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Appearance of osteoporosis in rat experimental autoimmune encephalomyelitis
Ahn, Meejung,Kang, Sohi,Park, Channam,Kim, Jeongtae,Jung, Kyungsook,Yang, Miyoung,Kim, Sung-Ho,Moon, Changjong,Shin, Taekyun The Korean Society of Veterinary Science 2016 大韓獸醫學會誌 Vol.56 No.2
Experimental autoimmune encephalomyelitis (EAE) in Lewis rats is characterized by transient paralysis followed by recovery. To evaluate whether transient paralysis in EAE affects bone density, tibiae of EAE rats were morphologically investigated using micro-computed tomography and histology. The parameters of bone health were significantly reduced at the peak stage of EAE rats relative to those of controls (p < 0.05). The reduction of bone density was found to remain unchanged, even in the recovery stage. Collectively, the present data suggest that osteoporosis occurs in paralytic rats with monophasic EAE, possibly through the disuse of hindlimbs and/or autoimmune inflammation.
Factors Associated with the Timeliness of Electronic Nursing Documentation
Meejung Ahn,최모나,YoungAh Kim 대한의료정보학회 2016 Healthcare Informatics Research Vol.22 No.4
Objectives: To investigate the factors associated with the timeliness of electronic nursing documentation using the entry time on the Electronic Medical Record (EMR) system. Methods: As a retrospective study, data were extracted from January 1 to February 28, 2014 from a hospital EMR system and a nurses’ personnel information system. The timeliness of instances of nursing documentation was categorized into ‘timely’ or ‘untimely’ according to whether the entry time was time-stamped within the working hours during each day, evening, or night shift. Factors associated with the timeliness of the electronic nursing documentation were included in the logistic regression models as nurse- and patient-associated factors. Results: Among 1,700,247 instances of electronic nursing documentation, 79.3% (n = 1,347,711) were completed within the working hours. Years of nursing experience, nursing shift, days of the week, patients’ age, and medical department had a statistically significant associated with the timeliness of nursing records. Nurses with experience of more than 1 year entered nursing records over 2 times more during their working hours than did less experienced nurses. During the evening and night shifts, nurses were 1.49 times and 9.19 times more likely to enter nursing documents in a timely manner, respectively, as compared to those in the day shift. Conclusions: Nursing documentation was typically completed outside of working hours when a nurse had little experience, worked during the day shift or weekdays, and when tasks were unpredictable. This shows that new nurses need support to familiarize them with various tasks and the overall workflow.
Ahn, Meejung,Moon, Jihwan,Park, Changnam,Bang, Hyojin,Kim, Gi Ok,Kim, Sun-Ju,Kim, Ki-heung,Shin, Taekyun Kyung Hee Oriental Medicine Research Center, Kyung 2016 Oriental Pharmacy and Experimental Medicine Vol.16 No.1
We evaluated whether crude juice extract of chungpihongsim radish (Raphanus sativus L. cv. Chungpihongsim) (CH radish), with its characteristic red flesh and white skin, ameliorated ethanol-induced gastric injury in rats. Animals were divided into five groups: normal control, a group given CH radish extract (1000 mg/kg) only, two groups orally administered CH radish extract (500 and 1000 mg/kg, respectively, daily for 2 weeks) with ethanol treatment (5 mL/kg) 24 h after final administration of CH radish extract, and a group treated with ethanol alone. Tissues of stomach were collected after sacrifice, and the gastric mucosal injury index using hemorrhagic lesions were measured. Lipid peroxidation was evaluated based on malondialdehyde concentration. The radical-scavenging enzymes superoxide dismutase (SOD) and catalase (CAT) were also measured. Rats treated with CH radish extract (500 or 1000 mg/kg) for 2 weeks experienced no change in body weight. Pretreatment with the extract at both doses significantly ameliorated ethanol-induced hemorrhagic lesions in the gastric mucosa (p< 0.05), decreased malondialdehyde concentration (p< 0.05), and increased the levels of SOD (p< 0.05) and CAT (p< 0.05), compared to ethanol-alone treatment. These findings suggest that pretreatment with CH radish extract reduces ethanol-induced damage in the gastric mucosa, mediated partly by a decrease in lipid peroxidation and an increase in the cytoprotective radical-scavenging enzymes SOD and CAT.
Meejung Ahn,Poornima D. E. Weerasinghe-Mud,Hyobin Kim,Minju Kwon,Jeongtae Kim,Taekyun Shin 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
Progranulin (PGRN) which is a secreted neurotrophin mediates cell cycle progression and cell motility that contribute to MHC-mediated antigen processing, pathogen removal, and autoimmunity. To evaluate the involvement of PGRN in experimental autoimmune neuritis (EAN) pathogenesis, as a model of human demyelinating diseases such as Guillain- Barré Syndrome. The expression of PGRN in rat sciatic nerves with EAN was studied. PGRN expression was increased significantly in EAN-affected sciatic nerves compared with normal rat sciatic nerves. The elevated levels of PGRN in the sciatic nerves of rats with EAN at the peak stage and then its expression was decreased significant at the recovery stage. The cellular phenotype of PGRN in EAN lesions consisted mainly of inflammatory cells including macrophages and Schwann cells whereas it was expressed constitutively in axons. Collectively, this study suggests that PGRN secreted by a variety of cells including macrophage, vascular endothelial cells and Schwann cells, plays either pro-inflammatory or tissue regenerative effects, or both depending on PGRN containing cell type, during the course of EAN, an animal model of human demyelinating disease. (Acknowledgement: This work was supported by the National Research Foundation of Korea: Grant number NRF-2017R1A2B4012478)
Ahn, Meejung,Min, Do Sik,Kang, Jongchul,Jung, Kyungsook,Shin, Taekyun 제주대학교 생명과학기술혁신센터 2002 제주생명과학연구 Vol.5 No.-
Phospholipase D1 (PLD1) expression was studied in the central nervous system (CNS) under the condition of induced experimental autoimmune encephalomyelitis (EAE) in Lewis rats. After inducing EAE, the expression of PLD1 was analyzed by Western blot and immunohistochemistry. Western blot analysis showed that expression of the isozymes PLD1 significantly increased in the spinal cord at the peak stage of EAE, and declined thereafter. Immunohistochemistry showed that PLD1 positive cells increased in number in EAE lesions, which consisted mainly of ED1 positive macro phages and glial fibrillary acidic protein positive astrocytes. In contrast, PLD1 was only weakly expressed in some spinal cord astrocytes in control rats. These results suggest that PLD1 is increased in autoimmune CNS inflammation, and possibly involved in the activation of macrophages and astrocytes in EAE lesions. ⓒ 2001 Elsevier Science Ireland Ltd, All rights reserved.