspond to chemical characteristics. Therefore we have to consider Japan as well as China in the air pollution aspect.

동물 뼈를 이용한 중금속처리에 관한 연구

정태섭,이재용,유재연 全北大學校 附設 都市및環境硏究所 1997 都市 및 環境硏究 Vol.12 No.1

The purpose of this study is to estimate the removal efficiency of heavy metals and reclamation of wastewater and application to field plant as a new technology development using powder and ceramic filter made lf waste hard tissue. The major crystal structure is hydroxyapatite(Ca_10(PO_4)_6(OH)_2). The rising of pH according to powder dosage was showed up to pH8.0. However, these tendencies do not showed upper pH8.0. The hard tissue powder showed the preference of removal efficiency for heavy metals in the sequence of Zn>Cd>Pb, adsorption efficiency by competition in mixed component does not showed. The removal efficiency depend upon powder quantity at mixed component shows in sequence of Cd>Zn>Pb in shortage of powder dosage, Pb>Zn>Cd in sufficient. In the treatment of single component with the variation of heavy metal concentration, the break-point was showed in 20㎎/ℓ heavy metal conc., and in mixed component 10㎎/ℓ heavy metal conc. Reuse of waste hard tissue will give profits because quantity of waste disposal will be decrease and environmental purification will be accelerated by using the ceramic filter made from the waste disposal. And we can have the hard tissue cheaply.

본태성 고혈압쥐의 성장에 따른 뇌신경 세포막 Na, K-ATPase변동에 관한 연구

류석천,허강민,석정호,이재흔 충남대학교 의과대학 지역사회의학연구소 1992 충남의대잡지 Vol.19 No.1

To investigate the development change of synaptosomal Na, K-ATPase of hypertensive rat, Na, K-ATPase activity and ouabain binding sites were measured in the synaptosomal membrane prepared from 3 days-, 2 weeks-, 20 weeks- old Sprague-Dawley rats and spontaneously hypertensive rats Resulrs are as follows; 1. in the synaptosomal Na, K-ATPase of the normotensive and hypertensive rats, there were 2 kinds of isozymes, high affinity site(IC_(50):80-260 nM) and low affinity site(IC_(50):30-60 μM) 2. Synaptosomal Na, K-ATPase activity was increased in 2 and 20 weeks(high affinity site) or 2 weeks(low affinity site) old compared to that in 3 days old rat, and showed a tendency of decrease in 33 weeks old compared to that in 20 weeks old rats(high affinity site) in both groups. 3. Synaptosomal Na, K-ATPase activities of hypertensive rats were low in 3 days and 2 weeks old(high affinity site) or 3 days old (low affinity site) compared to that age groups of normotensive rats. 4. In the ouabain binding experiments, Kd value(0.1-0.2 μM) for ouabain was slightly increased with increase of age, but no difference between normotensive and hypertensive rats was detected. 5. The numbers of ouabain binding sites were increased in 2 weeks and 20 weeks old compared to those in 3 days old rats, and showed a tendency of decrease in 33 weeks old compared to that in 20 weeks old rats. 6. In the hypertensive rats, the number of ouabain binding sites was low in 3 days, compared to that of the correponding age group of normotensive rats. From the above results, it is suggested that in the spontaneously hypertensive rat, 1) synaptosomal Na, K-ATPase of high affinity site or low affinity site is increased significantly after birth as well as in the normotensive rat, 2) but significantly less than that of normotensive rats in early periods after birth and this may due to the low concentration in both high and low affinity Na, K-ATPase isozymes for ouabain.

산재보상을 신청한 뇌심혈관질환의 특성 분석

유재홍,하은희,김수근,김정연,김용규,이의철,이철호,손준석 대한산업의학회 2007 대한직업환경의학회지 Vol.19 No.1

목적: 이 연구는 뇌 · 심혈관 질환으로 업무상재해를 신청한 사례 중에서 승인된 사례와 불승인된 사례의 특성을 비교하여 뇌 · 심혈관 질환의 업무상 재해여부를 판단하는데 필요한 기초 자료를 제공하고자 한다. 방법: 2000년부터 2004년까지 근로복지공단에 업무상 재해로 요양이 신청되어 승인여부가 결정된 뇌 · 심혈관 질환자 12,309명을 대상으로 하였다. 승인여부와 관련된 특성을 확인하기 위해 연도별, 업종별, 규모별, 직업별, 성별, 연령별, 질환별, 생존유무별 그리고 기존질환 유무에 대하여 카이제곱 검정과 다변량 로지스틱 회귀분석을 이용하였다. 결과: 다변량 로지스틱 분석에서 뇌 · 심혈관 질환의 불승인에 대한 승인의 비차비는 광업을 기준으로 하였을 때에 전기가스 상수도업이 4.18(95% CI=1.43~12.17), 건설업이 2.39 (95% CI=1.22~4.69), 제조업이 2.10 (95% CI=1.08~4.07)이었고, 장치기계조작원 및 조립원에 비하여 서비스 근로자 및 상점과 시장 판매근로자 군이 1.90(95% CI=1.47~2.47), 전문가 군이 1.83(95% CI=1.50~2.23), 기술공 및 준전문가 군이 1.63(95% CI=1.35~1.97), 입법 공무원과 고위 임직원 및 관리자 군이 1.62(95% CI=1.24~2.12)이었고, 여성이 남성에 비하여 1.31(95% CI=1.13~1.53), 심장질환에 비하여 뇌혈관질환이 2.75(95% CI=2.42~3.13), 사망한 경우가 생존한 경우에 비하여 6.01(95% CI=4.89~7.38)이었다. 결론: 우리나라에서 뇌심혈관질환으로 업무상 재해를 신청하는 건수는 증가하고 있고 승인율은 비교적 높았으며 승인에 영향을 미치는 요인으로는 업종, 규모, 직종, 성, 연령, 질환, 생존유무 등이 확인되었다. 특히 업종과 직종에 따라서 승인율의 차이가 큰 것이 어떠한 요인의 영향 때문인지에 대한 검토가 필요하고, 특히 뇌실질내 출혈의 경우에 다른 질환에 비하여 승인율이 매우 높았던 것은 업무수행성에 대한 인정기준의 잘못된 적용의 결과 이므로 시정이 필요하겠다. Objectives: This study was performed to provide fundamental data to judge whether or not cerebro and cardiovascular diseases are work-related, by comparing the characteristics between approved and non-approved cases among the worker's compensation claims. Methods: We collected 12,309 cerebro and cardiovascular disease claims based on the worker's compensation records of the Labor Welfare Corporation from 2000 to 2004. The approved and non-approved cases were analyzed according to factors such as the calendar year, industry, company size, occupation, gender, age group, classification of cerebro and cardiovascular diseases, fatality and underlying diseases. We used x²-test and multivariate logistic regression for the analysis. Results: According to multivariate logistic regression, electricity gas and water supply (OR=4.18, 95% CI=1.43~12.17), construction (OR=2.39, 95% CI=1.22~4.69) and manufacturing (OR=2.10, 95% CI=1.08~4.07) industries had a higher approval rate than mining and quarrying industries. Service workers and sales & marketing department workers (OR=1.90, 95% CI=1.47~2.47), professionals (OR=1.83, 95% CI=1.50~2.23), technicians and associate professionals (OR=1.63, 95% CI=1.35~1.97) and legislators and senior officials and managers (OR=l.62, 95% CI=1.24~2.12) had a higher approval rate than plant and machine operators and assemblers. Female workers had a higher approval rate (OR=1.31, 95% CI=1.13~1.53) than male workers. Cerebrovascular diseases had a higher approval rate (OR=2.75, 95% CI=2.42~3.13) than cardiovascular diseases. Fatal cases had a higher approval rate (OR=6.01, 95% CI=4.89~7.38) than surviving cases. Conclusion: For cerebro and cardiovascular diseases, workers' compensation claims are increasing, approval rates are relatively high and factors such as industry, company size, occupation, gender and fatality are related. A remarkable difference in the approval rate was found according to industry and occupation, suggesting the need for further study to identify which factors influence the approval rate. The approval rate for intracerebral hemorrhage arising in the course of employment (COE) was significantly higher than that arising out of employment (AOE), suggesting the need to correct the approval criteria.

국내 정신과 의사의 항정신병 약물 장기 지속형 주사제 처방에 대한 인식조사

박한선,배승민,유재홍,김수인,임원정 大韓神經精神醫學會 2009 신경정신의학 Vol.48 No.3

Objectives Long acting injectable antipsychotic medication have the ability to sustain the drug effect for a long duration, thus enabling advances in the management of those psychiatric patients who have poor compliance or who have difficulty getting the oral form of their antipsychotic medications. Despite their benefits, previous studies have reported that depot antipsychotics have a much lower prescription ratein the treatment of schizophrenia or schizoaffective disorder. Psychiatrist's attitude toward depot antipsychotics clearly has an influence on the decision-making process regarding the selection of medications. Until now, there has been no data with respect to psychiatrists' attitudes regarding long-acting injectable antipsychotics in Korea. This Study examined these attitudes toward antipsychotic depot medications as well as the factors which could contribute to their choice of deports. Methods We questioned 347 psychiatrists, who had been attending a conference, about their attitudes toward depot antipsychotic treatment. Results The most important factor causing reluctance with respect to prescribing depot treatment (for both classes of antipsychotics) was a presumed sufficient level of compliance with available oral antipsychotic treatments. In addition, typical depots are not considered to be an appropriate treatment option for first-episode patients, and as a result, they are used sparingly. Lastly, atypical long-acting injectable drugs are avoided due to their strict criteria of insurance and high treatment costs. Conclusion Aversions to prescribe depot treatment are frequent among psychiatrists and appear to be unrelated to the antipsychotic class. The stated reasons for not choosing depots are generally not supported by the current literature. Further research is required to clarify the advantages using depot treatments.

Simultaneous Determination of Amitraz, Bromopropylate, Coumaphos, Cymiazole and 2,4-Dimethylaniline in Korean Honey Samples by High-Performance Liquid Chromatography

Ryoo, Jae-Jeong,Kim, Se-Hoon,Jeong, Young-Han,Do, Hwan-Suk,Ryu, Jeong-Eun,Kwon, Hae-Young,Jeong, Ji-Yoon,Park, Hye-Jin,Lee, Soon-Ho,Hong, Moo-Ki,Hong, Jong-Ki Korean Chemical Society 2008 Bulletin of the Korean Chemical Society Vol.29 No.5

Simultaneous determination of amitraz, bromopropylate, coumaphos, cymiazole and 2,4-dimethylaniline in 200 honey samples purchased in Korea was performed by reversed-phase high-performance liquid chromatography with multiple UV detection. 2% Acetone in hexane was used for a liquid-liquid extraction and 20-40% water in acetonitrile solutions were used as mobile phases. The LOD for the analytes varied between 0.4 and 1.5 $\mu$g/L and the recoveries were yielded between 64 and 94%. Relative standard deviation of the repeatability of the method is less than 15%. Amitraz was not present in amount above 10 $\mu$ g/L and one for coumaphos and cymiazole and two for bromopropylate, and three for 2,4-dimethylanilne were detected in amount above 10 $\mu$ g/ L. Levels of the acaricide residues found were less than 50 $\mu$ g/L.

Enantioseparation of Racemic 1,1'Binaphthyl-2,2'diamine by Preparative Liquid Chromatography

Ryoo, Jae-Jeong,Kwon, Woo-Jeong,Kim, Tae-Hyuk,Lee, Kwang-Pill,Choi, Seong-Ho Korean Chemical Society 2004 Bulletin of the Korean Chemical Society Vol.25 No.9

The same kind of chiral stationary phase with a commercialized chiral column was used to make preparative chiral columns and was applied to resolve racemic N-acetyl-1-naphthylethylamide (3) by preparative liquid chromatography. An improved chromatographic condition to resolve racemic 3 on the CSP was examined by changing flow rate and kind of the mobile phase and the sample injection volume. The optimized separation conditions were applied to resolve racemic 1,1'-Binaphthyl-2,2'-diamine(4).

An Important Application of Pirkle Type π-Acidic Chiral Stationary Phases: Resolution of Polynuclear Aromatic Hydrocarbon Mixtures by Normal-Phase Conventional and Capillary HPLC

Jae Jeong Ryoo 대한화학회 2009 Bulletin of the Korean Chemical Society Vol.30 No.4

Preparation of Three Different Style Packed Capillary Frits

Ryoo, Jae-Jeong,Song, Young-Ae,Lee, Kwang-Pill,Park, Ji-Yeon,Choi, Seong-Ho,Hyun, Myung-Ho,Ohta, Kazutoku,Fujimoto, Chuzo,Jin, Ji-Ye,Takeuchi, Toyohide,Lee, Jung-Whan Korean Chemical Society 2006 Bulletin of the Korean Chemical Society Vol.27 No.4

Three different style capillary columns, a packed capillary with temporary quartz wool frit, a packed capillary with immobilized frit, and an immobilized packed-capillary, were easily prepared with a commercially available (S)-N-(3,5-dinitro-benzoyl)leucine-N-phenyl-N-alkylamide derived chiral stationary phase. Liquid chromatographic chiral separations of some racemic amino acid derivatives on these columns were performed and the results were compared to each other. The packed capillary with immobilized frit showed some merits in chiral chromatography.