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RISS 인기검색어
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- 저자 : J. Illnait (검색결과 1 건)
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Effects of Policosanol on Patients with Ischemic Stroke: A Pilot Open Study
R. Mas,L.L.Ortega,J. Schez,L. Ferndez,S. Mendoza,R. Gamez,J.C. Fernadez,J. Illnait,E. Alvarez 한국식품영양과학회 2006 Journal of medicinal food Vol.9 No.3
Stroke is a major health problem worldwide. Its pharmacological management includes thrombolytic therapyfor the acute phase and antiplatelet drugs for stroke recovery and prevention. Statins can help in the acute phase and in pre-venting stroke in secondary prevention patients. Policosanol is a cholesterol-lowering drug with concomitant antiplatelet ef-fects, with protective effects in stroke models. This observational study investigated the effects of policosanol (20 mg/day)with antiplatelets and vitamins. After hospital discharge, patients were followed up every 3 (first year) and 6 (thereafter)months. Neurological improvement was assessed with the modified Canadian Neurological Scale. Adverse events wererecorded. Fifty patients were included; all completed the study. Neurological score improved throughout the study. No pa-tient died, and most [40 (80.0%)] did not experience new vascular events; only one (2.0%) suffered a new stroke, and two(4.0%) suffered more than one transient ischemic attack. The time to the first recurrent event was 46.2 months. Policosanolpersistently lowered serum total cholesterol, with such reduction correlating with the neurological improvement (R.chemic stroke treated with aspirin and vitamins showed good results on neurological outcomes and recurrent events. Thisstudy, however, has limitations, since it was open and uncontrolled, and patients also consumed aspirin and vitamins. Newrandomized, controlled studies are needed to assess the usefulness of policosanol in stroke management.
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