지역사회 정신의학 전공의 교육과정 실태조사

홍진표,황순찬,이영문,이선형,신나리,이종일,박종익,장동원,정인원 大韓神經精神醫學會 2008 신경정신의학 Vol.47 No.1

Objectives : There is a increasing need to recruit and retain more psychiatrists who can plan and implement organized programs to work with chronic mentally ill patients in community settings. The aim of study is to discover what training is currently in place to prepare psychiatrist for work in "community" or "public" settings. Methods : Survey questionnaires were mailed to 85 residency training directors and 10 leaders of community mental health in 2005. Response rate was 75%. Results : Academic seminar about community mental health were not administered to residents in 63% of training hospitals. Forty one out of 64 training hospitals had community mental health rotation programs, Community mental health center (50%) and day hospital (36%) were the most common type of programs. Few general hospital had affiliation with community mental health programs. The amount of time for clinical rotation varied from less than three months part time to 6 months fulltime, with most frequent form of one day per week for three month in second or third year of psychiatry residents. Conclusion : Further steps are needed to improve residency training curricula and to encourage well qualified psychiatrist to choose careers in community psychiatry.

일반계 고등학교 교육과정 특성화 방안 연구 : 예체능 과정 설치를 중심으로

홍후조,강익수,백경선 한국교육방법학회 2009 교육방법연구 Vol.21 No.2

This study deals with the problem of enlarging the kinds of courses of academic high schools by installing the ‘core’ school with particularized curriculum such as arts or physical education course tracks as well as academic tracks. For last 60 years Korean general high school have operated two tracks, humanities and social science track, and natural science track. Two traditional tracks did not meet the needs of students and society. Survey were administered to secondary school students and teachers, asking about the curricular needs of new tracks. Based on the results of questionnaires the simulation of allocating students and teachers, and installing facilities according to the curricular tracks was finished. About 30% of middle school graduates want to go to core high schools with particular track rather than traditional tracks.

이차 전기영동을 이용한 프로테오믹 접근을 통한 정맥 압박이 혈장 프로테옴에 미치는 영향

양광익,박선아,오형근,정두신,박형국,성기범,안무영,홍세용 순천향대학교 2006 Journal of Soonchunhyang Medical Science Vol.12 No.1

The human proteomics-based approaches, which examine the expressed proteins of a tissue or cell type, are increasingly being used. Venous occlusion is commonly employed for stimulating tissue-plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-l) release from venous endothelial cells, and this has been regarded as a parameter of the individual fibrinolytic capacity of plasma. The present work involved a detailed investigation of the plasma proteome and fibrinolytic activity in normal subjects, with the aim of determining whether correlations exist between various parameters of the fibhnolytic system before and after venous occlusion. We analyzed fibhnolytic parameters and plasma proteome before and after 15-min periods of venous occlusion in the forearm in 10 healthy 3rd-decade volunteers. Proteome analysis was performed using two-dimensional gels. The tryptic digests of some proteins were confirmed by MALDI-TOF and the MS-Fit algorithm. The fibrinolytic response as measured by the absolute amount of t-PA after venous occlusion was increased by venous occlusion (5.5 vs 9.6 ng/㎗, p<0.05), as was PAI-l (46.8 vs 56.1 ng/㎗, p<0.05). However, two-dimensional electrophoresis finding was virtually nonspecific and inconsistent after venous occlusion in healthy male subjects. Venous occlusion does not influence plasma proteome in healthy males. Although the fibhnolytic response to venous occlusion is attributed to an increase in free tUPA antigen, this change is not correlated with plasma proteome.

한국의 정신분열병 외래 환자의 직ㆍ간접비용

박종익,송선희,서동우,장현종,이종국,장안기,김윤,이철,홍진표 大韓神經精神醫學會 2000 신경정신의학 Vol.39 No.3

연구목적 : 정신분열병 외래 환자의 직접 비용과 간접 비용을 추산해 보고, 의료 자원의 적절한 운용과 효과적인 배분을 위한 보건 정책의 기초자료로 사용하고자 한다. 방 법 : 정신분열병 진단을 받은 289명의 환자를 대상으로 6개월간 외래를 방문하면서 사용한 의료비와 시간을 조사하여 직접 비용을 추산하였고, 이 기간 동안 소실된 생산성을 간접 비용으로 환산하였다. 만성질환인 관상동맥 질환을 앓고 있는 환자 82명을 대조군으로 하여 비용을 비교하였다. 결 과 : 정신분열병 환자의 실업률은 72.1%였으며, 직장을 가지고 있는 경우에도 단순노무직의 비율이 64.5%로 매우 높았다. 정신분열병의 직접 비용은 평균 81.5만원으로 관상동맥 질환의 평균 71.5 만원보다 상대적으로 많이 추산되었으나 유의하지는 않았다. 간접 비용은 평균 645.6만원, 258.9 만원으로 정신분열병군이 2.5배 정도 높았다. 결 론 : 정신분열병은 다른 만성질환에 비하여 상대적으로 매우 고비용이 요구되는 질환이며, 보다 체계적인 비용의 추산을 통하여 양질의 정신 보건 서비스를 제공할 수 있는 토대가 마련되어야 할 것이다. Objectives : We have aimed to estimate the direct and indirect costs of treating out-patients with schizophrenia in Korea, to use this fundamental data for the effective management and proper distribution of the medical resource. Method : To estimate the direct cost, we surveyed the medical cost and time of two hundred and eighty-nine out-patients with schizophrenia for six months. And the lost productivity as many months was converted into the indirect cost. Those of eighty-two coronary heart disease patients were also estimated as a comparison group. Results : An unemployement rate of schizophrenic patients was 72.1 percent. Moreover the ratio of the laborer in the sample was, even if employed, 64.5 percent. The mean direct cost of schizophrenic patients was, about 815,000 won, higher than that of coronary heart disease, 715,000 won however it was not statistically significant. The former was also estimated 2.5 times more than the latter for the indirect cost, or 6,456,000 won versus 2,589,000 won. Conclusion : Schizophrenia is a relatively costly illness compared to other chronic illness, so the systematic estimation of the cost is necessary to provide mental health service of high quality.

한국어판 예일 틱 증상 평가척도 : 신뢰도 및 타당도 연구

정선주,이정섭,유태익,구영진,전성일,김봉석,홍강의 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.5

목 적 : 틱 증상의 심한 정도를 평가하기 위한 도구인 예일 틱 증상 평가척도(Yale Global Tic Severity Scale)를 한국판 가정 평가용 설문지 및 임상 평가용 척도로 개발하기 위하여 본 연구를 시행하였다. 방 법 : 예일 틱 증상 평가척도는 뚜렛 장애 및 기타 틱 장애에서 나타나는 운동틱과 음성틱 각각의 증상의 수, 빈도, 심한 정도, 복합성, 방해 정도 및 장해도를 포괄적으로 평가하도록 고안되어져 있다. 틱 증상을 주소로 정신과외래를 방문한 만 4.3세에서 19세까지의 100명의 환아 및 부모들을 대상으로 한국어로 번역한 예일 틱 증상 평가척도의 가정평가용 설문지를 평가전에 완료하도록 한 후, 면담을 통한 임상평가용 척도를 실시하였으며 수렴타당도 및 변별타당도의 검증을 위해 총괄적인 임상 인상척도-뚜렛 증후군, 강박장애, 주의력결립/과잉운동장애(Clinical Global Impression-TS, OCD, ADHD)를 시행하였다. 결 과 : 자료분석결과 내적일치도, 수렴타당도, 변별타당도 및 검사자간 신뢰도 모두 매우 높게 나타났으며 요인분석상 전 항목척도와 장해도는 운동틱과 음성틱에 해당하는 2개의 요인으로 묶여졌다. 결 론 : 본 연구결과 한국판 예일 틱 증상 평가척도의 높은 타당도 및 신뢰도가 입증되었으며 이는 향후 틱 증상의 객관적인 평가 및 정량화를 위해 유용하게 사용되어질 수 있을 것이다. Objectives : This study was carried out to develop the Korean form of Yale Global Tic Severity Scale(YGTSS)-family & clinical rating version. The severity of motor and phonic tics was rated according to five separate dimensions : number, frequency, intensity, complexity, and interference. Methods : The Korean form of YGTSS was applied to 100 children who visited psychiatric outpatient clinic with chief complaints of tic symptom. Together with YGTSS, Clinical Global Impression for Tourette's syndrome(CGI-TS), Obsessive-Compulsive disorder(CGI-OCD), Attention-Deficit/Hyperactivity Disorder(CGI-ADHD) were administered to all subjects for examining convergent and discriminant validities. Results : We could confirm high internal consistency, convergent and discriminant validities and interrater reliability of YGTSS by analysing data from 100 children with tic disorder. In factor analysis, items were clustered to 2 factors which were identical to motor and phonic tic subscales. Conclusion : The results of this study indicate the Korean form of YGSS is a reliable and valid rating scale for rating tic symptom severity. It can be used to evaluate tic symptom objectively and to quantify the tic severity in the studies for tic disorder.

Pedunculagin(Purified tannin)의 BRM Response

이도익,장재권,이민원,홍순각 중앙대학교 약학연구소 1998 약학 논총 Vol.12 No.-

Pedunculagin, an ellagitannin from Alrus hirsuta var. microphylla, Betulaceae was evaluated on the antitumor activity. To investigate cytotoxicity of pedunculagin on tumor cells, the effect of the substance on three cell lines(P815, Yac-1, B16-F20) was examined. And the result was somewhat different among three cell lines. The growth-rate of P815 was not cut down significantly, but in contrast, the inhibitory activities on Yac-1 and B16-F10 were effective. ED_50s of pedunculagin against P815, Yac-1 and B16-F10 were 12.16, 1.89, 3.30㎍/㎖ respectively.

Diarylheptanoid의 일종인 Oregonin의 항암효과

이도익,장재권,이민원,홍순각 중앙대학교 약학연구소 1988 약학 논총 Vol.12 No.-

Oregonin, a diarylheptanoid derivative from Alrus hirsuta Turcz, Betulaceae was evaluated on the antitumor activity. Oregonin, a diarylheptarioid zyloside is a novel immunomodulator augmenting macrophage and natural killer cell activity related anti-tumor functions. To investigate cytotoxicity of oregonin on tumor cells, the effect of the substance on three cell lines(P815, Yac-1, B16-F10) was examined. The result was somewhat different between suspension and adhesion cells. The growth-rate of suspension cells(P815, Yac-1) was not cut down significantly, but in contrast, the inhibitory activity on adhesion cell(B16-F10) was effective. Its ED50 is 20.09㎍/㎖(4.19×10^-5mol/l)

아트리움 공간에서의 화재성상에 관한 축소모델 실험연구

김충익,유홍선,류승관 (社團法人) 韓國火災 ·消防學會 1999 한국화재소방학회논문지 Vol.13 No.4

Development of Sun-Glint Prediction Program For The Communication, Ocean and Meteorological Satellite

Park Jae-Ik,Choi Kyu-Hong,Park Sang-Young,Lee Byoung-Sun,Ahn Yu-Hwan 한국우주과학회 2004 한국우주과학회보 Vol.13 No.2

두개외 경동맥 협착증에 대한 스텐트 삽입술의 추적 결과

윤영섭,홍범기,최동훈,김선호,김동익,김승민,장양수,심원흠 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.11