Trichinella spiralis 感染이 마우스의 免疫反應에 미치는 影響

任善永,李黃浩,金文中,河大有 全北大學校 齒醫學硏究所 1983 전북치대논문집 Vol.1 No.1

Male, IcR mice weighing 20 to 25 gm were infected experimentally by esophageal intubation of 300 Trichinella spiralis infective muscle larvae prepared by acid-pepsin digestion of infected mice. Delayed type hypersensitivity and hemagglutinin antibody reactions to unrelated antigen, sheep red blood cell (SRBC) were measured at 37 and 83 days after infection, employing footpad and ear swelling reactions and microtitration technique. All mice were sensitized i.v. with SRBC. It was found that DTH and hemagglutinin responses to SRBC were depressed in infected mice when observed at 37 and 83 days postinfection, and degree of immunosuppression was more profound in mice observed at 83 days than in those at 37 days. The secondary cell-mediated immune response of DTH to SRBC were suppressed in Trichinella - infected mice, indicating the development of immunological memory cell is affected. In addition, immunodepression to SRBC in mice infected with T. spiralis was eliminated by pretreating infected mice by subcutaneous injection of cyclosphosphamide(100㎎/㎏) 2 days prior to infection. These results suggest that the immuno suppression in trichinellosis can be due to suppressor T cells.

전국 응급의학과 수련병원의 응급실 병력지에 대한 분석

임태호,임훈,이종호,강형구,장문준,조광현,장석준,김승호,정상원 대한응급의학회 2000 대한응급의학회지 Vol.11 No.4

Background: This study was designed to analyze the current emergency department(ED) medical records of teaching hospitals in Korea. Methods: The five-item questionnaires were mailed to the EDs of 40 hospitals. Among them, 27 questionnaires and 35 ED medical records were returned for reply rates of 67.5% and 87.5%, respectively. Results: 1) The actual number of data elements in the ED medical records used by each hospital varies widely. It ranges from 1 to 15 data elements with an average of 7.5 data elements. 2) Thirteen data elements, signature of nurse, checklist style in review of systems, checklist style in physical examination, neurologic examination, figure of face, Glasgow coma scale, trauma scale, treatment plan, mode of transfer, condition on transfer, documents sent with patient, condition on discharge or discharge instruction, use of pediatric chart and vaccination history are used by less than 50% of the medical records examined. 3) There was no difference in the total number of data elements or in redesign and computerization of ED medical record based on the location of the hospital, the type of hospital administration, or the number of years since the start of EM residency program. 4) There was a statistically increased number of data elements in redesigned medical records. 5) In the survey, 89% of the residents replied that medical records needed to be redesigned. With respect to uniformity, 58% of the residents disagreed. A well-designed checklist chart rather than a descriptive chart was preferred by 89% of the residents. Conclusion: The currently used ED medical records have much room for improvement. The age of the ED had little impact on the quality of ED medical records. More attention and effort in this field are needed. In addition, The Korean Society of Emergency Medicine should provide guidelines for ED medical records.

정상 초기 임신에서 갑상선 기능과 입덧의 심한 정도와의 상관관계에 관한 연구

이은찬,이임순,조태호 순천향의학연구소 1997 Journal of Soonchunhyang Medical Science Vol.3 No.1

Nausea and vomiting are extremely common symptoms in first trimester of the pregnancy. The reported frequency is ranging from 50-75% of all pregnancy. Hyperemesis gravidarum is clinically characterized by profuse vomiting which may some time be so severe as to cause electrolytes imbalance especially hypokalemia which can be like threatening or even fatal requiring hospitalization and intravenous therapy. Pregnant women with severe emesis might have a similar condition of non-thyroidal illness. However, little is known about the relation between morning sickness and thyroid function. Mori(1988) reported that increased free T₄and hCG and decreased TSH correlated with the severity of morning sickness, and these changes were especially marked in subject with nausea and vomiting. Thyroid gland is physiologically activated in early pregnancy, possibly by hCG or related substance, which may be gestational emesis. The purpose of this study was to determine thyroid function in early pregnancy with reference to morning sickness, using a highly sensitive immunoradiometric assay for TSH and a newly developed free T₄RIA that is not influenced by changes in thyroxine-binding globulin or albumin. The results were as follows: 1. Among groups in early pregnancy, the severity of morning sickness correlated significantly with changes of free T₄(p<0.05), TSH(p<0.01) and hCG(p<0.05) 2. The serum levels of free T₄in all 100 pregnant women correlated negatively with their TSH level (r=-0.451, p<0.001) and positively with their hCG levels (r=0.292, p<0.05). More their serum TSH levels correlated negatively with hCG levels(r=-0.279, p<0.05) 3. The increased free T₄and decreased TSH in subjects with emesis returned to the normal ranges of nonpregnant controls after improvement of emesis in five normal pregnant women. 4. An increased level of free T₄and a reduced level of TSH in early normal pregnancy are not indication of thyrotoxicosis and may not necessitate antithyroid drug treatment.

한국 소아, 가임여성, 및 임산부의 풍진항체 보유율에 관한 연구

이상주,이임순,김창휘,조태호,유훈 순천향대학교 1988 논문집 Vol.11 No.3

유방암의 재발양상과 이에 따른 생존율 및 혈청 표지자들의 변화 분석

임태호(Tai Ho Im),정파종(Pa Jong Jung) 대한외과학회 1998 Annals of Surgical Treatment and Research Vol.54 No.3

Anti-Toxoplasma Antibody Titers in Pregnant Women

Im,Kyung-il,Yong,Tai-Soon,Shin,Ho-Joon,Lee,Doo-Ho INSTITUTE OF TROPICAL MEDICINE YONSEI UNIVERSITY 1991 YONSEI REPORTS ON TROPICAL MEDICINE Vol.22 No.1

톡소플라스마의 감염은 태아의 유산이나 선천성 기형을 일으킬 수 있으므로, 일반임신부에 대한 감염 상황의 조사는 톡소플라스마증이 임신 및 태아에 어떠한 영향을 미치는지에 대한 간접적인 자료를 얻을 수 있을 것이다. 이 연구에서는 산전 관리를 위하여 1990년 8월부터 1991년 2월까지 연세의료원에 내원한 일반임신부 중 618명의 혈청내 IgG 항체가를 간접형광항체법 및 효소면역검사법(ELIAS)으로 측정하고그 결과를 서로 비교하였으며, 아룰러 병력을 검토하였다. 간접형광항체법을 위한 항원의 제조는 마우스 복강내에서 계대 배양한 툭소프라스마 RH주의 tachyzoite를 슬라이드에 고정하여 사용하였으며, 효소면역검사법을 위하여는 tachyzoite를 균질화하여 인산완충용액에 추출한 항원을 사용하였다. 간접형광체법의 측정 결과는 총 618명 중 41명(6.6%)에서 양성반응(1:16 이상)을 보였으며, 이 중 1:16은 37명, 1:32는 3명, 1:64는 1명으로 나타났다. 효소면역검사법(ELISA)의 결과는 43명(7.0%)에서 양성 반응(흡광도 0.36 이상을 보였다. 간접형광항체법과 효소면역검사법에서 모두 양성의 항체가를 보인 경우는 618명중 12명(1.9%)이었으며, 간접형광항체법과 효소면역검사법으로는 음성인 경우가 29명이었고, 반대로 간접형광항체법에는 음성이었으나, 효소면역검사법으로는 양성의 항체가를 나타낸 경우가 31명으로, 개별적인 결과는 두 검사 간에 불일치하는 경우가 많았다. 한편, 양성 반응을 보인 일반임산주의 병력을 조사한 결과, 톡소플라스마 감염과 연관지을 근거는 부족하나, 태아사망 등으로 인한 유산, 소두증(microcephalus)으로 인한 신생아 사망, 양수과다증(hydroamnious)등의 경우를 찾아볼 수 있었다. Congenital infection of T. Gondii has been revealed to cause chorioretinitis, meningoencephalitis, hydrocephaly, microcephaly and mental retardation in man. So prenatal detection of antibodies against T. gondii in pregnant women is very important in managing these serious congenital abnormalities. In this study, a total of 618 sera were collected from pregnant women, who visited Severance Hospital, Yonsei University College of Medicine, for prenatal obstetric care from June 1990 to Deember 1990. Serum IgG antibody itiers were examined by IFA and ELIS, and the results obtained by these two test were compared. Forth-one (6.6%) out of 618 serum samples of pregnant women showed positive titers (higher than 1:16) detected by IFA. Of them. 37 cases showed 1:16.3 showed 1:32 and only 1 case was found to be 1:64. Forty-three (7.0%) among 618 tested sera were revealed to be positives (O.D. 0.36). Twelve cases (1.9%) showed positive reactions by both IFA and ELISA. Post obstetric history reviewed through their medical records of the positive cases of either IFA or ELISA showed several ovstetirc complications, such as abortion due to intrauterine fetal death, neonatal death, microcephalus and hydroamnios. Any of these complications could be attributed to toxoplasmosis during pregnancy.

자궁경부 상피내종양의 치료로서 환상투열요법 시행 후 잔류병변의 예측인자

임태건(Tai Gun Im),황호명(Ho Myong Hwang),정영주(Young Ju Jeong),오병찬(Byung Chan Oh) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.8

N/A Objective : The purpose of this study was to determine whether unexplained elevation of second- trimester maternal serum beta-human chorionic gonadotropin (β-hCG) is associated with adverse pregnancy outcomes. Method : Between January 1998 and December 1999, we evaluated 2112 pregnant women undergoing second trimester triple marker screening test who delivered at our hospital. Inclusion criteria were singleton pregnancy, confirmed gestational age, and hCG level greater than 2.0 MoM. The exclusion criteria were fetal anomaly, abnormal karyotype, MSAFP level greater than 2.0 MoM, uE3 level less than 0.4 MoM, and referred patients with pregnancy-induced hypertension (PIH). A group of randomly selected women with normal maternal serum hCG and AFP levels served as control. Results : Women with unexplained elevation of hCG level showed increased risks for PIH (p<0.001) and preterm delivery (p<0.003). There were no significant diffrences between study and control groups with respect to placental abruption, fetal distress, PROM, intrauterine fetal death, and apgar score. Conclusion ; Pregnancies with unexplained elevation of hCG levels should be regarded as high-risk pregnancies and managed accordingly. The combination with these biomarkers such as VEGF, plasminogen activating factor I and AT-III as a screening test for PIH may be useful.

정상 임산부 혈청 알파 태아단백 수치에 관한 연구

이임순,차상헌,남정우,남계현,조태호 순천향대학교 1991 논문집 Vol.14 No.2

Prenatal screening test for maternal serum Alpha-fetoproten level is accepted as an efficient method of detecting congenital anomalies of the fetus including neural tube defects or other chromosomal anomalies. In this study, total 530 cases of uncomplicated pregnant woman with singleton fetus participated in maternal serum Alpha-fetoprotein screening program. The normal AFP range between 7 to 40 weeks was obtained by Radioimmunoassy RIABAED, ABBOT laboratories from January 1989 to October 1990 at Soonchunhyang University Hospital. The result were summarised as follows : The lowest level of MSAFT was 5.0 ng/ml at 7 weeks of gestation. During 7 to 30 weeks of gestational age, MSAFP levels showed progressively increasing trend, peak of MSAFP levels was 223 ·1 ng/ml at 31 weeks of gestational age. And then the MSAFP levels was showed.

Gastric Anisakiasis in Korea : with Review of 47 Cases

Yong,Tai-Soon,Shin,Ho-Joon,Kim,Byong-Hua,Moon,Seung-Il,Im,Kyung-il INSTITUTE OF TROPICAL MEDICINE YONSEI UNIVERSITY 1990 YONSEI REPORTS ON TROPICAL MEDICINE Vol.21 No.1

1985년 10월부터 1989년 5월까지 심와부통(31例), 驅吐 또는 惡心(8例)을 주소로 하는 환자 39例의 胃 內視鏡 관찰에서 胃 粘膜에 부착한 43마리의 蟲體를 얻을 수 있었고, 한 환자에서는 4마리를 적출하였다. 대부분 환자에서 胃 大灣部에서 충체를 적출하였으며 충체가 부착된 부위에서 부종(12例), 궤양(6例), 靡爛(6例), 出血(5例) 등이 관찰되었다. 회(바닷고기날것)를 먹고 증상이 나타날 때까지의 시간은 대부분 4∼17시간이었고 (16例), 3시간 미만이 2例, 2∼3일이 6例였다. 증상이 나타나고 충체가 제거되기까지 기간은 1∼3일이 27例였다. 이들 患者들이 섭취했던 魚種을 보면 오징어를 섭취했던 환자 6例, 조기 9例, 바다장어 4例, 히라스 6例, 광어, 방어, 숭어 각각 1例 등이었다. 환자 39명 중 남자는 22명, 여자는 17명이었으며, 20∼29세 5명, 30∼39세 15명, 40∼49세 13명, 50∼59세 3명이었다. 연중 발생 분포를 보면 겨울철에 발생된 경우는 20例, 봄철은 9例, 여름철은 4例였고 가을철에는 5例였다. 제거된 충체는 유백색이었고, 평균 길이 16.30mm, 폭 0.44mm였고, 16마리가 분류 同定이 가능하였으며, Anisakis type I이 13마리, Terranova type A가 1마리, Contracaecum sp. 가 2마리였다. Thirty nine cases of acute gastric anisakiasis are reported. Most patients had a history of eating raw marine fish with acute abdominal symptoms such as epigastric pain, nausea and vomiting. They were diagnosed and treated by gastrofiberscopic examination. Anisakis larvae removed from stomach were identified; Anisakis type I, Contracaecum sp. and Terranova type A.

직장에서 성충이 검출된 수입성 구충(鉤蟲) 감염 1례

용태순(Tai-Soon Yong),신호준(Ho-Joon Shin),임경일(Kyung-il Im),김원호(Won-Ho Kim) 대한기생충학열대의학회 1992 The Korean Journal of Parasitology Vol.30 No.1