요부수핵탈출증에서 Thermography의 진단적 가치

신현택,신승우,송재철,정석희,이종수,김성수,신현대 경희대학교 동서의학연구소 2001 東西醫學硏究所 論文集 Vol.2000 No.-

Objectives : Lumbar radiculopathy is a common disease in oriental rehabilitation medicine. It can be diagnosed by physical examination, plain X-ray, Myelography, CT, MRI, EMG etc. But those methods are not useful in observing the clinical procedure. Objectvie evaluating the clinical procedure is very important in treatment of lumbar radiculopathy. Mehthods : We studied the clinical efficacy of thermography in lumbar radiculopathy during conservative managements. We studied 36 patients with lumbar radiculopathy convinced by MRI. The had low back pain and radiating pain on one side. Thermography had taken before an after 4 weeks treatments, and compared with clinical procedure Results and conclusions : Thermography is not pertinent as a primary diagnostic method in lumbar radiculopathy, but useful in observing the clinical procedure. And it can be recommended as a objective evaluation for lumbar radiculopathy.

비만증 환자에서 한약제에 의한 체중 감소효과

Oh, Seung-Joon,Jeong, In-Kyung,Kim, Young-Seol,Choi, Young-Kil,Paeng, Jeong-Ryung,Bae, Jung-Hwan,Shin, Hyun-Dae 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1

Seung-Joon Oh, In-Kyung Jeong, Young-Seol Kim, Young-Kil Choi, Jeong-Ryung Paeng¹, Jung-Hwan Bae and Hyun-Dae Shin²Department of internal Medicine, College Medicine, Endocrine Research Institute¹. Department of Rehabilitation, College of Oriental Medicine², Seoul, korea. Bady Fat Reduction Effects of Red Ginseng Compound Preparation on the Patients with Obesity. Proceedings of International Symposium on East-West Medicine, Seoul. 244-254, 1999.-Obesity can be defined as a metabolic disease due to an increased state of fat tissues caused by an imbalance of calorie intake and use. Recently, in Korea by improvement and westernization of food intake, along with decrease in exercise activities, the prevalence of obesity has increased greatly. Our objectives were to study stability and effects of decrease in body fat by administering red ginseng compound preparation (known to have body fat decreasing effects in laboratory animals) to obesity patients on low calorie diets. Changes in weight and body fat were measured while carrying out calorie-restricted diets on patients for 4 weeks, then administering red ginseng compound preparation for another 4 weeks. The patients were 20 people whose BMI were 25kg/㎡ or over and whose percent body fat was also 30% or over when tested by bioelectrical conductivity. 1. Changes in weight were from 70.04kg(base line) to 67.43kg(after taking red ginseng compound preparation). 2. In similar sense, BMI decreased from 27.12kg/㎡(base line) to 26.56kg/㎡(after dieting), and further to 26.01kg/㎡ (after taking red ginseng compound preparation). The BMI seemed to decrease significantly compared to the baseline after the use of red ginseng compound. 3. Waist hip ratio was changed from 0.8858(base line) to 0.8728, but it was statistically insignificant. 4. The percent body fat was 35,16%(base line), 33.87%(after dieting), and 31.68%(after taking red ginseng compound preparation). 5. Complete blood cell count and blood chemisrty remained unaffected by the administration. 6. In concern to endocrinologic studies, T3 decreased from 118.7 to 98.2ng/dL, and T4 increased from 8.8 to 9.2㎕/ dL. Epinephrine showed a tendency to decreased from 0.27 to 0.25 ng/mL, and norepinephrine increased from 0.39 to 0.44ng/mL. 7. Leptin was not changed. 8. Some patients complained adverse effects; constipation(5 patients, may be due to diet therapy), fatigue (2 patients), pruritus(2 patients), flushing(s patients), dizziness(3 patients) and epigastric discomfort(2 patients). However their symptoms were mild, so medication did not stopped. In conclusion, loss of weight without significant side effects was observed during low calorie diet and red ginseng compound preparation administration. This is thought to be in relation to sympathetic nerve system rather than adrenal gland. Also, further long0term studies should be required, since the observed results were based on short-term changes in weight.

정형외과 영역에서 Sulperazon(Sulbactam/cefoperzon)의 Non-Comparative study

신현대,임상덕,안상로,이준규,이광진,윤승호 최신의학사 1989 最新醫學 Vol.32 No.2

加味薏苡仁湯의 消炎效果 및 成分에 關한 硏究

申鉉大,金性洙 慶熙大學校 1985 論文集 Vol.14 No.-

Kamieuiyeeintang is a combined herb medicine which is used to treat inflammatory illness in oriental medicine field. In order to make clear the anti-inflammatory effects on rats and to find the effective constituents of this herb medicine, author extracted the herbs with water and methanol.. The water extracted portion was administered through mouth to rats and the methanol extraction were used as the samples in HPLC injection to find out the anti-inflammatory constituent by comparing the standard oleanolic acid. The following results were obtained. 1. The extract of Kamieuiyeeintang (100 ㎎/㎏) showed high inhibitory percent of 35.40-47.12 on rat. The aspirin (400 ㎎/㎏) which was used as a control showed 10.42-16.68 of the inhibitory percent. 2. Among the nine herbs of this Kamieuiyeeintang Rheum coreanum Nakai showed the highest swelling percent of 80.60 on the rat hind paw and Taraxacum officinale Wigg was the lowest value of 21.85%. 3. On the HPLC chromatogram Rheum Coreanum Nakai has largest number of peaks and Trichosanthes kirilowii Regel had only 1 peak. 4. In comparing with the standard oleanoloic acid, Paterinia scabiosifolia Fischer showed same peak pattern and retention time with the oleanolic acid. 5. It did not make any relationship between of peak on the chromatogram and anti-inflammatory effect. According to the above results, it is concluded that Kamieuiyeeintang is recognized as a therapeutics for inflammatory diseases and contains the same constituent as oleanolic acid which is a standard therapeutics of inflammation.

奉化 智林寺 磨崖如來三尊像 小攷

申大鉉 한국문화사학회 2003 文化史學 Vol.0 No.19

경북 봉화 지림사 마애여래삼존좌상은 국보 제201호 봉화 북지리 마애여래좌상과 거의 비슷한 위치에 자리한다. 그 동안 한 번도 학술적 주목을 받은 바가 없었지만 7세기 중반에서 7세기 후반에 걸친 시기에 조성된 신라의 마애불로 학술적 가치가 높은 마애불이다. 현채 보존상태가 나빠 급속도로 풍화되고 있어서 이에 대한 연구가 시급하며, 앞으로 보존과 관리를 위해서는 국가 및 지방문화재로의 지정이 필요하다. 현재의 지림사 일대는 '한절'로 불리던 대규모 사찰이 자리한 곳으로, 북지리 석조 반가여래좌상도 같은 경내에서 출토되었다. 지림사 마애여래삼존좌상은 북지리 마애여래좌상과 영주 가흥동 마애여래좌상과 아울러 신라의 수도 慶州가 아닌 외곽 지역에 봉안된 대표적 신라 불상이라는 점에서 매우 주목되는 작품들이다. 그런데 북지리 마애 여래삼존좌상 역시 여러 가지 면에서 이들 불상과의 親緣性이 눈에 띠어 이 불상 조성시기의 下限이 7세기 후반을 넘지 않을 것으로 추정된다. 오히려 일부 양식에서는 통일신라 이전 삼국시대 말에 해당하는 7세기 중반의 요소가 있어 시기가 좀 더 올라갈 가능성도 있는 것이다. 지림사 마애여래삼존좌상은 갸름한 얼굴에 눈 둘레가 움푹 패인 모습이 뚜렷한데, 이것은 멀리 중국 남북조시대의 불상의 영향을 받은 것이고, 특히 좌우 협시상의 얼굴 가운데 도톰하게 표현된 두 뺨의 모습은 북지리 마애불과 가흥동 마애불의 풍만한 뺨과 흡사하지만, 도통하면서도 긴장감이 느껴지고 있어 兩 마애불보다 시기가 좀 더 앞서는 형식이 아닐까 추정해 볼 수 있다. 본존상의 경우에 특히 두드러지지만, 佛身 주위의 巖面을 깊숙이 파내어 마치 佛龕 안에 봉안된 것과 같은 효과를 주려고 한 점은 북지리 마애불과 비슷한 意匠이다. 삼존상 가운데 본존상과 우협시상 사이 아래에는 규모가 아주 작은 僧像이 조각되어 있는데, 배치된 자리가 자연스럽지 못하고 규모가 지나치게 작다는 점으로 볼 때 후대에 조각한 것으로 보인다. 좌협시상 옆에는 三層木塔像이 조각되어 있다. 마애목탑상은 경주 남산의 탑곡 마애불상군 등에서 類例를 살펴볼 수 있기는 하지만 매우 드문 일에 속한다. 그런데 석탑이 아니라 목탑을 표현한 것으로 볼 때 이 마애불상의 조성시기를 7세기 중반 이전으로 추정하는 일이 가능하다. 이와 같이 지림사 마애여래삼존좌상은 여러 가지 면에서 7세기 중후반의 자료로서, 이 시기의 국내 실물자료가 절대적으로 부족한 현실에서 당시의 마애불 및 불상 연구에 소중한 자료가 되는 것이다. Jilim-sa temple is build in 7th century in Silla-Dynasty located on Bukjili, Bongwha-gun, Gyoungsang-bukdo. There is Bukjiri Buddhist image carved on rock cliff dating to 7~8th century in this temple. That is found by reachers in 1964, and is regarded a major buddhist image of Silla-Dynasty by those of scholars. At that time another buddhist image carved on rock cliff is found, too. That is positioned near by Bukjiri Buddhist image carved on rock cliff, dating to 7th century. But this buddhist images carved on rock cliff are not concemrd to study by scholars. I studied for this seated buddhist images carved on rock cliff on way look-in jilim-sa temple three months ago, so I naming it "The three Buddhist images carved on rock cliff in Jilim-sa temple". And it carved on the rocks in the back of Wontongjon(圓通殿) which is the main hall of this temple. In the rocks, there are several carving of three buddha imagrs, a monk image, and wooden-stupa image. I will demonstrate each types of it. First, the middle buddha image is resembled from 5-6th century images of China. For examples, there are several special features in the shape of face. Especially, the eyes are dugged sunken, and the face is small and longish. The left buddha image has the circle light near the head(頭光). And carved more high-relief globally than other. The right budha image is smaller than left, the feather of this image is the expression of the buddha dress's wrinkles, the wrinkles are crossed each other in front of breast. the monk image is located between the middle seated buddha image and the right. Maybe, in my opinion, this image is carved in later ages because of the unmatural position of it and of its unskillful carving. The wooden-stupa image is located on the right of rocks, then the shape of it showed the style of early 7th century. So I reach a conclusion that the three seated Buddhist images carved on rock cliff in jilimsa temple are enshrined in the period from middle to late 7th century.

유지 투석중인 만성 신부전환자에서 허혈성 심질환의진단 지표로서의 심장트로닌-I의 유용성

신병철,강대웅,정지용,류봉관,서영욱,김정인,김범윤,김현리,정종훈 朝鮮大學校 附設 醫學硏究所 2004 The Medical Journal of Chosun University Vol.29 No.1

Background : Coronary disease is highly prevalent in patient with end stage renal disease (ESRD) and account for much of their observed morbidity and mortality. Troponin-I consistently maintains a high sensitivity and specificity and is most sensitive marker for ischemic heart disease (IHD). Method : We examed 49 hernodialyzed patients (22 male, 27 female) without evidence of acute coronary syndrome (ACS) for 6 months. Biochemical markers were measured in serial predialysis blood samples. For analysis, we used two cardio-specific assays for troponin-T (cTnT) as well as for troponin-I (cTnI) and compared the results with CK-MB (reference value ≤ 4.0 ng/mL) concentration. Results : Myocardial ischemia was observed in 47% (23/49) of patients. cTnT level above 0.1 ng/mL. and cTnI level above 0.5 ng/mL, were observed in 22% (11/49) and 20% (10/49) of patients respectively. cTnI revealed significantly higher positive rate in patients with myocardial ischemia than the patients without myocardial ischemia (43 % vs 30%) (p<0.05). cTnT and CK-MB revealed no difference in positive rate between the patients with and without myocardial ischemia (cTnT : 30% vs 15% and CK-MB : 30% vs 19%). The sensitivity and specificity of cTnI to myocardial ischemia were higher than those of cTnT and CK-MB (sensitivity 43% vs 30% and 30%. specificity 100% vs 85% and 81%). Conclusion: Both cTnT and cTnI are useful in ruling out myocardial injury in chronic renal failure patients. But. cTnI is a more sensitivity and excellent specificity of ischemic heart disease than cTnT and CK-MB in hemodialyzed patients. In patients with ischemic heart disease, the presences of DM and advanced age were higher than those in patients without ischemic heart disease (p<0.05). Among the baseline characteristics old age, elevated LDH and diabeties were significant more frequent in the patients with elevation of cardiac troponin-I (p>0.5 ng/mL) than those with cardiac troponin-I (p<0.5 ng/mL), p=0.038, p=0.049, and p=0.045, respectively. Our results suggest that these cTnI is the potential diagnostic marker for the prediction of IHD in ESRD patients.

축산페수처리를 위한 탈수기와 침전조 개발에 관한 연구

신대윤,최현규 조선대학교 환경공해연구소 1998 環境公害硏究 Vol.14 No.-

Centrifugal filter and filtration type sedimentation tank are built to investigate their capacity and the optimal condition to treat swine wastewater physical-mechamically. 1. As the result of the separation and the experiment of sludge which is over 0.2??of the diameter of the particles, in 180rpm of the rotation speed and 50 ??min of filtration velocity of centrifugal filter, 1.3-4.7kg of sludge, 60-70% of hydration rot per 1m^(3) of filtrates, was removed. 2. Removal rate of SS of filtrates through filtration type sedimentation tank was more than 90%, and BOD and COD more than 50% when filtrate had been kept for 6 months in air-tight container, it generated a little gas and little precipitation.

음이온에 의한 토마토 뿌리조직 마이크로솜 H^+-ATPase 활성 저해

신대섭,조광현,김영기 충북대학교 첨단원예기술개발연구센터 2000 연구보고서 Vol.5 No.-

식물 뿌리세포의원형질막 및 액포막에 위치하는 H+-ATPase들은 세포의 여러 가지 생리활성에 중요한 역할을 수행한다. H+-ATPase의 생리활성 특성을 조사하기 위하여 토마토 뿌리조직으로부터 마이크로솜을 분리하고, H+-ATPase 활성에 미치는 음이온의 효과를 조사하였다. 다양한 종류의 음이온들이 H+-ATPase의 활성을 저해함을 확인하였으며, 이들 중 특히 효소의 저해정도가 다른 citrate와 인산을 선택하여 작용특성을 조사하였다. Citrate에 의한 ATPase 활성저해는 3mM 이상에서 나타났고, 20 mM citrate는 활성을 50-60% 저해하였다. 그러나, citrate,의 저해효과는 MG2+의 농도를 증가시킬수록 감소하여, citrate에 의해 저해된 ATPase 활성은 Mg2+에 의해 회복되는 것으로 나타났다. 즉, 7 mM Mg2+을 첨가하였을 때, citrate에 의한 활성저해는 관측되지 않았고 ATPase 활성은 대조활성과 비슷한 수준으로 회복하였다. 이러한 결과는 citrate가 Mg2+을 chelation함으로써 H+-ATPase의 활성을 저해하기 때문이다. 한편, 인산에 의한 ATPase 활성저해는 3mM 이상의 농도에서 나타났고, 30 mM 인산은 ATPase의 활성을 50% 저해하였다. 인산에 의해서 저해된 ATPase의 활성은 MG2+의 농도증가에 의해 회복되지 않아, 인산에 의한 저해효과는 Mg2+과 무관하였다. H+-ATPases located on plasma and vacuolar membranes play major roles in various cellular physiological processes. In order to investigate the physiological roles of H+-ATPases, microsomes were prepared from tomato roots and the effects of various anions were measured on the activities of H+-ATPases. H+-ATPase was inhibited by various anions. Citrate and phosphate were chosen to investigate detailed inhibitory mechanisms on ATPases since they showed different levels of inhibition. Inhibitory effect of citrate was observed at the concentrations above 3 mM. when 20 mM citrate was added, the H+-ATPase activity was decreased by 50-60%. However, the inhibitory effect of citrate was decreased by increasing the concentration of Mg2+. The citrate-induced inhibited activity was recovered by the addition of Mg2+. Addition of 7 mM Mg2+ completely removed the inhibitory effect of citrate and the activity recovered to the level of the control experiment. These results imply that citrate chelates Mg2+ and thus inhibits H+-ATPases. Meanwhile, the inhibitory effect of phosphate was observed at the concentration above 3 mM and the activity was decreased by 50% in the presence of 30 mM phosphate. Further addition of Mg2+ showed no recovery on the activity. These results imply that the inhibitory effect of phosphate is not dependent upon the concentration of Mg2+. Key words: anion, citrate, phosphate, H+-ATPase, tomato roots Abbreviation: PK, pyruvate kinase; LDH, lactate dehydrogenase; HEPES, N-(2-hydroxyethyl)-piperazine-N'-(2-ethanesulfonic acid); NADH, nicotinamide adenine dinucleotide

Cholestyramine과 Polyvinylpyrrolidone에 對한 Bilirubin 吸着의 Photoenhancement에 關한 硏究

신대현,Henning, D.,St-pierre, L. E. 충남대학교 자연과학연구소 1983 忠南科學硏究誌 Vol.10 No.2

Shifts in the visible spectrum of aqueous bilirubin (BR) solutions resulting from the addition of soluble polyvinypyrrolidone (PVP) suggest specific interactions. Hence, isotherms were determined for the adsorption of BR from aqueous bilirubin solution onto solid, crosslinked PVP and onto cholestyramine (CA) at 0, 10, 20 and 25℃. Although the adsorption onto PVP reaches equilibrium more rapidly than onto CA, the latter adsorbent has a larger capacity of adsorption. Furthermore the isotherms for PVP are independent of temperature while those for CA show an increase in the amount of BR adsorbed with an increase in temperature. Totally internal hydrogen bonded ZZ form of bilirubin can be converted under photoirradiation with blue filtered light to three forms: EZ, ZE and EE, all of which gives greater accessibility to the polar functional groups. Accordingly, I have attempted to discern whether the photolized-bilirubin could be adsorbed more rapidly on the two adsorbents than do the ZZ form, particularly on CA which has slower equilibrium, but greater adsorption capacity. The rate of adsorption of photolized-bilirubin on CA is seen to be considerably faster than that of the ZZ form. Thus the adsorption equilibrium could be improved by pre-irradiation of aqueous bilirubin solution. It will be determined if this phenomenon may aid the phototherapy treatment of hyperbilirubinaemia cases.

축산폐수처리를 위한 탈수기와 침전조 개발에 관한 연구

신대윤,최현규 조선대학교 환경연구소 1998 環境硏究 Vol.14 No.1

Centrifugal filter and filtration type sedimentation tank are built to investigate their capacity and the optimal condition to treat swine wastewater physical-mechamically. 1. As the result of the separation and the experiment of sludge which is over 0.2㎜ of the diameter of the particles, in 180rpm of the rotation speed and 50ℓ/min of filtration velocity of centrifugal filter, 1.3∼4.7㎏ of sludge, 60∼70% of hydration rot per 1㎥ of filtrates, was removed. 2. Removal rate of SS of filtrates through filtration type sedimentation tank was more than 90%, and BOD and COD more than 50% when filtrate had been kept for 6 months in air-tight container, it generated a little gas and little precipitation.