Distribution of receptor for advanced glycation end products in bleomycin induced idiopathic pulmonary fibrosis mice

Hyosin Baek,Jooyeon Lee,Youngheon Park,Jaehyun Park,Se-Ran Yang 한국실험동물학회 2020 한국실험동물학회 학술발표대회 논문집 Vol.2020 No.7

Receptor for advanced glycation end products is decreased in bleomycin induced mice and patients with idiopathic pulmonary fibrosis

Hyosin Baek,Jooyeon Lee,Jimin Jang,Jaehyun Park,Se-Ran Yang 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7

Although Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive fibrotic lung disease, the detail and incidence is unclear. It has been shown that environmental factors, including stone dust, silica and cigarette smoking, are considered as risk factors in the pathogenesis of IPF. Receptor for advanced glycation end products (RAGE) is a member of the immunoglobulin super family of cell surface receptors. The interaction between RAGE and its ligands such as AGE and HMGB1, mediates cellular migration and regulation of pro-inflammation. In addition, RAGE is abundantly expressed in the lung, in particular in alveolar epithelial cells. Therefore, in this study, we investigated whether RAGE expression is associated with pathogenesis of IPF. To mimic of IPF animal model, we intratracheally injected bleomycin (BLM) into mice for each 1 or 2 weeks. Neutrophils and macrophages were increased in bronchoalveolar fluid after BLM injury. Moreover, histological changes were found that alveoli were destructed and mature fibrotic nodule formed after BLM injection. The accumulation of collagen was increased by Masson’s trichrome staining and protein levels of a-SMA and fibronectin were significantly increased in western blot analysis, quantitative real-time PCR and immunohistochemistry staining. As a result, BLM-induced IPF mimic mouse exhibited by inflammation response increase and collagen accumulation. In addition, RAGE expression in these mouse model and IPF patients was evaluated through immunohistochemistry or western blot analysis. During IPF progression, RAGE expression in the lung was decreased compared with non-IPF subjects. Taken together, as IPF that accumulated immune cells and fibrosis factors progresses, expression of RAGE was decreased in the lung. Therefore, the RAGE expression in the lung tissue could be applied with a potential marker in IPF treatment and its diagnosis. Acknowledgement : This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (NRF-2020R1A2C2010712 and NRF-2020R1A5A8019180.

Fabrication of porous SPS/PMMA particles through pickering emulsion

Hyosin Kim,Jungju Ryu,JooHuei Shin,Daewon Sohn 한국고분자학회 2016 한국고분자학회 학술대회 연구논문 초록집 Vol.41 No.2

Barriers to Effective Communication about Advance Care Planning and Palliative Care: A Qualitative Study

Hyosin Kim,Signe Peterson Flieger Korean Society for Hospice and Palliative Care 2023 한국호스피스.완화의료학회지 Vol.26 No.2

Purpose: The purpose of this study was to identify barriers to effective conversations about advance care planning (ACP) and palliative care reported by health care and community-based service providers in Massachusetts, USA. Methods: This qualitative research analyzed open-ended responses to two survey questions, inquiring about perceived barriers to having conversations about ACP and palliative care with patients and consumers. Data were collected between November 2017 and June 2019 from nine organizations in Massachusetts, including health care provider organizations, health insurers, community-based organizations, and a nursing education institution. Two researchers reviewed and coded the responses and identified common themes inductively. Results: Across 142 responses, primary barriers to ACP included hesitation and lack of understanding and knowledge, discomfort and resistance among service providers, lack of staff knowledge, difficulties with followup, and differences in ACP policies across regions. Common barriers to palliative care were misconceptions about palliative care and lack of knowledge, service providers' lack of preparedness, and limited policy support and availability. Challenges relevant to both ACP and palliative care were fear and discomfort around serious illness discussions, lack of knowledge and awareness, discussions that occur too late, and cultural and language barriers. Conclusion: Health care practitioners and community-based professionals reported consumer-, service provider-, and system-level barriers to facilitating conversations about ACP and palliative care with patients experiencing serious illness. There is a need for more tools and support to strengthen service providers' ACP and palliative care competencies and to promote a structured approach to health care planning conversations.

정부 주도의 여성 권리 보장과 영아 및 모성사망 간의 관계에 대한 탐색적 연구

김효신(Hyosin Kim),임도희(Dohee Lim),강민아(Minah Kang) 이화여자대학교 생명의료법연구소 2012 생명윤리정책연구 Vol.6 No.2

While maternal and infant mortality are pressing issues in the global society, the pace of decreases in maternal and infant mortality is still very slow. Furthermore, gender equality still persists in a number of countries and a large number of women, mostly in developing countries, are in a precarious state economically, politically, and socially. This article tests two hypotheses: (a) the more women’s economic, political, and social rights are protected, the fewer maternal, neonatal, and postneonatal mortality deaths would occur and (b) rights that are actually implemented or enforced have more significant impact in terms of progress in foregoing mortality indicators than rights that are only declared but not implemented in practice. To test these hypotheses, we conducted a cross-national statistical test with data from multiple sources. We find that women’s economic and social rights has a significant correlation with maternal and infant mortality, while legal rights did not show such an impact. Also, women’s rights that are protected through actual implementation and enforcement have more significant influence on our dependent variables than women’s rights protection under law.

Downsampled Iterative Learning Controller for Flyback CCM Inverter

Kim, Hyosin,Lee, Jin S.,Kim, Minsung Institute of Electrical and Electronics Engineers 2018 IEEE transactions on industrial electronics Vol.65 No.1

<P>We propose a downsampled iterative learning controller (ILC) for a flyback inverter operating in continuous conduction mode (CCM). The flyback CCM inverter features step-up/-down ability, small number of circuit components, and high conversion efficiency, so it is well suited to the distributed renewable energy systems. But the conventional proportional-integral (PI) controller for the flyback CCM inverter shows poor steady-state response because the inverter itself suffers from time-varying grid-voltage disturbances and its transfer function has a right-half plane zero. The ILC itself achieves acceptable steady-state response of the flyback CCM inverter but can excite large overshoot in the iteration domain; this overshoot may destroy the solid state devices in the power circuit. To overcome this problem, we use a downsampled ILC technique that guarantees monotonic convergence of tracking error. The proposed ILC is computationally simple and easy to implement. Numerical simulations and experimental tests validate the proposed control approach.</P>

Laser Rangefinder를 이용한 로봇의 추정위치 보정

김효신(Hyosin Kim),한경룡(Kyung L. Han),이진수(Jin S. Lee) 대한전자공학회 2010 대한전자공학회 학술대회 Vol.2010 No.6

Iterative Learning Controller With Multiple Phase-Lead Compensation for Dual-Mode Flyback Inverter

Kim, Hyosin,Lee, Jin S.,Lai, Jih-Sheng,Kim, Minsung IEEE 2017 IEEE transactions on power electronics Vol.32 No.8

<P>This paper proposes an iterative learning control (ILC) scheme for a dual-mode flyback inverter operating in both discontinuous conduction mode (DCM) and continuous conduction mode (CCM). In dealing with more than 200-W power applications, the dual-mode flyback inverter takes advantage of both DCM and CCM operations. However, it is difficult to control the output current because the system gain is quite low in DCM and the system transfer function has a right-half plane zero in CCM. To overcome the problems occurring in DCM and CCM operations, we propose an ILC scheme with multiple phase-lead compensation. The ILC is proposed to achieve accurate reference tracking and to reject periodic disturbances. The multiple phase-lead compensation technique is then employed to compensate for the effect of different system dynamics. As a theoretical result, we derive the asymptotic stability of the closed-loop system. We also performed the numerical simulations and experimental tests to validate the proposed control approach.</P>

상 보조용언 ‘-고 있-’과 ‘-어 있-’의 교수·학습 방안 연구 - 도입, 제시를 중심으로 -

김효신 ( Kim Hyosin ),노지현 ( Roh Jihyun ) 연세대학교 언어연구교육원 한국어학당 2019 외국어로서의 한국어교육 Vol.52 No.-

Auxiliary verbs ‘-go iss2-’ and ‘-eo iss-’ are grammatically different but they have the same aspectual meaning while auxiliary verb ‘-go iss-’ has different aspectual meanings (‘-go iss1-’ and ‘-go iss2-’) and it can stay in the same grammatical forms. This paper presents a specific teaching method in regard to Korean language education aimed to facilitate effective acquisition of their grammatical forms and a better understanding of the aspectual meanings of auxiliary verbs ‘-go iss-’ and ‘-eo iss-’. For sequencing grammar rules, grammar items with definite functions should be presented first. Therefore, this paper suggests that auxiliary verb ‘-go iss1-(Progressive)’ should be presented first followed by ‘-go iss2-(Nonprogressive)’ and ‘-eo iss-’ because ‘-go iss1-’ is more grammaticalized than the other two, thus it has definite functions. Frequency of use, level of difficulty of grammar, and level of difficulty of preceding verbs are considered in deciding the order of auxiliary verbs ‘-go iss2-’ and ‘-eo iss-’ since they have the same aspectual phase. This paper analyzed six Korean language textbooks, only one of which was in the same sequence that this paper suggests. In Chapter four, this paper provides detailed descriptions of the warm-up stage and the presentation stage of the teaching-learning method for these grammar items. Our teaching-learning method is developed by selecting verbs from the vocabulary for beginners that show the clear forms and meanings of the auxiliary verbs after considering that the aspectual meanings of ‘-go iss-’ and ‘-eo iss-’ have been dictated by their preceding verbs. (Hankuk University of foreign studies)

한국어 상 보조용언 ‘가다’와 ‘오다’의 문법화 연구

김효신(Kim, Hyosin) 담화·인지언어학회 2018 담화와 인지 Vol.25 No.4

This study provides a comparison of the degrees of grammaticalization between the Korean aspectual auxiliary verbs ‘ga-da’(‘go’) and ‘o-da’(‘come’), with an investigation into their uses in terms of grammaticalization. Until recently, many studies have mainly dealt with the overall properties of auxiliary verbs or their semantic distinctions but have failed to look into the degrees of grammaticalization of these two auxiliary verbs with similar shades of meaning. This paper analyzes the distribution of uses of the auxiliary verbs ‘ga-da’ and ‘o-da’ based on corpus building upon the previous studies. Specific to this paper are analyses of frequency of appearance of the auxiliary verbs, frequency of use of main verbs ‘ga-da’ and ‘o-da’, and the grammatical elements combined with the auxiliary verbs. The analyses show that their word formation patterns and grammaticalization process point to the fact that the auxiliary verb ‘ga-da’ is more grammaticalized than the auxiliary verb ‘o-da.’ Furthermore, the analysis has shown that both the auxiliary verbs have continued to develop to take compound forms combined with connective endings as the auxiliary verb ‘ga-da’ is grammaticalized into ‘-eo gamyeonseo’ and the auxiliary verb ‘o-da’ into ‘-eo wanneunnde’. In this grammaticalization process, the auxiliary verbs ‘ga-da’ and ‘o-da’ have lost what they used to have in meaning only to signify future-oriented durative and past-oriented durative state respectively.