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      • Clinical Features of Patients with Esophageal and Second Primary Cancers

        Tsai, Huang-Wen,Chang, Chih-Chun,Sun, Jen-Tang,Liou, Ching-Biau,Lin, Hsiu-Chen,Lin, I-Hsin,Yu, Yun-Chieh,Weng, Wei-Ling,Leong, Ka-I,Yen, Tzung-Hai,Wu, Jiann-Ming Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.22

        Background: The prevalence of esophageal cancer (EC) with second primary cancers (SPC) is increasing worldwide. This study was aimed to understand the clinical features of EC patients with SPC in the Taiwanese population. Materials and Methods: Clinical and laboratory data for 180 EC patients with or without SPC were collected between January 2009 and December 2013. Information on treatment approaches, location of SPCs and ABO blood type were also collected and stratified. Results: The most common SPC in EC patients was hypopharyngeal cancer, followed by laryngeal cancer and hepatocellular carcinoma in our study. Malignancies of colon, prostate and lung were also found. There was a significant higher portion of blood type A in the EC patients with SPC compared with those without (42.4% vs 19.5%, P=0.006). Conclusions: The frequency and SPC site distribution and blood type A should be considered in clinical evaluation of EC patients with a high risk of developing SPC in the Taiwanese population.

      • Clinical Practice of Blood Transfusion in Orthotopic Organ Transplantation: A Single Institution Experience

        Tsai, Huang-Wen,Hsieh, Fu-Chien,Chang, Chih-Chun,Su, Ming-Jang,Chu, Fang-Yeh,Chen, Kuo-Hsin,Jeng, Kuo-Shyang,Chen, Yun Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.17

        Background: Orthotopic organ transplantation, a treatment option for irreversible organ dysfunction according to organ failure, severe damaged organ or malignancy in situ, was usually accompanied with massive blood loss thus transfusion was required. We aimed to evaluate the adverse impact of blood transfusion on solid organ transplantation. Materials and Methods: From January, 2009 to December, 2014, patients who received orthotopic organ transplantation at Far Eastern Memorial Hospital medical center were enrolled. Clinical data regarding anemia status and red blood cell (RBC) transfusion before, during and after operation, as well as patient outcomes were collected for further univariate analysis. Results: A total of 105 patients who underwent orthotopic transplantation, including liver, kidney and small intestine were registered. The mean hemoglobin (Hb) level upon admission and before operation were $11.6{\pm}1.8g/dL$ and $11.7{\pm}1.7g/dL$, respectively; and the nadir Hb level post operation and the final Hb level before discharge were $8.3{\pm}1.6g/dL$ and $10.2{\pm}1.6g/dL$, respectively. The median units (interquartile range) of RBC transfusion in pre-operative, peri-operative and post-operative periods were 0 (0-0), 2 (0-12), and 2 (0-6) units, respectively. Furthermore, the median (interquartile range) length of hospital stay (LHS) from admission to discharge and from operation to discharge were 28 (17-44) and 24 (16-37) days, respectively. Both peri-operative and post-operative RBC transfusion were associated with longer LHS from admission to discharge and from operation to discharge. Furthermore, it increased the risk of post-operative septicemia. While peri-operative RBC transfusion elevated the risk of acute graft rejection in patients who received orthotopic transplantation. Conclusions: Worse outcome could be anticipated in those who had received massive RBC transfusion in transplantation operation. Hence, peri-operative RBC transfusion should be avoided as much as possible.

      • KCI등재

        A retrospective analysis of 20-year data of the surgical management of ulcerative colitis patients in Taiwan: a study of Taiwan Society of Inflammatory Bowel Disease

        ( Chun-chi Lin ),( Shu-chen Wei ),( Been-ren Lin ),( Wen-sy-tsai ),( Jinn-shiun Chen ),( Tzu-chi Hsu ),( Wei-chen Lin ),( Tien-yu Huang ),( Te-hsin Chao ),( Hung-hsin Lin ),( Jau-min Wong ),( Jen-kou 대한장연구학회 2016 Intestinal Research Vol.14 No.3

        Background/Aims: With the recent progress in medical treatment, surgery still plays a necessary and important role in treating ulcerative colitis (UC) patients. In this study, we analyzed the surgical results and outcomes of UC in Taiwan in the recent 20 years, via a multi-center study through the collaboration of Taiwan Society of IBD. Methods: A retrospective analysis of surgery data of UC patients from January 1, 1995, through December 31, 2014, in 6 Taiwan major medical centers was conducted. The patients’ demographic data, indications for surgery, and outcome details were recorded and analyzed. Results: The data of 87 UC patients who received surgical treatment were recorded. The median post-operative follow-up duration was 51.1 months and ranged from 0.4 to 300 months. The mean age at UC diagnosis was 45.3±16.0 years and that at operation was 48.5±15.2 years. The 3 leading indications for surgical intervention were uncontrolled bleeding (16.1%), perforation (13.8%), and intractability (12.6%). In total, 27.6% of surgeries were performed in an emergency setting. Total or subtotal colectomy with rectal preservation (41.4%) was the most common operation. There were 6 mortalities, all due to sepsis. Emergency operation and low pre-operative albumin level were significantly associated with poor survival (P =0.013 and 0.034, respectively). Conclusions: In the past 20 years, there was no significant change in the indications for surgery in UC patients. Emergency surgeries and low pre-operative albumin level were associated with poor survival. Therefore, an optimal timing of elective surgery for people with poorly controlled UC is paramount.

      • A Study on the Development Strategy of the Taiwan Beauty SPA Industry

        Hsin Fen Chien,Teng Tsai Tu,Chun Yu Chen 한국유통과학회 2017 KODISA ICBE (International Conference on Business Vol.2017 No.-

        This study focuses on the future development strategy of Taiwan beauty SPA industry. The analysis is based on the PEST analysis of external environment, five forces analysis of internal industry, SWOT analysis of dealer K and in-depth interviews with senior executives of distributors. The results indicate that under the trend of the pursuit of health care, the products of the beauty industry are primarily healthy and environmentally friendly, naturally organic certificated, cosmetic beauty and natural non-toxic biotechnology products. In response to the advent of the era E, beauty SPA industry should make good use of digital platform marketing functions and establish beauty APP application software. At the same time, the beauty SPA industry can also use the e-commerce channel to carry out the business model of clicks and mortar to create greater economic benefits. The beauty SPA industry should integrate alliances with its peers to develop new customers and to innovate their revenue structure. Based on the results of this study, this research hopes to help the beauty SPA industry and individual companies to find the most suitable development strategies so as to enhance the competitiveness of the beauty SPA industry.

      • KCI등재

        An Intelligent Agriculture Network Security System Based on Private Blockchains

        Hsin-Te Wu,Chun-Wei Tsai 한국통신학회 2019 Journal of communications and networks Vol.21 No.5

        Countries around the world are nowadays actively promotingdevelopment in intelligent agriculture. Each of them mustdevelop a specific plan tailored to environmental farming indices ofeach individual farm, and such information would be both importantand sensitive. This is why information in intelligent agriculturerequires protection from network security to ensure data privacyand integrity. This study proposes applying dark web technologyto ensure the privacy of blockchains and servers. The study willmonitor packet transmission frequency in intelligent agriculture toprevent distributed denial-of-service (DDOS) attacks. The mainfeatures of system include: (1) An identity authentication mechanism,(2) secure transmission of information, (3) establishment ofprivate blockchains, (4) a faster, improved authentication systemfor blockchain information, and (5) resistance against DDOS attacks. The proposed scheme can safeguard network security for theIoT as well as the servers by way of applying dark web technology,which can avoid exposure of blockchains and server ID addressesand thus in turn lower the risks of DDOS attack damages. Experimentresults indicate that the application of lightweight encryptionof proposed scheme does indeed improve the authentication speedwhile also satisfying requirements of network security.

      • Research on Near Infrared Spectroscopy Application for Aflatoxin Testing on Rice

        ( I-chun Tung ),( Tsung-hsin Wu ),( Han-chun Hsu ),( Suming Chen ),( Chao-yin Tsai ),( Yung-kun Chuang ) 한국농업기계학회 2018 한국농업기계학회 학술발표논문집 Vol.23 No.1

        Rice is one of the most important staple food in the world. In many countries, environments with high temperature/humidity may provide favorable conditions for fungal propagation and production of aflatoxins during rice storage. Aflatoxin B<sub>1</sub> (AFB<sub>1</sub>), one of the secondary metabolites produced by Aspergillus flavus and Aspergillus parasiticus, is particularly carcinogenic to humans. People might very likely cause severe illness once rice is contaminated by aflatoxins. Therefore, the objective of this study is to develop a nondestructive method for rapid and accurate detection of the AFB<sub>1</sub> content in rice. In the present study, evaluation of AFB<sub>1</sub> contaminated rice were conducted by using near infrared spectroscopy (NIRS) technique with chemometrics. NIR Spectra and the AFB<sub>1</sub> contents of the artificially contaminated rice samples were measured by FOSS NIRS 6500 spectrometer and LC-MS/MS, respectively. Modified partial least square regression (MPLSR), a commonly used multivariate analysis method was then used to build calibration models. In summary, NIRS associated with chemometrics could provide a useful tool for rapid and accurate detection of AFB<sub>1</sub> content in rice.

      • KCI등재

        Increased Readmission Risk and Healthcare Cost for Delirium Patients without Immediate Hospitalization in the Emergency Department

        I Chun Ma,Kao Chin Chen,Wei Tseng Chen,Hsin Chun Tsai,Chien-Chou Su,Ru-Band Lu,Po See Chen,Wei Hung Chang,Yen Kuang Yang 대한정신약물학회 2018 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.16 No.4

        Objective: Hospitalization of patients with delirium after visiting the emergency department (ED) is often required. However, the readmission risk after discharge from the ED should also be considered. This study aimed to explore whether (i) immediate hospitalization influences the readmission risk of patients with delirium; (ii) the readmission risk is affected by various risk factors; and (iii) the healthcare cost differs between groups within 28 days of the first ED visit. Methods: Using the National Health Insurance Research Database, the data of 2,780 subjects presenting with delirium at an ED visit from 2000 to 2008 were examined. The readmission risks of the groups of patients (i.e., patients who were and were not admitted within 24 hours of an ED visit) within 28 days were compared, and the effects of the severities of different comorbidities (using Charlson’s comorbidity index, CCI), age, gender, diagnosis and differences in medical healthcare cost were analyzed. Results: Patients without immediate hospitalization had a higher risk of readmission within 3, 7, 14, or 28 days of discharge from the ED, especially subjects with more severe comorbidities (CCI≥3) or older patients (≥65 years). Subjects with more severe comorbidities or older subjects who were not admitted immediately also incurred a greater healthcare cost for re-hospitalization within the 28-day follow-up period. Conclusion: Patients with delirium with a higher CCI or of a greater age should be carefully considered for immediate hospitalization from ED for further examination in order to reduce the risk of re-hospitalization and cost of healthcare.

      • Determination of Geographical Origin of Tea using Near Infrared Spectroscopy

        ( Tsung-hsin Wu ),( I-chun Tung ),( Han-chun Hsu ),( Suming Chen ),( Chao-yin Tsai ),( Yung-kun Chuang ) 한국농업기계학회 2018 한국농업기계학회 학술발표논문집 Vol.23 No.1

        Tea is one of the most consumed beverages in the world. Every tea has its own aroma and flavor characteristics due to geographic differences in environment and climate. Oolong tea, a very popular kind of partial fermentation tea in Taiwan, is generally more expensive and enjoyable. While tea leaves produced from the other countries are generally cheaper and not easily discernible, many stores mainly use cheaper tea leaves which are imported from Vietnam, India, and China, where adulteration and counterfeit may happen in tea market. To date, determination of geographical origin of tea is mainly depends on sensory evaluation, which lacks of objectivity in science. Therefore, determination of geographical origin of tea is necessary. Near infrared spectroscopy (NIRS) is a rapid and nondestructive analytical method which has become a powerful tool by associating with chemometrics for food industry. In the present study, the quality-related constituents of tea, including total polyphenols, total free amino acids, pH value, and water were evaluated by NIRS with modified partial least square regression (MPLSR). The calibration models built by MPLSR showed satisfied results. For total polyphenols, the results of the calibration model were Rc = 0.983 and SEC = 4.268 mg/g. The results of free amino acids were R<sub>c</sub> = 0.913 and SEC = 3.368 mg/g. The results of pH value were R<sub>c</sub> = 0.972 and SEC = 0.105. The results of moisture were R<sub>c</sub> = 0.969 and SEC = 0.470 %. To identify the geographical origin of tea, the qualitative method of support vector machine (SVM) will also be applied in this study. The SVM result of identify the partially fermented tea origins was achieved and the accuracies for calibration and prediction sets were both 100%. In summary, NIRS associated with chemometrics provides a useful tool for internal quality inspection and origin identification of tea.

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