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Hypoallergenic and Physicochemical Properties of the A2 β-Casein Fraction of Goat Milk
Tae-Hwan Jung,Hyo-Jeong Hwang,Sung-Seob Yun,Won-Jae Lee,Jin-Wook Kim,Ji-Yun Ahn,Woo-Min Jeon,Kyoung-Sik Han2.6* 한국축산식품학회 2017 한국축산식품학회지 Vol.37 No.6
Goat milk has a protein composition similar to that of breast milk and contains abundant nutrients, but its use in functional foods is rather limited in comparison to milk from other sources. The aim of this study was to prepare a goat A2 β-casein fraction with improved digestibility and hypoallergenic properties. We investigated the optimal conditions for the separation of A2 β-casein fraction from goat milk by pH adjustment to pH 4.4 and treating the casein suspension with calcium chloride (0.05 M for 1 h at 25°C). Selective reduction of β- lactoglobulin and αs-casein was confirmed using sodium dodecyl sulphate-polyacrylamide gel electrophoresis and reverse-phase high-performance liquid chromatography. The hypoallergenic property of A2 β-casein fraction was examined by measuring the release of histamine and tumor necrosis factor alpha from HMC-1 human mast cells exposed to different proteins, including A2 β-casein fraction. There was no significant difference in levels of both indicators between A2 β-casein treatment and the control (no protein treatment). The A2 β-casein fraction is abundant in essential amino acids, especially, branched-chain amino acids (leucine, valine, and isoleucine). The physicochemical properties of A2 β-casein fraction, including protein solubility and viscosity, are similar to those of bovine whole casein which is widely used as a protein source in various foods. Therefore, the goat A2 β-casein fraction may be useful as a food material with good digestibility and hypoallergenic properties for infants, the elderly, and people with metabolic disorders.
Hwang, Sang-Ill,Yoon, Soon-Ock,Park, Han-San Korea Association For Quaternary Research 2003 제사기학회지 Vol.17 No.2
The existence of coastal terraces, HH(High higher) surfaces found at Gampo of southeast coast and at Jeongdongjin of the central east coast were confirmed at Jigyeong-Ri, the areal border between Gyeongju- and Ulsan city on the southeast coast of Korea Peninsula. Especially this study reports HH JK-surface located on the 155m a.s.l., which is the highest altitude among the ancient shorelines of the coastal terraces in Korea. The HH surfaces on the study area are classified into HH JK at 155m, HH-I at 140m and HH-II at 115m, and each formation stage is related to MIS 17(720∼690ka BP), MIS 15(630∼560ka BP) and MIS 13(510∼480ka BP) respectively. The HH-surfaces remain to be larger than those of H- and L-surfaces. The reason is caused by the unique factors of the coastal geology and morphology on the study area during the formation stage. And also the areal difference by the magnitude of upheaval doesn't exist from north to south because the altitude system of ancient shoreline on each coastal terrace is same along the east coast. The upheaval rate of the eastern coastal areas was measured in the relation to the ancient shoreline and formation stage among the coastal terraces such as HH JK-, HH-I, HH-II, H-III and H-IY surface, and was almost same as 0.23mm/y.
Han, Hee-Sung,Kee, Sun-Ho,Hwang, Soon-Bong,Kim, Hyung-Jun,Cho, Kyung-A,Kim, Yoon-Won,Cho, Min-Kee,Chang, Woo-Hyun The Korean Society of Virology 1998 Journal of Bacteriology and Virology Vol.28 No.1
Human papillomavirus (HPV) 16, E7 proteins derived from the prototype (Bac73) and natural variant (Bac101) E7 open reading frame were produced in Sf9 insect cells. The variant E7 gene occurred naturally by substitution mutation at the position of 88 nucleotide, resulting serine instead of asparagine. Using E7 specific monoclonal antibody (VD6), both E7 proteins were identified in recombinant baculovirus infected SF9 cells. Radiolabelling and immunoprecipitation analysis revealed that both E7 proteins were phosphoproteins. Immunostaining result showed that E7 proteins were mainly localized in the cytoplasm. Nuclear form of E7 proteins was also detected after a sequential fractionation procedure for removing chromatin structure. Considering that the VD6 recognition site in E7 protein is located within 10 amino acid at the N-terminus, this region appears to be blocked by the nuclear component. Western blot analysis revealed that nuclear form was more abundant than cytoplasmic E7 proteins. Time course immunostaining showed that the primary location of E7 protein was the nucleus and exported to the cytoplasm as proteins were accumulated. These events occurred similarly in both Bac73 and Bac101 infected Sf9 cells, suggesting that these two proteins may have similar biological functions.
Hwang, In-Chang,Kang, Dong-Ho,Han, Jong-Woo,Park, In-Sung,Lee, Chul-Hee,Park, Sun-Young The Korean Neurosurgical Society 2007 Journal of Korean neurosurgical society Vol.42 No.4
Objective : The objective of this study is to investigate the safety, surgical efficacy, and advantages of a polyaxial screw-rod system for posterior occipitocervicothoracic arthrodesis. Methods : Charts and radiographs of 32 patients who underwent posterior cervical fixation between October 2004 and February 2006 were retrospectively reviewed. Posterior cervical polyaxial screw-rod fixation was applied on the cervical spine and/or upper thoracic spine. The surgical indication was fracture or dislocation in 18, C1-2 ligamentous injury with trauma in 5, atlantoaxial instability by rheumatoid arthritis (RA) or diffuse idiopathic skeletal hyperostosis (DISH) in 4, cervical spondylosis with myelopathy in 4, and spinal metastatic tumor in 1. The patients were followed up and evaluated based on their clinical status and radiographs at 1, 3, 6 months and 1 year after surgery. Results : A total of 189 screws were implanted in 32 patients. Fixation was carried out over an average of 3.3 spinal segment (range, 2 to 7). The mean follow-up interval was 20.2 months. This system allowed for screw placement in the occiput, C1 lateral mass, C2 pars, C3-7 lateral masses, as well as the lower cervical and upper thoracic pedicles. Satisfactory bony fusion and reduction were achieved and confirmed in postoperative flexion-extension lateral radiographs and computed tomography (CT) scans in all cases. Revision surgery was required in two cases due to deep wound infection. One case needed a skin graft due to necrotic change. There was one case of kyphotic change due to adjacent segmental degeneration. There were no other complications, such as cord or vertebral artery injury, cerebrospinal fluid leak, screw malposition or back-out, or implant failure, and there were no cases of postoperative radiculopathy due to foraminal stenosis. Conclusion : Posterior cervical stabilization with a polyaxial screw-rod system is a safe and reliable technique that appears to offer several advantages over existing methods. Further biomechanical testings and clinical experiences are needed in order to determine the true benefits of this procedure.
( Han Seok Ryu ),( Joo Hun Park ),( Seung Soo Sheen ),( Tae Hwan Kim ),( Sung Dam Han ),( Ju-yang Jung ),( Chang-hee Suh ),( Sung Chul Hwang ) 대한류마티스학회 2017 대한류마티스학회지 Vol.24 No.4
Diffuse alveolar hemorrhage (DAH) is a life-threatening condition associated with many disorders. Here, we report a case of 59-year-old female who had diffuse alveolar hemorrhage associated with methimazole. She had been treated with methimazole for two weeks due to the recurrence of Grave`s disease, before visiting the emergency room. She had to be intubated on the 3rd day of hospitalization because of unabated massive hemoptysis and rapid progression of diffuse alveolar infiltration on chest radiographs. Since her clinical condition improved substantially after cessation of methimazole and steroid pulse therapy, she was extubated on the 9th day of hospitalization and then discharged. After discharge, DAH did not recur with cessation of steroid and she had radioactive iodine therapy for her Grave`s disease. This was a rare and interesting case of life-threatening DAH associated with cytoplasmic-antineutrophil cytoplasmic antibody and methimazole. (J Rheum Dis 2017;24:236-240)
Han, Sung Min,Kim, Do Young,Uddin, Md. Romij,Hwang, Ki Seon,Lee, Bumkyu,Kim, Chang-Gi,Park, Kee Woong The Korean Society of Weed ScienceThe Turfgrass So 2014 Weed & Turfgrass Science Vol.3 No.3
Genetically modified (GM) crops are not permitted to be cultivated in Korea, but can only be imported as food or feed purposes. The import of GM crops has sharply increased in recent years, thus raising concerns with regard to the unintentional escape of these crops during transport and manufacturing as well as the subsequent contamination of local, non-GM plants. Hence, monitoring of GM crops was studied in or outside of grain receiving ports as well as from feed-processing plants in Korea during July 2008. We observed spilled maize grains and established plants primarily in storage facilities that are exposed around the harbors and near transportation routes of the feed-processing areas. Based on the PCR analyses, a total of 17 GM maize plants and 11 seeds were found among the samples. In most cases, the established maize plants found in this study were at the vegetative stage and thus failed to reach the reproductive stage. This study concludes that, in order to prevent a genetic admixture in the local environment for GM crops or seeds, frequent monitoring work and proper action should be taken.
Hwang, Jin Ho,Han, Seung Seok,Huh, Wooseong,Park, Su-Kil,Joo, Dong Jin,Kim, Myoung Soo,Kim, Yu Seun,Min, Sang-Il,Ha, Jongwon,Kim, Sang Joon,Kim, Suhnggwon,Kim, Yon Su Springer International ; Oxford University Press 2012 Nephrology, dialysis, transplantation Vol.27 No.6
<P>Idiopathic focal segmental glomerulosclerosis (FSGS) occurring at young age is known to predispose to poor graft outcome, but the outcome of adulthood-onset FSGS (A-FSGS) has not been thoroughly investigated. Here, we compared the graft outcomes between kidney recipients with A-FSGS and childhood-onset FSGS (C-FSGS).</P>
Cortex Mori Extract Induces Cancer Cell Apoptosis Through Inhibition of Microtubule Assembly
Hwang, Pyoung-Han,Nam, Sang-Yun,Yi, Ho-Keun,Lee, Jung-Chang,Kim, Jae-Cheol,Song, Chang-Ho,Park, Jin-Woo,Lee, Dae-Yeol,Kim, Jung-Soo The Pharmaceutical Society of Korea 2002 Archives of Pharmacal Research Vol.25 No.2
The water extract from the root bark of Cortex Mori (CM, Morus alba L.: Sangbaikpi), a mulberry tree, has been known in Chinese traditional medicine to have antiphlogistic, diuretic, and expectorant properties. In this study, the cytotoxicity of CM against tumor cells and its mechanism was examined . CM exhibited cytotoxic activity on K-562, B38O human leukemia cells and B16 mouse melanoma cells at concentrations of > 1 mg/ml. A DNA fragmentation, PARP cleavage, and nuclear condensation assay showed that those cells exposed to CM underwent apoptosis. The water extract of Scutellarie Radix (SR) was used as a negative control and showed no cytotoxicity in those cells. The flow cytometric profiles of the CM-treated cells were also indicative of apoptosis. However, they did not appear to exert the G1 arrest, which is observed in other tubulin inhibitor agents such as vincristine, taxol. The protein-binding test using Biacore and a microtubule assembly-disassembly assay provided evidence showing that CM bound to the tubulins resulting in 3 markets inhibition of the assembly, but not the disassembly of microtubules. The possible nonspecific effect of the CM extract could be excluded due to the results using SR, which did not affect the assembly process. Overall, the water extract of CM induces apoptosis of tumor cells by inhibiting microtubule assembly.
ALGORITHM FOR FINDING 90/150 TRIDIAGONAL MATRICES
Sung Jin CHO,Un Sook CHOI,Han Doo KIM,Yoon Hee HWANG,Jin Gyoung KIM 한국산업응용수학회 2006 한국산업응용수학회 학술대회 논문집 Vol.1 No.2
In this paper, we propose a new method for finding 90/150 Linear Hybrid Group Cellular Automata(LHGCA) for CA-polynomials.