기분장애 및 기분관련장애에서 세로토닌 수용체 유전자 프로모터 다형성

지익성,Chee, Ik-Seung 대한생물정신의학회 2002 생물정신의학 Vol.9 No.1

Genes involved in the serotonin system are good candidates for the pathogenesis of mood disorder and mood-related disorders, such as eating disorder, obsessive-compulsive disorder, alcoholism, and suicide. Serotonin type 2A(5-HT2A) receptor gene promoter polymorphism(-1438A/G) has been reported. In this article, authors reviewed the literatures regarding association studies between -1438A/G and mood disorder and mood-related disorders. There are controversial results with limited data to date. Further researches on the -1438A/G in psychiatric disorders are required.

T102C Polymorphism of the 5-HT<SUB>2A</SUB> Receptor Gene is not Associated with Homicide in Male Schizophrenics

Ik-Seung Chee(지익성),Seung-Keun Wang(왕성근),Sun-Woo Lee(이선우),Jeong-Lan Kim(김정란),Young-Ho Lee(이영호),Sang-Sup Choi(최상섭),Chung-Suk Lee(이충숙) 대한생물치료정신의학회 2007 생물치료정신의학 Vol.13 No.2

목적:세로토닌체계의 변화가 정신분열병이나 폭력행동과 관련이 있다고 알려져 있다. 저자 등은 5-HT2A 수용체 유전자 다형성(T102C)이 살인을 범한 남성 정신분열병과 관련이 있는지 알아보기 위하여 본 연구를 시행하였다. 방법:살인을 범한 정신분열병 환자 105명, 비폭력 정신분열병 환자 102명, 정상 대조군 104명을 대상으로 중합효소 연쇄반응을 이용하여 5-HT<SUB>2A</SUB> 수용체 유전자 다형성(T102C)의 유전자형과 대립유전자의 빈도를 비교하였다. 모든 대상은 한국인 남자였다. 결과:살인을 범한 정신분열병군, 비폭력 정신분열병군, 정상대조군을 비교한 결과 세군간에 유전자형(χ²=8.090, df=4, p=0.088)이나 대립유전자(χ²=2.880, df=2, p=0.237)에서 통계적인 차이가 없었다. 또한 살인을 범한 정신분열병군과 비폭력 정신분열병군, 살인을 범한 정신분열병군과 정상 대조군, 그리고 비폭력 정신분열병군과 정상 대조군을 각각 비교하였을 때도 유전자형과 대립유전자에서 통계적인 차이가 없었다. 결론:이러한 결과는 5-HT<SUB>2A</SUB> 수용체 유전자 다형성(T102C)이 남성 정신분열병환자의 살인행동과는 관련이 없음을 제시한다. 향후 살인을 범한 여성정신분열병환자와 살인을 범한 일반 범죄인을 포함한 연구가 필요할 것으로 사료된다.

범법 조현병 환자에서 발병연령에 따른 범죄인구특성과 대인관계문제 및 성격장애의 차이

차승민(Seung Min Cha),최종혁(Jong Hyuk Choi),이미지(Mi-Ji Lee),지익성(Ik-Seung Chee) 대한생물치료정신의학회 2018 생물치료정신의학 Vol.24 No.3

Objectives:The purpose of this study was to investigate the differences in forensic demographic characteristics, interpersonal problems and personality disorder between early and late onset criminal patients with schizophrenia. Methods:The participants included 187 inpatients with schizophrenia who had committed crimes. They filled out the Korean Inventory of Interpersonal Problem Personality Disorder Scales and Psychopathic Personality Inventory-Revised. They were divided into early onset group and late onset group according to onset age of schizophrenia at 26 years old(under 26 versus 26 and older) and forensic demographic characteristics, interpersonal problem and personality disorders including psychopathy were compared between two groups. Results:There were no differences in gender, education years and family history between the two groups. Early onset group was associated with lower age, earlier onset of age and earlier age at the time of the crime. Duration from onset to diagnosis was not different between the two groups. Duration from onset to crime and after diagnosis to crime was shorter in late onset group. There were no differences between the two groups in the interpersonal problems, personality disorder and psychopathic personality evaluation. Conclusion:These results suggested that there may be forensic demographic differences related to crime between early and later onset schizophrenia. Psychiatrists should consider the age at onset of schizophrenia when assessing the risk of violence in patients with schizophrenia. In the future. it will be needed other study of age classification such as admixture analysis.

젊은 성인에서 대인관계문제 및 신체불만족이 자살사고에 미치는 영향

이재민,김정란,왕성근,지익성,Lee, Jae-Min,Kim, Jeong-Lan,Wang, Seong-Keun,Chee, Ik-Seung 대한불안의학회 2014 대한불안의학회지 Vol.10 No.2

Objective : The aim of this study was to investigate the relationship between interpersonal problems, body dissatisfaction, and suicidal idea. Methods : Two hundred ninety-four participants filled out the self-reporting questionnaires : Body dissatisfaction was measured with Body Dysmorphic Disorder Examination-Self Report (BDDE-SR) ; Interpersonal problems was measured with Korean Inventory of Interpersonal Problem (KIIP) ; Suicidal Ideation Questionnaire (SIQ) was used to assess suicidal idea. A path analysis was conducted to identify the impact of interpersonal problems and body dissatisfaction on the suicidal ideas. Results : 'Socially inhibited (KIIP_C4)', 'overly-accommodating (KIIP_C6)', age, and gender had a direct effect on their body dissatisfaction, and those factors had a indirect effect on the suicidal ideas. Also, 'cold (KIIP_C3)' and body dissatisfaction had a direct effect on the suicidal ideas. Conclusions : These findings can help to identify how interpersonal problems and body dissatisfaction influence the suicidal ideas of people. It would be useful to consider and assess suicidal ideas in the patients with 'cold (KIIP_C3)', 'socially inhibited (KIIP_C4)', 'overly-accommodating (KIIP_C6)'.

젊은 성인에서 신체 불만족과 성격 특성 및 스트레스와의 관계

김재헌,김정란,왕성근,지익성,Kim, Jae-Heon,Kim, Jeong-Lan,Wang, Seong-Keun,Chee, Ik-Seung 대한불안의학회 2014 대한불안의학회지 Vol.10 No.2

Objective : The aims of this study was to evaluate relationship between body dissatisfaction, personality characteristic, and stress in young adults. Methods : One hundred and ninety five young, healthy, and normal participants filled out all 3 types of self-reported questionnaire, the Body Dysmorphic Disorder Examination-Self Report (Korean version of BDDE-SR ; K-BDDE-SR), Neuroticism, Extraversion, Openness-Five Factor Inventory (NEO-FFI) and Stress Scale of Korean version of the Depression Anxiety Stress Scale (K-DASS-21). Results : Out of the 195 participants, 30% (n=59) was male and 70% (n=136) was female. There was no statistical difference between high K-BDDE-SR group (K-BDDE-SR score 75 percentile or higher, n=50) and low K-BDDE-SR group (K-BDDE-SR score below than 75 percentile, n=145) in terms of weight, height, and BMI. In high K-BDDE-SR group, neuroticism was significantly higher than low K-BDDE-SR group, and extraversion, agreeableness, conscientiousness were significantly lower than low K-BDDE-SR group. Also, level of stress in high K-BDDE-SR group was significantly higher than low K-BDDE-SR group. Conclusion : Our study revealed that individual's with more body dissatisfaction were more neurotic and stressful. Thus, body dissatisfaction and diverse psychiatric diseases should be considered in treating neurotic and stressful young adults.

정신과 외래 우울증 환자에서 분노 경험

안병훈(Byung-Hoon Ahn),지익성(Ik-Seung Chee),왕성근(Seong-Keun Wang),홍주봉(Joo-Bong Hong),박권수(Kwon-Soo Park),김영란(Young-Lan Kim),김정란(Jeong-Lan Kim) 대한생물치료정신의학회 2009 생물치료정신의학 Vol.15 No.2

Objectives: This study was conducted to evaluate the degree and type of anger experienced by patients with depressive disorders and to determine which type of anger is correlated with symptom severity. Methods: One hundred-six psychiatric outpatients with depressive disorders and ninety normal control subjects completed the Korean version of Aggression Questionnaire(AQ) and Korean version of Depression, Anxiety, and Stress Scale (DASS). Comparison between two groups was conducted to evaluate which type of anger are prominent in the depressed group. Therefore, correlation and partial correlation between the scores of 4 subscales(Anger, Hostility, Verbal aggression, and Physical aggression) of AQ and the scores of 3 subscales(Depression, Anxiety, and Stress) of DASS were assessed. A multiple regression analysis was performed to determine which type of anger predicted symptom severity. Results: Total AQ score, hostility, anger and physical aggression scores were significantly higher in patients with depressive disorders. After the score of Stress and Anxiety subscale of DASS were controlled; the depression score was significantly correlated with total AQ score, physical aggression and hostility score. The Hostility score was a major predictor of the depressive symptom severity. In addition, the Anger score was a major predictor of the anxiety and stress symptom severity. Conclusion: Anger is frequently found symptom in patients with depressive disorders. Therefore, it is important that clinicians routinely evaluate the degree and type of anger in patients with depressive disorders.

치료 감호중인 조현병 환자에서 정신병질 성격과 대인관계문제

왕성근,권지현,이재우,지익성,Wang, Seung-Keun,Kwon, JeeHyun,Lee, Jae-Woo,Chee, Ik-Seung 대한불안의학회 2014 대한불안의학회지 Vol.10 No.2

Objective : This study was conducted to evaluate the validity of the Korean Inventory of Interpersonal Problems (K-IIP) with Psychopathic Personality Inventory-Revised (PPI-R) to assess interpersonal problems in Korean criminal offenders with schizophrenia. Methods : The sample consisted of 187 inpatients with schizophrenia who had committed crimes. All participants filled out self-report questionnaires ofPPI-R and K-IIP. Results : The result showed that all scales of K-IIP were correlated highly with the PPI-R total score (r range=0.25-0.65). Correlations with K-IIP scales were highest for Blame Externalization, Rebellious Nonconformity, and Machiavellian Egocentricity scales (r range=0.50-0.66, 0.43-0.64, 0.39-0.58, respectively). All scales of K-IIP exhibited a negative correlation with Social Influences, Stress Immunity, Coldheartedness (C) scale ofPPI-R. Cold/Distant scale ofK-IIP was not correlated with C scale of PPI-R. All scales of K-IIP was highly correlated with PPI-R-factor-2 (r range=0.44-0.71) and negatively correlated with PPI-R-factor-l (r range=-0.03-0.38). Conclusions : Despite of strong correlation between PPI-R total score and K-IIP total score, K-IIP was not correlated with PPI-R-I that represents affective and interpersonal deficits. It suggests K-IIP may not proper for measuring the interpersonal problems of criminal offenders with schizophrenia. It will be needed other assessment scale for measuring the interpersonal problems of psychopathy in criminal schizophrenia.

주정중독에서 발병나이에 따른 아형 분류 기준의 타당성

이선우(Sun-Woo Lee),지익성(Ik-Seung Chee),이정규(Jeong Gyoo Lee) 한국중독정신의학회 1998 중독정신의학 Vol.2 No.2

Objective:This study tried to evaluate the validity of criteria for subgrouping inpatients alcoholics based primarily on age-at-onset factors. Method:We interviewed a selected group of inpatients (N=42). Subjects had a psychiatric interview, including completion of various alcohol drinking related questionnaires. Results:We found that there were differences between subgroups of alcoholics when divided according to Von Knorring’s age of onset criteria. The Type 2 early age of onset alcoholics (n=12) had a significantly higher percentage of positive family histories of alcoholism, (p<0.05), a higher percentage of past delinquent behavior (p<0.05), moree past delinquent behavior (p<0.05), more antisocial persanality trait(p<0.05) and a low score antisocial personality trait (p<0.05) and a low score of Quality of Life scale relative to the Type 1 late age of onset alcoholics (n=30). Conclusion:We concluded that there is validity to alcohol typology theory in relation to inpatients alcoholics and that age of onset is a useful defining criterion and other factor that family history, past delinquent history and antisocial personality trait are important factor to classify of alcohol subgroups.

의학전문대학원 신입생의 성별에 따른 스트레스 대처방식의 비교

김현진(Hyun-Jin Kim),지익성(Ik-Seung Chee),이선우(Sun-Woo Lee),김정란(Jeong Lan Kim) 대한생물치료정신의학회 2019 생물치료정신의학 Vol.25 No.2

Objectives:This study was conducted to evaluate the gender differences in stress-coping methods that affect stress responses in graduate medical students. Methods:The participants were 209 students of C medical school in Daejeon, Korea. Stress response was measured using the Stress Response Inventory. Coping methods were measured through the Ways of Coping Checklist and Problem-solving Style Scale. Data were analyzed using T-Tests, a correlation analysis, and stepwise multiple regression analysis. Results:The mean±standard deviation score of the stress response inventory was 23.56±20.20 in males and 32.34±23.44 in females. The stepwise multiple regression analysis revealed the following factors related to stress response: helplessness, problem-solving control, approach style in males and helplessness, social readjustment rating scale, problem-solving confidence in females. No relationship between stress-coping style and academic performance was found in both genders. Conclusion:Hopelessness seemed to be the main reason for the stress response in medical students of both genders. We also found differences in coping methods affecting the stress response by genders. Future studies need to identify more such factors that lead to differences in coping methods and help adapt to stress in medical education.

한국판 단축형 체형 만족도 설문지의 신뢰도와 타당도

이준희(Junehee Lee),지익성(Ik-Seung Chee) 대한생물치료정신의학회 2016 생물치료정신의학 Vol.22 No.3

Objectives:This study aimed at evaluating the reliability and validity of a Korean short version of the Body Shape Questionnaire(BSQ). Methods:The subjects included 467 adults in Daejeon, Korea. All subjects filled out the Korean version of BSQ, Body Dysmorphic Disorder Examination-Self Report; Korean version(Korean version : BDDE-SR), and Eating Disorder Inventory-2(EDI-2). Confirmatory factor analysis was used to evaluate the fit index of a different version of BSQ. The reliability and validity was checked. The BSQ was initially administrated to general adults(N=467), and the second time it was administered to a subset of subjects(N=88). Results:Confirmatory factor analysis of the different version of BSQ suggested that BSQ-8B was the best Korean BSQ in nonclinical samples. Test-retest Pearson’s coefficient was 0.907, the Cronbach’s alpha was 0.861. The correlation between the K-BSQ-8B and the BDDE-SR was 0.685(p<0.001) and correlation between the K-BSQ-8B and the EDI-2 was 0.655(p<0.001). Conclusion:This finding suggests that the K-BSQ-8B possesses good psychometric properties. The K-BSQ-8B is an useful tool for assessing the level of body concern among Korean adults.