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RISS 인기검색어
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- 저자 : Huang Jingyan (검색결과 4 건)
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Huang Jingyan,Huang Siyun,Li Jinhong,Li Minhua,Gong Lin,Li Tongshun,Gu Lian 한국유전학회 2022 Genes & Genomics Vol.44 No.4
Background: Calmodulin 1 (CALM1) mutations are involved in the development of coronary artery disease (CAD). However, the relationship of CALM1 rs3179089 polymorphism with CAD is unknown. Objective: This study aimed to identify the relationship of CALM1 rs3179089 polymorphism with CAD susceptibility, CALM1 expression, blood pressure, blood glucose, blood coagulation and serum lipid levels of CAD patients. Methods: 550 CAD patients and 550 control subjects were genotyped for CALM1 using Sequenom MassARRAY technology. CALM1 expression level was measured by quantitative real time polymerase chain reaction (qRT-PCR). Results: CALM1 mRNA expression was higher in CAD patients than that in control subjects (P < 0.001). CAD patients with CC genotype had higher CALM1 mRNA expression level than control subjects with CC genotype (P = 0.006). Genotypic frequency of rs3179089 was different between male patients of CAD and control subjects (P = 0.045). Rs3179089 polymorphism was related to CAD risk of males in recessive model (P = 0.039). Moreover, rs3179089 polymorphism was associated with systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting plasma glucose (FPG), and D-Dimer (D-D) level of patients with CAD in recessive model (P = 0.013 for SBP; P = 0.034 for DBP; P = 0.004 for FPG; P = 0.046 for D-D). In addition, rs3179089 polymorphism was correlated with low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) serum levels of patients with CAD in both addictive (P = 0.025 for LDL-C; P = 0.001 for TC) and recessive models (P = 0.001 for LDL-C; P = 0.001 for TC). Conclusion: CALM1 expression is associated with development of CAD. CALM1 rs3179089 polymorphism affects CAD susceptibility in males, and blood pressure, blood glucose, blood coagulation and serum lipid of CAD patients.
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Liwei Wu,Jingyan Ban,Qian Jiang,Ting-Ting Li,Bing-Chiuan Shiu,Shih-Yu Huang,Ching-Wen Lou,Jia-Horng Lin 한국섬유공학회 2019 Fibers and polymers Vol.20 No.6
Polyethylene terephthalate (PET) nonwoven fabrics, carbon fabrics (CF), and flexible polyurethane (PU) foamsare made into novel sandwich composites using one-step molding. The flame retradance and mechanical properties of thesandwich composites are evaluated, examining the influences of the content of flame retardant agent (20, 30, 40, and 50 wt%)and areal density of PET panels (200, 300, and 400 g/m2). The test results show that the PET/CF/PU sandwich composites arerated flame retardant as V0 and do not generate melts. The failure mode of PET/CF/PU sandwich composites converts fromoverall fracture to layered fracture as a result of increasing the flame retardant agent. The tensile strength at break of PET/CF/PU sandwich composites with corresponding PET panels is 650 N for 200 g/m2, 928 N for 300 g/m2, and 1744 N for 400 g/m2,which are 42.63 %, 60.48 %, and 77.85 % greater than those of the PET/PU sandwich composites. Moreover, the burstingstrength of PET/CF/PU sandwich composites with corresponding PET panels is 3322 N for 200 g/m2, 3869 N for 300 g/m2,and 4978 N for 400 g/m2, which are 195 %, 180 %, and 143 % greater than those of the PET/PU sandwich composites.
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Yao Zhiming,Fan Jingyan,Dai Jun,Yu Chen,Zeng Han,Li Qingzhi,Hu Wei,Yan Chaoyue,Hao Meilin,Li Haotian,Li Shuo,Liu Jie,Huang Qi,Li Lu,Zhou Rui 한국미생물·생명공학회 2023 Journal of microbiology and biotechnology Vol.33 No.6
Tylosin is a potent veterinary macrolide antibiotic produced by the fermentation of Streptomyces fradiae; however, it is necessary to modify S. fradiae strains to improve tylosin production. In this study, we established a high-throughput, 24-well plate screening method for identifying S. fradiae strains that produce increased yields of tylosin. Additionally, we constructed mutant libraries of S. fradiae via ultraviolet (UV) irradiation and/or sodium nitrite mutagenesis. A primary screening of the libraries in 24-well plates and UV spectrophotometry identified S. fradiae mutants producing increased yields of tylosin. Mutants with tylosin yield 10% higher than the wild-type strain were inoculated into shake flasks, and the tylosin concentrations produced were determined by highperformance liquid chromatography (HPLC). Joint (UV irradiation and sodium nitrite) mutagenesis resulted in higher yields of mutants with enhanced tylosin production. Finally, 10 mutants showing higher tylosin yield were re-screened in shake flasks. The yield of tylosin A by strains UN-C183 (6767.64 ± 82.43 μg/ml) and UN-C137 (6889.72 ± 70.25 μg/ml) was significantly higher than that of the wild-type strain (6617.99 ± 22.67 μg/ml). These mutant strains will form the basis for further strain breeding in tylosin production.
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Jialin Wu,Danyu Huang,Jingyan Liu,Rob Law 한국관광학회 2013 International Journal of Tourism Sciences Vol.13 No.2
The theoretical perspective of this study is to integrate Visitor Environmental Learning (VEL) into the Theory of Planed Behavior (TPB). The Xiangjiang Safari Park, which is one of the largest theme parks in Asia,was selected to test the conceptual model to examine whether Post-Visit Action Resources (PVAR), Ease of Behavior (EB), and Sunk Cost (SC) have the mediate/moderate effect on the relationship between short-term pro-environment intentions and long-term behaviors. The sample consisted of 269 tourists who have travel experience with the Xiangjiang Safari Park. Findings from a Structural Equation Model analysis show that post-visit action resources partially mediate the relationship between tourists’ short-term pro-environmental intentions and behaviors, and that ease of behavior and sunk cost both have moderating effects on this relationship. These findings indicate that a high level of post-visit action resources, ease of behavior and sunk cost are instrumental in encouraging visitors’ pro-environmental intentions to turn into behaviors.
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