Ginsenoside Rb1 ameliorates cisplatin-induced learning and memory impairments

Chen Chen,Haifeng Zhang,Hongliang Xu,Yake Zheng,Tianwen Wu 고려인삼학회 2019 Journal of Ginseng Research Vol.43 No.4

Background: Ginsenoside Rb1 (Rb1), a dominant component from the extract of Panax ginseng root,exhibits neuroprotective functions in many neurological diseases. This study was intended to investigatewhether Rb1 can attenuate cisplatin-induced memory impairments and explore the potentialmechanisms. Methods: Cisplatin was injected intraperitoneally with a dose of 5 mg/kg/wk, and Rb1 was administeredin drinking water at the dose of 2 mg/kg/d to rats for 5 consecutive wk. The novel objects recognition taskand Morris water maze were used to detect the memory of rats. Nissl staining was used to examine theneuron numbers in the hippocampus. The activities of superoxide dismutase, glutathione peroxidase,cholineacetyltransferase, acetylcholinesterase, and the levels of malondialdehyde, reactive oxygen species,acetylcholine, tumor necrosis factor-a, interleukin-1b, and interleukin-10 were measured by ELISAto assay the oxidative stress, cholinergic function, and neuroinflammation in the hippocampus. Results: Rb1 administration effectively ameliorates the memory impairments caused by cisplatin in bothnovel objects recognition task and Morris water maze task. Rb1 also attenuates the neuronal loss inducedby cisplatin in the different regions (CA1, CA3, and dentate gyrus) of the hippocampus. Meanwhile, Rb1 isable to rescue the cholinergic neuron function, inhibit the oxidative stress and neuroinflammation incisplatin-induced rat brain. Conclusion: Rb1 rescues the cisplatin-induced memory impairment via restoring the neuronal loss byreducing oxidative stress and neuroinflammation and recovering the cholinergic neuron functions.

Shear bond strength of zirconia to resin: The effects of specimen preparation and loading procedure

Bingzhuo Chen,Lu Yang,Zhicen Lu,Hongliang Meng,Xinyi Wu,Chen Chen,Haifeng Xie 대한치과보철학회 2019 The Journal of Advanced Prosthodontics Vol.11 No.6

PURPOSE. Shear bond strength (SBS) test is the most commonly used method for evaluating resin bond strength of zirconia, but SBS results vary among different studies even when evaluating the same bonding strategy. The purpose of this study was to promote standardization of the SBS test in evaluating zirconia ceramic bonding and to investigate factors that may affect the SBS value of a zirconia/resin cement/composite resin bonding specimen. MATERIALS AND METHODS. The zirconia/resin cement/composite resin bonding specimens were used to simulate loading with a shear force by the three-dimensional finite element (3D FE) modeling, in which stress distribution under uniform/non-uniform load, and different resin cement thickness and different elastic modulus of resin composite were analyzed. In vitro SBS test was also performed to validate the results of 3D FE analysis. RESULTS. The loading flat width was an important affecting factor. 3D FE analysis also showed that differences in resin cement layer thickness and resin composite would lead to the variations of stress accumulation area. The SBS test result showed that the load for preparing a SBS specimen is negatively correlated with the resin cement thickness and positively correlated with SBS values. CONCLUSION. When preparing a SBS specimen for evaluating bond performance, the load flat width, the load applied during cementation, and the different composite resins used affect the SBS results and therefore should be standardized.

Tri-metal-based hollow nanorods-on-microrod arrays as efficient water splitting electrocatalysts

Jianzhi Wang,Hongliang Yu,Xianming Wang,Chen Chen,Shuaijie Li,Ning Cai,Weimin Chen,Yanan Xue,Hui Li,Faquan Yu 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.105 No.-

Constructing ordered hierarchical porous electrocatalysts while maintaining their high efficiency and stabilityfor oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) is highly desirable butstill remains challenging. Herein, hierarchical tri-metal-based hollow nano/micro rod-on-rod array structures,including hydroxides and phosphates, are vertically grown on Cu foam by the cation-exchangingand anion exchanging approaches. Such ordered porous architecture, providing multi metal center, regularinterconnection of macropore channel, large electrochemical surface area, small charge-transferresistance, efficient mass transport and electron transfer for overall water splitting in alkaline media. These obtained hydroxide OER catalysts (CoMn LDH@Cu(OH)2/CF) and phosphide HER catalysts(CoMnP@Cu3P/CF) exhibited low onset potential, low Tafel slope, and prominent durability. Such excellentperformance, ordered porous structure and simple preparation methods indicate that this study providesa new strategy for assembling promising catalysts for water splitting and other applications.

A back-drivable linear force actuator for adaptive grasping

Hongliang Hua,Zhenqiang Liao,Xiaofeng Wu,YongJiang Chen,Chun Feng 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.8

Robotic gripper is a fundamental component of robot to achieve grasping operations. Grasping force control is an essential requirement for the robotic gripper to achieve adaptive grasping and safety. This paper presents a linear series elastic actuator (LSEA) for robotic grasping applications. The proposed LSEA is characterized as miniature, back-drivable, compact and modular, which could effectively reduce the integrating difficulty of the robotic gripper system. A novel blocking control strategy for actuating force control is proposed to enhance the control stability of the LSEA. Model identification experiments are performed to identify the control models for the actuating force control and self-sensing. Actuating force control experiments are then performed to verify the effectiveness of the established control models. Experimental results reveal that the LSEA could achieve stable actuating force control when interacting with the objects with variable stiffness. An underactuated finger mechanism is utilized to experimentally verify the effectiveness of the proposed LSEA in robotic grasping applications. Results reveal that the grasping adaptability and strength could be controlled by the LSEA in a feedforward approach without the requirement of fingertip force sensor.

Ultrasonic Synthesis of Au/AgCl Hybrid Cubes and Their Evolution Under Electron Beam Irradiation

Hongliang Cao,Xiaoli Miao,Mengqin Zhu,Chang Li,Feifei Wei,Xin Chen 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2015 NANO Vol.10 No.6

The utilization of ultrasound offers a facile tool for the synthesis of Au/AgCl hybrid particles. We have obtained the architectures of Au nanoparticles on AgCl sub-micrometer cubes by simply ultrasonic irradiating their precursors in ethylene glycol (EG). The formation process of Au/AgCl hybrid particles in the reaction solution has been studied based on the optical absorption spectra and the scanning electron microscope (SEM) images of the particles obtained at different ultrasonic irradiation stages. The dynamic changes of Au/AgCl hybrid particles under electron beam irradiation have been investigated in both SEM and in situ liquid cell transmission electron microscope (TEM). Hollow Au/AgCl hybrid particle structures have been obtained under the electron beam irradiation in liquid, with the cuboid contour shape preserved.

A 1-Dof bidirectional graspable finger mechanism for robotic gripper

Hongliang Hua,Zhenqiang Liao,YongJiang Chen 대한기계학회 2020 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.34 No.11

The grasping flexibility and control simplicity are essential requirements for robotic gripper. Take above requirements into consideration, we present a 1-Dof four-bar finger mechanism which could produce bidirectional symmetric grasping motion and exhibit a bidirectional grasping ability like soft gripper. The finger mechanism could not only to grasp the object’s outer surface from outside to inside, but also able to extend itself from inside to outside and “grasp” the inner surface of the object. The effects of structural parameters of the finger mechanism on kinematic behavior have been investigated by kinematic modeling and simulations, and some design suggestions are given. A gripper prototype composed of two finger mechanisms is developed, and the effectiveness of the finger mechanism in bidirectional grasping is validated by grasping experiments. Results reveal that due to the symmetrical movement of the two finger mechanisms, they could apply a pair of symmetrical grasping force to the object and keep the stability of the grasping.

Dual-stream Co-enhanced Network for Unsupervised Video Object Segmentation

Hongliang Zhu,Hui Yin,Yanting Liu,Ning Chen 한국인터넷정보학회 2024 KSII Transactions on Internet and Information Syst Vol.18 No.4

Unsupervised Video Object Segmentation (UVOS) is a highly challenging problem in computer vision as the annotation of the target object in the testing video is unknown at all. The main difficulty is to effectively handle the complicated and changeable motion state of the target object and the confusion of similar background objects in video sequence. In this paper, we propose a novel deep Dual-stream Co-enhanced Network (DC-Net) for UVOS via bidirectional motion cues refinement and multi-level feature aggregation, which can fully take advantage of motion cues and effectively integrate different level features to produce high-quality segmentation mask. DC-Net is a dual-stream architecture where the two streams are co-enhanced by each other. One is a motion stream with a Motion-cues Refine Module (MRM), which learns from bidirectional optical flow images and produces fine-grained and complete distinctive motion saliency map, and the other is an appearance stream with a Multi-level Feature Aggregation Module (MFAM) and a Context Attention Module (CAM) which are designed to integrate the different level features effectively. Specifically, the motion saliency map obtained by the motion stream is fused with each stage of the decoder in the appearance stream to improve the segmentation, and in turn the segmentation loss in the appearance stream feeds back into the motion stream to enhance the motion refinement. Experimental results on three datasets (Davis2016, VideoSD, SegTrack-v2) demonstrate that DC-Net has achieved comparable results with some state-of-the-art methods.

EXISTENCE AND MULTIPLICITY OF SOLUTIONS FOR NONLINEAR SCHRÖDINGER-KIRCHHOFF-TYPE EQUATIONS

CHEN, HAIBO,LIU, HONGLIANG,XU, LIPING Korean Mathematical Society 2016 대한수학회지 Vol.53 No.1

In this paper, we consider the following $Schr{\ddot{o}}dinger$-Kirchhoff-type equations $\[a+b\({\int}_{{\mathbb{R}}^N}({\mid}{\nabla}u{\mid}^2+V(x){\mid}u{\mid}^2)dx\)\][-{\Delta}u+V(x)u]=f(x,u)$, in ${\mathbb{R}}^N$. Under certain assumptions on V and f, some new criteria on the existence and multiplicity of nontrivial solutions are established by the Morse theory with local linking and the genus properties in critical point theory. Some results from the previously literature are significantly extended and complemented.

Evaluation of Solar Temperature Field under Different Wind Speeds for Shanghai 65 m Radio Telescope

Hongliang Qian,Deshen Chen,Feng Fan,Ye Liu,Shi-zhao Shen 한국강구조학회 2016 International Journal of Steel Structures Vol.16 No.2

The Shanghai 65 m radio telescope is currently the largest full range rotatable radio telescope in Asia. Gravity, wind and temperature are the three main factors which may have a bad effect on the reflector’s surface precision. To study the effect of the thermal deformation caused by daily non-uniform temperature fields on the surface precision of the main reflector, both the temperature field and its effect were studied in detail for two typical days (January 15th and July 15th). The method to simulate temperature fields was studied initially, considering heat conduction, solar radiation, shadowing, air convection, sky radiation and ground radiation. Then, an integral parametric thermal finite element model (FEM) of the telescope was established using the ANSYS thermal analysis module. Finally, the effect of non-uniform temperature fields on the surface precision of the main reflector was estimated in terms of the Root Mean Square (RMS) deformation based on temperature transient analysis. The proposed methods and conclusions drawn can provide valuable information for thermal design, thermal monitoring and thermal control of the Shanghai 65 m radio telescope and other similar giant antenna structures.

A Prospective Study of the Surgical Outcome of Simple Uvulopalatopharyngoplasty (UPPP), UPPP Combined With Genioglossus Advancement or Tongue Base Advancement for Obstructive Sleep Apnea Hypopnea Syndrome Patients With Multilevel Obstruction

Shicai Chen,Song Shi,Yanghui Xia,Minhui Zhu,Caiyun Zhang,Siwen Xia,Hongliang Zheng 대한이비인후과학회 2015 Clinical and Experimental Otorhinolaryngology Vol.8 No.2

Objectives. To investigate the surgical outcomes of different uvulopalatopharyngoplasty (UPPP). Methods. All subjects underwent overnight polysomnography and were evaluated using the Epworth sleepiness scale (ESS), the Quebec sleep questionnaire and the snoring scale at the baseline and 3 and 12 months following operation. The primary endpoint was the overall effective rate representing the sum of the surgical success rate and effective rate. Results. The overall effective rate at 12 months post surgery was 55.6% for simple UPPP, 95.8% for UPPP+GA, and 92.3% for UPPP+TBA. The surgical success rate at 3 and 12 months postoperation for UPPP+GA or UPPP+TBA was significantly higher than simple UPPP (P<0.05). Marked improvement was observed in all patients in the snoring scale score and the ESS score 3 and 12 months following surgery compared to the baseline (P<0.05 in all). Conclusion. UPPP, UPPP+GA, and UPPP+TBA are all effective in improving the surgical outcome of obstructive sleep apnea hypopnea syndrome (OSAHS) patients with multilevel obstruction. UPPP+TBA appears to be the most effective in treating OSAHS patients.