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Metastasis Risk Reduction Related with Beta-Blocker Treatment in Mexican Women with Breast Cancer
Parada-Huerta, E,Alvarez-Dominguez, TP,Uribe-Escamilla, R,Rodriguez-Joya, JF,Ponce-Medrano, JA Diaz,Padron-Lucio, S,Alfaro-Rodriguez, A,Bandala, C Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.6
Background: Breast Cancer (BCa) is the most common malignant tumour in Mexican women. In BCa, several studies have linked ${\beta}2-adrenergic$ receptor activation with increased tumour growth and progression as related with Epinephrine-NorEpinephrine (E-NE) stimulation. The aim of this study was to describe Beta-Blocker (BB) treatment related with reduction of the risk of metastasis in Mexican patients with BCa. Materials and Methods: We collected data of 120 patients seen at the High-Specialty Naval General Hospital in Mexico City (HOSGENAES), all of these with a histopathological diagnosis of BCa. Four groups of patients were divided as follows: without Systemic Arterial Hypertension (SAH); with SAH treatment with non-selective BB; with SAH treatment with selective BB, and with SAH treatment with other antihypertensive drugs. Chi-square, Mantel-Haenszel, Student t, and ANOVA tests were performed for data analysis. Results: On average, patients were $54.8{\pm}11.8$ years of age. Risk factors such as smoking and consuming alcohol exhibited a frequency of 33 and 36.5% respectively. Clinical stages III- IV were found in 50% of patients, while, 30% of patients had arterial hypertension (n=29 and N=96, respectively) and 17.5% used BB. One hundred percent of patients with arterial hypertension treated with BB for ${\beta}1$ - and ${\beta}2$ -adrenergic-receptors did not present metastasis globally, but patients treated with ${\beta}1$ BB presented 30% of metastasis while patients treated with no BB or without SAH had around 70% of metastasis. Conclusions: In Mexican patients with BCa and SAH treated with non-selective (${\beta}1$- and ${\beta}2-adrenergic$ receptors) BB, a decrease in the risk for metastasis was observed at the time of diagnosis.
Rollinia occidentalis extract as green corrosion inhibitor for carbon steel in HCl solution
Patricia E. Alvarez,M. Victoria Fiori-Bimbi,Adriana Neske,Silvia A. Brandán,Claudio A. Gervasi 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.58 No.-
An extract of Rollinia occidentalis as well as pure solutions of two acetogenins isolated from this extract,namely Rolliniastatin-1 and Motrilin, were tested as corrosion inhibitors for carbon steel in acidicsolutions. Weight loss measurements were performed in the 298–328 K temperature range and theobtained data were used to calculate corrosion rate and inhibition efficiency. It was found that the extractand the acetogenins solutions act as good corrosion inhibitors for the tested C-steel in 1 M HCl media. Moreover, results from potentiodynamic polarization measurements indicate that R. occidentalis and thetwo tested acetogenins act as mixed-type inhibitors. Data collected from EIS studies were modeled withan equivalent circuit containing a single time constant what can be understood in terms of a corrosioninhibition process resulting from the geometric blocking effect of the carbon steel surface by an adsorbedinhibitor species. Inhibitor adsorption follows a Langmuir adsorption isotherm. The inhibition efficiencydecreases with increasing temperature and extract concentration. Spectroscopic analysis points to theformation of a complex between metal cations and compounds present in the R. occidentalis extract. Thisadditional aspect is considered in the proposed inhibition mechanism of C-steel.
Flagel, L. E.,Rapp, R. A.,Grover, C. E.,Widrlechner, M. P.,Hawkins, J.,Grafenberg, J. L.,Alvarez, I.,Chung, G. Y.,Wendel, J. F. Wiley (John WileySons) 2008 American journal of botany Vol.95 No.6
<P>The study of recently formed species is important because it can help us to better understand organismal divergence and the speciation process. However, these species often present difficult challenges in the field of molecular phylogenetics because the processes that drive molecular divergence can lag behind phenotypic divergence. In the current study we show that species of the recently diverged North American endemic genus of purple coneflower, Echinacea, have low levels of molecular divergence. Data from three nuclear loci and two plastid loci provide neither resolved topologies nor congruent hypotheses about species-level relationships. This lack of phylogenetic resolution is likely due to the combined effects of incomplete lineage sorting, hybridization, and backcrossing following secondary contact. The poor resolution provided by molecular markers contrasts previous studies that found well-resolved and taxonomically supported relationships from metabolic and morphological data. These results suggest that phenotypic canalization, resulting in identifiable morphological species, has occurred rapidly within Echinacea. Conversely, molecular signals have been distorted by gene flow and incomplete lineage sorting. Here we explore the impact of natural history on the genetic organization and phylogenetic relationships of Echinacea.</P>
Improved Immune Response to Recombinant Influenza Nucleoprotein Formulated with ISCOMATRIX
( Cargnelutti Diego E. ),( Maria V. Sanchez ),( Paula Alvarez ),( Lorena Boado ),( Graciela Glikmann ),( Nora Mattion ),( Eduardo A. Scodeller ) 한국미생물 · 생명공학회 2012 Journal of microbiology and biotechnology Vol.22 No.3
Current influenza vaccines elicit antibodies effective against homologous strains, but new strategies are urgently needed for protection against emerging epidemic or pandemic strains. Although influenza vaccine candidates based on the viral nucleoprotein (NP) or matrix protein do not elicit sterilizing immunity, they have the advantage of inducing immunity that may cover a larger number of viral strains. In this study, recombinant NP produced in Escherichia coli was purified and formulated in combination with the adjuvant ISCOMATRIX. This formulation increased a NP-specific immunity in mice, with a Th1 profile, and may constitute a promising low-cost influenza vaccine candidate, with ability to stimulate humoral and cellular immune responses.
D. Cano-Ott,F. Alvarez-Velarde,E. Gonzalez-Romero,C. Guerrero,T. Martinez,E. Mendoza,D. Villamarin,M. C. Vicente,U. Abbondanno,N. Colonna,M. H. Meaze,S. Marrone,G. Tagliente,R. Terlizzi,F. Belloni,K. 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.23
The successful development of advanced nuclear systems for sustainable energy production and nuclear waste management depends on high quality nuclear data libraries. Recent sensitivity studies and reports [1][2][3] have identified the need for substantially improving the accuracy of neutron cross-section data for minor actinides. The n_TOF collaboration has initiated an ambitious experimental program for the measurement of neutron capture cross sections of minor actinides. Two experimental setups have been constructed for this purpose: a Total Absorption Calorimeter (TAC) [4] for measuring neutron capture cross-sections of low-mass and/or radioactive samples and a set of two low neutron sensitivity C_6D_6 detectors for the less radioactive materials.
Study of Photon Strength Function of Actinides: the Case of ^(235)U, ^(238)Np and ^(241)Pu
C. Guerrero,F. Alvarez-Velarde,D. Cano-Ott,T. Martinez,E. Mendoza,D. Villamarin,N. Colonna,M. H. Meaze,S. Marrone,G. Tagliente,R. Terlizzi,F. Belloni,U. Abbondanno,K. Fujii,P. M. Milazzo,C. Moreau,G. 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.23
The decay from excited levels in medium and heavy nuclei can be described in a statisticalapproach by means of Photon Strength Functions and Level Density distributions. The study of electromagnetic cascades following neutron capture based on the use of high eciency detectors has been shown to be well suited for probing the properties of the Photon Strength Function of heavy (high level density) and/or radioactive (high background) nuclei. In this work we have investigated for the first time the validity of the recommended PSF of actinides, in particular ^(235)U, ^(238)Np and ^(241)Pu. Our study includes the search for resonance structures in the PSF below S_n and draws conclusions regarding their existence and their characteristics in terms of energy, width and electromagnetic nature.
Y. Ayyad,J. Benlliure,E. Casarejos,H. Alvarez-Pol,C. Paradela,D. Perez-Loureiro,D. Tarrio,A. Bacquias,T. Enqvist,V. Fohr,A. Kelic,R. Pleskac,A. Boudard,,K. Kezzar,S. Leray 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.23
Total fission cross sections of ^(181)Ta ions colliding with hydrogen atoms at 300, 500, 800, and 1000 A MeV have been measured. The combined use of the inverse kinematics technique with an efficient detection set-up made it possible to determine these cross sections with high accuracy ranging between 8% and 17%. The new data put some light in the controversial results obtained so far and contribute to the understanding of the fission process at high excitation energies.
J. P. Morán-Lázaro,F. López-Urías,E. Muñoz-Sandoval,M. Courel-Piedrahita,A. Carreon-Alvarez,V. M. Rodríguez-Betancourtt,I. Zamudio-Torres,E. S. Guillén-López,A. Palafox-Corona 대한금속·재료학회 2023 ELECTRONIC MATERIALS LETTERS Vol.19 No.1
The acetone contained in human breath is of great interest for the health sector as it is a marker that allows to diagnoseand control diabetes in a non-invasive way. However, its concentration is extremely low. Therefore, high-performanceacetone sensors are still a challenge. With this in mind, MgCo 2 O 4 nanoparticles were synthesized using a microwaveassistedcolloidal route with subsequent calcination. Structural and morphological characterizations were done through varioustechniques. The MgCo 2 O 4 sensor was fabricated with the sample calcined at 500 °C. The sensing results showed that thesensor could detect acetone vapors ranging from 0.5 to 50 ppm at an optimum operating temperature of 250 °C with a highresponse, repeatability, stability, and selectivity. These sensing characteristics revealed that MgCo 2 O 4 could be used as a newsensor material to detect acetone in exhaled human breath.