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- 저자 : Huimin Niu (검색결과 2 건)
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Yanliang Niu,Huimin Li,Kunhui Ye,Amin Mahmoudi,Xiaopeng Deng 대한토목학회 2022 KSCE JOURNAL OF CIVIL ENGINEERING Vol.26 No.5
The mileage of high-speed rail (HSR) is expected to grow in the foreseeable future. Fierce international competition and HSR business uniqueness have facilitated the broad application of international joint ventures (IJVs) globally. However, the interaction between competition and cooperation complicates IJVs, and IJVs partners’ implementation has rarely been informed concerning the fluent operation of IJVs for HSR projects. This study aims to examine the determinants of IJVs coopetition for HSR projects. We identified 35 variables along with their clusters through literature review and pilot study, and collected data from the international HSR industry using a questionnaire survey. Eight clusters verified by the confirmatory factor analysis come from three levels: macro-level, project-level, and firm-level. Based on the partial least squares structural equation modeling (PLS-SEM), a path model for the coopetition relationship has been established, demonstrating that macro-level and project-level determinants affect the coopetition relationship via the firm-level determinants. Furthermore, the path model indicates recommendations corresponding to various situations (isolating situation, partnering situation, contending situation, and adapting situation) for IJVs members to find a way to improve the coopetition relationship. Thus, this study not only contributes to the existing knowledge body on coopetition theory, but also enhances HSR contractors’ comprehension of the coopetition relationship determinants as well as the interactions.
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Ning Song,Jun Luo,Lian Huang,Xiaoying Chen,Huimin Niu,Lu Zhu Asian Australasian Association of Animal Productio 2023 Animal Bioscience Vol.36 No.10
Objective: α<sub>S1</sub>-Casein is more closely associated with milk allergic reaction than other milk protein components. microRNA (miRNA) is a class of small non-coding RNAs that modulate multiple biological progresses by the target gene. However, the post-transcriptional regulation of α<sub>S1</sub>-casein expression by miRNA in ruminants remains unclear. This study aims to explore the regulatory roles of miR-380-3p on α<sub>S1</sub>-casein synthesis in goat mammary epithelial cells (GMEC). Methods: α<sub>S1</sub>-Casein gene and miR-380-3p expression was measured in dairy goat mammary gland by quantitative real-time polymerase chain reaction (qRT-PCR). miR-380-3p overexpression and knockdown were performed by miR-380-3p mimic or inhibitor in GMEC. The effect of miR-380-3p on α<sub>S1</sub>-casein synthesis was detected by qRT-PCR, western blot, luciferase and chromatin immunoprecipitation assays in GMEC. Results: Compared with middle-lactation period, α<sub>S1</sub>-casein gene expression is increased, while miR-380-3p expression is decreased during peak-lactation of dairy goats. miR-380-3p reduces α<sub>S1</sub>-casein abundance by targeting the 3'-untranslated region (3'UTR) of α<sub>S1</sub>-casein mRNA in GMEC. miR-380-3p enhances β-casein expression and signal transducer and activator of transcription 5a (STAT5a) activity. Moreover, miR-380-3p promotes β-casein abundance through target gene α<sub>S1</sub>-casein, and activates β-casein transcription by enhancing the binding of STAT5 to β-casein gene promoter region. Conclusion: miR-380-3p decreases α<sub>S1</sub>-casein expression and increases β-casein expression by targeting α<sub>S1</sub>-casein in GMEC, which supplies a novel strategy for reducing milk allergic potential and building up milk quality in ruminants.
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