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朴恩希(Eun-Hee Park),谢,菁(Xie Jing),贾,春华,(Jia Chun Hua) 한국의사학회 2012 한국의사학회지 Vol.25 No.1
Dysuria has been mentioned several times in “Treatise on cold” and “Golden Chamber” of Zhang Zhong-jing in Han Dynasty. This article makes a detailed discussion of etiology, pathogenesis, treatment and prescription of Dysuria from three periods that is Han and Tang Dynasty, Song and Yuan Dynasty, Ming and Qing Dynasty. It has demonstrated the inheritance, development and innovation of academe ideas of later physicians from Zhang Zhong-jing, which enriched and developed the theory of Zhong-jing.
Jing-Lei Zhao,Xu Chen,Gui-Lin She,Yan Jing,Ru-Qing Bai,Jin Yi,Hua-Yan Pu,Jun Luo 국제구조공학회 2022 Steel and Composite Structures, An International J Vol.43 No.6
This paper presents an investigation on the free vibration characteristics of functionally graded nanocomposite double-beams reinforced by single-walled carbon nanotubes (SWCNTs). The double-beams coupled by an interlayer spring, resting on the elastic foundation with a linear layer and shear layer, and is simply supported in thermal environments. The SWCNTs gradient distributed in the thickness direction of the beam forms different reinforcement patterns. The materials properties of the functionally graded carbon nanotube-reinforced composites (FG-CNTRC) are estimated by rule of mixture. The first order shear deformation theory and Euler-Lagrange variational principle are employed to derive the motion equations incorporating the thermal effects. The vibration characteristics under several patterns of reinforcement are presented and discussed. We conducted a series of studies aimed at revealing the effects of the spring stiffness, environment temperature, thickness ratios and carbon nanotube volume fraction on the nature frequency.
A Novel Intelligent Fault Diagnosis Method and Its Application
Jing-Hua Zhu 보안공학연구지원센터 2015 International Journal of Multimedia and Ubiquitous Vol.10 No.8
In order to improve fault diagnosis precision and decrease misinformation diagnosis, rough set theory(RST) and RBF neural network (RBFNN) are introduced to overcome respective deficiency in order to propose a novel intelligence fault diagnosis(NCIRRFD) model and method in this paper. In this NCIRRFD method, the RST as a new mathematical tool is used to process inexact and uncertain knowledge in order to reduce decision tables for obtaining the minimum fault characteristic subset. At the same time, RST is used to serve for pretreatment data so that RBFNN structure is simplified and learning efficiency is improved in order to get an optimized NCIRRFD model for solving the inference complexity. An actual application case is selected to test and verify the proposed NCIRRFD method. The applied results show that the proposed NCIRRFD method can effectively eliminate false and improve the diagnostic accuracy.
Assessment of the Cytotoxic and Apoptotic Effects of Chaetominine in a Human Leukemia Cell Line
( Jing Yun Yao ),( Rui Hua Jiao ),( Chang Qing Liu ),( Yu Peng Zhang ),( Wan Guo Yu ),( Yan Hua Lu ),( Ren Xiang Tan ) 한국응용약물학회 2016 Biomolecules & Therapeutics(구 응용약물학회지) Vol.24 No.2
Chaetominine is a quinazoline alkaloid originating from the endophytic fungus Aspergillus fumigatus CY018. In this study, we showed evidence that chaetominine has cytotoxic and apoptotic effects on human leukemia K562 cells and investigated the pathway involved in chaetominine-induced apoptosis in detail. Chaetominine inhibited K562 cell growth, with an IC50 value of 35 nM, but showed little inhibitory effect on the growth of human peripheral blood mononuclear cells. The high apoptosis rates, morphological apoptotic features, and DNA fragmentation caused by chaetominine indicated that the cytotoxicity was partially caused by its pro-apoptotic effect. Under chaetominine treatment, the Bax/Bcl-2 ratio was upregulated (from 0.3 to 8), which was followed by a decrease in mitochondrial membrane potential, release of cytochrome c from mitochondria into the cytosol, and stimulation of Apaf-1. Furthermore, activation of caspase-9 and caspase-3, which are the main executers of the apoptotic process, was observed. These results demonstrated that chaetominine induced cell apoptosis via the mitochondrial pathway. Chaetominine inhibited K562 cell growth and induced apoptotic cell death through the intrinsic pathway, which suggests that chaetominine might be a promising therapeutic for leukemia.
Jing Si,Jian-hui Wang,Li-jing Zhang,Hua Zhang,Ya-jie Liu,Li-zhe An 한국식물학회 2009 Journal of Plant Biology Vol.52 No.6
Rapid amplification of cDNA ends was performed to isolate cold-regulated CbCOR15 (EF208112) from Chorispora bungeana. This alpine species is distributed in subnival areas. Transcripts were detected in the leaves, but not the roots, of plants acclimated to cold temperatures. Expression was induced at high levels at both 4°C and −4°C. In comparing its deduced protein sequence to that of AtCOR15a (cold-regulated 15a in Arabidopsis thaliana), the N terminus had less homology than the C terminus while still containing a region analogous to the chloroplast-targeted signal peptide of AtCOR15a. We also introduced CbCOR15, with the CaMV 35S promoter, into tobacco. Second-generation (T1) plants had significantly increased tolerance to chilling, as determined by their electrolyte leakage, chlorophyll content, and relative water content. Further freezing-stress experiments showed that the tolerance of transgenic lines was significantly greater than that of the nontransgenics. Although the degree of chilling and freezing tolerance in the transgenic plants was not directly correlated with the accumulated levels of CbCOR15, we could conclude that this gene confers cold tolerance.
Jing-Hua Wang,Seung-Ju Hwang,Chang-Gue Son 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
As a medicinal herb, CA contains lots of active components and possesses various pharmacological activities. Recently l CA has been frequently applied in cosmetics for skin whitening. However, there are still many issues to be figured out, like consistent effects and unknown mechanisms. This study aimed to demonstrate the anti-melanogenesis activity of hexane fraction of CA (HCA) on UVB-induced skin hyperpigmentation. C57BL/6j mice were irradiated by UVB (100 mJ/cm², 5 times/week) for 4 weeks. HCA was applied to the left ear after irradiation for 8 weeks, and the right ear was used as an inter control. According to the gray value and Mexameter melanin index, HCA reduced melanin in ear skin compared to all controls. HCA notably declined melanin generation in αMSH-triggered B16/F10 melanocyte in a concentration-dependent manner. HCA treatment also markedly diminished the tyrosinase activity, gene expression, and protein level in B16/F10. Cellular cAMP and MITF were noticeably down-regulated by HCA. Consequently, we suggested that CA exerts an effect of anti-melanogenesis via reduction of tyrosinase that might be mainly mediated by regulating cAMP cascade and MITF pathway.
NF-κB in Cellular Senescence and Cancer Treatment
Jing, Hua,Lee, Soyoung Korean Society for Molecular and Cellular Biology 2014 Molecules and cells Vol.37 No.3
The NF-${\kappa}B$ pathway transcriptionally controls a large set of target genes that play important roles in cell survival, inflammation, and immune responses. While many studies showed anti-tumorigenic and pro-survival role of NF-${\kappa}B$ in cancer cells, recent findings postulate that NF-${\kappa}B$ participates in a senescence-associated cytokine response, thereby suggesting a tumor restraining role of NF-${\kappa}B$. In this review, we discuss implications of the NF-${\kappa}B$ signaling pathway in cancer. Particularly, we emphasize the connection of NF-${\kappa}B$ with cellular senescence as a response to chemotherapy, and furthermore, present examples how distinct oncogenic network contexts surrounding NF-${\kappa}B$ produce fundamentally different treatment outcomes in aggressive B-cell lymphomas as an example.