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Jang-Young Jeong,Byoung-Keol Ryu,Hae-Young Yang,Sun-Young Kang,Dae-Youn Hwang,Insurk Jang 한국실험동물학회 2009 Laboratory Animal Research Vol.25 No.4
The present study was carried out to investigate whether dietary supplementation of Pleurotus eryngii to the purified diet containing high fat (16%) and cholesterol (0.3%) could affect blood lipid profiles, liver fat contents, adiposity and intestinal digestive enzymes. A total of 48 male SD rats were allotted into three dietary treatments: (1) control (CON), 5% cellulose (CELL), and 5% Pleurotus eryngii (PLEU) groups. As a result of the experiment for 8 weeks, there was no difference in growth performance among the SD rats fed the diets supplemented with cellulose and Pleurotus eryngii compared with those fed the control diet. However, the PLEU group showed a significantly lower (P<0.05) abdominal fat deposition compared with the CON and CELL groups. The level of NEFA (non-esterified fatty acid), cholesterol and LDL-cholesterol in blood significantly decreased (P<0.05) in the SD rats fed the diet containing 5% Pleurotus eryngii. Hepatic lipid content was also markedly lower (P<0.05) in the PLEU group compared with the other groups. As regarding intestinal enzymes, the specific activity of maltase was remarkably reduced (P<0.05) in the PLEU group. However, the specific activities of sucrase, alkaline phosphatase and leucine aminopeptidase were not affected by dietary sources of fiber. This study suggests that dietary Pleurotus eryngii plays a potential role in down-regulation of adiposity via altering lipid metabolism and digestion of carbohydrate in SD rats.
Jang, Insurk,Kwon, Chang Hoon,Ha, Duck Min,Jung, Dae Yun,Kang, Sun Young,Park, Man Jong,Han, Jeong Hee,Park, Byung-Chul,Lee, Chul Young Korean Society of Animal Sciences and Technology 2014 한국축산학회지 Vol.56 No.8
This study compared the effects of varying lipid content and dietary concentration of a lipid-encapsulated (LE) ZnO product to those of native ZnO and thereby to find insights into optimal lipid coating and dosage of the Zn supplement. A total of 192 21-d-old weanling pigs were allotted to 48 pens, after which each six pens received a ZnO-free basal diet supplemented with 125 ppm ZnO (100 ppm Zn; BASAL), 2,500 ppm Zn as native ZnO (HIGH), or 100 or 200 ppm Zn as LE ZnO (LE-100 or LE-250) containing 8%, 10%, or 12% lipid [LE-8%, LE-10%, or LE-12%, respectively; $2{\times}3$ factorial arrangement within the LE-ZnO diets (LE-ALL)] for 14 d. Forty pigs were killed at the end for histological and biochemical examinations. None of ADG, ADFI, gain:feed, and fecal consistency score differed between the LE-ALL and either of the BASAL and HIGH groups. Hepatic and serum Zn concentrations were greater (p <0.05) in the HIGH vs. LE-ALL group, but did not differ between LE-ALL and BASAL, between LE-100 and -250, or among LE-8%, -10%, and -12% groups. Villus height (VH), crypt depth (CD), and the VH:CD ratio in the duodenum, jejunum, and ileum did not differ between the LE-ALL and either of the BASAL and HIGH groups, except for a greater CD in the duodenum in the LE-ALL vs. HIGH group. Additionally, VH and CD in the duodenum and VH:CD in the jejunum were greater in the LE-250 vs. LE-100 group. Specific activities of sucrase, maltase, and leucine aminopeptidase in these intestinal regions and those of amylase and trypsin in the pancreas were not influenced by the lipid content or dietary concentration of LE ZnO and also did not differ between the LE-ALL and either of the BASAL and HIGH groups, except for a greater pancreatic amylase activity in the former vs. HIGH group. In conclusion, the present results indicate that the LE ZnO, regardless of its lipid percentage or supplementation level examined in this study, has no significant effect on growth performance, fecal consistency, or digestive enzyme activities of weanling pigs under the experimental conditions.
비만 Zucker(fa/fa) 랫드에서 주령에 따른 지방대사 관련 혈액 생화학성분, 호르몬 및 체지방 합성 유전자의 변화
장인석(InSurk Jang),황대연(Dae Youn Hwang),채갑용(Kab Ryong Chae),이주은(Ju Eun Lee),조정식(Jung Sik Cho) 한국실험동물학회 2005 Laboratory Animal Research Vol.21 No.2
The aim of the present study was to investigate the age-related onset of obesity in obese Zucker(fa/fa) rats as indicated by adipogenic biomarkers and genes. The Zucker rats aged 6, 8, 10, 12, and 16 wk were used to determine age-related changes in biochemical components including triglyceride, glucose, cholesterol, insulin and leptin in serum, and the expression of adipogenic genes such as acetyl CoA carboxylase (ACC) and peroxisome proliferator activated receptor y (PPARγ) in the epididymal fat pads. As a result, the serum levels of glucose and cholesterol did not significantly affected by ages. However, the level of triglyceride in serum resulted in a significant (p<0.05) increase after 8 wk of age and stayed at this level till 16 wk of age we examined. The level of insulin at 6 wk of age was significantly (p<0.05) lower than any other ages examined. Also, the Zucker rats aged 16 wk showed a markedly (p<0.05) higher serum leptin level when compared with the rats aged 6 and 8 wk. Especially, leptin level at 16 wk of age increased by a two-fold as compared with that at 6 wk old. We also observed age-related differences in the expressions of ACC and PPARy in the epididymal fats. In particular, ACC mRNA expression did show much of an age-associated alteration in fat tissues. The PPARγ expression in rats aged 6 wk was to be much lower (p<0.05) compared with the rats aged 8, 10, 12 and 16 wk. From the evidences we observed here, it is suggested that preobese status at 6 wkold Zucker(fa/fa) rats rapidly developed obesity around at 8 wk of age as indicated by biomarkers and consequently showed pathophysiological symptom of obesity after 8 wk of age.
Young Hee Kim,Mi Sook Ha,Inae Kim,Insurk Jang,Wan Sung Choi,Chul Young Lee 한국실험동물학회 2006 Laboratory Animal Research Vol.22 No.4
Insulin-like growth factor-binding protein-3 (IGFBP-3) is the major plasma carrier and reservoir of IGF-1 which mediates most of the growth-promoting action of growth hormone. The present study was undertaken to examine the effect of administration of a phosphorothioate anti-sense deoxyribouncleotide (AODN; 5'-CATGGCGCTGGCGGAGGGC-3') targeted to a 5'-untranslated region of IGFBP-3 mRNA in growing rats. After confirming the effectiveness of the AODN in reducing the IGFBP-3 mRNA abundance in C6 rat glial cells in culture, male Sprague-Dawley rats weighing approximately 200 g were intra-peritoneally injected with 0.08-, 0.8-, 8-㎎ AODN or 8-㎎ random ODN per kg body weight every 12 h for 3 days. Blood samples were taken from the tail vein on d-1, 0, 1 and 3 of the experiment. Internal organs were excised and weighed at sacrifice following the last blood sampling. Hepatic IGFBP-3 mRNA abundance analyzed by Northern blotting, as well as plasma levels of IGFBP-3 and other IGFBPs resolved by Western ligand blotting, did not differ among the four groups. Plasma IGF-1 concentrations tended to increase with increasing doses of the AODN, with 0.09 of p-value for the effect of the treatment. Interestingly, weight of spleen, a most IGF-1-responsive organ, exhibited an identical trend with respect to IGF-1 concentration, whereas weights of liver, lung, kidney and heart had no relation to the plasma variable. In summary, the present AODN is judged to be minimally effective in blocking IGFBP-3 translation. Further studies are therefore necessary to find a more effective AODN and also to determine if blood IGF-1 concentration and spleen growth have any relation to IGFBP-3 expression.
( Byung Chul Park ),( Jeong Cheol Han ),( Young Hyun Ko ),( Duck Mm Ha ),( Doo Hwan Kim ),( Insurk Jang ),( C Young Lee ) 한국동물자원과학회(구 한국축산학회) 2013 한국축산학회지 Vol.55 No.2
The aim of the present study was to investigate the effects of partial substitution of an extruded or extruded-pelleted corn product for unprocessed corn of the starter diet on growth performance and incidence of diarrhea in weanling pigs. Seventy-two 21-day-old weanling pigs were allotted to 24 pens and provided ad libitum with one of the four experimental diets for 3 wk in two serial feeding trials during summer beginning from late June. The treatments were a milk product-soy-corn-based control diet containing 25% unprocessed corn and the other three diets only substituted with 12.5% extruded corn Suprex, Optigrain, an extruded mixture of wheat, rye and durum, or extruded-pelleted corn for an equal percentage of unprocessed corn of the control diet. All diets were supplemented with 100 ppm sulfathiazone, 50 ppm penicillin, and 100 ppm chlortetracycline for preventive medication. The initial and final weights as well as gain: feed were less in the second trial than in the first one (p<0.05). However, effects of the dietary treatments were not detected in any of the performance variables including final weight, ADG, ADFI, and fain: feed, nor were there any interactions between the trial and dietary treatment. In addition, almost all pigs exhibited normal firm feces in both trials and therefore there was no main effect in the fecal consistency score. Results suggest that partial substitution of the thermally processed corn for unprocessed corn of the milk product-corn-soy-based and medicated starter diet has no effect on growth performance or incidence of diarrhea in weanling pigs.
육계 사료 내 매실 및 오미자 첨가가 성장, 혈액 생화학 성분 및 항산화 작용에 미치는 영향
고영현(Young-Hyun Ko),문양수(Yang-Soo Moon),손시환(Sea-Hwan Sohn),정장용(Chang-yong Jung),장인석(Insurk Jang) 韓國家禽學會 2012 韓國家禽學會誌 Vol.39 No.2
To investigate the effect of dietary supplementation of freeze-dried plum (Prunus mume Siebold and Zucc., PMS) or omija meal (Schizandra chinensis Baill.; SCB) on growth performance, organ weights, blood biochemical profiles and antioxidant defense system, a total of 96, 3-day-old male broiler chickens were assigned to three dietary groups: (1) control diet, (2) control diet supplemented with PMS at 0.2%, (3) control diet supplemented with SCB at 0.2%. In vitro antioxidant activity, plum and omija extracts showed a significantly higher radical scavenging activity (RSA). In particular, omija extract showed much higher RSA than plum extract. Dietary addition of plum or omija did not affect body weight, feed intake, feed conversion and the relative weight of digestive organ in birds. Plasma triglyceride significantly (P<0.05) increased in birds fed the diet supplemented with omija compared with those fed control diet without affecting the other blood biochemical components. Furthermore, reduced form of glutathione (GSH) in the liver or muscle significantly (P<0.05) increased in birds fed the diet fortified with plum and omija. However, the specific activities of superoxide dismutase (SOD), glutathione peroxidase (GPX) and glutathione-S-transferase (GST) and MDA (malondealdehyde) in the intestine, liver and muscle were not altered by dietary antioxidant sources. In conclusion, dietary plum and omija resulted in a positive effect on some antioxidant indicators such as increased in vitro RAS in extracts and in vivo GSH level in the liver and muscle without affecting growth performance. Therefore, dietary addition of 0.2% of plum or omija could be applicable as potential antioxidant sources in broiler chick production.