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RISS 인기검색어
- 검색키워드
- 저자 : Islam Md. Emdadul (검색결과 3 건)
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Islam Md. Emdadul,Islam Kazi Mohammed Didarul,Billah Md. Morsaline,Biswas Rana,Sohrab Md. Hossain,Rahman S. M. Mahbubur 경희대학교 융합한의과학연구소 2020 Oriental Pharmacy and Experimental Medicine Vol.20 No.2
The antioxidant and anti-inflammatory potential of Heritiera fomes ethanolic extract was evaluated.Query Ethanolic extraction of dried and grinded plant leaves and bark was performed. Antioxidant activity was evaluated by 1, 1-diphenyl-2-picryl-hydrazil (DPPH) free radical scavenging assay, ferric reducing antioxidant power (FRAP) and β-carotene bleaching inhibition assay. Total phenolic and flavonoid content were also determined. Anti-inflammatory activity was evaluated by in vitro human RBC membrane stabilizing assay and in vivo mice paw edema test. Ethanolic bark and leaf extracts of H. fomes (S1 and S2, respectively) showed significant scavenging effect on DPPH scavenging 68.51 µg/ml for S1 and 108.64 µg/ml for S2. Potent reduction potential (FRAP) was observed in S1 (83.75 mM of ferrous equivalent) while the FRAP of standard ascorbic acid was found 86.66 μM of ferrous equivalent. S1 also exhibited 87.43% β-carotene bleaching inhibition as comparable to standard butylated hydroxytoluene with 98.85% inhibition. Substantial phenolic and flavonoid content was also observed in S1 (136.83 μg gallic acid equivalent/g of extract and 76.67 μg quercetin equivalent/g of extract, respectively). S1 could provide 61.73% and 53.27% protection of RBC membrane in hypotonicity and heat induced lysis of RBC, respectively while the standard diclofenac sodium provided 91.66% and 86.66% protection, respectively. Furthermore, 44.16% reduction in mice paw edema at 40 μg/kg bw concentration was observed in S1 as compared to standard indomethacine (53.54% in 10 μg/kg bw concentration). The results revealed that the bark extract (S1) of H. fomes possesses significant antioxidant and anti-inflammatory activity.
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Active and passive surveillance of bovine spongiform encephalopathy in Bangladesh
Halder, Shukla,Chowdhury, Emdadul Haque,Parvin, Rokshana,Rahaman, Mohammad Moshiyour,Rahman, Seikh Masudur,Saha, Shib Shankar,Sultana, Sajeda,Marium, Nadira,Islam, Azharul,Rahman, Md. Siddiqur,Song, H The Korean Society of Veterinary Service 2009 韓國家畜衛生學會誌 Vol.32 No.4
The aim of the present study was to investigate whether Bovine Spongiform Encephalopathy (BSE) is present in this country and to analyze the Global BSE Risk (GBR) status in Bangladesh. A total of 2,000 brain samples were collected from cattle older than 30 months of age, slaughtered for human consumption in the district slaughter houses from 2005 to 2006. The brainstem (obex), Pyriform lobe, cerebrum and cerebellum were subjected to histopathological study. Samples that showed some nonspecific lesions were subjected to immunohistochemistry and only brain stem to ELISA for the detection of abnormal prion protein $PrP^{sc}$. In passive surveillance, annual overall diseases of cattle, buffalo, sheep and goats in Bangladesh were collected from Department of Livestock Services (DLS), Dhaka to investigate the occurrences of neurological diseases. Import related data were collected from "National Export Promotion Bureau" Kawran Bazar, Bangladesh Bank and DLS to analyze the importing products of animal origin (cattle, buffalo, sheep and goats) from different countries to find whether or not the imported products posed any risk for the BSE. In an actire surveillance conducted in slaughter house, histopathologically BSE specific lesions were not detected in any of the brain samples, but other nonspecific lesions were observed. No $PrP^{sc}$ was detected from the samples by immunohistochemistry and ELISA. DLS report also supported the absence of BSE in cattle and buffalo and scrapie in sheep and goats in Bangladesh. It was also clearly recorded that Bangladesh imported livestock products from countries in GBR level I and II but not from countries in GBR level III and IV. From this study it apparently seems that BSE is not currently present in the indigenous animals in Bangladesh and poses no or negligible risk to human and animal health.
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Antioxidant and antibacterial activity of three herbs belonging to Zingiber genus of Bangladesh
Afiya Aunjum,Rana Biswas,Tauhidur Rahman Nurunnabi,S.M. Mahbubur Rahman,Md. Morsaline Billah,Md. Emdadul Islam,Kazi Mohammed Didarul Islam 경희대학교 융합한의과학연구소 2020 Oriental Pharmacy and Experimental Medicine Vol.20 No.3
Apart from boosting flavor, herbs and spices are also known for their preservative, antioxidant, antimicrobial and other medicinal properties. Bioactive metabolites with aspiring prospect have guided the present study to screen for antibacterial and antioxidant activity of three Zingiber plants available in Bangladesh. For that purpose, rhizomes of Zingiber officinale, Z. montanum and Z. zerumbet were extracted with ethanol as solvent system for bioactivity analysis. Antioxidant activity was assessed by employing DPPH free radical scavenging assay, reducing power assay and ferric reducing antioxidant power (FRAP) assay. Z. officinale extract demonstrated the highest free radical scavenging activity ( IC50: 43.65 μg/ml), reducing power ( EC50: 189.026 μg/ml) and FRAP value (137.18 ± 0.116 μM Fe(II)/100 μg dry weight of extract). Moreover, total phenolic, flavonoid and tannin content were determined which significantly correlated (Pearson correlation) with the antioxidant activities. For the evaluation of antibacterial activity, zone of inhibition (ZOI) was measured by disc diffusion bioassay against four Gram positive bacteria Bacillus megaterium, Staphylococcus aureus, Micrococcus spp., and S. epidermidis as well as ten Gram negative bacteria Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi, S. paratyphi, Vibrio cholera, Shigella dysenteriae, S. flexneri, Proteus spp., Mycobacterium spp., and Campylobacter spp. Z. montanum extract exhibited significant activity against E. coli (13.67 ± 0.577 mm ZOI) and Micrococcus spp. (14.33 ± 0.763 mm ZOI) if compared to standard erythromycin with ZOI 15.33 ± 0.577 mm and 15.67 ± 0.577 mm, respectively. Furthermore, minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of Z. montanum extract were determined against B. megaterium, Micrococcus spp., E. coli and S. paratyphi. Thus, Z. officinale and Z. montanum extracts could be utilized as source and template for the synthesis of potential drugs and food supplements as well.
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