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      • KCI등재
      • SCOPUSKCI등재

        Validity of Tono-pachymetry for Measuring Corrected Intraocular Pressure in Non-surgical and Post-photorefractive Keratectomy Eyes

        In Kyun Hahn,Jae Yong Kim,Myoung Joon Kim,Hungwon Tchah,Chan Hee Moon1 대한안과학회 2017 Korean Journal of Ophthalmology Vol.31 No.1

        Purpose: To assess the validity of central corneal thickness (CCT) and corrected intraocular pressure (IOP) values obtained by tono-pachymetry in non-surgical and post-photorefractive keratectomy (PRK) eyes. Methods: For the study, 108 young healthy participants and 108 patients who had PRK were enrolled. Measurements were randomly performed by tono-pachymetry, ultrasonic (US) pachymetry, and Goldmann applanation tonometry (GAT). CCT measurement by tono-pachymetry was compared to that of US pachymetry. The corrected IOP value obtained by tono-pachymetry was compared to that obtained by US pachymetry and GAT. The corrected IOP from US pachymetry and GAT was calculated using the identical compensation formula built into the tono-pachymetry. Bland-Altman plot and paired t-test were conducted to evaluate the between- method agreements. Results: The mean CCT measurement using tono-pachymetry was significantly greater by 7.3 μm in non-surgical eyes (p < 0.001) and 17.8 μm in post-PRK eyes (p < 0.001) compared with US pachymetry. Differences were significant in both Bland-Altman plotand paired t-test. The mean difference of corrected IOP values obtained by tono-pachymetry and calculated from measurements by US pachymetry and GAT was 0.33 ± 0.87 mmHg in non-surgical eyes and 0.57 ± 1.08 mmHg in post-PRK eyes. The differences in the Bland-Altman plot were not significant. Conclusions: The CCT measurement determined using tono-pachymetrywas significantly thicker than that of US pachymetry. The difference in CCT was greater in post-PRK eyes than in non-surgical eyes. However, the corrected IOP value obtained by tono-pachymetry showed reasonable agreement with that calculated from US pachymetry and GAT measurements.

      • KCI등재
      • KCI등재
      • KCI등재

        중앙 일간지 경제기사에 취재원으로 인용된 기업체 홍보실무자 및 해당 기사의 특성 연구

        한균태(Kyun-Tae Hahn),이종혁(Jong-Hyuk Lee) 한국언론정보학회 2003 한국언론정보학보 Vol.23 No.-

        본 연구는 경제 섹션을 발행하고 있는 국내 3대 종합지(조선, 중앙, 동아)의 경제기시에 의견이나 주장 등이 인용(quote)된 기업체 홍보 실무자 특성(성별, 조직, 산업군, 직급, 실명여부, 지역)및 해당 기사의 특성(취재경로, 기사주제, 갈등포함 여부)을 분석하였다. 그 결과, 경제기사에 인용된 홍보실무자들의 특성은 남성, 부장 및 과장급 관리자, 대기업, 서울 수도권지역, 전자IT 및 금융분야에 편중된 것으로 나타났다. 특히 이러한 편중에 있어 갈등이 포함된 사건사고의 경우에는 더욱 뚜렷하게 차이가 드러났다. 시기별로 비교해 보면, 이들 종합지가 전문 경제섹션을 발행하기 시작한 2002년부터 앞에 도출된 편중 현상이 완화되고 있는 것으로 드러났다. 취재경로, 기사주제, 갈등포함 여부 등 기사 특성에 따른 홍보 실무자들의 특성에 있어서도 각각 편중된 차이점이 발견되었다. 또한 전문경제 섹션 이전과 이후의 시기로 나누어 비교 분석해 본 결과 홍보실무자의 특성과 해당 기사의 특성에 있어 모두 차이점이 드러나는 경우가 많았다. The main purpose of this study was to examine the characteristics of corporate PR practitioners whose opinions were quoted as news sources and of the related articles in the economic section of the nation's three largest newspapers. The results revealed that the PR practitioners were mostly males with the job title of general manager or manager working for large electronics/IT or financing companies in Seoul and near metropolitan areas. In particular, such overwhelming features were more clearly salient in the articles related to conflicts. However, the phenomena seem to have been somewhat eased since 2002 when the newspapers came out with the specialized economic section. Analyzing the articles in terms of the channel of covering news, theme of news, and the existence of any conflict, we found statistically significant differences in the characteristics of PR practitioners. In addition, the comparison between each period before and after the emergence of the specialized economic section also showed statistically significant differences in the characteristics of the PR practitioners in many cases.

      • KCI등재
      • KCI등재

        녹내장으로 오인된 MT-TL1 유전자 변이 관련 비전형 레버유전시신경병증

        한인균(In Kyun Hahn),임현택(Hyun Taek Lim) 대한안과학회 2017 대한안과학회지 Vol.58 No.1

        Purpose: Leber hereditary optic neuropathy (LHON) is one of the most common hereditary optic neuropathies caused by mutations of mitochondrial DNA. Three common mitochondrial mutations causing LHON are m.3460, m.11778, and m.14484. We report a rare mutation of the mitochondrial tRNA (Leu [UUR]) gene (MT-TL1) (m.3268 A > G) in a patient with bilateral opticatrophy. Case summary: A 59-year-old female diagnosed with glaucoma 3 years earlier at a community eye clinic presented to our neuro-ophthalmology clinic. On examination, her best corrected visual acuity was 0.4 in the right eye and 0.7 in the left eye, and opticatrophy was noticed in both eyes. Optical coherence tomography revealed retinal nerve fiber layer (RNFL) thinning in both eyes; average RNFL thickness was 52 μm in the right eye and 44 μm in the left eye, but the papillomacular bundle was relatively preserved in both eyes. Goldmann perimetry demonstrated peripheral visual field defects, mostly involving superotemporal visual field in both eyes. Mitochondrial DNA mutation test showed an unusual mutation in MT-TL1 gene seemingly related to this opticneuropathy. Conclusions: We found a rare mutation (m.3268 A > G) of the mitochondrial DNA in a patient having bilateral optic atrophy, which led to the diagnosis of LHON. There have been previous reports about mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) and infantile myopathy caused by MT-TL1 mutation, but this is the first case of LHON associated with the same mutation. In this case of LHON associated with MT-TL1 mutation, atypical clinical features were observed with a relatively mild phenotype and peripheral visual field defects.

      • KCI등재후보

        광폭 인공수정체 SuperflexⓇ의 임상성적

        한인균(In Kyun Hahn),선재홍(Jae Hong Sun),조수근(Soo Geun Joe),김재용(Jae Yong Kim),김명준(Myoung Joon Kim),최철영(Chul Young Choi),박혜영(Hye Young Park),차흥원(Hungwon Tchah) 대한검안학회 2016 Annals of optometry and contact lens Vol.15 No.4

        Purpose: To evaluate the clinical outcomes after in the bag insertion of Superflex?? intraocular lens (IOL) which has 0.25 mm bigger optic diameter than the conventional IOL. Methods: Retrospective chart review was performed for 15 eyes of 13 patients who had undergone phacoemulsification with in the capsular bag insertion of Superflex?? IOL (experimental group) and for 28 eyes of 25 patients with in the bag insertion of Akreos?? (control group). Best-corrected visual acuity (BCVA), manifest refraction, refractive error (RE; [postoperative spherical equivalent]–[preoperative target refraction]), corneal topography, higher-order aberration and contrast sensitivity were measured preoperatively and at 1 week, 1 month and 3 months postoperatively. Their changes after surgery were compared between both groups. Results: At 3 months after the surgery, RE was 0.22 ± 0.39 D in the experimental group and -0.17 ± 0.58 D in the control group, showing more hyperopic RE in the experimental group than the control group (p=0.007). BCVA, spherical equivalent, higher-order aberration, contrast sensitivity, and anterior chamber depth had no significant difference between two groups at 1 week, 1 month, and 3 months after the surgery. Conclusions: Superflex?? IOL showed no significant difference in the clinical outcomes compared with Akreos?? IOL until 3 months after the surgery. However, the target refraction of Superflex?? IOL should be considered more myopic, since its postoperative refraction would be hyperopic.

      • KCI등재

        한국인 선천성 무홍채증의 임상양상과 분자유전학적 특성

        한인균(In Kyun Hahn),김대희(Dae Hee Kim),임현택(Hyun Taek Lim) 대한안과학회 2016 대한안과학회지 Vol.57 No.9

        목적: 한국인 선천성 무홍채증 환자의 임상양상과 분자유전학적 특성을 분석하여 소개한다. 대상과 방법: 홍채형성저하증을 특징으로 임상적으로 진단된 한국인 선천성 무홍채증 환자를 대상으로 하였다. 최대교정시력, 홍채형성저하증의 정도, 황반형성저하증의 정도 및 동반된 이상소견을 기록하여 분석하였다. PAX6 유전자의 변이분석, 복합결찰의존프로브증폭법 분석, 유전체의 분자 핵형 분석 및 후보 유전자 염기서열 분석을 통한 분자유전학적 검사결과를 분석하였다. 결과: 18가계의 총 28명의 환자가 포함되었다. 최대교정시력은 다양하여 시표로 측정이 가능하였던 19명에서 20/400에서 20/25의 범위였고, 그중 20/200 이하의 시력을 보인 환자는 9명이었다(47%). 황반형성저하증은 전 예에서 관찰되었고, 그중 1명은 매우 경증이었다. PAX6 유전자 분석을 시행한 18가계 중 13가계에서 유전자 변이가 발견되었으며, 2개의 새로운 변이(p.Trp162Leufs*38, p.Gly409Arg)가 발견되었다. 발견된 변이 중 3가계에서는 과오돌연변이(missense mutation), 또 다른 3가계에서는 PAX6 유전자 부위의 큰 결손(large chromosomal deletions)을 보였다. 결론: 선천성 무홍채증과 연관된 2개의 새로운 변이를 발견하여 보고하는 바이다. 선천성 무홍채증은 시력을 위협하는 심각한 안구기형이지만, 중심시력, 홍채형성저하증의 정도는 매우 다양하였다. 전체 가계의 72%에서 PAX6 유전자의 돌연변이가 발견되었고, 돌연변이 유무에 관계없이 경증에서 중증까지 다양한 스펙트럼의 임상양상을 보여주었다. Purpose: To introduce clinical features and molecular characteristics of Korean patients with congenital aniridia. Methods: Patients with iris hypoplasia were diagnosed clinically as congenital aniridia and were included in the study. Best corrected visual acuity (BCVA) and associated ocular abnormalities (including severity of iris hypoplasia, nystagmus, keratopathy, and foveal hypoplasia), and findings in optical coherence tomography were analyzed. PAX6 analysis,multiplex ligation-dependent probe amplification (MLPA), genomic molecular karyotyping, and candidate gene sequencing were performed to detect genetic abnormalities. Results: 28 patients from 18 families were included in the study. BCVA varied from hand motion to 20/25. No manifest nystagmus was found in 3 patients, but the rest of the patients had pendular horizontal nystagmus. Keratopathy was found in 23 patients, cataracts in 12 patients, and glaucoma in 4 patients. All patients had foveal hypoplasia, including one case with a subtle phenotype. The PAX6 mutation was detected in 13 families out of 18;2 (p.Trp162Leufs*38,p.Gly409Arg) were novel,3 families had the miss ensemutation, and 3 families had alargedeletion in the PAX6 gene. Conclusions: This study adds 2 novel PAX6 mutations related to congenital aniridia to those previously reported. Congenital aniridia is a serious, sight-threatening ocular malformation, but central vision and the degree of iris hypoplasia were highly variable. The PAX6 mutation was detected in 72% of the patients in this study, and there were no specific clinical features differentiating aniridia with and without PAX6 mutations.

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