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Kumagai, Hideki,Yokoyama, Koji,Imagawa, Tomoyuki,Inoue, Shun,Tulyeu, Janyerkye,Tanaka, Mamoru,Yamagata, Takanori The Korean Society of Pediatric Gastroenterology 2016 Pediatric gastroenterology, hepatology & nutrition Vol.19 No.3
Fecal microbiota transplantation (FMT) is a treatment designed to correct gut dysbiosis by administration of feces from a healthy volunteer. It is still unclear whether FMT for children with ulcerative colitis (UC) is effective or hazardous. Here we describe a young patient to have received FMT for UC. A three-year-old girl was admitted to our hospital with severe active UC, and treated with aminosalicylates and various immunosuppressive drugs. As remission was not achieved, we decided to try FMT before colectomy. We administered donor fecal material a total of six times by retention enema (${\times}2$) and via a nasoduodenal tube (${\times}4$) within 10 days. The patient developed abdominal pain and pyrexia after each FMT session. Analyses revealed the transferred donor fecal microbiota had not been retained by the patient, who ultimately underwent colectomy. The severity of the UC and/or timing of FMT may have partly accounted for the poor outcome.
Liver Pathology : Composite Liver tumors: A radiologic-pathologic
( Megha Nayyar ),( David K Imagawa ),( Temel Tirkes ),( Aram N Demirjian ),( Roozbeh Houshyar ),( Kumar Sandrasegaran ),( Chaitali S Nangia ),( Tara Seery ),( P Bhargava ),( Joon Ii Choi ),( Chandana 대한간학회 2014 Clinical and Molecular Hepatology(대한간학회지) Vol.20 No.4
Bi-phenotypic neoplasm refers to tumors derived from a common cancer stem cell with unique capability to differentiate histologically into two distinct tumor types. Bi-phenotypic hepatocellular carcinoma-cholangiocarcinoma (HCC-CC), although a rare tumor, is important for clinicians to recognize, since treatment options targeting both elements of the tumor are crucial. Imaging findings of bi-phenotypic HCC-CC are not specific and include features of both HCC and CC. A combination of imaging and immuno-histochemical analysis is usually needed to make the diagnosis. (Clin Mol Hepatol 2014;20:406-410)
Akihiro Tamura,Masafumi Kobune,Kazuki Imagawa,Hisashi Oshima,Yusuke Daiko,Atsushi Mineshige,Tetsuo Yazawa,Hiroshi Nishioka,Hironori Fujisawa,Masaru Shimizu,Hideshi Yamaguchi,Koichiro Honda 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.31
3.0-mm-thick a- and b-axis-oriented (Bi_(3.25)Nd_(0.75))Ti_3O_(12) (BNT-0.75) films were fabricated on conductive Nb:TiO_2(101) (Nb = 0, 0.048, 0.46, 0.79 mass%) single crystal substrates by high-temperature sputtering. A BNT films grown on undoped TiO_2 substrates have no orientation, whereas BNT films deposited on Nb:TiO_2 substrates with 0.46-0.79 mass% Nb show strong (h00/0k0) diffractions and grow with a heteroepitaxial relationship to the underlying Nb:TiO_2 substrates. The BNT-0.75 film deposited on Nb:TiO_2(101) substrate with 0.79 mass% Nb was indicated the peculiar shape of approximately 100-150-nm-thick nanoplates. We speculate that the driving force for producing a plate-like structure for BNT films is attributed to the large anisotropy of linear expansion coefficients for Bi_4Ti_3O12, and the comparatively small lattice matching between Nb:TiO_2 substrate and BNT film.
Hideki Kumagai,Koji Yokoyama,Tomoyuki Imagawa,Shun Inoue,Janyerkye Tulyeu,Mamoru Tanaka,Takanori Yamagata 대한소아소화기영양학회 2016 Pediatric gastroenterology, hepatology & nutrition Vol.19 No.3
Fecal microbiota transplantation (FMT) is a treatment designed to correct gut dysbiosis by administration of feces from a healthy volunteer. It is still unclear whether FMT for children with ulcerative colitis (UC) is effective or hazardous. Here we describe a young patient to have received FMT for UC. A three-year-old girl was admitted to our hospital with severe active UC, and treated with aminosalicylates and various immunosuppressive drugs. As remission was not achieved, we decided to try FMT before colectomy. We administered donor fecal material a total of six times by retention enema (×2) and via a nasoduodenal tube (×4) within 10 days. The patient developed abdominal pain and pyrexia after each FMT session. Analyses revealed the transferred donor fecal microbiota had not been retained by the patient, who ultimately underwent colectomy. The severity of the UC and/or timing of FMT may have partly accounted for the poor outcome.
Masafumi Kobune,Hisashi Oshima,Akihiro Tamura,Kazuki Imagawa,Yusuke Daiko,Atsushi Mineshige,Tetsuo Yazawa,Hitoshi Morioka,Keisuke Saito,Hideshi Yamaguchi,Koichiro Honda 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.31
a- and b-axis-oriented (Bi_(3.25)Nd_(0.75))Ti_3O_(12) films, 3.0 mm thick, were fabricated on conductive IrO_2(101)/Al_2O_3(012) and Nb:TiO_2(101) [Nb = 0, 0.05 and 0.79 mass%] substrates by high-temperature sputtering. A BNT film grown on an IrO_2(101)/Al_2O_3(012) substrate had a low crystallinity (2.83˚), a low degree of a- and b-axis orientations [a_((h00/0k0)) = 49.2%] and a dense microstructure that a- and b-axis-oriented crystals existed locally in the film, while a BNT film grown on Nb:TiO_2(101) substrate with 0.79 mass% Nb showed a high crystallinity (0.57˚), a high a_((h00/0k0)) (99.9%) and a porous microstructure that was comprised of many nanoplate-like crystals. It is shown that the BNT film grew with a heteroepitaxial relationship to the underlying Nb:TiO_2 substrate has a symmetric loop shape, with a remanent polarization (2P_r) of 29 mC/cm^2 and a coercive field (2E_c) of 297 kV/cm.
Plasma free amino acid profiles of canine mammary gland tumors
Kazuo Azuma,Takeshi Tsuka,Tomohiro Imagawa,Saburo Minami,Yoshiharu Okamoto,Tomohiro Osaki 대한수의학회 2012 JOURNAL OF VETERINARY SCIENCE Vol.13 No.4
The purpose of this study was to elucidate the relationship between plasma free amino acid (PFAA) levels and the clinical stages of mammary gland tumors (MGT) in dogs. PFAA levels in canines with malignant mammary tumors were decreased compared to those of healthy animals. The levels of aspartate and ornithine, in the dogs with tumor metastasis were significantly decreased when compared to those of dogs that did not have metastases. Results of this study indicate that PFAA levels could be a risk factor or biomarker for canine MGT metastasis.
Masaki Onoyama,Takeshi Tsuka,Tomohiro Imagawa,Tomohiro Osaki,Saburo Minami,Kazuo Azuma,Kazuhiko Kawashima,Hiroshi Ishi,Takahiro Takayama,Nobuhiko Ogawa,Yoshiharu Okamoto 대한수의학회 2014 JOURNAL OF VETERINARY SCIENCE Vol.15 No.1
Sixteen cases of malignant soft tissue sarcoma (STS; 10canines and six felines) were treated with a novel tripletherapy that combined photodynamic therapy, hyperthermiausing indocyanine green with a broadband light source, andlocal chemotherapy after surgical tumor resection. This tripletherapy was called photodynamic hyperthermal chemotherapy(PHCT). In all cases, the surgical margin was insufficient. Inone feline case, PHCT was performed without surgicalresection. PHCT was performed over an interval of 1 to 2 weeksand was repeated three to 21 times. No severe side effects,including severe skin burns, necrosis, or skin suture rupture,were observed in any of the animals. No disease recurrence wasobserved in seven out of 10 (70.0%) dogs and three out of six(50.0%) cats over the follow-up periods ranging from 238 to1901 days. These results suggest that PHCT decreases the riskof STS recurrence. PHCT should therefore be considered anadjuvant therapy for treating companion animals with STS inveterinary medicine.