위암에서 Helicobacter pylori cagA, vacA, iceA 유전자와 숙주 Interleukin-1β및 Interleukin-1 수용체 길항제 유전자 다형성

이성훈 ( Seong Hun Lee ),김태오 ( Tae Oh Kim ),이동현 ( Dong Hyun Lee ),박원일 ( Won Il Park ),김광하 ( Gwang Ha Kim ),허정 ( Jeong Heo ),강대환 ( Dae Hwan Kang ),송근암 ( Geun Am Song ),조몽 ( Mong Cho ) 대한내과학회 2006 대한내과학회지 Vol.71 No.1

Background: Both Helicobacter pylori (H. pylori) cagA, vacA, iceA genotype and host IL-1B/IL-1RN polymorphisms play a role in determining the clinical consequences of H. pylori infection. This study aimed to investigate whether there might be any combinations of H. pylori cagA, vacA, iceA genotype and host IL-1B/IL-1RN polymorphisms that are particularly associated with the occurrence of gastric carcinoma in Korean patients. Methods: This study population was comprised of 239 patients with H. pylori infection: 122 with gastric carcinoma and 117 with gastritis only. DNA was isolated from gastric biopsy sample and H. pylori cagA, vacA and iceA genotype were determined by PCR. IL-1B-511 polymorphisms were genotyped by PCR-RFLP and IL-1RN polymorphisms were analyzed with variable number of tandom repeat after PCR. Results: H. pylori cagA, vacA, and iceA genotype were not associated with an increased risk for gastric carcinoma. IL-1B-511*T carriers and IL-1RN*2 carriers did not show increased risk for gastric carcinoma. On combination of bacterial/host genotypes, cagA+/IL-1B-511*T carriers and cagA+/IL-1RN*2 carriers, vacA s1/IL-1B-511*T carriers, vacA s1/IL-1RN*2 carriers, vacA m1/IL-1B-511*T carriers, vacA m1/IL-1RN*2 carriers, iceA1/IL-1B-511*T carriers, iceA1/IL-1RN*2 carriers showed no increased risk of gastric carcinoma. Conclusions: Combined H. pylori cagA, vacA, iceA genotype and host IL-1B/IL-1RN polymorphisms shows no increased risk of gastric carcinoma. Therefore, it seems other endogenous or exogenous factors may play more important role in the development of gastric carcinoma in Korean.(Korean J Med 71:24-37, 2006)

Anti-photoaging effect of fermented agricultural by-products on ultraviolet B-irradiated hairless mouse skin

CHOI, SUN-IL,JUNG, TAE-DONG,CHO, BONG-YEON,CHOI, SEUNG-HYUN,SIM, WAN-SUP,HAN, XIONGGAO,LEE, SANG JONG,KIM, YOUNG-CHEUL,LEE, OK-HWAN UNKNOWN 2019 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Vol.44 No.2

<P> Processed products from agricultural produce generate a large number of agricultural by-products that contain a number of functional substances. These are often discarded owing to the lack of suitable processing methods. The present study investigated the anti-photoaging properties of fermented rice bran (FRB), soybean cake (FSB) and sesame seed cake (FSC) on ultraviolet B (UVB)-irradiated hairless mouse skin. Results indicated that the oral administration of FRB, FSB and FSC effectively inhibited the UVB irradiation-induced expression of matrix metalloproteinase (MMP)-2, MMP-9, MMP-3 and MMP-13. Reverse transcription-quantitative polymerase chain reaction results also demonstrated that FRB, FSB and FSC significantly inhibited the UVB-induced expression of the genes encoding tumor necrosis factor-α, inducible nitric oxide synthase, interleukin (IL)-6 and IL-1β when compared with the UVB-vehicle group (P<0.05). Additionally, collagen degradation and mast cell infiltration were reduced in hairless mouse skin. Furthermore, UVB-induced wrinkle formation was also significantly reduced in mouse skin compared with the UVB-vehicle group (P<0.05). These results reveal that fermented agricultural by-products may serve as potential functional materials with anti-photoaging activities. </P>

共同不法行爲責任에 대한 類型化의 試圖

曺日煥,張守福 東義大學校 法政硏究所 1998 공공정책연구 Vol.14 No.-

人格權의 法的 承認에 관한 硏究

曺日煥 東義大學校 法政大學 1995 공공정책연구 Vol.11 No.-

경쟁불안이 양궁선수들의 기록에 미치는 영향

조현일,노일환 公州大學校스포츠科學硏究所 1999 스포츠科學硏究所論文集 Vol.- No.13

To accomplish the pupose of this study, l have compared two groups : Superior group of 30 players and less-superior proup of 30 platers to examone the effect of competition anxiety for western style acheries tournament records and training records. The superior group contains the players who have won the prize for national tournament and less-superior group does not but same record in training stage. The differences of tournament records, training records and SCAT score between these two groups have been verified by using t-verification. In addition, pearson's correlationship of these two groups and SCAT score. The results of this study has shown : Frist, SCAT score shows statistical differences between two groups (P〈001) Second. No statistical differences in single and frand training records, but in tournament records(P〈001) Third, the meaninful differences of SCAT score has shown between male and female superior group and less-superior group Fourth, No difference of training records of single and grand but in tournament records of these two groups. Fifth, the SCAT score, has a reliable relation between two groups. Finally, the SCAT score, single and grand training records shows no difference statistically but in tournament records has high correlation between these superior group and less-superior group. According to this study, the competition anxiety has a negative effect for Western-Style acheries in tournament records. The level of this negative effect is greater among less-superior players compared to superior group.

종합병원 입원환자의 알코올중독 유병율과 주치의의 인지도 조사

조석군,김경빈,장환일 大韓神經精神醫學會 1993 신경정신의학 Vol.32 No.6

The authors studied prevalence and physician's detection rate of alcoholism in 478 adult patients admitted at Kyung-Hee Medical Center from June to July in 1992. In this study, the authors used self-report questionnaire consisting of Korean version of DSM-Ⅲ-R, MAST, NAST(I)(Alcoholism Screening Test of Seoul National Mental Hospital(I)), and additional demographic questions. The results were as following : 1) Among 478 patients, prevalence of alcoholism was 26.8%(76 patients) in male and 1.6%(e patients) in female. 2) Among the patients who are identified as alcoholism by the authors, detection rates of alcoholism by the charge physicians were 24.2% in internal medicine and none in other departments. 3) Compared to the alcoholic patients who are not detected by the charge physicians, the alcoholic patients who are detected are more aged patients showing high scored MAST significantly and having liver diseases.

수산물에 대한 Grapefruit 종자추출물의 항균 및 항산화효과

조성환,서일원,최종덕,주인생 國立統營水産專門大學 附設 水産科學硏究所 1990 수산과학연구소보고 Vol.2 No.-

연속 추출장치를 이용하여 grapefruit 종자를 gl-ycerine으로 추출하고 농축, 조제한 grapefruit 종자추출물(GFSE)의 항균 및, 항산화성 효과를 검토하기 위하여 정어리, 고등어 및 새우와 같은 수산물을 재료로 하여 GFSE를 처리하지 않은 대조구와 GFSE용액 (100, 250, 500, 750, 1,000PPM)으로 처리한 시험구로 나누어 Salmonella tylhi를 접종하여 일정 온도에서 저장하면서 총균수, 과산화물가 및 texture의 변화를 측정하고 GFSE처리후 저장한 수산물을 대조구와 외관, 냄새를 중심으로 관능검사를 실시하였다. 정어리와 고등어의 경우, 최초 균수가 1.9*10^6, 1.8*10^6이었는데 500PPM 농도 첨가하여 5℃에서 50일 저장후 1.1*10^4과 9.0*10^3으로 감소되었고, 새우의 경우 균의 검출이 확인되지 않아 상당히 좋은 항균효과를 나타내었다. 그리고, 3종의 수산물 모두 GFSE처리구가 대조구에 비하여 유의적인 항산화효과가 있음을 나타내었으며, 500~750PPM 농도의 용액을 처리하여 30℃에서 30일간 저장한 수산시료 추출유의 과산화물가는 정어리는 최초 28~45meq/kgdptj 92~143meq/kg(대조구,490meq/kg)로, 고등어는 64~75meq/kg에서 98~137meq/kg(대조구, 406meq/kg)로, 새우는12~20meq/kg에서 21~32meq/kg(대조구, 72meq/kg)로 증가하여 뚜렷한 산패 억제효과를 볼 수 있었다. Texture도 저장기간이 경과함에 따라 감소하는 경향을 나타내었으나 3종 수산물 모두 GFSE용액 처리시험구에서 감소율이 크게 낮아졌다. GFSE를 처리하여 0℃, 0일간 보관한 시험구와 대조구에 관한 관능검사 결과, GFSE를 처리하지 않은 대조구는 열등한 기호도를 보여준 반면, GFSE용액을 500PPM 이상의 농도로 처리한 시험구 모두가 높은 기호도의 관능검사 결관를 나타내었다. The antimicrobial and antioxidant activities of grapefruit seed extract(GFSE), which was extracted with glycerine in the special schematic extraction apparatus, were investigated for handling and processing of fishery products. The effectivity of GFSE has been tried on sardine, mackerel and shrimp divided into six lots for each fishery product: control(no treatment) and five GFSE-treated samples. Samples were inoculated with Salmonella typhi, incubated for 24hrs at 30℃ in dextrose-tryptone broth medium and prepared for microbiological & chemical analysis and organoleptic assessment. The bacteriological analytical results with GFSE(250ppm) showed the reduction of 1.8×10^6→2.0×10^4, 1.9×10^6→1.8×10^4 and 1.6×10^6→2.7×10^3 in total bacterial count for sardine, mackerel and shrimp, respectively. The test results with GFSE(500ppm) showed a 100% reduction of bacterial mackerel treated with GFSE(500ppm) was reduced to 1.1×10^4 and 9.0×10^3 respectively. Antioxidant effect of treatment with GFSE at 500ppm level for three products was significant. LSD test results on organoleptic parameter for the samples treated with various showed a significant influence on the appearance, odor and texture in which at concentration 500ppm level give the excellent scours compared to each control.

重化學工業機械의 國産化方案에 關한 硏究 : 特히 窯業에 있어서의 燒成爐, 粉碎機, 排風機, 冷却機, 電氣集마器 自動枰量供給器 等의 製作을 目的으로

趙哲衡,朴碩喆,丁太權,宋鐵,桭達福,金基玉,朴煥奎,趙煥從,朴善鐘,金種一,李茂錫 朝鮮大學校 1977 綜合論文集 Vol.1977 No.-

This is to investigate the posibility of home manufacturing of heavy chemical industry machines, such as rotary kiln, crusher, blower, cooler, electrostatic precipitator and weighing feeder of cement plant. It is concluded that even though we can not make all of them (some of them are made now and some others are going to be made in the near future, some of them are made whole and some others are made partially), we can build or export the cement plant by importing the important machines which we can not make now and by substituting them with ours gradually.

危險責任論에 關한 再檢討

曺日煥 東義大學校 法政大學 1993 공공정책연구 Vol.9 No.-

環境汚染의 民事責任에 關한 硏究(Ⅰ)

曺日煥,金宗植 東義大學校 法政大學 1992 공공정책연구 Vol.8 No.-