치주질환 환자에서 치근이개부 병변의 발생빈도 및 심도에 관한 연구

노영서,이만섭,권영혁,Rho, Young-Seo,Lee, Man-Sup,Kwon, Young-Hyuk 대한치주과학회 1990 Journal of Periodontal & Implant Science Vol.20 No.2

구강 편평세포암종의 Matrix Metalloproteinase(MMP)-1, 2, 3, 9와 Tissue Inhibitors of MMP(TIMP)-1, 2의 발현 양상의 비교 및 상호 연관성

노영서,한지용,김용환,윤혜경,김우형,이희철 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.4

Objective : nvasiveness of squamous cell carcinoma in oral cavity is associated with poor prognosis, and MMPs have an important role in degradation of extracellular matrix and bawement membrane of vessil walls. Increased expressions of MMPs is related to infiltrative growth and lymph node metastases in human cancers. In normal tissue, there is balanced secretions of MMPs and TIMPs, but impaired balance of MMPs and TIMPs was noted in cancer tissue. The aim of this study is to evaluate the expression rates of MMP-1, 2, 3 and TIMP 1 and 2 in squamous cell carcinoma of the oral cavity, and relationship between MMPs and TIMPs expression and histologic grade and invasion pattern. Methods and Material : Pathologic review of fifty cases of squamous cell carcinoma during a period of Mar. 1994 to Feb. 2000 based on histologic grade and invasion pattim and immunohistochemical stains for MMP-1, 2, 3 and 9 and TIMP-1, 2 were done. Statistical analysis between MMPs and TIMP s expression rate and pathologic parameters and relationship between MMPs and TIMPs were performed. Results : Expression rates of MMP-1, 2, 3 and 9were 32.0%, 38.0%, 22.0% and 20.0%, respectively. MMP-2 expression rate was higher in well differentiated carcinomas and in cases with less-infiltrative pattern. Other MMPs show slightly higher expression rate in well differentiated carcinomas, but there were no statistical significances. There were no significant differences of MMP-1, 2, 3 and 9 expression rates according to invasion pattern. Expression rates of TIMP-1 and TIM-2 were 22.2% and 48.0%, respectively, and there were no significant differences according to histologic grade and invasion pattern. Significant correlations of MMP-1, 2, 3 and 9 expressions except between MMP-2 and MMP-3 were noted, but there were no significant correlations between MMPs and TIMPs expression. Conclusion : Conclusions: In well differentiated and less infiltrative squamous cell carcinomas of the oral cavity, expression rates of MMPs, especially MMP-2, were high. And there were positive correlation between MMPs, but no correlation between MMPs and TIMPs. These findings suggest that MMPs may have a role in tumor developent of a subset of squamous cell carcinoma with less aggressive behavior and MMPs may involve in early stage of tumor progression.

베이비 붐 세대의 고령화를 대비한 UI디자인 사용성 연구

노영서(Noh, Young Seo),김보연(Kim, Boyeun) 한국디지털디자인협의회 2013 디지털디자인학연구 Vol.13 No.1

우리나라는 2009년 고령화 사회로 진입하였고, 2026년에는 초 고령화 사회로 진입할 것으로 예측되고 있다. 우리나라가 초 고령화 사회로 진입하는 데는 720만 베이비붐 세대의 노령화와 은퇴가 많은 영향을 미치고 있는데, 베이비붐 세대는 이전의 시니어 세대와는 다른 특성을 가지는데, 특히 베이비붐 세대는 이전의 시니어 계층과는 다르게, 디지털 기기를 사용하는 것이 익숙하다. 특히 스마트폰의 경우 처음에는 젊은 층에 편중되어있던 이용률이 2011년 이후 베이비 붐 세대인 40~50대까지 확산되었다. 따라서 이전의 시니어 계층과는 다른 경험을 가지고 있지만, 노령화가 진행되고 있는 베이비붐 세대의 UI상의 니즈를 알아보기 위한 목적으로 연구를 시작하였다. 이에 본 연구는 첫째, 문헌연구를 통하여 고령화의 특징과 베이비 붐 세대의 특징을 알아보았다. 둘째, 베이비붐 세대들도 보편적으로 사용하는 카카오톡을 중심으로 심층인터뷰와 사용성 테스트를 진행하여, 스마트폰 사용행태를 알아 보았다. 셋째, 베이비붐 세대의 라이프스타일과 사용성 평가에서 나타난 행태를 기반으로 베이비 붐 세대를 고려한 UI 디자인에 대한 결론을 내렸다. Korea is rapidly aging country. Demographic status of Korea entered the aging society stage since 2009 and it is anticipated to be in super-aging society stage by 2026. Major contribution on this demographic trend has been made by aging and retirements of Baby boomers generation. Baby boomers generation is currently the largest population age group populated around 7.2 million. Baby boomers have distinctive characteristics from the eider generations. Especially, baby boomers are familiar with the usage of electronic devices. The main users of smart phone that was only the young age-range has spread to the wider age band until 4-50s because of baby boomer’s consumption. Therefore, this study aims to investigate the needs of Baby boomers on UI. This paper consists of following steps. Firstly, population aging and characteristics of baby boomers were researched through literature review. Secondly, usability tests and in-depth-interviews were held to investigate the smart phone usages of baby boomers by focusing on the usage of specific application "Kakaotalk" and then, based on the harvested data, better UI design was deducted to apply the life style and usability of baby boomers generation.

하악 우각부 및 악하부에 발생한 경부수활액낭종

박성원,이희철,신명상,전인성,윤규호,노영서 大韓顎顔面成形再建外科學會 1994 Maxillofacial Plastic Reconstructive Surgery Vol.16 No.2

Cystic hygroma remains a complex entity in terms of its development and management. Most recently, cystic hygroma has been categorized as part of a larger spectrum that include lymphangioma. The majorities of lymhangioma occur in the head and neck as cystic hygromas with the posterior cervical region as the most common site. Cystic hygromas usually present in infancy or early childhood as compressible masses that may rapidly and intermittently enlarge. While they may arise in any anatomic locatin, hygromas of the head and neck re especially difficult and speech pthology. Since as airway obstruction, feeding difficulties, and speech pathology. Since its original description, there have been many attepmts at treatment modalities: surgical excision remains the treatment of choice. Complete extirpation of these lesions is often impossible, and recurrence rates are accordingly high. This is report of a case bout 5-year-old female patient with cystic hygroma, resulted in facial asymmetry and swallowing difficulty, in left submandibular area. We obtained the successful functionl and esthetic results by simple surgical excision of tumor mass. Thefore, we represents the case with literatural reviews.

하악골에 발생한 재발성 법랑아 세포종의 치험례

전인성,박성원,노영서,윤규호,신명상 大韓顎顔面成形再建外科學會 1994 Maxillofacial Plastic Reconstructive Surgery Vol.16 No.2

The Ameloblastoma is a true neoplasm of enamel organ-type tissue histopathologically. Ameloblastoma is recognized as a benign tumor, but its clinical behavoir is locally invasive. Therefore treatment of choice is surgical resection rather than conservtive enucleation. This is a case report about En-bloc excision of granular ameloblstoma arising from dentigerous cyster in the right mandibular angle area of 50-year male patient. He visited local clinic with chief complaint of facial swelling on the right mandibular angle area. Surgical removal was performed by cyster enucleation and En-bloc excision with perservation of inferior border of mandible. After 1 year, iliac bone graft was done and hyperbaric oxygen therapy was applied. We obtained a good result of bony regeneration without any sign of recurrence.

HALOTHANT 전신마취후 발생한 독성간염

백운봉,윤규호,노영서,박성원,신명상,허남오,Paik, Un-Bong,Yoon, Kyu-Ho,Rho, Young-Seo,Park, Sung-Won,Shin, Myoung-Sang,Heo, Nam-Oh 대한악안면성형재건외과학회 1994 Maxillofacial Plastic Reconstructive Surgery Vol.16 No.3

General anesthesia is necessary to operation in dept. of oral and maxillofacial surgery. Halothane is one of the most commonly used anesthetic agent for general anesthesia because of its property of nonexplosive, inexpensive, strong activeness and chemical stability. Halothane is fluorinated hydrocarbone anesthetic agent and structurally similiar to chloroform. On the contrary halothane has been reported to result in severe hepaitc necrosis in a small number of individuals. Although the mechanism of halothane induced toxic hapatitis is unclear, it appears to be closely related to reducting metabolite, reactant intermediate product, immune reaction, hypersensitivity and so on. This is a case report of 27 years old male patient occured halothane induced hepatitis following after operation of mandible fracture.

하악골 골절의 임상통계학적 연구

박준호,허남오,전인성,신명상,노영서,윤규호,Park, Jun-Ho,Heo, Nam-Oh,Jeon, In-Seong,Shin, Myoung-Sang,Rho, Young-Seo,Yoon, Kyu-Ho 대한악안면성형재건외과학회 1994 Maxillofacial Plastic Reconstructive Surgery Vol.16 No.3

This is a clinical study on 235 inpatients who sustained a total of 350 mandibular fractures and who were treated in our department during the period of Oug., 1989 through Dec., 1993. The results obtained are as follows : 1. The mumber of patients has not been increased year after year. In respect of incidence, there were the highest frequency as 67 patients(28.5%) in 1991 and the least frequency as 16 patients(6.8%) in 1989 and the highest frequency as 28 patients(11.9%) in October and the least frequncy as 12 patients(5.2%) in February. 2. The age frequency was the highest in the second decade(30.6%). The youngest patient was 8 months and the eldest patient was 80 years and mean age was 27.8 years. The ratio of men to Wemen was 4 : 1. 3. The most frequent cause was fall down as 86 patients(36.6%) and the next was fist blow 4 as 75 patients(31.9%), traffic accident as 56 patients(23.9%) in order. 4. The most common location was symphysis as 141 numbers(40.3%) and the next was condyle as 96 numbers(27.4%), angle as 94 numbers(26.8%), body as 14 numbers(4.0%) in order. The sum of fracture sites were 350 and there were 1.49 fracture sites per one patient and multiple fractures occured in 100 patients(40.5%) of the 235 patients. The ratio of Left to Right except for symphysis was 1.71 : 1. 5. Among the 333 associated injuries, facial laceration was 136(57.9%) and tooth injury was 58(24.7%) and extremity was 31(13.2%). 6. Among the 350 mandibular fractures, complications after treatment occured in 51(14.6%) and infection as 20(5.7%) was the most frequent complication. 7. In respect of treatment of mandibular fracture, close reduction was 64 patients(27.2%) and open reduction was 164 patients(69.8%) and other were 7 patients(3.0%) of all and so open reduction was the most common in type of treatment.