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김형수,장성훈,이원진,최재욱,박종태,백남원,김록호 大韓産業醫學會 2001 대한직업환경의학회지 Vol.13 No.1
목 적 : 본 연구는 직업성 연 폭로근로자에서 연폭로가 남성 생식기계 독성중 성호르몬에 미치는 영향과 그 정도를 평가하고자 시도되었다.방 법 1998년 하반기에 실시한 일반, 특수건강진단자중 경기도 지역 직업성 연 폭로 근로자 33명과 과거 직업력에서 연 폭로가 없었던 사무직 근로자 33명을 연구대상으로 선정하였다. 연의 생물학적지표로는 혈색소, ZPP, 혈중 연, 및 요중 연을 이용하였으며, 성호르몬으로는 LH, FSH, testos-terone, SHBG 및 FTI를 이용하였다. 연 폭로 지표와 성호르몬과의 상관관계를 조사하였다. 결 과 : 연의 생물학적 지표중 혈색소는 폭로군에서 대조군보다 유의하게 낮았으며, ZPP, 혈중 연및 요중 연등은 폭로군에서 대조군보다 유의하게 높았다. 성호르몬에서 FSH, testosterone, SHBG및 FTI는 모두 폭로군에서 대조군보다 낮았으나 통계적 유의성은 없었다. 폭로군의 성호르몬중에서 연령은 FSH 및 FTI, ZPP는 FSH, 혈중 연은testosterone과 유의한 상관관계가 있었다. 대조군에서 연령은 FSH, testosterone, SHBG 및 FTI와 흡연량은 FSH와 유의한 상관관계가 있었다. 연령군별 폭로군과 대조군의 성호르몬 비교에서 30-39세군의 FTI에서 폭로군이 대조군보다 유의하게 낮았으며 그 밖의 호르몬에서는 모두 유의한 차이가 없었다. 결 론 : 연 폭로군의 FSH, Testosterone, SHBG 및 FTI가 대조군에 비교하여 낮았으나 통계적 유의성은 없었다. 그러나 폭로군에서 연의 생물학적 지표와 일부 성호르몬간에 유의한 상관관계를보였으며 이는 본 연구 대상 근로자의 연 폭로 수준이 일부 성호르몬에 영향이 있음을 보여주는 것으로 판단된다. 향후 이에 대한 지속적인 연구가 진행되어 야 할 것이다. Objectives : This study was performed to evaluate the relationship between biological markers of lead exposure and level of sex. hormones in men occupationally exposed to lead. Methods : In this study, 33 male workers who employed at smelting and battery factories were compared with 33 male workers who were not exposed to lead. As biological markers of lead exposure, hemoglobin, ZPP, blood lead and urine lead were measured. As sex hormones, FSH, LH, testosterone, SHBG and FTI were determined. Results : Hemoglobin level was significantly lower in exposed than in nonexposed group. Level of ZPP, blood lead, and urine lead were significantly higher in exposed than in nonexposed group. There was a trend that level of FSH, testosterone, SHBG, and FTI was lower in exposed than in nonexposed group respectively, but there were no statistical significance. In exposed group, FSH level was correlated with age, ZPP, and blood lead; testosterone level was correlated with hemoglobin, blood lead, urine lead, and SHBG ; and FTI level was correlated with age. Conclusions : Level of some sex hormones were lower in exposed than in nonexposed group but there were no statistical significance between the exposed and the nonexposed group. But level of sex hormones were correlated with several biological markers of lead in exposed group. It suggests that occupational lead exposure might affect sex hormones.
[PE-0005] A White Waxy Hybrid Corn, ?Dodamchal? with Good Eating Quality
Sang-Woo Kim(Sang-Woo Kim),Jong Hyeong Lee(Jong Hyeong Lee),Byoung Rourl Choi(Byoung Rourl Choi),Eun Kyu Jang(Eun Kyu Jang),Young Rok Kim(Young Rok Kim),Hae Chan Jung(Hae Chan Jung),Jung-Hee Jang(Jung 한국육종학회 2022 한국육종학회 공동학술발표집 Vol.2022 No.-
Metformin Alleviates Radiation-Induced Skin Fibrosis via the Downregulation of FOXO3
Kim, Jin-Mo,Yoo, Hyun,Kim, Jee-Youn,Oh, Sang Ho,Kang, Jeong Wook,Yoo, Byung Rok,Han, Song Yee,Kim, Cha Soon,Choi, Won Hoon,Lee, Eun-Jung,Byeon, Hyeong Ju,Lee, Won Jai,Lee, Yun-Sil,Cho, Jaeho S. Karger AG 2018 CELLULAR PHYSIOLOGY AND BIOCHEMISTRY Vol.48 No.3
<P><B><I>Background/Aims:</I></B> Radiation-induced skin fibrosis is a common side effect of clinical radiotherapy. Our previous next-generation sequencing (NGS) study demonstrated the reduced expression of the regulatory α subunit of phosphatidylinositol 3-kinase (PIK3r1) in irradiated murine skin. Metformin has been reported to target the PIK3-FOXO3 pathway. In this study, we investigated the effects of metformin on radiation-induced skin fibrosis. <B><I>Methods:</I></B> Metformin was orally administered to irradiated mice. Skin fibrosis was analyzed by staining with H&E and Masson’s trichrome stain. The levels of cytokines and chemokines associated with fibrosis were analyzed by immunohistochemistry and quantitative RT-PCR. The roles of PIK3rl and FOXO3 in radiation-induced skin fibrosis were studied by overexpressing PIK3rl and transfecting FOXO3 siRNA in NIH3T3 cells and mouse-derived dermal fibroblasts (MDF). <B><I>Results:</I></B> The oral administration of metformin significantly reduced radiation-induced skin thickening and collagen accumulation and significantly reduced the radiation-induced expression of FOXO3 in murine skin. Additionally, the overexpression of PIK3r1 reduced the radiation-induced expression of FOXO3, while FOXO3 silencing decreased the radiation-induced expression of TGFβ <I>in vitro</I>. <B><I>Conclusions:</I></B> The results indicated that metformin suppresses radiation-induced skin injuries by modulating the expression of FOXO3 through PIK3r1. Collectively, the data obtained in this study suggested that metformin could be a potent therapeutic agent for alleviating radiation-induced skin fibrosis.</P>
김영진,김현종,김동의,조철균,김형록,구희동 대한외상학회 1998 大韓外傷學會誌 Vol.11 No.1
As the mordern society progress, the traffic and industrial accidents are increasing, so the abdominal traumas are increased and more complexed. The diagnosis of intraabdominal solid organ injuries is easy for accuray of the imaging studies, but that of hollow viscus injuries is relatively difficult. And the diagnosis of lower gastrointestinal tract injuries can be missed and delayed because of early wrapping with other bowels and omentum, this delay in the diagnosis resulted in high morbidity and mortality, so the aggressive and rapid diagnostic work-up may be needed to decrease the rate of complications. The treatment of the injuries of the duodenum and colon is variable to condition and state of the patients such as the presence of combined injuries, degree of the shock and soilage, delay of the diagnosis and general condition of the patients. So we reviewed the 204 patients with the injuries of the intraabdominal hollow viscus operated in Chonnam University Hospital. We retrospectively analyzed the operative methods, complication and mortality rate. Also we tried to predict the outcome of the patients according to the trauma scores with APACHE-II and RTS(revised traurna score).
Mitochondrial ROS-derived PTEN oxidation activates PI3K pathway for mTOR-induced myogenic autophagy
Kim, Jin-Hwan,Choi, Tae Gyu,Park, Seolhui,Yun, Hyeong Rok,Nguyen, Ngoc Ngo Yen,Jo, Yong Hwa,Jang, Miran,Kim, Jieun,Kim, Joungmok,Kang, Insug,Ha, Joohun,Murphy, Michael P.,Tang, Dean G.,Kim, Sung Soo Nature Publishing Group 2018 Cell death and differentiation Vol.25 No.11