Association of polymorphisms in microRNA machinery genes (DROSHA, DICER1, RAN, and XPO5) with risk of idiopathic primary ovarian insufficiency in Korean women

Rah, HyungChul,Jeon, Young Joo,Lee, Bo Eun,Kim, Jung O,Shim, Sung Han,Lee, Woo Sik,Choi, Dong Hee,Kim, Ji Hyang,Kim, Nam Keun by The North American Menopause Society. 2013 Menopause Vol.20 No.10

OBJECTIVE: The aim of our study was to investigate whether polymorphisms in microRNA machinery genes are associated with the risk of primary ovarian insufficiency (POI). METHODS: We genotyped 136 POI patients and 236 controls among Korean women for nine single nucleotide polymorphisms (SNPs; DROSHA rs6877842 and rs10719; DICER1 rs13078 and rs3742330; RAN rs14035; and XPO5 rs34324334, rs2257082, rs11544382, and rs11077) by polymerase chain reaction–restriction fragment length polymorphism analysis. Differences in genotype frequencies between patients and controls were compared, and odds ratios (ORs) and 95% CIs were determined as measures of the strength of the association between genotype and POI. RESULTS: Of the nine SNPs, XPO5 rs34324334 and rs11544382 were monomorphic and were not analyzed further. The XPO5 rs2257082 CT and CT + TT variant genotypes were more frequent in patients (OR, 2.097; 95% CI, 1.207-3.645) than in controls (OR, 2.030; 95% CI, 1.196-3.445). The combined frequencies of XPO5 rs2257082 CT + TT and rs11077 AC + CC genotypes were higher in patients than in controls (OR, 2.526; 95% CI, 1.088-5.865). An association of POI risk with other polymorphisms was not found. A haplotype-based analysis of seven polymorphisms of the microRNA machinery genes for gene-gene interactions suggests that ***ACTA, ***GCCA, ***G*C*, *T*ATTA, and ***ACT* haplotypes (asterisk indicates SNP locus not included; DROSHA rs6877842 and rs10719, DICER1 rs13078 and rs3742330, RAN rs14035, and XPO5 rs2257082 and rs11077 polymorphisms) are associated with higher POI prevalence, and that ***GCTA, ***ACCA, *C*ATTA, and *C*ATT* haplotypes are associated with lower POI prevalence. CONCLUSIONS: Our data demonstrate that the XPO5 rs2257082 T variant allele occurs more frequently in POI patients than in controls, suggesting that this allele may be associated with increased POI risk.

Analysis of Social Network Service Data to Estimate Tourist Interests in Green Tour Activities

Rah, HyungChul,Park, Sungho,Kim, Miok,Cho, Youngbeen,Yoo, Kwan-Hee The Korea Contents Association 2018 International Journal of Contents Vol.14 No.3

Social network service (SNS) data related to green tourism were used to estimate preferred tour sites and users' interests. Keywords related with green tour activities were employed to search the SNS data. SNS data were collected from Korean blogs such as Naver and Daum from June $1^{st}$ to August $31^{st}$ between 2015 and 2017 using text-mining solution. During the study period, seven hundred and five posts were analyzed. Associated words that frequently co-occurred with keywords were classified into different categories depending on the nature of associated words. Associated words included swimming pools and camping sites (location); experience and swimming pools (attribute); and water play and culture (culture/leisure). Our data suggest that SNS users with experience of green tourism in Korea exhibited interest in green tourism with swimming pools, camping sites, experience, water play and/or culture rather than particular popular sites. Based on the findings, it is recommended that preferred facilities such as swimming pools should be provided at green tourism sites to meet the users' needs and to facilitate green tourism.

Association between kinase insert domain-containing receptor polymorphisms (−604T>C, 1192G>A, 1719A>T) and premature ovarian failure in Korean women

Rah, HyungChul,Jeon, Young Joo,Choi, Youngsok,Shim, Sung Han,Ko, Jung Jae,Yoon, Tae Ki,Cha, Sun Hee,Kim, Nam Keun The North American Menopause Society 2012 Menopause Vol.19 No.9

OBJECTIVE: The aim of the study was to investigate whether the −604T>C, 1192G>A, and 1719A>T polymorphisms in the kinase insert domain-containing receptor (KDR) gene confer risk for premature ovarian failure (POF) in Korean women. METHODS: DNA samples from 133 POF patients and 230 controls were genotyped for the three KDR single nucleotide polymorphisms by polymerase chain reaction–restriction fragment length polymorphism analysis. RESULTS: The POF patients had significantly increased frequencies of the KDR −604TC and −604TC + CC genotypes (odds ratio [OR], 1.975; 95% CI, 1.219-3.201 and OR, 1.948; 95% CI, 1.221-3.109, respectively) and of the −604TC + CC/1192GG combined genotype (OR, 2.271; 95% CI, 1.359-3.795) and a decreased frequency of the 1192GA genotype (OR, 0.457; 95% CI, 0.231-0.905) compared with the controls. The genotype frequency of the 1719A>T polymorphism was not significantly different between the two groups. The frequencies of the KDR −604C/1192G/1719T, −604C/1192G, and −604C/1719T haplotypes (OR, 3.319; 95% CI, 1.564-7.041; OR, 2.083; 95% CI, 1.351-3.212; and OR, 1.979; 95% CI, 1.073-3.649, respectively) were significantly higher among POF patients than controls, whereas the −604T/1719T haplotype frequency (OR, 0.657; 95% CI, 0.472-0.915) was lower among POF patients. CONCLUSIONS: Carriers of the KDR −604C variant allele (−604TC and −604TC + CC genotypes; −604TC + CC/1192GG combined genotype; −604C/1192G/1719T haplotype, −604C/1192G haplotype, −604C/1719T haplotype) are consistently more prevalent among POF patients than among controls, suggesting that the KDR −604C allele may increase the risk of POF development in Korean women.

Analysis of Social Network Service Data to Estimate Tourist Interests in Green Tour Activities

HyungChul Rah,Sungho Park,Miok Kim,Youngbeen Cho,Kwan-Hee Yoo 한국콘텐츠학회 2018 International Journal of Contents Vol.14 No.3

Association of methylenetetrahydrofolate reductase (MTHFR 677C>T) and thymidylate synthase (TSER and TS 1494del6) polymorphisms with premature ovarian failure in Korean women

Rah, HyungChul,Jeon, Young Joo,Choi, Youngsok,Shim, Sung Han,Yoon, Tae Ki,Choi, Dong Hee,Cha, Sun Hee,Kim, Nam Keun The North American Menopause Society 2012 Menopause Vol.19 No.11

OBJECTIVE: The aim of our study was to investigate whether methylenetetrahydrofolate reductase (MTHFR) gene variant (MTHFR 677C>T) and thymidylate synthase (TS) gene variants (TS enhancer region [TSER] and TS 1494del6) confer a risk for premature ovarian failure (POF). METHODS: We genotyped 136 POF patients and 236 controls among Korean women for the three single nucleotide polymorphism sites using polymerase chain reaction restriction fragment length polymorphism analysis. Differences in the MTHFR 677C>T, TSER, and TS 1494del6 genotype frequencies between POF patients and controls were compared, and odds ratios (ORs) and 95% CIs were determined as a measure of the strength of the association between genotypes and POF. RESULTS: The MTHFR 677CT and CT + TT variant genotypes were more frequent in POF patients than in controls (OR, 2.249; 95% CI, 1.317-3.843; and OR, 2.132; 95% CI, 1.268-3.585, respectively). The combined genotype frequencies of MTHFR 677CT + TT/TSER 3R3R and 677CT + TT/TS 1494del6 del6/del6 were higher in patients than in controls (OR, 2.300; 95% CI, 1.219-4.337; and OR, 3.314; 95% CI, 1.623-6.767, respectively). The T-3R-del6 and T-2R-del6 (MTHFR 677C>T/TSER/TS 1494del6) haplotypes were more frequent in patients (OR, 1.450; 95% CI, 1.050-2.002; and OR, 2.911; 95% CI, 1.191-7.117, respectively), whereas the C-2R-del6 haplotype was less frequent in patients (OR, 0.372; 95% CI, 0.152-0.912). The T-del6 (MTHFR 677/TS 1494del6) haplotype frequency was higher among patients (OR, 1.653; 95% CI, 1.206-2.266), whereas the C-del6 haplotype frequency was lower among patients (OR, 0.700; 95% CI, 0.516-0.950). We did not find an association between TSER or TS 1494del6 polymorphisms and POF. CONCLUSIONS: Our data suggest that the MTHFR 677T allele may increase the risk for POF, which could lead to the development of novel genetic markers for predicting the risk of POF in patients.

Solute Carrier Family 19, Member 1 (<i>SLC19A1</i>) Polymorphisms (−43T>C, 80G>A, and 696C>T), and Haplotypes in Idiopathic Recurrent Spontaneous Abortion in a Korean Population

Rah, HyungChul,Choi, Yi Seul,Jeon, Young Joo,Choi, Youngsok,Cha, Sun Hee,Choi, Dong Hee,Ko, Jung Jae,Shim, Sung Han,Kim, Nam Keun Springer-Verlag 2012 Reproductive sciences Vol.19 No.5

<P>The objective was to investigate the association between idiopathic recurrent spontaneous abortion (RSA) and 3 SLC19A1 polymorphisms (-43T>C, 80G>A, and 696C>T). DNA from 269 patients with RSA and 125 controls were genotyped for the 3 SLC19A1 single nucleotide polymorphisms (SNPs) by polymerase chain reaction-restriction fragment length polymorphism. Homocysteine and folate levels of 100 patients with RSA were available for analysis. The combination genotypes of SLC19A1 -43TC/80GG, -43TC/80AA, and -43CC/80GA; 80GA/696TT, 80AA/696CC; and -43TC/696CC were less frequent in patients with RSA compared to controls (P < .05 for each). The -43C/80A/696??T and -43T/80G/696C haplotypes were more frequent in patients than controls, whereas -43T/80A/696C, -43C/80A/696C, -43C/80G/696C, -43C/80G/696T, and -43T/80G/696T haplotypes were less frequent in patients (P < .05 for each). The -43T/80G and 80A/696T haplotypes were more frequent in patients, while -43T/80A, -43C/80G, 80A/696C, 80G/696T, and -43C/696C haplotypes occurred less frequently in patients (P < .05 for each). The associations between idiopathic RSA occurrence and SLC19A1 -43T>C/80G>A/696C>T polymorphisms were identified and can be developed as biomarkers for RSA risk.</P>

정형 및 비정형 빅데이터를 이용한 양파 소비 예측

나형철(HyungChul Rah),오은화(Eunhwa Oh),유도일(Do-il Yoo),조완섭(Wan-Sup Cho),아지즈 나스리디노프(Aziz Nasridinov),박성호(Sungho Park),조용빈(Youngbeen Cho),류관희(Kwan-Hee Yoo) 한국콘텐츠학회 2018 한국콘텐츠학회논문지 Vol.18 No.11

인터넷 시대를 살아가는 현대인의 식품 소비는 다양한 대충 매체 및 소셜 미디어를 통해 신속하고 방대한 정보 전달에 영향을 받는 것으로 알려져 있다. 2018년 4월 국내 언론 보도에 따르면, 양파 재배 면적이 증가하고 양파 생산량이 증가할 것으로 예상되며, 이후에 양파 가격은 폭락할 것으로 예상되었다. 이러한 상황을 고려하여 SNS, 인터넷 정보 검색, 방송 프로그램에서 언급된 양파 관련 정보를 분석하여, 실제 가격폭락이 발생하기 전에, 양파 소비를 촉진할 수 있는 요인을 파악할 필요가 있다. 2018년 양파 생산량 증가에 따른 양파 가격 폭락이 예상되는 상황에, 가장 최근 양파 생산량 증가에 따라 가격 폭락을 경험하였던 2014년의 방송 프로그램 및 SNS가 양파 소비와 연계되었는지 파악하고자, 양파 소비 촉진과 관련된 정형 및 비정형 빅데이터를 수집하여, 양파 소비 촉진과 관련된 변수를 찾아 양파 가격 하락이 예상되는 2018년에 소비 촉진에 활용하고자 본 연구를 수행하였다. 연구 결과, 방송 뉴스의 양파 언급 기사 수(3~6주), 양파와 건강을 언급하는 방송 프로그램 수(11주), 양파의 효능을 언급하는 블로그의 댓글 빈도(5주)가 양파 구매금액 증가에 시차를 두고 양의 상관관계를 갖는 것을 확인한 본 연구 결과를 근거로, 양파 생산량 증가에 따른 양파 가격 폭락 시, 양파 소비 촉진을 위한 홍보에, 뉴스, 먹방, 쿡방 등의 방송 프로그램 및 블로그 등의 매체를 활용하는 소비촉진에 기여할 것으로 여겨진다. The social media data and the broadcasting data related to onion as well as agri-food consumer panel data were collected and investigated if the amount of money spent to purchase onion in year 2014 when onion price plunged latest were correlated with the frequencies of onion-related keywords in the social media data and the broadcasting programs because onion price in year 2018 is expected to plunge due to overproduction and there has been needs to analyze impacts of social media and broadcasting program on onion purchase in the previous similar events, and identify potential factors that can promote onion consumption in advance. What we identified from our study include a) broadcasting news programs mentioning words “onion,” were correlated with onion purchase with 3 - 6 weeks in advance; b) broadcasting entertainment programs mentioning words “onion and health,” were correlated with onion purchase with 11 weeks in advance; c) blog mentioning words “onion and efficacy,” were correlated with onion purchase with 5 weeks in advance. Our study provided a case on how social media and broadcasting programs could be analyzed for their effects on consumer purchase behavior using big data collection and analysis in the field of agriculture. We propose to use the findings from the study may be applied to promote onion consumption.

쿡방 콘텐츠 노출이 농식품 소비에 미치는 효과: 감자 소비를 중심으로

나형철(HyungChul Rah),김현웅(Hyeon-Woong Kim),고현석(Hyeonseok Ko),신재훈(Jaehoon Shin),조용빈(Yongbeen Cho),아지즈 나스리디노프(Aziz Nasridinov),류관희(Kwan-Hee Yoo) 한국콘텐츠학회 2021 한국콘텐츠학회논문지 Vol.21 No.12

최근 TV와 유튜브 채널에서 먹방과 쿡방 프로그램이 증가하면서 다양한 매체를 통한 음식 및 요리 프로그램 시청이 식품 소비에 미치는 영향력도 점차 증가하고 있다. 최근 유명 요리연구가인 백종원 씨가 방송에서 언급한 농식품 소비가 급증했다는 백종원 효과에 대한 여러 뉴스 기사가 있었고, 백종원 씨의 이름을 딴 식품까지 시장에 출시되었다. 본 연구에서는 다양한 매체를 통해서 영향력 있는 요리 콘텐츠를 생산하는 백종원 씨를 쿡방 콘텐츠의 대표적 사례로 삼고, 백종원 씨가 집밥 백선생 TV 프로그램에서 요리법을 방송한 농식품 중 감자를 선정하여, 백종원 효과가 감자 소비에 미치는 영향을 평가했다. 집밥 백선생 프로그램에서 감자 요리법이 처음 방송된 후 방송 전후 감자 구매금액의 차이를 농식품 소비자 패널의 감자 구매금액 데이터와 이중차분법을 이용하여 방송 전후 6개 시점(3, 6, 9, 12, 24, 36개월)에 비교하였다. 사용된 데이터는 감자 구매금액, 감자 소매가격, 감자 도매가격 등의 정형 데이터와 TV 프로그램과 블로그 데이터 등의 비정형 데이터가 활용되었다. 분석 시점 모두에서 방송 후 감자 구매금액이 방송 전 구매금액보다 적었으며, 감자 소비에서 집밥 백선생 프로그램을 통한 백종원 효과의 존재를 시사하는 결과는 본 연구에서 관찰되지 않았다. Recently, mukbang and cookbang or cooking shows on TV and YouTube channels have increased, and the influences of these broadcasts on food consumption have been gradually increasing. There were several news articles on Baek Jong-won effect, in which the consumption of the agri-food Mr. Jong-won Baek mentioned on his broadcast soared, and even foods named after him are on the market. In this study, Mr. Jong-won Baek, who produces influential cooking contents through various media, was taken as a representative example. We evaluated if Baek Jong-won effect exists on potato consumption, which Mr. Jong-won Baek broadcasted potato cooking recipes on TV and YouTube. After the potato recipe was broadcasted for the first time on the TV show called HomeFoodRescue, the differences in the amount of money to purchase potatoes before and after the broadcast were estimated by using the money amount to purchase data of Agri-food consumers panel and the difference-in-differences method at 6 time points (3, 6, 9, 12, 24, and 36 months). Among the time points analyzed, the potato purchases at post-broadcast were less than those at pre-broadcast. No results were observed suggesting the existence of Baek Jong-won effect on potato consumption through HomeFoodRescue show in the study.

Deep Convolutional Neural Network(DCNN)을 이용한 계층적 농작물의 종류와 질병 분류 기법

MIN BORIN,나형철(HyungChul Rah),류관희(Kwan-Hee Yoo) 한국멀티미디어학회 2022 멀티미디어학회논문지 Vol.25 No.11

A Comparison of Predictive Models for News Sentiment Analysis-based Pork Price Prediction

Yifan Zhu(주일범),Jonghyeok Choi(최종혁),Hyungchul Rah(나형철),Kwanhee Yoo(류관희),Aziz Nasridinov(아지즈) 한국정보과학회 2021 한국정보과학회 학술발표논문집 Vol.2021 No.6