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Inhibition of acute lethal pulmonary inflammation by the IDO–AhR pathway
Lee, Soung-Min,Park, Ha Young,Suh, Young-Sill,Yoon, Eun Hye,Kim, Juyang,Jang, Won Hee,Lee, Won-Sik,Park, Sae-Gwang,Choi, Il-Whan,Choi, Inhak,Kang, Sun-Woo,Yun, Hwayoung,Teshima, Takanori,Kwon, Byungsu National Academy of Sciences 2017 Proceedings of the National Academy of Sciences Vol.114 No.29
<P>The lung is a prototypic organ that was evolved to reduce immunopathology during the immune response to potentially hazardous endogenous and exogenous antigens. In this study, we show that donor CD4(+) T cells transiently induced expression of indoleamine 2,3-dioxygenase (IDO) in lung parenchyma in an IFN-gamma-dependent manner early after allogeneic hematopoietic stem cell transplantation (HSCT). Abrogation of host IDO expression by deletion of the IDO gene or the IFN-gamma gene in donor T cells or by FK506 treatment resulted in acute lethal pulmonary inflammation known as idiopathic pneumonia syndrome (IPS). Interestingly, IL-6 strongly induced IDO expression in an IFN-gamma-independent manner when deacetylation of STAT3 was inhibited. Accordingly, a histone deacetylase inhibitor (HDACi) could reduce IPS in the state where IFN-gamma expression was suppressed by FK506. Finally, L-kynurenine produced by lung epithelial cells and alveolar macrophages during IPS progression suppresses the inflammatory activities of lung epithelial cells and CD4(+) T cells through the aryl hydrocarbon receptor pathway. Taken together, our results reveal that IDO is a critical regulator of acute pulmonary inflammation and that regulation of IDO expression by HDACi may be a therapeutic approach for IPS after HSCT.</P>
李善鏞,金永銓,張忠根,徐日煥 충남대학교 자연과학연구소 1982 忠南科學硏究誌 Vol.9 No.1
The crystal structure of potassium chloride and potassium bromide have been determined by X-ray diffraction method. Both unit cells are face-centered cubic, F(4/m)3 ̄(2/m) z=4 but a=5.2857Å, V=248,348Å^3, D_c=1.989 gr/㎤ for KCl and a=6.5891Å, V=286.074Å^3, D_c=2.756 gr/㎤ for KBr. the structures were solved by graphical method using thirteen KCl and eleven KBr powder diffractometer data. The agreement between the experimental and theoretical integrated intensities of the reflecting planes is fairly good. The crystal are aggregates of positive and negative ionic atoms. Each atom has six nearest neighbors of the other kind. The distances between unlike atoms are 3.1429Å in KCl and 3.2945Å in KBr.
李善鏞,金永銓,尹和重,徐日煥 충남대학교 자연과학연구소 1982 忠南科學硏究誌 Vol.9 No.1
The crystal structure of silicon has been determined by X-ray powder diffraction study (Cu Kα radiation). The unit cell is cubic (diamond-type), F(2/d)3, with a=5.42 A˚, V=159.22 A˚^3, z=8, D_c=2.34gr/㎤. The structure was solved by graphical method using eleven powder diffraction data. The experimental and theoretical integrated intensities of the reflecting planes are in good agreement with each other. The silicon atoms have tetrahedral arrangement to form covalent bonds with four other atoms. The nearest interatomic distance is 2.34Å.
Suh,Tae-Suk,Suh,Doug-Young,Park,Sung-Hun,Jang,Hong-Seok,Choe,Bo-Young,Yoon,Sei-Chul,Shinn,Kyung-Sub,Bahk,Yong-Whee,Kim,Il-Hwan,Kang,Wee-Sang,Ha,Sung-Whan,Park,Charn-Il 대한방사선 방어학회 1995 방사선방어학회지 Vol.20 No.1
본 연구는 방사선 수술시 필수적으로 이용되는 환자의 정위적 데이터 및 방사선 측정 데이터를 효율적으로 처리하여 종래의 시행착오적 방식을 통한 수술 계획상의 오류 및 부정확성을 지양하고 능률적이고 효율적인 수술이 될 수 있도록 하는데 목적이 있다. 정위시스템 개발을 위하여 Fisher 프레임이 사용되었으며, 뇌혈관 촬영 및 CT의 정위적 방법에 의하여 병변의 위치를 3 차원적으로 정확히 얻을 수 있는 알고리듬을 개발하였다. 정위시스템 과정은 컴퓨터에 의해 쉽게 운열될 수 있도록 프로그램화하였으며, 환자 영상을 컴퓨터에 입력하는 과정, 입력된 영상으로부터 병소 및 위치측정 보조기구 (localizer)에 대한 정보를 추출하는 과정, 입력된 영상의 위치 정보로부터 병소의 3 차원적 정위좌표로 변환하는 과정 등으로 나누었다. 좌표 변환 계산은 실시산에 구해졌으며, CT 및 혈관촬영술의 정위적 방법에 의하여 얻어진 병소의 3차원 좌표를 서로 비교한 결과 오차는 통상적으로 인정되는 2 mm 이내였다. NEC 6 MVX 선형 가속기를 사용하여 소조사면 선량을 측정하였다. 사용된 측정기로는 전리함(ion chamber), 필름, 다이오드 등이며, 측정된 값은 출력 계수, 깊이선량률 (PDD), 최대조직선량비(TMR), 축선량비 (OAR) 등이다. 측정기의 종류에 따라, 측정치가 조금씩 상이했으나, 전반적으로 같은 경향을 보여 줌으로 써 측정치의 신뢰도를 확인할 수 있었다. 제작된 구형 물팬톰과 필름을 이용하여 표준 방사선 치료시 예측했던 선량 분포가 실제 나오는가를 실험을 통하여 확인하였으며, 예측한 선량 값을 얻을 수 있었다. 본 연구를 통하여 개인용컴퓨터에 의해 병소의 정위좌표를 정확히 얻을 수 있는 프로그램이 개발되었고, 소조사면을 간단하고 편리하게 잴 수 있는 방법을 개발함으로써 방사선 수술에 많은 도움이 될 것으로 사료된다. The purpose of this research is to develop stereotactic localization and radiation measurement system for the efficient and precise radiosurgery. The algorithm to obtain a 3-D stereotactic coordinates of the target has been developed using a Fisher CT or angio localization. The procedure of stereotactic localization was programmed with PC computer, and consists of three steps: (1) transferring patient images into PC; (2) marking the position of target and reference points of the localizaer from the patient image; (3) computing the stereotactic 3-D coordinates of target associated with position information of localizer. Coordinate transformation was quickly done on a real time base. The difference of coordinates computed from between Angio and CT localization method was within 2 mm, which could be generally accepted for the reliability of the localization system developed. We measured dose distribution in small fields of NEC 6 MVX linear accelerator using various detector; ion chamber, film, diode. Specific quantities measured include output factor, percent depth dose (PDD), tissue maximum ratio (TMR), off-axis ratio (OAR). There was small variation of measured data according to the different kinds of detectors used. The overall trends of measured beam data were similar enough to rely on our measurement. The measurement was performed with the use of hand-made spherical water phantom and film for standard arc set-up. We obtained the dose distribution as we expected. In conclusion, PC-based 3-D stereotactic localization system was developed to determine the stereotactic coordinate of the target. A convenient technique for the small field measurement was demonstrated. Those methods will be much helpful for the stereotactic radiosurgery.
Effect of Goggle Slippage on the Video Head Impulse Test Outcome and Its Mechanisms
Suh, Myung-Whan,Park, Jae Hong,Kang, Seong Il,Lim, Jae Hyun,Park, Moo Kyun,Kwon, Seong Keun Lippincott Williams Wilkins 2017 Otology & Neurotology Vol.38 No.1
<P>Conclusions: Slippage-induced artifacts are presumed to be because of the slingshot-like movement of the goggles during head movement in three different phases (lagging, overshooting, and bouncing of the goggles). Monitoring the pressure of the strap tightness may be a solution for minimizing this slippage. A strap tightness of at least 45 cm H2O is required for reliable vHIT recording and gain calculations.</P>
Il Woo Suh,Cheol Whan Lee,Young Hak Kim,Myeong Ki Hong,Jae Won Lee,Jae Joong Kim,Seong Wook Park,Seung Jung Park 대한의학회 2008 Journal of Korean medical science Vol.23 No.2
Pheochromocytoma is a rare disorder and functioning tumor composed of chromaffin cells that secrete catecholamines. Patients with a pheochromocytoma ‘crisis’ have a high mortality in spite of aggressive therapy. We present a case with a severe acute catecholamine cardiomyopathy presenting ST segment elevation with cardiogenic shock after hemorrhage into a left suprarenal tumor. Intra-aortic balloon pump (IABP) support, combined with inotropic therapy, was performed. However, the patient deteriorated rapidly and was unresponsive to a full dose of inotropics and IABP. We decided to apply extracorporeal membrane oxygenation (ECMO) device for the patient. His clinical state began to improve 3 days after ECMO. After achieving hemodynamic stabilization, he underwent successful laparoscopic left adrenalectomy. He needed no further cardiac medication after discharge
3-Dimensional reconstruction of the venous system in patients suffering from pulsatile tinnitus
Cho, Il-Kwon,Jung, Jae Yoon,Yoo, Dong Soo,Suh, Myung-Whan Informa Healthcare 2012 Acta oto-laryngologica Vol.132 No.3
<P><I>Conclusions:</I> An abrupt change in the venous caliber, producing turbulent flow, may be a cause of pulsatile tinnitus (PT). The largest area/smallest area (L/S) ratio >4.75 may be a criterion indicating abrupt caliber change and causing PT. <I>Objectives:</I> Contrast-enhanced CT is recommended as an initial work-up modality in PT. But, in the majority of cases, no definite pathology can be found, even after extensive work-up. In these cases, the unilateral dominant venous system may be the cause of PT. The aim of this study was to compare, through 3D-reformatted images of the intracranial venous system, the volume, cross-sectional area, and caliber changes in patients with PT and normal controls. <I>Methods:</I> This was a cross-sectional study set in a tertiary referral center. Eleven patients (11 unilateral PT ears) and 12 normal control ears were enrolled. All the subjects were confirmed with normal CT angiography findings. The intracranial venous structure was three-dimensionally reconstructed. Three areas with the largest and the smallest dimension were selected for further analysis: the transverse sinus (T), isthmus (I), and the jugular bulb (B). The total volume, cross-sectional area, and cross-sectional area ratios of the three areas were compared in the PT group and the normal control group. <I>Results:</I> The L/S ratio was significantly increased in the PT group (5.01), compared with the control group (3.42). When the threshold value of the L/S ratio was assessed by the ROC method, 4.75 seemed to be the significant dissecting point. The sensitivity of this method was 0.64 and the specificity was 0.83.</P>