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      • KCI등재후보

        A new proof of generalized Tychonoff theorem in $(L,M)$-fuzzy topological spaces

        Hu Zhao,Hong-ying Zhang 원광대학교 기초자연과학연구소 2018 ANNALS OF FUZZY MATHEMATICS AND INFORMATICS Vol.16 No.2

        In this paper, using the structures of $(L,M)$-fuzzy topological product spaces which were introduced by Hu Zhao, Sheng-Gang Li and Gui-Xiu Chen, we directly give another version on the proof of generalized Tychonoff theorem in $(L,M)$-fuzzy topological spaces which was introduced by Hong-Yan Li and Fu-Gui Shi

      • Electrochemical Reductive Removal of Nitrate from Water and Wastewater

        Hu, Hong-Ying,Fujie, Koichi,Goto, Naohiro 영남대학교 환경문제연구소 2000 環境硏究 Vol.20 No.1

        The purpose of this study is to evaluate the possibility of some zero-valent metals such as aluminum, zinc and iron as reductants to convert nitrate in water into nitrogen gas under acidic conditions. Based on the results of comparative studies on the reduction of nitrate by metallic iron, zinc and aluminum, respectively, metallic iron was selected as a reductant of nitrate in this study. The effect of pH on the reduction rate and products of nitrate was investigated with a fixed dosage of iron powder (size: 80 mesh) of 12 mol-Fe/mol-N under acidic (pH=2-5) and aerobic conditions. The reduction of nitrate by metallic iron was a pseudo-first order reaction under our experimental conditions. The reduction rate of nitrate was increased with decreasing pH of the reaction solution, arid the pseudo-first order reaction rate constants were 0.49, 0.40, 0.75 and 0.01 1/h at pH =2, 3, 4 and 5, respectively. The reduction products of nitrate were ammonia and nitrogen, and their yields were strongly affected by pH. The yields of nitrogen was 30%, 31% and 45% at pH=3, 4 and 5, respectively, but no formation of nitrogen was found at pH=2. It was also demonstrated that the indirect reduction of nitrate by hydrogen generated from the reaction between proton and metallic iron was a major mechanism for the reduction of nitrate under the experimental conditions.

      • KCI등재

        Identification of peroxiredoxin II and its related molecules as potential biomarkers of dermal mesenchymal stem cell homing using network analysis

        Han Ying-Hao,Mao Ying-Ying,Feng Yao-Yuan,Xiang Hong-Yi,Sun Hu-Nan,Jin Mei-Hua,Kwon Taeho 한국응용생명화학회 2022 Applied Biological Chemistry (Appl Biol Chem) Vol.65 No.3

        In this study, we performed RNA sequencing of Prx II +/+ and Prx II −/− dermal mesenchymal stem cells (DMSCs) to identify differentially expressed genes (DEGs). To explore the role of Prx II in DMSCs, we performed Gene Ontology analysis of the DEGs. The results showed that the DEGs were mainly involved in the biological processes of cell migration, intercellular adhesion, and coordination of the regulation of stem cell homing. Through the construction of protein–protein interaction network, four hub genes Cd274 , Ccl5 , Il1b , and Stat1 involved in cell adhesion and cell homing were screened. Quantitative reverse transcription PCR analysis showed that Cd274 , Ccl5 , Il1b , and Stat1 were down regulated in Prx II −/− DMSCs. miRwalk and Starbase databases were further used to screen the upstream molecules miRNA and lncRNA regulating hub gene. Prx II was found to be involved in the regulation of stem cell homing via the Tctn2/miR-351/Stat1/Il1b axis. Thus, we demonstrated that Prx II is a key molecule in the regulation of the homing ability of DMSCs. Our results provide a theoretical foundation for improving the homing ability of DMSCs by targeting Prx II.

      • KCI등재

        Flexible (Ba0.7Sr0.3)TiO3 thick films with mechanically stable dielectric tunability

        Hong Jung Ehy,Hu Ying Chieh,Ko Young Joon,Jung Jong Hoon,Woo Do Hyeon,Koo Chang Young 한국물리학회 2022 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.81 No.7

        We report the fabrication and electrical properties of fexible (Ba0.7Sr0.3)TiO3 (BST) thick flms. Fluorophlogopite mica substrates enable the growth of high-quality BST flms because of their high melting temperature and fexible functionality for both concave and convex curvatures. The BST flms are fat with quite small roughness of 4.2 nm, and dense without any pores or cracks. The BST flms show a small remanent polarization of 3.8 μC/cm2 , a high dielectric constant of 1390 at 10 kHz, a small leakage current density of 2.2× 10–3 A/cm2 at 200 kV/cm, and a dielectric tunability of 45%. The dielectric tunability is slightly higher for concave bending and is robust with respect to successive mechanical bending up to 10,000 cycles.

      • SCIESCOPUSKCI등재

        Adenovirus vector-mediated FAM176A overexpression induces cell death in human H1299 non-small cell lung cancer cells

        ( Hong Xie ),( Jia Hu ),( Huan Pan ),( Ya Xin Lou ),( Ping Lv ),( Ying Yu Chen ) 생화학분자생물학회 2014 BMB Reports Vol.47 No.2

        FAM176A (family with sequence similarity 176 member A) is a novel molecule related to programmed cell death. A decreased expression of FAM176A has been found in several types of human tumors in including lung cancers. In the present study, we investigated the biological activities of FAM176A on the human non-small cell lung cancer cell line H1299 cells. We constructed a recombinant adenovirus 5-FAM176A vector (Ad5-FAM176A) and evaluated the expression and anti-tumor activities in vitro. Cell viability analysis revealed that the adenovirus-mediated increase of FAM176A inhibited the growth of the tumor cells in a dose- and time-dependent manner. This inhibitory effect was mediated by both autophagy and apoptosis that involved caspase activation. In addition, cell cycle analysis suggested that Ad5-FAM176A could induce cell cycle arrest at the G2/M phase, all of which suggested that adenovirus-mediated FAM176A gene transfer might present a new therapeutic approach for lung cancer treatment. [BMB Reports 2014; 47(2): 104-109]

      • KCI우수등재

        Effects of dietary energy and crude protein levels on growth performance, blood profiles, and carcass traits in growing-finishing pigs

        ( Lin Hu Fang ),( Ying Hai Jin ),( Sung Ho Do ),( Jin Su Hong ),( Byung Ock Kim ),( Tae Hee Han ),( Yoo Yong Kim ) 한국축산학회 2019 한국축산학회지 Vol.61 No.4

        This experiment was conducted to evaluate the effect of dietary energy and crude protein (CP) levels on growth performance, blood profiles, and carcass traits in growing-finishing pigs. A total of 180 crossbred pigs ([Yorkshire × Landrace] × Duroc) with an average body weight of 30.96 ± 3.068 kg were used for a 12-week feeding trial. Experimental pigs were allotted to a 2 × 3 factorial arrangement using a randomized complete block (RCB) design. The first factor was two levels of dietary metabolizable energy (ME) density (13.40 MJ/kg or 13.82 MJ/kg), and the second factor was three dietary CP levels based on subdivision of growing-finishing phases (high: 18%/16.3%/16.3%/13.2% middle: 17%/15.3%/15.3%/12.2% and low: 16%/14.3%/14.3%/11.2%). Average daily gain (ADG) and gain-feed ratio (G:F ratio) decreased as dietary CP level was decreased linearly (linear, p < 0.05; p < 0.05, respectively) in the early growing period, and G:F ration also decreased as dietary CP level was decreased linearly (linearly, p < 0.05) over the whole growing phase. Over the entire experimental period, G:F ratio decreased as dietary ME level decreased (p = 0.01). Blood urea nitrogen (BUN) concentration was increased as dietary energy level decreased in growing period (p < 0.01). During finishing period, total protein concentration was decreased by lower dietary energy level (p < 0.05). In this study, there were no significant differences in proximate factors, physiochemical properties, muscle TBARS assay results, pH changes, or color of pork by dietary treatments. However, saturated fatty acid (SFA) increased (p < 0.01) and polyunsaturated fatty acid (PUFA) decreased (p < 0.05) when ME was decreased by 0.42 MJ/kg in growing-finishing pig diets. In addition, monounsaturated fatty acid (MUFA) tended to increase when CP level was decreased in growing-finishing pig diets (p = 0.06). A growing-finishing diet of 13.82 MJ/kg diet of ME with the high CP level can improve growth performance and show better fatty acids composition of pork.

      • KCI우수등재

        Effects of dietary energy and protein levels on reproductive performance in gestating sows and growth of their progeny

        ( Lin Hu Fang ),( Ying Hai Jin ),( Jae Hark Jeong ),( Jin Su Hong ),( Woo Lim Chung ),( Yoo Yong Kim ) 한국축산학회(구 한국동물자원과학회) 2019 한국축산학회지 Vol.61 No.3

        This experiment was conducted to evaluate the effect of dietary energy and crude protein (CP) levels on reproductive performance, litter performance, milk quality, and blood profiles in gestating sows. A total of 59 multiparous sows (Yorkshire × Landrace) with similar body weights (BW), backfat thickness (BF), and parity were assigned to one of six treatments with 9 or 10 sows per treatment using a 2 × 3 factorial arrangement and completely randomized design. The first factor was two levels of dietary metabolizable energy (ME) density (13.40 or 13.82 MJ/kg) and the second factor was three dietary protein levels based from 35 day in gestating phases (10.5%, 12%, and 13.5%). Backfat thickness change in lactating sows decreased linearly as CP level increased (p = 0.03). Increased energy level in the gestating sow diet tended to increase the total number of piglets born (p = 0.07), but piglet weight decreased (p = 0.02). Dietary CP level had a negative effect on colostrum quality. Casein, protein, total solid, and solids-not-fat concentrations decreased linearly and lactose level increased linearly as CP level in the gestating sow diet increased (casein%: p = 0.03; protein%: p = 0.04; lactose%: p = 0.06; total solids: p = 0.03; solid-not-fat: p = 0.03, respectively). However, improving ME by 0.42 MJ/kg had no significant effect on the chemical composition of sow colostrum. There were no significant differences in blood glucose concentration in gestating sows when sows were fed different levels of energy during gestation, but blood glucose increased at 21 day of lactation when energy increased by 0.42 MJ/kg (p = 0.04). Blood urea nitrogen concentration increased linearly when dietary CP levels increased at 110 day in gestation, 24-hours postpartum, and 21 days of lactation (linear, p < 0.05, p < 0.05, and p < 0.05, respectively), and it also increased when dietary energy increased at 110 days of gestation and 24-hours postpartum (p < 0.01, and p < 0.01, respectively). A gestating sow diet containing 13.82 MJ/kg ME and 10.5% CP can improve reproductive performance, litter performance, and colostrum quality.

      • Estrogen Receptor Alpha Gene Polymorphisms and Breast Cancer Risk: a Case-control Study with Meta-analysis Combined

        Lu, Hong,Chen, Dong,Hu, Li-Ping,Zhou, Lian-Lian,Xu, Hui-Ying,Bai, Yong-Heng,Lin, Xiang-Yang Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11

        Molecular epidemiological studies have shown that gene polymorphisms of estrogen receptor alpha gene (ESR-${\alpha}$) are associated with breast cancer risk. However, previous results from many molecular studies have been inconsistent. In this study, we examined two polymorphisms (PvuII and XbaI RFLPs) of the ESR-${\alpha}$ gene in 542 breast cancer cases and 1,016 controls from China. Associations between the polymorphisms and breast cancer risk were calculated with an unconditional logistic regression model. Linkage disequilibrium and haplotypes were analyzed with the SHEsis software. In addition, we also performed a systematic meta-analysis of 24 published studies evaluating the association. No significant associations were found between the PvuII polymorphism and breast cancer risk. However, a significantly decreased risk of breast cancer was observed among carriers of the XbaI 'G' allele (age-adjusted OR = 0.80; 95% CI = 0.66- 0.97) compared with carriers of the 'A' allele. Haplotype analysis showed significantly decreased cancer risk for carriers of the 'CG' haplotype (OR = 0.79; 95% CI = 0.66- 0.96). In the systematic meta-analysis, the XbaI 'G' allele was associated with an overall significantly decreased risk of breast cancer (OR = 0.90, 95% CI = 0.82- 1.00). In addition, the PvuII 'C' allele showed a 0.96- fold decreased disease risk (95% CI = 0.92- 0.99). In subgroup analysis, an association between the PvuII 'C' and XbaI 'G' alleles and breast cancer risk was significant in Asians ('C' vs. 'T': OR = 0.93, 95% CI = 0.85- 1.00; 'G' vs. 'A': OR = 0.82, 95% CI = 0.68- 0.98), but not in Euro-Americans. Thus, our results provide evidence that ESR-${\alpha}$ polymorphisms are associated with susceptibility to breast cancer. These associations may largely depend on population characteristics and geographic location.

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