Classification of postoperative edema based on the anatomic division with mandibular third molar extraction

Yeong Kon Jeong,Jeong-Kui Ku,Sung Hyun Baik,유재식,임대호,Sun-Kyu Choi 대한악안면성형재건외과학회 2021 Maxillofacial Plastic Reconstructive Surgery Vol.43 No.-

Purpose: Several investigations have been performed for a postoperative edema after extraction, but the results have been controversial due to low objectivity or poorly reproducible assessments of the edema. The aim of this study was to suggest a classification and patterns of postoperative edema according to the anatomical division associated with extraction of mandibular third molar as a qualitative evaluation method. Methods: This study was conducted forty-four mandibular third molars extracted and MRI was taken within 48 h after extraction. The postoperative edema space was classified by MRI (one anatomic component—buccinator muscle—and four fascial spaces—supra-periosteum space, buccal space, parapharyngeal space, and lingual space), and evaluated independently by two examiners. The inter-examiner reliability was calculated using Kappa statistics. Results: The evaluation of buccinator muscle edema showed good agreement and the fascial spaces showed constant high agreement. The incidence of postoperative edema was high in the following order: supra-periosteum space (75.00%), buccinator muscle (68.18%), parapharyngeal space (54.55%), buccal space (40.91%), and lingual space (25.00%). Conclusion: Postoperative edema could be assessed clearly by each space, which showed a different tendency between the anatomic and fascial spaces.

Characteristics and electrochemical performance of silicon coated carbon nanofibers composite as anode material for lithium secondary batteries

Jin-Yeong CHOI,Yura HYUN,Heai-Ku PARK,Chang-Seop LEE 한국진공학회 2016 한국진공학회 학술발표회초록집 Vol.2016 No.8

Platelet-activating factor-induced NF-κB activation enhances VEGF expression through a decrease in p53 activity

Ko, Hyun-Mi,Jung, Hae Hyun,Seo, Kook Heon,Kang, Yeong-Rim,Kim, Han-A,Park, Sung Jun,Lee, Hern-Ku,Im, Suhn-Young Elsevier 2006 FEBS letters Vol.580 No.13

<P><B>Abstract</B></P><P>We investigated the role of p53 in nuclear factor (NF)-κB dependent, platelet-activating factor (PAF)-induced vascular endothelial growth factor (VEGF) expression. Transfected NF-κB subunits in ECV304 cells increased the tumor necrosis factor-α promoter activity, which was completely inhibited by p53. Transfected p53 increased p53RE promoter activity, which was completely inhibited by NF-κB subunits, indicating that cross-regulation occurs between NF-κB and p53. PAF-induced increase in VEGF expression was correlated with decreased p53 activity. These data suggest that NF-κB-dependency of the PAF-induced increase in VEGF expression is due to decreased p53 activity, which is reciprocally regulated by increased NF-κB activity.</P>

고정층 흡착계의 점근해와 유효확산계수

이현구,남영우 한국화학공학회 1977 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.15 No.1

고정층 흡착계의 농도분포에 관하여 점근해가 존재함은 일반적으로 증명이 된 바 있다. 본 연구에서는 Freundlich 등온식을 만족하는 흡착계에 대하여 흡착질 농도 분포의 점근해를 해석적으로 구하고 흡착영역의 폭이 축방향의 유효확산계수에 직접 비례하는 점에 착안하여 간단한 실험으로 축방향의 유효확산계수를 결정하는 소위 "점근해법"을 제시하였다. 한편 초산-물-charcoal계에 대하여 흡착실험을 실시하고 breakthrough 곡선을 구하여 점근해의 응용성을 검토하였다. 농도분포의 실험치와 점근해를 대비하여 서로 일치함을 관찰하였고 흡착영역의 폭을 구하여 이로부터 축방향의 유효확산계수를 산출하였다. 동일한 방법으로 여러 유속에 대하여 유효확산계수의 값을 결정하고 문헌에 보고된 실험치와 잘 부합함을 확인하였다. 따라서 본 연구의 점근해법은 축방향의 유효확산계수를 결정하는 편리한 방법으로 활용될 수 있음이 입증되었다. It is well understood that under certain circumstances there exists an asymptotic solution for the adsorbate concentration profile in a fixed-bed adsorption system. The present study gives an analytical form of the asymptotic solution for an adsorption system subject to the isotherm of Freundlich type. It is also noticed that the adsorption zone thickness is directly proportional to the effective axial dispersion coefficient. This enables us to propose a scheme, the so-called asymptotic solution technique, to determine the effective axial dispersion coefficient. Breakthrough curves are measured for the acetic acid-water-charcoal system and comparison of those obtained from beds of different height demonstrates the applicability of the asymptotic solution. The experimental profile of the adsorbate concentration is then used to determine the adsorption zone thickness, from which the effective axial dispersion coefficient is computed. The dispersion coefficients determined in this manner turn out to be in good agreement with literature values. Consequently, the asymptotic solution technique may be used as a convenient method for measuring the effective axial dispersion coefficient.

Occurrence of Virulence Determinants in Fecal Enterococcus faecalis Isolated from Pigs and Chickens in Korea

( In Yeong Hwang ),( Suk Kyung Lim ),( Hyun Ok Ku ),( Choi Kyu Park ),( Suk Chan Jung ),( Yong Ho Park ),( Hyang Mi Nam ) 한국미생물 · 생명공학회 2011 Journal of microbiology and biotechnology Vol.21 No.12

Forty-one Enterococcus faecalis (E. faecalis) isolates from feces of pigs and chickens in Korea were screened for the presence of virulence factors. Gelatinase activity (85.4%, 35/41) was the more commonly observed phenotype of virulence in E. faecalis, compared with hemolytic activity (12.2%, 5/41). Thirty-one of 35 (88.6%) gelatinase-positive E. faecalis isolates harbored the gelE and fsrABC genes. A gene encoding for the enterococcal surface protein (Esp) was detected in 24.4% (10/41) of the isolates. All betahemolysin- producing isolates harbored the esp gene.

Critical role for matrix metalloproteinase-9 in platelet-activating factor-induced experimental tumor metastasis

Ko, Hyun-Mi,Kang, Jee-Hae,Jung, Bongnam,Kim, Han-A,Park, Sung Jun,Kim, Kyoung-Jin,Kang, Yeong-Rim,Lee, Hern-Ku,Im, Suhn-Young Wiley Subscription Services, Inc., A Wiley Company 2007 International journal of cancer: Journal internati Vol.120 No.6

<P>In this study, the roles of matrix metalloproteinase (MMP)-2 and MMP-9 in platelet-activating factor (PAF)-induced experimental pulmonary metastasis of the murine melanoma cell, B16F10, were investigated. An injection of PAF resulted in increases in mRNA expression, protein levels and the activities of both MMP-2 and MMP-9 in the lungs. The overall expression of MMP-9 was stronger than that of MMP-2. The increased MMP-9 expression was inhibited by both NF-κB and AP-1 inhibitors, whereas the increased MMP-2 expression was inhibited by only AP-1 inhibitors. Immunohistochemical analysis revealed that MMP-9 was expressed in bronchial epithelial cells as well as in the walls of blood vessels, whereas MMP-2 expression was observed only in bronchial epithelial cells. PAF significantly enhanced the pulmonary metastasis of B16F10, which was inhibited by both NF-κB and c-jun inhibitors. MMP-9 inhibitor, but not that of MMP-2, completely inhibited PAF-induced B16F10 metastasis. These data indicate that MMP-9, the expression of which was regulated by NF-κB and AP-1, plays a critical role in PAF-induced enhancement of pulmonary melanoma metastasis. © 2006 Wiley-Liss, Inc.</P>

Development and validation of a difficulty index for mandibular third molars with extraction time

Jeong-Kui Ku,Na-Hee Chang,Yeong-Kon Jeong,Sung Hyun Baik,Sun-Kyu Choi 대한구강악안면외과학회 2020 대한구강악안면외과학회지 Vol.46 No.5

Objectives: This study aimed to validate the effectiveness of a recently proposed difficulty index for removal of impacted mandibular third molars based on extraction time and suggest a modified difficulty index including the presence of pathologic conditions associated with third molars. Materials and Methods: This retrospective study enrolled 65 male patients younger than 25 years with third molars. Extraction time was calculated from start of the incision to the last suture. The difficulty scores for third molars were based on spatial relationship (1-5 points), depth (1-4 points), and ramus relationship (1-3 points) using cone-beam computed tomography. The difficulty index was defined as follows: I (3-4 points), II (5-7 points), III (8-10 points), and IV (11-12 points). The modified difficulty score was calculated by adding one point to the difficulty score if the third molar was associated with a pathologic condition. Two modified difficulty indices, based on the presence of pathologic conditions, were as follows: the half-level up difficulty index (HDI) and the one-level up difficulty index (ODI) from the recently proposed difficulty index. Results: The correlations between extraction time and difficulty index and or modified difficulty indices were significant (P<0.001). The correlation coefficient between extraction time and difficulty index was 0.584. The correlation coefficients between extraction time and HDI and ODI were 0.728 and 0.764, respectively. Conclusion: Extraction time of impacted third molars exhibited a moderate correlation with difficulty index and was strongly correlated with the modified indices. Considering the clinical implications, the difficulty index of surgical extraction should take into consideration the pathologic conditions associated with third molars.

한국인 안드로젠 저항성 증후군 환자의 안드로젠 수용체 유전자 변이 양상

박서영(Seo Yeong Park),최영민(Young Min Choi),박성효(Sung Hyo Park),양세원(Se Won Yang),구승엽(Seung Yup Ku),김석현(Seok Hyun Kim),김수응(Soo Woong Kim),백제승(Jai Seung Paik),양도훈(Do Hoon Yang),최두석(Doo Seok Choi),권혁찬(Hyuck C 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.4

N/A Androgen insensitivity syndrome (AIS) is a X-linked disorder of sexual differentiation resulting from defective androgen receptor (AR) function. Androgens are secreted by the testes of 46,XY individuals, but there is loss of target organ response to the hormone. The abnormalities of AR are due to defects in the AR gene, and many mutations causing AIS have been reported since the cloning of AR gene. In this study, we analyzed the AR genes in twelve Korean patients with androgen insensitivity syndrome: 9 patients with complete AIS and 3 patients with partial AIS. DNAs were isolated from patients with AIS, and the coding region of AR gene was amplified by a polymerase chain reaction using 7 pairs of primers (exon B-H). Sequence analysis of the AR gene was performed using direct sequencing and single strand conformational polymorphism (SSCP). The AR gene mutations were identified in 7 out of 12 patients: 6 of 9 patients with complete AIS, and one of 3 patients with partial AIS. Mutations found were as follows: the point mutation (ATT→ACT) at position 680 of exon D, point mutation (TGG→TGC) at position 751 of exon E, point mutation (CAA→TAA) at position 792 of exon F, point mutations (CGC→TGC, GTG→ATG) at position 855 and 866 of exon G, and the deletion of 13 nucleotides (CGTATCATTGCAT) at position 840 of exon G, respectively. To the best of our knowledge, the point mutations found in exon D, exon E, and exon F, and the deletion in exon G have not been observed before. SSCP revealed bands with abnormal mobility in 10 out of 12 patients tested. Mutations were found 5 out of these 10 patients. The other two patients showed no abnormal band on SSCP, but showed mutations by direct sequencing. In conclusion, we have demonstrated the AR gene mutations, including three novel mutations, in Korean patients with AIS, and these abnormalities might be related to the pathogenesis of androgen insensitivity syndrome.

크라우드소싱 기반의 지식창조 프레임워크 개발

정승현(Seung Hyun Chung),이시종(Shi Jong Lee),엄진영(Jin Yeong Um),조성구(Sung Ku Cho) 한국경영과학회 2012 한국경영과학회 학술대회논문집 Vol.2012 No.5

웹2.0기반의 인터넷 서비스가 확산되면서 아웃소싱을 초월한 대중에게 지식을 구하는 크라우드 소싱의 개념이 확산되고 있다. 크라우드소싱은 지식창출에 있어서 중요한 역할을 수행할 수 있는 잠재력을 가지고 있으며 실제 활용방법을 다룬 연구는 많지만 크라우드 소싱의 유형, 특징 그리고 프로세스 등을 체계적으로 분석한 연구는 미비한 실정이다. 이 연구에서는 현재까지의 문헌연구를 통하여 크라우드 소싱을 통합적 크라우드 소싱과 선택적 크라우드 소싱으로 분류하였고 노나카의 지식창조 모형을 이용한 분석을 통해 기업관점에서의 지식창조를 위한 통합적 크라우드 프로세스를 제시하였다. 또한 문헌연구와 특징분석을 기반으로 선택적 및 통합적 크라우드 소싱을 기업차원에서 활용할 수 있는 프레임워크를 설계하였고 크라우드 소싱을 활용하고자 하는 기업이 이를 적용할 수 있도록 가이드라인을 제시하였다.

크라우드소싱 기반의 지식창조 프레임워크 개발

정승현(Seung Hyun Chung),이시종(Shi Jong Lee),엄진영(Jin Yeong Um),조성구(Sung Ku Cho) 대한산업공학회 2012 대한산업공학회 춘계학술대회논문집 Vol.2012 No.5

웹2.0기반의 인터넷 서비스가 확산되면서 아웃소싱을 초월한 대중에게 지식을 구하는 크라우드 소싱의 개념이 확산되고 있다. 크라우드소싱은 지식창출에 있어서 중요한 역할을 수행할 수 있는 잠재력을 가지고 있으며 실제 활용방법을 다룬 연구는 많지만 크라우드 소싱의 유형, 특징 그리고 프로세스 등을 체계적으로 분석한 연구는 미비한 실정이다. 이 연구에서는 현재까지의 문헌연구를 통하여 크라우드 소싱을 통합적 크라우드 소싱과 선택적 크라우드 소싱으로 분류하였고 노나카의 지식창조 모형을 이용한 분석을 통해 기업관점에서의 지식창조를 위한 통합적 크라우드 프로세스를 제시하였다. 또한 문헌연구와 특징분석을 기반으로 선택적 및 통합적 크라우드 소싱을 기업차원에서 활용할 수 있는 프레임워크를 설계하였고 크라우드 소싱을 활용하고자 하는 기업이 이를 적용할 수 있도록 가이드라인을 제시하였다.