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RISS 인기검색어
- 검색키워드
- 저자 : J.S. Byun (검색결과 769 건)
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Rosiglitazone-mediated dendritic cells ameliorate collagen-induced arthritis in mice
Byun, S.H.,Lee, J.H.,Jung, N.C.,Choi, H.J.,Song, J.Y.,Seo, H.G.,Choi, J.,Jung, S.Y.,Kang, S.,Choi, Y.S.,Chung, J.H.,Lim, D.S. Pergamon Press 2016 Biochemical pharmacology Vol.115 No.-
<P>Rosiglitazone is a selective ligand for peroxisome proliferator-activated receptor-gamma (PPAR-gamma), which serves diverse biological functions. A number of autoimmune disease models have been used to examine the anti-inflammatory and immunosuppressive effects of tolerogenic dendritic cells (tDCs). The aim of the present study was to investigate whether rosiglitazone-mediated DC (Rosi-DC) therapy suppressed arthritis in a collagen-induced arthritis (CIA) mouse model. Rosi-DCs were generated by treating immature DCs with TNF-alpha, type II collagen, and rosiglitazone. CIA mice then received subcutaneously (s.c.) two injections of Rosi-DCs. The severity of arthritis was then assessed histopathologically. The phenotypes of the DC and regulatory T (Treg) cell populations in CIA mice were determined by flow cytometry and the effect of Rosi-DCs on the secretion of autoimmunity-inducing cytokines was examined by ELISA. Rosi-DCs expressed lower levels of DC-related surface markers than mature DCs. Histopathological examination revealed that the degree of inflammation in the paws of Rosi-DC-treated mice was much lower than that in the paws of PBS-treated CIA mice. Taken together, these results clearly show that rosiglitazone-mediated DCs ameliorate CIA, most likely via the induction of antigen-specific Treg cells. (C) 2016 Elsevier Inc. All rights reserved.</P>
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鄭元采,盧載榮,安長憲,卞珠燮 충북대학교 엽연초연구소 1974 煙草硏究 Vol.2 No.-
This works has been carried out in order to study the influence of different condition of soil moisture on the growth and yield of tobacco leaves. It was investigated the soil moisture on the cultivating farm of tobacco for the study on the variation in soil moisture. The results are summarized as follow; 1.In the deficient supply of soil moisture, S1 treatment at the setting stage caused the delay of growth, and S3 treatment at the period vigrous growth influenced eriousely on the yield. Dry leaf weight decreased gradually in order S1>S6>S2>S3>S5>S4. 2.The dry leaf weight was decreased according to the increase of treatment duration, the results showed as T1=T2=T3<C 3.In the excessive supply of soil moisture, 90% (maximum water holding capacity) treatment during 10~20 days was damaged at early stage more than latter stage treatment in the growth. 4.In the deficient or excessive supply of soil moisture, excessive supply treated plots in long period and the replication plots in the deficient supply treated influenced on the yields.
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Hwang, S.R.,Seo, D.H.,Al-Hilal, T.A.,Jeon, O.C.,Kang, J.H.,Kim, S.H.,Kim, H.S.,Chang, Y.T.,Kang, Y.M.,Yang, V.C.,Byun, Y. Elsevier Science Publishers 2012 Journal of controlled release Vol.163 No.3
The regulation of angiogenesis is an interesting area to consider for novel therapeutic approaches to rheumatoid arthritis (RA). Chemically modified heparins have been developed as possible candidates for angiogenesis inhibitor; however, they have a major clinical drawback in exhibiting poor oral bioavailability. Here, orally absorbable O-desulfated low molecular weight heparin (ODS-LMWH) derivatives were newly synthesized by conjugating 2-O- or 6-O-desulfated LMWH with deoxycholic acid (DOCA) or bisDOCA (a dimer of DOCA), and their physicochemical properties, antiangiogenic potency and pharmacokinetic profiles were assessed. After selecting the best candidate among those derivatives, its therapeutic efficacy on arthritis was investigated in a murine collagen antibody-induced arthritis (CAIA) model. ODS-LMWH derivatives significantly inhibited the capillary-like tube formation of human umbilical vein endothelial cells (HUVECs) and basic fibroblast growth factor (bFGF)-induced angiogenesis in the Matrigel plug assay. Among all the compounds, 6ODS-LHbD showed the highest oral bioavailability in rats (19.3%). In the CAIA mouse model, 6ODS-LHbD (10mg/kg, p.o., S.I.D.) significantly inhibited neovascularization in the joint, the increase of hind-paw thickness, and the structural damage in the bone. Therefore, 6ODS-LHbD would be a promising candidate for an orally active drug for the treatment of RA.
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Manufacture of ice cream with improved microbiological safety by using gamma irradiation
Lee, J.-W.,Kim, H.-J.,Yoon, Y.,Kim, J.-H.,Ham, J.-S.,Byun, M.-W.,Baek, M.,Jo, C.,Shin, M.-G. Pergamon 2009 Radiation physics and chemistry Vol.78 No.7
Children suffered from leukemia want to eat delicious dishes, such as cake and ice cream. However, it is very difficult to serve these foods to immune-compromised patients without application of any adequate sanitary measures. This study was conducted to evaluate application of irradiation to frozen ready-to-eat food, ice cream. Three ice creams with flavors of vanilla, chocolate and strawberry were manufactured and gamma irradiated at the absorbed doses of 1, 3, and 5kGy at -70<SUP>o</SUP>C. Total microflora and coliform bacteria were determined, and Listeria spp., Escherichia coli and Salmonella spp. were also tested by the use of API 20E Kit. Aerobic bacteria, yeast/mold and coliforms were contaminated in the levels of 2.3 to 3.3, 2.3 to 2.7 and 1.7 to 2.4 log CFU/g, respectively. In samples irradiated at 5kGy, the growth of any microorganisms could not be observed. Listeria spp. and E. coli were detected at non-irradiated samples, but S. spp. was not existed. D<SUB>10</SUB> values of L. ivanovii and E. coli were 0.75 and 0.31kGy, respectively, in ice cream. From these results, irradiation technology can reduce the risk by the food-borne pathogens of ice cream.
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盧載榮,鄭元采,安長憲,卞珠燮,姜信寓 충북대학교 엽연초연구소 1974 煙草硏究 Vol.2 No.-
I.Influence of deficient or excessive supply of soil moisture. The variety used in this study were Turkish varieties (Smyrna, Samsun, Zichna and Xanthi). Soil moisture content were 30%, 45% and 60% to maximum water-holding capacity for whole growth period. This experiment was carried out to study on the influence of soil moisture to growth and physiology of Turkish varieties. The results are summarized as follow ; a. Dry weight of Samsun and Zichna were-increased at 45% soil moisture content, but Smyrna and Xanthi at 60%. In every soil moisture treatmennt, there were significant difference between D plot and M, W plot but there were no significant difference between M plot and W plot. b. Percentage of dry matter of Smyrna was higher then those of the other varieties in the D plot and W plot. c. Leaf area was increased ill the Samsun of which process was slightly late. In every soil moisture treatment, M plot and W plot were higher than D plot. d. Dry weight per unit leaf area of Smyrna and Zichna were higher than that of Xanthi and Samsun. e. Percentage of dried up leaves was the W plot, and lower at the D and M plot. Smyrna was lower at M plot, Zichna at D and M plot, Xanthi at D plot, but Samsun was no difference among plots. f. In the number of harvested leaves, Smyrna was increased in order W>M>D. In the number of harvested leaves, Smyrna showed difference according to the soil moisture in order W>M>D plot, but Samsun and Zichna showed no difference among each treatments, Xanthi was higher in M plot than D and W plot. From those results, Smyrna showed the highest dry weight on account of the weight of leaf area and percentage of dry weight increased, it was decreased in order Zichna>Samsun Xanthi in the each soil moisture contents. Number of harvested leaves, dried up leaves, leaf area and number of harvested leaves but decreased, percentage of dry matter W treatment increased the number of total leaves, number of dried up leaves, leaf area, percentage of dried up leaves and percentage of dry matter. Yields were the lowest at D treated, there were no difference between M and W treatment. II.Influence of deficient or excessive supply of soil moisture at different growing stages. This experiment was carried out to study on the influence to the growth and physiology according to the soil moisture content during each growth stage on Turkish varieties culture. The varieties used in this study were Samsun, Zichna and Xanthi. The results are summarized as follow; a. Dry leaf weight was decreased in order Zichna>Samsun>Xanthi, there were remakable difference among every variety. In each soil moisture content, weight of dry matter was increased by M and W treated at late stage after MW and MM treated at early and middle stage of growth DWM and MDM plot. Dry leaf weight was decreased at D plot more than M and W plot late stage after early stage was treated by MW and MM. Dry leaf weight was the highest at WWM treate, dthere were high significant difference between varieties and soil moisture contents. b. Percentage of dry matter was decreased in order Zichna=Xanthi>Samsun. In soil moisture treated, it was increased in D treated at the latter stage after MM, MW and WM treated at early and middle stage, but it was decreased by DDM, DWD, MDM, WWD, WMM, and WWM treated. There were high significant interaction between varieties and soil moisture contents. c. Leaf area showed in order Samsun=Zichna>Xanthi. In soil moisture treated, leaf area was increased by WM, MM and MW treated at the middle and latter stage after D treated at early stage, but it was decreased at WWD, WMD, WWM, MWD and MMD treated. d. Dry weight per unit leaf area were no difference among varieties, in soil moisture treated, it was increased by the MMW, MWD, MMD, WMD and DMW treated, weight of per unit leaf area showed significant difference interaction between varieties and soil moisture contents. d. Percentage of dried up leaves showed as follow, Samsun>Xanthi, Samsun=Zichna, Zihna=Xanthi. In soil moisture treated, it was increased by M and W treated at early stage than D treated. f. Number of harvested leaves was decreased in order Xanthi>Samsun>Zichna, there were no difference among soil moisture contents, but appeard high significant difference at the interaction between varieties and soil moisture contents. As the results of this experiment, especially, this experiment will be continue on the influence of soil moisture condition in order to development of home production system.
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