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        Respiratory Health, Sleep Dysfunction, and Mental Health in Children and Adolescents With a Neuromuscular Disorder: A Descriptive Qualitative Study

        Meg Huston,Adelaide L Withers,Jenny Lam,Andrew Wilson,Jenny Downs 대한수면연구학회 2023 Journal of sleep medicine Vol.20 No.1

        Objectives: To explore how respiratory health and sleep problems affect mental health in children and adolescents with neuromuscular disorders (NMDs).Methods: A qualitative descriptive study was carried out with content analysis of in-depth interviews conducted with children with NMDs and their parents. Data were collected during semi-structured interviews with children with NMDs and their parents. A total of 14 families were recruited (17 parents and 7 children and adolescents with NMD aged 5–17 years). Each interview was conducted with 1–3 family member(s).Results: Engagement in community activities, meaningful relationships, feeling well, and achieving independence each contributed positively to children’s mental health. Additional challenges to mental health during periods of poor respiratory and/or sleep health included: 1) challenges to behavioral regulation, 2) changes to mood, and 3) challenges to thinking. Parents and children reported nurturing and coping self-management strategies when their physical and mental health were dually challenged in addition to medical management strategies such as non-invasive ventilation (NIV).Conclusions: This study supports the notion that changes in mental health may indicate poor physical health in children with NMDs. Treating respiratory and sleep problems, such as by early NIV implementation, may improve the mental health of children with NMDs and thus support their overall wellbeing and health outcomes.

      • How Can Public Policy Improve Quality of Early Care and Education?

        Aletha C. Huston 육아정책연구소 2008 International Journal of Child Care and Education Vol.2 No.1

        The major purpose of this paper is to suggest ways that public policy can improve the quality of child care and early education for children from infancy to school age. Quality can be defined by such structural features as group composition, caregiver qualifications, and health and safety practices, and by such process indicators as sensitive, responsive, stimulating activities and interactions. Both predict children’s development. Among the structural indicators, specific training in early education is the most consistent predictor of children’s development, but small ratios and group sizes may also be important, especially for infants and toddlers. Early care and education policies in the U.S. have two means of affecting quality: providing funds and regulation or setting standards. When government agencies fund programs directly, they can hold the programs to structural and process quality standards. Regulations and standards can affect quality largely by dictating such structural features as teacher qualifications, child-to-adult ratios, and group sizes. Quality in all programs for young children can be enhanced by integrating child care and early education into a single system of early education and care.

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        Versatile robotic platform for structural health monitoring and surveillance

        Esser, Brian,Huston, Dryver R. Techno-Press 2005 Smart Structures and Systems, An International Jou Vol.1 No.4

        Utilizing robotic based reconfigurable nodal structural health monitoring systems has many advantages over static or human positioned sensor systems. However, creating a robot capable of traversing a variety of civil infrastructures is a difficult task, as these structures each have unique features and characteristics posing a variety of challenges to the robot design. This paper outlines the design and implementation of a novel robotic platform for deployment on ferromagnetic structures as an enabling structural health monitoring technology. The key feature of this design is the utilization of an attachment device which is an advancement of the common magnetic base found in the machine tool industry. By mechanizing this switchable magnetic circuit and redesigning it for light weight and compactness, it becomes an extremely efficient and robust means of attachment for use in various robotic and structural health monitoring applications. The ability to engage and disengage the magnet as needed, the very low power required to do so, the variety of applicable geometric configurations, and the ability to hold indefinitely once engaged make this device ideally suited for numerous robotic and distributed sensor network applications. Presented here are examples of the mechanized variable force magnets, as well as a prototype robot which has been successfully deployed on a large construction site. Also presented are other applications and future directions of this technology.

      • KCI등재후보

        Versatile robotic platform for structural health monitoring and surveillance

        Brian Esser,Dryver R. Huston 국제구조공학회 2005 Smart Structures and Systems, An International Jou Vol.1 No.4

        Utilizing robotic based reconfigurable nodal structural health monitoring systems has many advantages over static or human positioned sensor systems. However, creating a robot capable of traversing a variety of civil infrastructures is a difficult task, as these structures each have unique features and characteristics posing a variety of challenges to the robot design. This paper outlines the design and implementation of a novel robotic platform for deployment on ferromagnetic structures as an enabling structural health monitoring technology. The key feature of this design is the utilization of an attachment device which is an advancement of the common magnetic base found in the machine tool industry. By mechanizing this switchable magnetic circuit and redesigning it for light weight and compactness, it becomes an extremely efficient and robust means of attachment for use in various robotic and structural health monitoring applications. The ability to engage and disengage the magnet as needed, the very low power required to do so, the variety of applicable geometric configurations, and the ability to hold indefinitely once engaged make this device ideally suited for numerous robotic and distributed sensor network applications. Presented here are examples of the mechanized variable force magnets, as well as a prototype robot which has been successfully deployed on a large construction site. Also presented are other applications and future directions of this technology.

      • KCI등재

        Cortical Thinning in High-Grade Asymptomatic Carotid Stenosis

        Randolph S. Marshall,David S. Liebeskind,John Huston III,Lloyd J. Edwards,George Howard,James F. Meschia,Thomas G. Brott,Brajesh K. Lal,Donald Heck,Giuseppe Lanzino,Navdeep Sangha,Vikram S. Kashyap,Cl 대한뇌졸중학회 2023 Journal of stroke Vol.25 No.1

        Background and Purpose High-grade carotid artery stenosis may alter hemodynamics in the ipsilateral hemisphere, but consequences of this effect are poorly understood. Cortical thinning is associated with cognitive impairment in dementia, head trauma, demyelination, and stroke. We hypothesized that hemodynamic impairment, as represented by a relative time-to-peak (TTP) delay on MRI in the hemisphere ipsilateral to the stenosis, would be associated with relative cortical thinning in that hemisphere. Methods We used baseline MRI data from the NINDS-funded Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis–Hemodynamics (CREST-H) study. Dynamic contrast susceptibility MR perfusion-weighted images were post-processed with quantitative perfusion maps using deconvolution of tissue and arterial signals. The protocol derived a hemispheric TTP delay, calculated by subtraction of voxel values in the hemisphere ipsilateral minus those contralateral to the stenosis. Results Among 110 consecutive patients enrolled in CREST-H to date, 45 (41%) had TTP delay of at least 0.5 seconds and 9 (8.3%) subjects had TTP delay of at least 2.0 seconds, the maximum delay measured. For every 0.25-second increase in TTP delay above 0.5 seconds, there was a 0.006-mm (6 micron) increase in cortical thickness asymmetry. Across the range of hemodynamic impairment, TTP delay independently predicted relative cortical thinning on the side of stenosis, adjusting for age, sex, hypertension, hemisphere, smoking history, low-density lipoprotein cholesterol, and preexisting infarction (P=0.032). Conclusions Our findings suggest that hemodynamic impairment from high-grade asymptomatic carotid stenosis may structurally alter the cortex supplied by the stenotic carotid artery.

      • SCISCIESCOPUS

        Cyclic AMP Controls mTOR through Regulation of the Dynamic Interaction between Rheb and Phosphodiesterase 4D

        Kim, Hyun Wook,Ha, Sang Hoon,Lee, Mi Nam,Huston, Elaine,Kim, Do-Hyung,Jang, Sung Key,Suh, Pann-Ghill,Houslay, Miles D.,Ryu, Sung Ho American Society for Microbiology 2010 Molecular and cellular biology Vol.30 No.22

        <B>ABSTRACT</B><P>The mammalian target of rapamycin complex 1 (mTORC1) is a molecular hub that regulates protein synthesis in response to a number of extracellular stimuli. Cyclic AMP (cAMP) is considered to be an important second messenger that controls mTOR; however, the signaling components of this pathway have not yet been elucidated. Here, we identify cAMP phosphodiesterase 4D (PDE4D) as a binding partner of Rheb that acts as a cAMP-specific negative regulator of mTORC1. Under basal conditions, PDE4D binds Rheb in a noncatalytic manner that does not require its cAMP-hydrolyzing activity and thereby inhibits the ability of Rheb to activate mTORC1. However, elevated cAMP levels disrupt the interaction of PDE4D with Rheb and increase the interaction between Rheb and mTOR. This enhanced Rheb-mTOR interaction induces the activation of mTORC1 and cap-dependent translation, a cellular function of mTORC1. Taken together, our results suggest a novel regulatory mechanism for mTORC1 in which the cAMP-determined dynamic interaction between Rheb and PDE4D provides a key, unique regulatory event. We also propose a new role for PDE4 as a molecular transducer for cAMP signaling.</P>

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