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사람의 비후성 반흔에서 면역조직화학기법에 의한 형질전환인자 알파와 표피성장인자 발현의 차이에 관한 면역조직화학적 연구
박영란,김현곤,김종중,문정석,송준섭,설경수,정윤영 朝鮮大學校 附設 醫學硏究所 2008 The Medical Journal of Chosun University Vol.33 No.2
Background and Objectives: Transforming growth factor-α (TGF-α) and epidermal growth factor (EGF) are polypeptides which interact with the epidermal growth factor receptor (EGFR) to produce their biological effects. The aim of the present investigation was to elucidate the immunolocalization of TGF-α and EGF in normal human skin, hypertrophic scar with skin graft on soft tissue defect, and postburn hypertrophic scar without graft. Methods: The data presented in this paper focused attention on differences of expression between two kinds of hypertrophic scars in relation to skin graft using immunohistochemistry. Formalin-fixed and paraffin-embedded tissues from 3 normal skin tissues, 3 hypertrophic scars after skin graft and 8 postburn hypertrophic scars without graft were immunolabelled with antibodies directed against TGF-α and EGF. Results: In normal epidermis of skin, strong TGF-α immunoreactivity (IR) was observed in all epidermal layers except the stratum (S.) basale, whereas EGF was immunopositive in a few cells over all epidermal layers. The staining for TGF-α was found in cell membrane, and EGF was seen either diffuse cytoplasmic or peripheral part of cells in normal epidermis. In hypertrophic scar after six months postoperation, TGF-α IR was observed in the upper part of S. spinosum and S. corneum, whereas EGF was diffusely expressed in the S. spinosum, also its intensity was slightly increased compared to normal skin. In hypertrophic scar without skin graft, very strong expression of EGF was detected in the S. spinosum and S. corneum, and intensity of EGF was increased when compared to normal skin and postoperative hypertrophic scar. EGF and TGF-α coexisted in the cells of S. spinosum in normal skin as well as hypertrophic scars. Double-labeled cells were increased in postburn hypertrophic scar compared to normal skin and postoperative hypertrophic scar. In addition, intensity of EGF and TGF-α double IR was the strongest in postburn hypertrophic scar. Conclusion: These results indicate that EGF may have a more complex regulatory role not only in the early stages of wound healing but also in hypertrophic scar.
( Hyun Soo Park ),( Won Joon Seong ),( Joon Seok Hong ),( Hyun Joo Seol ),( Han Sung Hwang ),( Kunwoo Kim ),( Hyun Sun Ko ),( Dong Wook Kwak ),( Soo Young Oh ),( Moon Young Kim ),( Sa Jin Kim ) 대한산부인과학회 2015 Obstetrics & Gynecology Science Vol.58 No.6
Objective To analyze practice patterns and checklists of second trimester ultrasonography, and to investigate management plans when soft markers are detected among Korean Society of Ultrasound in Obstetrics and Gynecology (KSUOG) members. Methods An internet-based self-administered questionnaire survey was designed. KSUOG members were invited to the survey. Checklists of the second trimester ultrasonography were also requested. In the questionnaire survey, general practice patterns of the second trimester ultrasonography and management schemes of soft markers were asked. In the checklists analysis, the number of items were counted and also compared with those recommended by other medical societies. Results A total of 101 members responded. Eighty-seven percent routinely recommended second trimester fetal anatomic surveillance. Most (91.1%) performed it between 20+0 and 23+6 weeks of gestation. Written informed consents were given by 15.8% of respondents. Nearly 60% recommended genetic counseling when multiple soft markers and/or advanced maternal age were found. Similar tendencies were found in the managements of individual soft markers. However, practice patterns were very diverse and sometimes conflicting. Forty-eight checklists were analyzed in context with the number and content of the items. The median item number was 46.5 (range, 17 to 109). Of 49 items of checklists recommended by International Society of Ultrasound in Obstetrics and Gynecology and/or American Congress of Obstetricians and Gynecologists, 14 items (28.6%) were found in less than 50% of the checklists analyzed in this study. Conclusion Although general practice patterns were similar among KSUOG members, some of which were conflicting, and there is a need for standardization of the practice patterns and checklists of second trimester ultrasonography, which also have very wide range of spectrum.
Optimal Design Strategy for Improved Operation of IPM BLDC Motors With Low-Resolution Hall Sensors
Seol, Hyun-Soo,Lim, JongSuk,Kang, Dong-Woo,Park, Joon Sung,Lee, Ju IEEE 2017 IEEE transactions on industrial electronics Vol.64 No.12
<P>This study proposes an interior permanent magnet (IPM) brushless dc (BLDC) motor design strategy that utilizes BLDC control based on Hall sensor signals. The magnetic flux of IPM motors varies according to the rotor position and abnormal Hall sensor problems are related to magnetic flux. To find the cause of the abnormality in the Hall sensors, an analysis of the magnetic flux density at the Hall sensor position by finite element analysis is conducted. In addition, an IPM model with a notch structure is proposed to solve abnormal Hall sensor problems and its magnetic equivalent circuit (MEC) model is derived. Based on the MEC model, an optimal rotor design method is proposed and the final model is derived. However, the Hall sensor signal achieved from the optimal rotor is not perfect. To improve the accuracy of the BLDC motor control, a rotor position estimation method is proposed. Finally, experiments are performed to evaluate the performance of the proposed IPM-type BLDC motor and the Hall sensor compensation method.</P>
( Hyun-joo Seol ),( Ji-hee Sung ),( Won Joon Seong ),( Hyun Mi Kim ),( Hyun Soo Park ),( Hayan Kwon ),( Han-sung Hwang ),( Yun Ji Jung ),( Ja-young Kwon ),( Soo-young Oh ) 대한산부인과학회 2020 Obstetrics & Gynecology Science Vol.63 No.1
Objective To provide a standardized protocol for the measurement of cervical strain elastography, present its reproducibility, and analyze baseline clinical factors affecting the measurement of elastographic parameters. Methods This study was performed by the Korean Research Group of Cervical Elastography. We enrolled pregnant women according to our study protocol. After measuring the cervical length, elastography was performed using the E-Cervix™ quantification tool to measure the strain of the cervix using intrinsic compression. We evaluated 5 elastographic parameters, namely, the strain of the internal os of the cervix (IOS), strain of the external os of the cervix (EOS), ratio of the strain of IOS and EOS, elasticity contrast index, and hardness ratio. For baseline clinical factors, we examined the maternal body mass index, blood pressure, heart rate, uterine artery Doppler indices, and fetal presentation. Results We established a specific protocol for the measurement of cervical elastography using the E cervix program. For all elastographic parameters, the intra-observer intraclass correlation coefficient (ICC) ranged from 0.633 to 0.723 for single measures and from 0.838 to 0.887 for average measures, and the inter-observer ICC ranged from 0.814 to 0.977 for single measures and from 0.901 to 0.988 for average measures. Regression analysis showed that the measurement of the elastographic parameter was not affected by baseline clinical factors. Conclusion We present a standardized protocol for the measurement of cervical elastography using intrinsic compression. According to this protocol, reproducibility was acceptable and the measurement of elastographic parameters was not affected by the baseline clinical factors studied.
Design of 3-Times Magnetizer and Rotor of Spoke-Type PMSM Considering Post-Assembly Magnetization
Seol, Hyun-Soo,Jeong, Tae-Chul,Jun, Hyun-Woo,Lee, Ju,Kang, Dong-Woo IEEE 2017 IEEE transactions on magnetics Vol.53 No.11
<P>Unlike the existing bar-type permanent magnets, it is difficult to magnetize the ferrite spoke-type permanent magnet synchronous motor (PMSM), because the permanent magnet is placed deep inside the shaft. In order to magnetize permanent magnet, a high magnetic field intensity is required. However, the high magnetic field intensity may cause demagnetization of surrounding permanent magnets. It has a bad effect on the magnetization of the permanent magnet and the performance of the spoke-type PMSM. In this paper, we proposed magnetizer models for magnetization of spoke-type 10 pole rotor and the inter-pole winding to reduce the demagnetization of surrounding permanent magnets. Finally, the optimally designed model was manufactured and the performance of the magnetizer was verified.</P>