골반 골절 환자에 있어서 골절 위치에 따른 하부 요로 손상의 연관성

신대은,문형윤,박성운,노준 朝鮮大學校 附設 醫學硏究所 2008 The Medical Journal of Chosun University Vol.33 No.3

Background and Objectives: Lower urinary tract injuries in pelvic bone fracture can lead to significant complication. We tried to find out the relationship between the fracture location and the bladder, urethra injury in patients who sustaining pelvic bone fracture. We thought that the fracture locations could serves as markers for injury. Materials and Methods: A clinical study was made on 43 patients who sustaining pelvic bone fracture with bladder or urethra injury in the Chosun University hospital during the period of 5 years from January, 2002 to December 2006. Diagnosis was done by retrograde cystography, retrograde urethragraphy, abdomenpelvic computed tomography. Results: Of the 43 patients reviewed, 27 patients had intraperitoneal type bladder rupture, and 12 patients had extra-peritoneal type bladder rupture. 9 patients had urethral rupture. Intraperitoneal type bladder rupture cases are most commonly associated with infrapubic ramus, suprapubic ramus and acetabulum. but the statistically significance is abscent (p= 0.642). Also extraperitoneal type bladder rupture cases are most commonly associated with infrapubic ramus, suprapubic ramus and acetabulum. but the statistically significance is abscent (p= 0.548). And all type bladder rupture cases are most commonly associated with infrapubic ramus, suprapubic ramus and acetabulum. but the statistically significance is abscent (p= 0.775). And urethral rupture cases are most commonly associated with infrapubic ramus, suprapubic ramus and acetabulum but the statistically significance is abscent (p= 0.528). Lastly, Combineded bladder rupture and urethral rupture cases are most commonly associated with infrapubic ramus, llium, Symphysis pubis. But the statistically significance is abscent (p= 0.462). Conclusions: In our study when there is a pelvic bone fracture, the fractured site of pelvic bone have no statistically association with lower urinary tract injury. But most common pelvic bone fracture site of all lower urinary tract injury cases is infrapubic ramus. Therefore, if infrapubic ramus fracture is found in the condition of pelvic bone fracture, it is highly likely to have lower urinary tract injury. More careful observation and diagnosis is necessary for this case.

방광에 발생한 염증성 근섬유아세포종

강윤일,문형윤,노준,김철성 朝鮮大學校 附設 醫學硏究所 2007 The Medical Journal of Chosun University Vol.32 No.1

Inflammatory myofibroblastic tumor of urinary bladder is a rare benign entity that clinically and radiologically simulates a malignant tumor. This benign lesion must be differentiated histoloeically from several malignant lesion of the bladder. Complete surgical excision, either by transurethral resection or partial cystectomy, appears to be curative. We report a case of inflammatory myofibroblastic tumor of the urinary bladder in a 25-year-old female.

여성 복압성요실금에 대한 Tension-free Vaginal Tape(TVT) 수술 성적

문찬,강윤일,김경영,문형윤,노준,김철성 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.3

Background: We wanted to evaluated the long term results of the tension-free vaginal tape (TVT) Procedure for treating strss urinary incontinence in women. Method: During Octover 1, 1998 to December 31, 2005, we evaluated the 52 women who underwent the TVT procedure for stress urinary incontinence at least 1 year following surgery. Preoperatively, Patients were evaluated with history taking, Physical examinations and urodynamic study, Operation and hospitalization data were evaluated with duration of procedure, hospital days, foley catheter removal days and use of analgesics, Postoperative evaluations included the uroflowmetry, residual urine volume, surgical outcomes, complications and patients' satisfaction with the procedure. Results: The follow-up period was a mean of 16 months. Preoperative I-QoL total score was 58.0. Comparision the result between preoperative and postoperative Q max was significantly shoter in the postoperative result. TVT procedure remained cure in 96.2% (cured: 82.7%, improved: 13.5%) and successful in 96.1%. Also, 49(94.2%) Patients would like to recommended the TVT procedure to others. There was no serious or long-term complications, Conclusions: The TVT procedure appear to be effective and safe for the surgical treatment of female stress urinary incontinence and showed a good long-term cure rate.

음낭외상시 고환파열에 대한 초음파 검사의 진단적 유용성

김경영,한동준,신대은,노준,문형윤,임동훈,김철성,박성운 朝鮮大學校 附設 醫學硏究所 2007 The Medical Journal of Chosun University Vol.32 No.3

Purpose: We determined the use of scrotal ultrasonography in the initial diagnosis and management of testicular injuries due to blunt scrotal trauma. Mateiials and Methods: We reviewed 54 patients of scrotal trauma in the last 8 years. Forty patients were evaluated by ultrasonography preoperatively. A heterogeneous echo pattern of the testicular parenchyma with loss of oval shape, contour definition was the basis for diagnosis of testicular rupture. Among them, 33 cases underwent scrotal exploration and 7 cases were managed conservatively. The remaining 14 patients were evaluated only by physical examination, 8 patients of them were explored immediately because of suspicious testicular mpture. The accuracy of ultrasonography were determined by comparing radiographic interpretations with intraoperative findings. Results: Among the 33 patients who were evaluated by ultrasonography and explored immediately, there were 26 suspected testicular ruptures on ultrasonography. Surgical exploration revealed testicular rupture in 23 and simple hematoma in 10. The testicular rupture was correctly diagnosed by ultrasonography in the 22 cases, and there were 4 false-positive and 1 false-negative diagnoses of testicular rupture. The sensivity and specificity for the diagnosis of testicular rupture are 96% and 60%, and the positive and negative predictive values are 85% and 86%, respectively, Conclusions: Scrotal ultrasonography, with the main radiographic finding of a heterogeneous echo pattern of the testicular parenchyma with loss of oval shape, contour definition, is highly sensitive on the diagnosis of testicular rupture. And it increases the salvage rate for testicular rupture with preservation of the testicular function and prevents delayed complications of chronic pain, atrophy and orchiectomy associated with missed testicular rupture.

폐내 기관지 낭종

이석열,이숭진,박형주,이철세,이길노,김윤정,나주옥 순천향의학연구소;Soonchunhyang Medical Research Institute 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

A 33-year-old female was admitted to our hospital due to removal of lung mass which indicentally detected Chest radiography. Chest computerized tomography revealed lung parenchymal cystic lesion. Open thoracotomy was done for diagnosis and therapy. Cystic lesion was communicated to bronchus and wedge resection including cystic lesion was done. Bronchogenic cyst is congenital disease and mainly locate in mediastinum. It is rare in lung parenchyme. Herein we report a case of intrapulmonary bronchogenic cyst.

후복막강경 근치적 신적출술 : 개복 근치적 신적출술과의 비교

김경영,임동훈,문형윤,노준,김철성 朝鮮大學校 附設 醫學硏究所 2009 The Medical Journal of Chosun University Vol.33 No.S

Purpose: Although kidney is located in the retroperitoneal space laparoscopic radical nephrectomy is usually performed by the transperitoneal approach. At our institution the retroperitoneal approach is preferred. We evaluated the surgical outcomes, safety, oncologic outcomes, and compared with the results those of open radical nephrectomy in a contemporary cohort. Materials and Methods: Between January 2000 and December 2005 we performed retroperitoneal laparoscopic radical nephrectomy for renal cell carcinoma in 37 patients with clinical stage cT1 and cT2. Data from the these patients were retrospectively compaired with 30 contemporary cases treated with open radical nephrectomy. The clinical parameters including perioperative outcomes, complications, pathologic data, learning curve and recurrence were evaluated. Results: For the 37 retroperitoneal radical nephrectomies mean tumor size was 4.6cm (range 2.3 to 8.0), surgical time was 203.6min (range 110-410) and blood loss was 241.8cc. Mean specimen size was 10.4cm (8.7-14.4). Mean analgesic used day was 1.3 (0-4) and mean postoperative hospital stay was 4.2 days. minor complications occur in 16 cases and no major complications occurred. Surgical margins were negative for tumor in all patients. Variable parameters were comparable between patients undergoing laparoscopic and open radical nephrectomy. However, laparoscopy resulted in decreased blood loss, surgical times, analgesia use, time to oral intake, time to drain removal and postoperative hospital stay. No different complication rate is between two groups Conclusions: Retroperitoneal laparoscopic radical nephrectomy can be a safe and effective treatment in renal cell carcinoma. Although no long-term follow-up is available, our follow up to mean 31 months confirm the effectiveness of retroperitoneal laparoscopic radical nephrectomy in terms of surgical principles and oncological effectiveness.

Facile synthesis of monodispersed silica-coated magnetic nanoparticles

Rho, Won-Yeop,Kim, Hyung-Mo,Kyeong, San,Kang, Yoo-Lee,Kim, Dong-Hyuk,Kang, Homan,Jeong, Cheolhwan,Kim, Dong-Eun,Lee, Yoon-Sik,Jun, Bong-Hyun Elsevier 2014 Journal of industrial and engineering chemistry Vol.20 No.5

<P><B>Abstract</B></P> <P>Silica-coated magnetic nanoparticles (MNPs) have great potential for use in field of biotechnology owing to their unique properties, which can be manipulated by an external magnetic field gradient. Herein, we describe a method for facile synthesis of monodispersed silica-coated MNPs (MNP@SiO<SUB>2</SUB> NPs). Commercially available oleate-MNPs were successfully converted to polyvinylpyrrolidone-MNPs (PVP-MNPs), and then coated with silica by the modified Stöber method. More than 95% of MNPs were individually coated with a silica shell; non-magnetic core silica nanoparticles (NPs) were not detected. Notably, the MNP@SiO<SUB>2</SUB> NPs are highly monodispersed in size (size distribution<2.5%) and synthesis at the scale of grams was easily obtained by a simple scale up process. Moreover, aggregation was not detected upon storage of over three months.</P>

CCI_4 가 家兎의 알코올 代謝에 미치는 影響

윤대중,임철완,김형로 전북대학교 의과학연구소 1983 全北醫大論文集 Vol.7 No.1

Serum alanine aminotransferase activity was increased to the highest level 24 hours after single CCl_4 injection, whereas alcohol dehydrogenase(ADH) was not detected in the sera of both control and CCl_4 poisoned rabbits. Among various rabbit organs observed, ADH activity was found only in the liver and in the stomach. Hepatic ADH and acetaldehyde dehydrogenase activities in chronic CCl_4 poisoned rabbits were severely reduced to 77% and 15% of control group respectively. Since ethanol metabolism which occurs mainly in the liver was greatly reduced in chronic CCl_4 poisoned rabbits, ethanol clearance rats can be expected as a useful indicator for the diagnosis of chronic liver disease.

구강 편평세포암종의 Matrix Metalloproteinase(MMP)-1, 2, 3, 9와 Tissue Inhibitors of MMP(TIMP)-1, 2의 발현 양상의 비교 및 상호 연관성

노영서,한지용,김용환,윤혜경,김우형,이희철 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.4

Objective : nvasiveness of squamous cell carcinoma in oral cavity is associated with poor prognosis, and MMPs have an important role in degradation of extracellular matrix and bawement membrane of vessil walls. Increased expressions of MMPs is related to infiltrative growth and lymph node metastases in human cancers. In normal tissue, there is balanced secretions of MMPs and TIMPs, but impaired balance of MMPs and TIMPs was noted in cancer tissue. The aim of this study is to evaluate the expression rates of MMP-1, 2, 3 and TIMP 1 and 2 in squamous cell carcinoma of the oral cavity, and relationship between MMPs and TIMPs expression and histologic grade and invasion pattern. Methods and Material : Pathologic review of fifty cases of squamous cell carcinoma during a period of Mar. 1994 to Feb. 2000 based on histologic grade and invasion pattim and immunohistochemical stains for MMP-1, 2, 3 and 9 and TIMP-1, 2 were done. Statistical analysis between MMPs and TIMP s expression rate and pathologic parameters and relationship between MMPs and TIMPs were performed. Results : Expression rates of MMP-1, 2, 3 and 9were 32.0%, 38.0%, 22.0% and 20.0%, respectively. MMP-2 expression rate was higher in well differentiated carcinomas and in cases with less-infiltrative pattern. Other MMPs show slightly higher expression rate in well differentiated carcinomas, but there were no statistical significances. There were no significant differences of MMP-1, 2, 3 and 9 expression rates according to invasion pattern. Expression rates of TIMP-1 and TIM-2 were 22.2% and 48.0%, respectively, and there were no significant differences according to histologic grade and invasion pattern. Significant correlations of MMP-1, 2, 3 and 9 expressions except between MMP-2 and MMP-3 were noted, but there were no significant correlations between MMPs and TIMPs expression. Conclusion : Conclusions: In well differentiated and less infiltrative squamous cell carcinomas of the oral cavity, expression rates of MMPs, especially MMP-2, were high. And there were positive correlation between MMPs, but no correlation between MMPs and TIMPs. These findings suggest that MMPs may have a role in tumor developent of a subset of squamous cell carcinoma with less aggressive behavior and MMPs may involve in early stage of tumor progression.

Geographical Patterns of Morphological Variation in Soybean Germplasm

Yoon, Mun-Sup,Ahn, Jong-Woong,Park, Sei-Joon,Baek, Hyung-Jin,Park, Nam-Kyu,Rho, Young-Deok The Korean Society of Crop Science 2000 Korean journal of crop science Vol.45 No.4

A total of 1,830 soybean collections were grown in the field and characterized for 10 morphological traits to determine the diversity and relationship within and among geographical regions. Phenotypic variation was found within all regions for most characters. The Shannon-Weaver diversity index ranged from 0.49 to 0.62 across regions, and 0.09 to 1.00 across characters. Canonical discriminant analysis and clustering of the canonical means delineated 3 regional clusters: (ⅰ) Kyunggi, Chungchong, Kangwon, Chulla, and Kyungsang; (ⅱ) Heilongjiang; and (ⅲ) Jilin, Manchuria, central China, south China, Others (China), Hokkaido, Honshu, and Others (Japan).