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Hyungsik Jeon,Dawun Yang,Nam Ho Lee,Meejung Ahn,Giok Kim 한국식품영양과학회 2020 Preventive Nutrition and Food Science Vol.25 No.4
Black radish (Raphanus sativus L. var. niger), which is cultivated worldwide, is used in traditional medicine as it aids liver function, gastric secretion, gallbladder function, and gallstone mitigation. In this study, we examined the anti-inflammatory effects of black radish extract (BRE) on the lipopolysaccharide (LPS)- and interleukin (IL)-6-mediated inflammatory responses in the RAW 264.7 cell lines. Our findings show that BRE significantly ameliorated LPS-induced nitric oxide (NO) release and production of pro-inflammatory cytokines, such as IL-1β, IL-6, tumor necrosis factor (TNF)-α,and prostaglandin E2. The levels of cyclooxygenase (COX)-2 and inducible NO synthase (iNOS) in LPS-stimulated RAW 264.7 cells were found to be suppressed by BRE. Further, BRE significantly suppressed the LPS-induced expression of mRNAs encoding COX-2, iNOS, IL-1β, IL-6, and TNF-α in a concentration-dependent manner. BRE treatment significantly inhibited Janus kinase 2 (JAK2) and signal transducer and activator of transcription 3 (STAT3) phosphorylation in IL-6- and LPS-treated RAW 264.7 cells. In addition, BRE decreased the levels of phosphorylated extracellular signal-regulated protein kinases and c-Jun N-terminal kinase under the same conditions. Moreover, BRE induced high nuclear factor erythroid 2-related factor 2 (NRF2) levels and its target gene heme oxygenase 1 (HO-1) in the absence of LPS. These data demonstrate that BRE may be beneficial for treating inflammation through selective immunomodulatory effects, which may be mediated by inhibition of the STAT3/JAK2 and activation of the NRF2/HO-1 signal transduction pathways.
대류 효율을 극대화한 PAR 냉각홀 방열 구조의 특성 연구
박준철(JunChurl Park),전완호(WanHo Jeon),신형식(HyungSik Shin),권순환(SoonHwan Kwon),조장형(JangHyung Cho) 한국조명·전기설비학회 2011 한국조명·전기설비학회 학술대회논문집 Vol.2011 No.11
LED(발광 다이오드) 조명은 낮은 소비 전력에 대한 대체 조명 장치로 주목받고 있다. 그러나 열관리에 대한 중요한 문제가 있으며 빛의 강도의 저하 및 LED 조명의 수명 단축에 문제가 있음이 알려져 있다. 본 논문에서는 열 문제의 해결을 위해 측면 Hole을 제안 한다. 이 측면 Hole은 충분히 자연 대류를 유도하고 온도를 낮춘 것으로 LED 조명 시스템의 측면 모두에서 방열을 한다. 이런 메인 Hole 효과를 증명하기 위해 CFD(computational fluid dynamics) 방법은 LED 온도를 예측할 수 있으며 LED 조명 시스템을 최적화하기 위해 사용된다. LED(Light-Emitting Diode) lighting is noticed as substitute lighting device for low consumption electric power. But there is a hot issues of heat management. Known issues are degradation of light intensity and shortened life time of LED light. In this paper, the side hole is proposed for the solution of thermal problem. This side hole induces enough natural convection and makes heat dissipation on the both side of LED light system to be lowered temperature. To prove the main hole effect, CFD(computational fluid dynamics) method was used to predict LED temperature and optimize LED light system.