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Hossein GhorbaniMenghari,Hamed Ziaei Poor,Mahmoud Farzin,Ricardo J. Alves De Sousa 국제구조공학회 2014 Structural Engineering and Mechanics, An Int'l Jou Vol.50 No.4
In hydroforming, the general technique employed to overcome the problem of die corner filling consist in increasing the maximum fluid pressure during the forming process. This technique, in other hand, leads to other difficulties such as thinning and rupturing of the final work piece. In this paper, a new technique has been suggested in order to produce a part with complete filled corners. In this approach, two moveable bushes have been used. So, the workpiece moves driven by both bushes simultaneously. In the first stage, system pressure increases until a maximum of 15 MPa, providing aninitial tube bulge. The results showed that the pressure in this stage have to be limited to 17 MPa to avoid fracture. In a second stage, bushes are moved keeping the constant initial pressure. The punches act simultaneously at the die extremities. Results show that the friction between part and die decreases during the forming process significantly. Also, by using this technique it is possible to produce a part with reasonable uniform thickness distribution. Other outcomes of applying this method are the lower pressures required to manufacture a workpiece with complete filled corners with no wrinkling.
GhorbaniMenghari, Hossein,Poor, Hamed Ziaei,Farzin, Mahmoud,Alves De Sousa, Ricardo J. Techno-Press 2014 Structural Engineering and Mechanics, An Int'l Jou Vol.50 No.4
In hydroforming, the general technique employed to overcome the problem of die corner filling consist in increasing the maximum fluid pressure during the forming process. This technique, in other hand, leads to other difficulties such as thinning and rupturing of the final work piece. In this paper, a new technique has been suggested in order to produce a part with complete filled corners. In this approach, two moveable bushes have been used. So, the workpiece moves driven by both bushes simultaneously. In the first stage, system pressure increases until a maximum of 15 MPa, providing aninitial tube bulge. The results showed that the pressure in this stage have to be limited to 17 MPa to avoid fracture. In a second stage, bushes are moved keeping the constant initial pressure. The punches act simultaneously at the die extremities. Results show that the friction between part and die decreases during the forming process significantly. Also, by using this technique it is possible to produce a part with reasonable uniform thickness distribution. Other outcomes of applying this method are the lower pressures required to manufacture a workpiece with complete filled corners with no wrinkling.
Hamid Aboutaleb Kadkhodaeian,Taki Tiraihi,Hamid Ahmadieh,Hossein Ziaei,Narsis Daftarian,Taher Taheri 한국조직공학과 재생의학회 2019 조직공학과 재생의학 Vol.16 No.3
BACKGROUND: Retinal degeneration causes blindness, and cell replacement is a potential therapy. The purpose of this study is to formation of pigmented neurospheres in a simple medium, low-cost, high-performance manner over a short period of time while expressing markers of RPE cells and the activation of specific genes of the pigment cells. Also, these neurospheres have the ability to produce a monolayer of retinal pigment epithelium-like cells (RPELC) with the ability of photoreceptor outer segment phagocytosis. METHODS: BMSC were isolated from pigmented hooded male rats and were immunoreactive to BMSC markers, then converted into neurospheres, differentiated into pigmented spheres (PS), and characterized using Retinal pigment epithelium-specific 65 kDa protein (RPE65), Retinaldehyde-binding protein 1 (CRALBP) and orthodenticle homeobox 2 (OTX2) markers by immunocytochemistry, RT-PCR and RT-qPCR. The PS were harvested into RPELC. The functionality of RPELC was evaluated by phagocytosis of fluorescein-labeled photoreceptor outer segment. RESULTS: The BMSC immunophenotype was confirmed by immunostained for fibronectin, CD90, CD166 and CD44. These cells differentiated into osteogenic and lipogenic cells. The generated neurospheres were immunoreactive to nestin and stemness genes. The PS after 7–14 days were positive for RPE65 (92.76–100%), CRALBP (95.21–100%) and OTX2 (94.88–100%), and after 30 days RT-PCR, qPCR revealed increasing in gene expression. The PS formed a single layer of RPELC after cultivation and phagocyte photoreceptor outer segments. CONCLUSION: Bone marrow stromal stem cells can differentiate into functional retinal pigmented epithelium cells in a simple, low-cost, high-performancemanner over a short period of time. These cells due to expressing theRPELCgenes andmarkers can be used in cell replacement therapy for degenerative diseases including age-relatedmacular degeneration as well as retinitis pigmentosa.
Other Side of Breast Cancer: Factors Associated with Caregiver Burden
Maryam Vahidi,Nader Mahdavi,Elnaz Asghari,Hossein Ebrahimi,Jamal Eivazi Ziaei,Mina Hosseinzadeh,Hossein Namdar Areshtanab,Iraj Asvadi Kermani 한국간호과학회 2016 Asian Nursing Research Vol.10 No.3
Purpose: This study aimed to determine factors associated with caregiver burden among primary caregivers of women with breast cancer in Iran. Methods: This was a descriptive correlation study conducted in 2012 on 150 main caregivers of patients with breast cancer who came to the oncology clinic of Shahid Ghazi hospital in Tabriz, Iran. A questionnaire which included caregiving-related factors and the Zarit Burden Interview was used for data collection after its validity and reliability were determined. Data was analyzed using SPSS 13.0 software with descriptive and analytic statistics. The association between significant variables and the dependent variable with an observation of the effects of other variables was assessed using the multiple linear regression model. Results: The mean age of caregivers was 39.60 ± 13.80 years old, and 77 (51.3%) of them were men. The mean score of the Zarit Burden Interview was 30.55 ± 19.18. In the regression model, the mean score of activities of daily living, level of education, gender, and financial status were identified as the determining factors of the burden of caregivers. Conclusions: Primary caregivers need to be financially supported by the relevant organizations. Care skills training and providing palliative care seem helpful in reducing the pain and the burden of family caregivers for patients with breast cancer.