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유환희(Hwanhee Yu),김재철 한남대학교 교육연구소 2017 교육연구 Vol.25 No.-
본 연구의 의의는 효과적인 상담과 맞춤형 교육을 위해 온라인과 오프라인 공격적피해자의 심리상태를 진단하는데 있다. 이에 학교폭력의 친 사회적 변인인 공감과 반사회적 변인인 공격성의 관점에서 온 · 오프라인의 차이와 각각의 성별 차이를 비교 분석하였다. 본 연구의 연구문제는 첫째, 온라인과 오프라인 학교폭력 공격적피해자의 공감의 양상과 차이점, 둘째, 온라인과 오프라인 학교폭력 공격적피해자의 공격성의 양상과 차이점, 셋째, 온라인과 오프라인 학교폭력 공격적피해자의 공감과 공격성의 성별 차이점이다. 위와 같이 수행한 본 연구의 결과는 첫째, 온라인 공격적피해자의 공감은 관점취하기 낮은 것으로 나타나 선행연구와 일치하였다. 그러나 선행연구와 달리 상상하기와 개인적 고통은 일반학생 집단보다 높은 것으로 나타났으며 이는 오프라인 공격적피해자의 공감의 양상과도 일치하였다. 둘째, 온라인과 오프라인 공격적피해자의 공격성의 일차 특징이 반응적-외현적이라는 점에서는 둘 다 공통점을 보인다. 그러나 이차 특징이 온라인은 주도적-관계적 공격성, 오프라인은 주도적-외현적 공격성이라는 점에서 차이점이 있었다. 셋째, 온라인과 오프라인 공격적피해자의 공감과 공격성은 남녀 성별차이가 있었으며 온 · 오프라인이 서로 다른 차이점을 보였다. 결론적으로, 온 · 오프라인 공격적피해자의 고유한 심리 특성인 적대적귀인 양식이 그들의 공감과 공격성의 특성에서 비롯되었음을 발견하였다. 그러므로 위와 같은 심리 특성과 성별 차이를 반영한 교육 및 상담이 온 · 오프라인 학교폭력의 예방과 재발방지를 위한 효과적인 해결책임을 제안하고자 한다. The main concerns of this study are the psychological traits and gender differences between online and offline bullying aggressive-victims. There was a need for much more detailed measures in order to make a psychological diagnosis of these aggressive-victims, as well as create baseline data for more effective and tailored educational materials and counseling methods. Thus, the results of this study were as follows; First, the empathy traits of online aggressive-victims showed low perspective taking levels and high fantasy and personal distress levels. Second, the aggression traits of online aggressive-victims showed high reactive-externalizing aggression levels, which was the same results as is showed in offline bullying. Third, the gender differences of online aggressive-victims in empathy and aggression traits showed low perspective taking levels for boys and high personal distress levels for girls. On the other hand, there was no gender difference between offline aggressive-victims in empathy traits, which was low perspective taking levels for boys and girls. In addition, this result showed differences from online bullying depending on the gender. In conclusion, this study suggested hostile attribution as psychological traits of online and offline bullying aggressive-victims originated from their empathy and aggression traits. Therefore, more effective cyberbullying countermeasures as to what tailored counseling and educational method should be made by aggressive-victims’ psychological traits.
S100A8, S100A9, and S100A12: Expression and Regulation During the Estrous Cycle in Pigs
Hwanhee Jang,Inkyu Yu,Jisoo Han,Minjeong Kim,Soogil Chae,Suhyung Lee,Hakhyun Ka 한국수정란이식학회 2016 한국수정란이식학회 학술대회 Vol.2016 No.10
S100As are calcium-binding proteins with two EF-hand calcium-binding motifs. In several studies, S100A proteins are described to play important roles in pro-inflammatory responses including damage-associated molecular pattern (DAMP) signaling and in the establishment of pregnancy. However, the role of S100As have not been determined in the uterine endometrium during the estrous cycle in pigs. Thus, this study was performed to investigate expression and regulation of S100A8, S100A9, and S100A12 in the uterine endometrial tissues during the estrous cycle in pigs. Real-time RT-PCR analysis showed that S100A8, S100A9, and S100A12 mRNAs were expressed in the uterine endometrium during the estrous cycle with higher levels on days 15 and 18 of the estrous cycle than other days of cycle. To investigate the effects of steroid hormones, estradiol (E2) and progesterone (P4), on expression of S100A8, S100A9, and S100A12 mRNAs, endometrial tissue explants from immature pigs were treated with steroid hormones. Levels of S100A8, S100A9, and S100A12 were increased by the treatment of P4, and the increased levels of S100A8, S100A9, and S100A12 by P4 were not inhibited by the treatment of progesterone receptor antagonist, RU486. However, levels of S100A8, S100A9, and S100A12 were decreased by treatment of MEK inhibitor, U0126. These results exhibited that S100As were expressed in the uterine endometrium during the estrous cycle in a cyclic stage-specific manner, and their expression was affected by P4. These suggest that S100As may play an important role in endometrial function during the proestrous period of the estrous cycle in pigs. [Supported by the Next Generation Biogreen 21 program (#PJ01119103), Rural Development Administration, and by Korea Research Foundation (#2015R1D1A1A01058356)]
FOXO protects against age‐progressive axonal degeneration
Hwang, Inah,Oh, Hwanhee,Santo, Evan,Kim, Do‐,Yeon,Chen, John W.,Bronson, Roderick T.,Locasale, Jason W.,Na, Yoonmi,Lee, Jaclyn,Reed, Stewart,Toth, Miklos,Yu, Wai H.,Muller, Florian L.,Paik, Jihy John Wiley and Sons Inc. 2018 AGING CELL Vol.17 No.1
<P><B>Summary</B></P><P>Neurodegeneration resulting in cognitive and motor impairment is an inevitable consequence of aging. Little is known about the genetic regulation of this process despite its overriding importance in normal aging. Here, we identify the Forkhead Box O (FOXO) transcription factor 1, 3, and 4 isoforms as a guardian of neuronal integrity by inhibiting age‐progressive axonal degeneration in mammals. FOXO expression progressively increased in aging human and mouse brains. The nervous system‐specific deletion of <I>Foxo</I> transcription factors in mice accelerates aging‐related axonal tract degeneration, which is followed by motor dysfunction. This accelerated neurodegeneration is accompanied by levels of white matter astrogliosis and microgliosis in middle‐aged <I>Foxo</I> knockout mice that are typically only observed in very old wild‐type mice and other aged mammals, including humans. Mechanistically, axonal degeneration in nerve‐specific <I>Foxo</I> knockout mice is associated with elevated mTORC1 activity and accompanying proteotoxic stress due to decreased Sestrin3 expression. Inhibition of mTORC1 by rapamycin treatment mimics FOXO action and prevented axonal degeneration in <I>Foxo</I> knockout mice with accelerated nervous system aging. Defining this central role for FOXO in neuroprotection during mammalian aging offers an invaluable window into the aging process itself.</P>
Tahir, Muhammad Nazir,Jeong, Daham,Kim, Hwanhee,Yu, Jae-Hyuk,Cho, Eunae,Jung, Seunho Korean Chemical Society 2014 Bulletin of the Korean Chemical Society Vol.35 No.1
Glass discs functionalized with alkynyl (GDA) terminated monolayers were prepared and incubated in $AgNO_3$ solution (GDA-Ag). The modified functional glass surfaces were characterized by X-ray photoelectron microscopy (XPS). The potential of GDA and GDA-Ag as antimicrobial surfaces was investigated. Anti-microbial efficacies of GDA against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus cereus, and Candida albicans was relatively low ranging from 4.67 to 17.00%. However, the GDA-Ag was very effective and its antimicrobial efficacy ranged from 99.90 to 99.99% against the same set of microbial strains except for C. albicans where it was 95.50%. The durability of the Ag bonded to the terminal alkynyl groups was studied by placing the GDA-Ag in PBS buffer solution (pH 7.4) for two weeks. Initially, the silver release was relatively fast, with 40.05 ppb of silver released in first 24 h followed by a very slow and constant release. To study the potential of GDA-Ag for medical applications, in vitro cytotoxicity of GDA-Ag against Human Embryonic Kidney 293 (HEK293) cell lines was studied using WST-assay. The cytotoxicity of the GDA-Ag was very low (5%) and was almost comparable to the control (blank glass disc) indicating that GDA-Ag has a promising potential for medical applications.