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THE <i>COSMIC INFRARED BACKGROUND EXPERIMENT</i> ( <i>CIBER</i> ): THE WIDE-FIELD IMAGERS
Bock, J.,Sullivan, I.,Arai, T.,Battle, J.,Cooray, A.,Hristov, V.,Keating, B.,Kim, M. G.,Lam, A. C.,Lee, D. H.,Levenson, L. R.,Mason, P.,Matsumoto, T.,Matsuura, S.,Mitchell-Wynne, K.,Nam, U. W.,Renbarg IOP Publishing 2013 The Astrophysical journal, Supplement series Vol.207 No.2
O-Sullivan, I,Chopra, A,Kim, T S,Magnuson, S,Falduto, M T,Huang, J,Cohen, E P Nature Publishing Group 2007 Cancer gene therapy Vol.14 No.4
This study describes a new strategy for the identification of squamous carcinoma antigens tumor-associated antigens (TAA). The antigens were discovered by comparing microarrays of squamous carcinoma vaccines highly enriched for immunotherapeutic cells with non-enriched vaccines. The vaccines were prepared by transferring sheared genomic DNA fragments (25 kb) from KLN205 cells, a squamous carcinoma cell line (DBA/2 mouse origin (H-2<SUP>d</SUP>) into LM fibroblasts (C3H/He origin, H-2<SUP>k</SUP>). The transferred tumor DNA segments integrate spontaneously into the genome of the recipient cells, replicate as the cells divide and are expressed. As only a small proportion of the transfected cell population was expected to have incorporated DNA segments that included genes specifying TAA (the vast majority specify normal cellular constituents), a novel strategy was employed to enrich the vaccine for TAA-positive cells. Microarrays were used to compare genes expressed by enriched and non-enriched vaccines. Seventy-five genes were overexpressed in cells from the enriched vaccine. One, the gene for Cytochrome P450 (family 2, subfamily e, polypeptide 1) (Cyp2e1), was overexpressed in the enriched but not the non-enriched vaccine. A vaccine for squamous carcinoma was prepared by transfer of a 357 bp fragment of the gene for Cyp2e1 into the fibroblast cell line. Robust immunity, sufficient to result in indefinite survival, was induced in tumor-bearing mice immunized with cells transfected with this gene fragment.Cancer Gene Therapy (2007) 14, 389–398. doi:10.1038/sj.cgt.7701023; published online 2 February 2007
Investigating the Effect of Bending on the Seismic Performance of Hollow-Core Flooring
Ana I. Sarkis,Timothy J. Sullivan,Emanuele Brunesi,Roberto Nascimbene 한국콘크리트학회 2023 International Journal of Concrete Structures and M Vol.17 No.3
Even if precast pre-stressed hollow-core (PPHC) slabs are usually designed as simply supported elements, continuity with the supporting beam may exist when constructed together with a reinforced concrete topping and continuity reinforcing bars. During an earthquake (and possibly other lateral load), this continuity may result in bending moments being induced close to the supports as the buildings sway laterally. The response of precast floors to earthquake-induced demands has been addressed by past research. However, further investigation is required to improve understanding of several aspects of precast floor behaviour either revealed or emphasized by recent earthquakes in New Zealand. This paper proposes a mechanics-based modelling approach for the analysis of PPHC slab-to-beam seating connections. The model has been calibrated against existing test data to predict the failure of a PPHC slab under negative bending moments. The numerical outcomes allow comparison of the moment–drift response, principal tensile stresses, and crack progression during loading. The developed modelling approach will allow future studies to exhaustively investigate all aspects of precast floor behaviour by varying the properties and geometry of the PPHC seating connection.
Chopra, A,O-Sullivan, I,Carr, J,Kim, T S,Cohen, E P Nature Publishing Group 2007 Cancer gene therapy Vol.14 No.6
In a prior report (Int J Cancer 2006; 119: 339–348), we described a new vaccination strategy for squamous cell carcinoma (SCC). The vaccine was prepared by transfer of unfractionated DNA-fragments (25 kb) from KLN205 cells, a squamous carcinoma cell line (DBA/2 origin; H-2<SUP>d</SUP>) into LM cells, a highly immunogenic mouse fibroblast cell line (C3H/He origin; (H-2<SUP>k</SUP>)). As only a small proportion of the transfected cell population was expected to have incorporated DNA segments that included genes specifying antigens associated with the squamous carcinoma cells, we devised a novel strategy to enrich the vaccine for immunotherapeutic cells. Enhanced immunity to squamous carcinoma was induced in tumor-bearing mice treated solely by immunization with the enriched vaccine, which translated into prolonged survival without toxicity. Here, we describe the characteristics of the cell populations infiltrating established squamous carcinomas undergoing regression in mice immunized with vaccines enriched for immunotherapeutic cells. The results indicated that CD8+ T cells were predominant and that T-regulatory cells (FoxP3+, CD4/CD25+, CD4/CD62L<SUP>high</SUP>, CD4/CTLA-4e) were relatively deficient in the regressing tumors. Inflammatory infiltrates were not detected in various organs and tissues of mice immunized with the DNA-based vaccine.Cancer Gene Therapy (2007) 14, 573–582. doi:10.1038/sj.cgt.7701040; published online 23 March 2007
Analysis of Dark Data of the PICNIC IR Arrays in the CIBER
이대희,김민규,M. Zemcov,남욱원,J. Bock,J. Battle,V. Hristov,T. Renbarger,T. Matsumoto,I. Sullivan,L. R. Levenson,P. Mason,김건희,K. Tsumura,S. Matsuura 한국우주과학회 2010 Journal of Astronomy and Space Sciences Vol.27 No.4
We have measured and analyzed the dark data of two PICNIC IR arrays (P574 and P560) obtained through the Cosmic Infrared Background ExpeRiment (CIBER). First, we identified three types of bad pixels: the cold, the hot, and the transient, which are figured in total as 0.06% for P574 and 0.19% for P560. Then, after the bad pixels were masked, we determined the dark noise to be 20.5 ± 0.05 e- and 16.1 ± 0.05 e-, and the dark current to be 0.6 ± 0.05 e-/sec and 0.7 ± 0.05 e-/sec for P574 and P560, respectively. Finally, we discussed glitches and readout modes for a future mission.
Lee, D.H.,Nam, U.W.,Kim, G.H.,Pak, S.,Zemcov, M.,Bock, J.J.,Battle, J.,Sullivan, I.,Mason, P.,Tsumura, K.,Matsumoto, T.,Matsuura, S.,Renbarger, T.,Keating, B. 한국천문학회 2007 天文學論叢 Vol.22 No.4
The international cooperation project CIBER (Cosmic Infrared Background ExpeRiment) is a rocket-borne instrument, of which the scientific goal is to measure the cosmic near-infrared extra-galactic background to search for signatures of primordial galaxy formation. CIBER consists of a wide-field two-color camera, a low-resolution absolute spectrometer, and a high-resolution narrow-band imaging spectrometer. Currently, all the subsystems have been built, and the integration, testing, and calibration of the CIBER system are on process for the scheduled launch in June 2008.
OBSERVATIONS OF THE NEAR-INFRARED SPECTRUM OF THE ZODIACAL LIGHT WITH CIBER
Tsumura, K.,Battle, J.,Bock, J.,Cooray, A.,Hristov, V.,Keating, B.,Lee, D. H.,Levenson, L. R.,Mason, P.,Matsumoto, T.,Matsuura, S.,Nam, U. W.,Renbarger, T.,Sullivan, I.,Suzuki, K.,Wada, T.,Zemcov, M. IOP Publishing 2010 The Astrophysical journal Vol.719 No.1