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Lee, Hyeryeong,Lee, Yoo Seok,Lee, Soo Kyung,Baek, Seungwoo,Choi, In-Geol,Jang, Jae-Hyung,Chang, In Seop Elsevier 2019 Biosensors & bioelectronics Vol.126 No.-
<P><B>Abstract</B></P> <P>In this study, the effect of inter-enzyme steric hindrance that occurs during enzyme immobilization on the electrode, on direct electrical communications of enzyme with electrode was investigated <I>via</I> nano-patterning of enzymes on the electrode. Here, the nano-patterning of enzymes was achieved through the combination of DET-capable enzyme that was produced <I>via</I> fusion of site-specific gold binding peptide (GBP) to catalytic subunit of enzyme and gold nanoparticle (AuNP) array with highly tunable dimensions of AuNPs, resulting in spatially controllable enzyme-electrode. The nano-scale spatial control between immobilized enzymes on the highly tuned AuNPs shows different DET efficiency across the enzyme-electrode interface, showing 18.47% of maximum electron recovery which is 3.2-fold enhanced electron recovery efficiency compared to spatially non-controlled enzymes on the electrode where showed 5.7% of electron recovery. The result affirms that inter-enzyme interaction is a significant parameter that decides the enzyme-electrode performance.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The fusion of GBP to the catalytic subunit of GDH enabled interfacial DET in the enzyme-electrode. </LI> <LI> The effect of inter-enzyme agglomeration on efficiency of interfacial DET was investigated, related to its effect on <I>R</I> <SUB>ct</SUB>. </LI> <LI> The enzyme nano-patterning was developed via combination of synthetic enzyme and AuNP-modified electrode. </LI> <LI> The nano-scale spatial control of synthetic GDHs on the electrode enhanced electroactive coverage of enzyme-electrode. </LI> <LI> The inter-enzyme agglomeration is the important parameter to consider for the development of DET-based bioelectronics. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Comparison of Preferred Real-Ear Insertion Gain between Open- and Closed-Canal Fitting Hearing Aids
Hyeryeong Jo,Hyekyung Kong,Suyeon Shin,Mikyung Lee,Kwangjae Kim,Hyungoo Lee,Soohyun Ahn,Kyoungwon Lee 한국청각언어재활학회 2021 Audiology and Speech Research Vol.17 No.2
Purpose: To calculate the real-ear insertion gain (REIG) according to the types of hearing aids, we evaluated the preferred REIGs of Korean hearing-impaired listeners and psychoacoustic differences between open-canal fitting (OF) and closed-canal fitting (CF). Methods: The subjects with sensorineural hearing loss were divided into OF group (4 monaural fittings, 15 binaural fittings with 34 ears), and CF group (8 monaural fittings, 13 binaural fittings with 34 ears). There were no statistical differences in hearing threshold level (HTL) at each octave frequencies, word recognition score (WRS) and Korean Adaptation of the International Outcome Inventory for Hearing Aids (K-IOI-HA) between the two groups. When there was no need for further electroacoustic adjustment of the hearing aid, sharpness and occlusion of amplified sound, clarity of sentence, and loudness of noise were evaluated based on the everyday experience. And REIGs with international speech test signal and WRS in sound-treated room were measured. Results: Preferred REIG for HTL was low for OF compared to CF in 0.5 kHz and 0.75 kHz at input SPL of 55 dB, 0.5 kHz at 60 dB SPL, 0.25 kHz and 0.5 kHz at 80 dB SPL. However, there were no differences in aided WRS and psychoacoustics between the two groups. Conclusion: In this study, the preferred REIG of OF and CF groups showed a difference under 0.75 kHz although there were no psychoacoustic differences between the two groups. Therefore, the results of this study should be considered when formulating Korean-type hearing aid fitting formula.
Analysis of external environmental factors affecting patient transport time
Hyeryeong LEE,박상웅,Eunjeong YUN,Dakyeong KIM,Hea Kyung CHOI 한국식품보건융합학회 2022 식품보건융합연구 (KJFHC) Vol.8 No.6
Emergency transport is directly related to the life of the patient, and rapid transport to the hospital is crucial. However, external environmental factors such as traffic or weather, interfere with hospital transport. In this study, we investigated the external environment affecting hospital transport time. We examined the transfer time and patient treatment time of emergency patients in an area of northern Gyeonggi-do from 2018 to 2020. Diagnosis after arrival at the hospital was used, and on-site treatment time was measured from paramedic arrival time at the scene to departure. Furthermore, we examined whether there was a correlation between the time paramedics left the scene and hospital arrival time through the reason for the delay as recorded in the emergency log. Traffic jams had the greatest impact on patient transport, while transport delays occurred due to heavy rain, but not snow. Among injured patients, electrical accidents were the most problematic in terms of on-site treatment time. This was because a lot of first aid is needed in electrical accidents. It must be necessary to mobilize two ambulances in an emergency through the expansion of infrastructure, prepare a plan for rapid transport in heavy rain, and implement strong laws against transport obstruction.
Lee, Kyung Mi,Moon, Jong Hun,Jeon, Hyeryeong,Chen, Xiaoqiang,Kim, Hee Jin,Kim, Sol,Kim, Sung-Jin,Lee, Jin Yong,Yoon, Juyoung Royal Society of Chemistry 2011 Journal of materials chemistry Vol.21 No.43
<P>Polydiacetylenes (PDAs), a family of conjugated polymers, are known to show stimulus-induced apparent blue-to-red transitions, which have led to the development of a variety of PDA-based chemosensors. However, in most cases, recognition sites were introduced at the terminal ends of PDAs, therefore, recognition processes on the surface of PDAs have been the primary stimulations to induce blue to red colorimetric changes. In this study, we reported that diverse colorimetric changes can be observed for PDA based sensors in which penetration of cationic surfactant into PDAs bearing benzoic acid groups can cause not only the typical blue to red change but also blue to violet, blue to yellow or blue to orange color change. We systematically demonstrated that these novel findings can be used effectively to discriminate different cationic surfactants by using three different PDAs. Furthermore, theoretical calculations and transmission electron microscope (TEM) images also confirm these unique colorimetric changes. These results suggest a new direction in which to design colorimetric sensors based on PDA polymers.</P> <P>Graphic Abstract</P><P>In this study, we report that diverse colorimetric changes can be observed for PDA based sensors in which penetration of cationic surfactant into PDAs bearing benzoic acid groups can cause not only the typical blue to red change but also blue to violet, blue to yellow or blue to orange color change. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c1jm12818c'> </P>
Analysis of external environmental factors affecting patient transport time
LEE, Hyeryeong,PARK, Sang Woong,YUN, Eunjeong,KIM, Dakyeong,CHOI, Hea Kyung Korea FoodHealth Convergence Association 2022 융합경영연구 Vol.8 No.6
Emergency transport is directly related to the life of the patient, and rapid transport to the hospital is crucial. However, external environmental factors such as traffic or weather, interfere with hospital transport. In this study, we investigated the external environment affecting hospital transport time. We examined the transfer time and patient treatment time of emergency patients in an area of northern Gyeonggi-do from 2018 to 2020. Diagnosis after arrival at the hospital was used, and on-site treatment time was measured from paramedic arrival time at the scene to departure. Furthermore, we examined whether there was a correlation between the time paramedics left the scene and hospital arrival time through the reason for the delay as recorded in the emergency log. Traffic jams had the greatest impact on patient transport, while transport delays occurred due to heavy rain, but not snow. Among injured patients, electrical accidents were the most problematic in terms of on-site treatment time. This was because a lot of first aid is needed in electrical accidents. It must be necessary to mobilize two ambulances in an emergency through the expansion of infrastructure, prepare a plan for rapid transport in heavy rain, and implement strong laws against transport obstruction.
Lee Jinmin,Lee Hyeryeong,Kang Minchae,Baday Murat,이상학 한국물리학회 2022 Current Applied Physics Vol.44 No.-
Recent advanced biophysical techniques allow us to monitor the cellular dynamics of biologically important molecules in real time. Bright, stable fluorophores are needed to accomplish this: photoblinking and photobleaching occurring in organic fluorophores and qdots make them an ill-suited option. In this study, we employed upconversion nanoparticles (UCNPs) since they exhibit no photobleaching or photoblinking. Another advantage of using UCNPs is that these particles absorb IR light (980 nm) and emit visible light (560 nm and 640 nm), which sig-nificantly eliminates background noise caused by autofluorescence. Moreover, excitation of UCNPs can occur using a CW-laser because they can be excited by wide-field illumination rather than requiring confocal illumination. Although a CW-laser would have been capable of exciting UCNPs, we were able to maximize the photon density and resulting number of photons emitted from UCNPs by employing a femto-second laser. Using a femto-second laser, we achieved 2.4 nm single-molecule localization accuracy with an exposure time of 2 ms. The UCNP particles and femto-second laser allowed us to stably monitor the molecular motors, kinesin and dynein, in cells.
Hyeryeong Jo,Mikyung Lee,Jihun Kim,Eunchul Choi,Hyungoo Lee,Kyoungwon Lee 한국청각언어재활학회 2022 Audiology and Speech Research Vol.18 No.2
Purpose: In this study, changes before and after adjustment in high frequency bands were assessed for aided threshold, psychoacoustic evaluation, word recognition scores (WRSs) in noise and sound quality to aid in electroacoustic adjustment, and to improve the satisfaction of hearing aids. Methods: The subjects were 16 sensorineural hearing impaired (25 ears) with 63.4 years old of mean age, 60.8% WRS and 46.6 months of aided experience. For the experiment, hearing aid gain of highfrequency bands adjusted to preferred gain was increased to a higher level. Aided threshold, Korean version of international outcome inventory for hearing aids (K-IOI-HA), Korean version of profile of hearing aid benefit-quick version (K-PHAB-Q), WRSs in noise for 10 dB and 5 dB signal-to-noise ratio (SNR) and sound quality were subsequently evaluated after two weeks and the results were quantitatively compared before and after gain adjustment in high-frequency bands. Results: This study results in as follows; first, improvement in aided threshold for frequencies above 2.0 kHz was shown. Second, K-IOI-HA and K-PHAB-Q in easy communication and localization categories resulted in significant enhancements. Third, WRS in 5 dB and 10 dB SNR was improved. Fourth, improvements were shown for occlusion and clarity of the sentence in the evaluation of sound quality, but significant results were not shown for sharpness and loudness of noise conditions. Conclusion: With sensorineural hearing loss, a sufficient gain in high frequency bands provides improved satisfaction to hearing aids and enhanced word recognition ability in various listening environments.