白鼠 肝障碍에 對한 補肝湯 瀉肝湯의 效果에 關한 實驗的 硏究

洪茂昌,李學仁,金完熙 慶熙大學校韓醫科大學韓醫學硏究所 1983 慶熙韓醫大論文集 Vol.6 No.-

Adiponectin Attenuates the Inflammation in Atopic Dermatitis-Like Reconstructed Human Epidermis

( Hee-seok Seo ),( Ki Hyun Seong ),( Chang-deok Kim ),( Seong Jun Seo ),( Byung Cheol Park ),( Myung Hwa Kim ),( Seung-phil Hong ) 대한피부과학회 2019 Annals of Dermatology Vol.31 No.2

Background: Atopic dermatitis (AD) is a chronic disorder, with a vicious cycle of repetitive inflammation and deterioration of the epidermal barrier function. Adiponectin, an adipokine, has anti-inflammatory effects on various metabolic and inflammatory disorders. Recently, its level was found to be reduced in serum and tissue samples from AD patients. Objective: We aimed to investigate the effects of adiponectin on epidermal inflammation and barrier structures in AD skin. Methods: A three-dimensional in vitro epidermal equivalent model mimicking AD was obtained by adding an inflammatory substance cocktail to normal human epidermal equivalents (HEEs). The expression of epidermal differentiation markers, primary inflammatory mediators, and lipid biosynthetic enzymes was compared between adiponectintreated AD-HEEs, untreated control AD-HEEs, and normal HEEs. Results: Adiponectin co-treatment 1) inhibited the increase in mRNA expression of major inflammatory mediators (carbonic anhydrase II, neuron-specific NEL-like protein 2, thymic stromal lymphopoietin, interleukin-8, tumor necrosis factor-alpha, and human beta-defensin-2) from keratinocytes in AD-inflammatory HEEs, 2) enhanced the expression of lipid biosynthetic enzymes (fatty acid synthase, HMG CoA reductase, and serine-palmitoyl transferase), and 3) promoted the expression of differentiation factors, especially filaggrin. We also found that the expression of adiponectin receptor-1 and -2 decreased in the epidermis of chronic AD lesion. Conclusion: Activation of the adiponectin pathway is expected to enhance epidermal differentiation and barrier function as well as attenuate inflammatory response to AD as a therapeutic approach. (Ann Dermatol 31(2) 186∼195, 2019)

日中時間 變動에 따른 白鼠의 生理變化에 對한 補肝湯 瀉肝湯의 影響에 關한 硏究

金成圭,洪茂昌,金完熙 慶熙大學校韓醫科大學韓醫學硏究所 1986 慶熙韓醫大論文集 Vol.9 No.-

조기 천장골염의 자기공명영상 소견

김태환 ( Tae Hwan Kim ),전재범 ( Jae Bum Jun ),심승철 ( Seung Cheol Shim ),장대국 ( Dae Kook Chang ),고회관 ( Hee Kwan Koh ),정성수 ( Sung Soo Jung ),이인홍 ( In Hong Lee ),배상철 ( Sang Cheol Bae ),유대현 ( Dae Hyun Yoo ),전의용 대한류마티스학회 1998 대한류마티스학회지 Vol.5 No.2

목적: 천장골염의 유무가 척추 관절염의 진단에 중요한데 단순 골반 검사에서 변화가 없는 환자를 대상으로 MRI를 이용하여 천장골염의 조기변화 소견 및 MRI방법에 따른 장점을 비교하고자 하였다. 대상 및 방법: 단순 골반 검사에서 천장골염 유무가 확실하게 구분되지 않은 혈청 음성 척추 관절염 환자 26명을 대상으로 MRI를 시행하고 염증의 주침범위치를 천측과 장측, 관절의 상하로 구분하고, MRI방법에 따른 변화를 비교하였다. 결과: 모든 예에서 조영 증강되는 판누스를 관찰할 수 있었고, Grade I 이하에서는 장골측과 관절하부, 인대성 관절보다 활막성 관절을 더 많이 침범하였다. Grade II 이상에서도 장골측과 관절 하부에 더 많았으나 인대성 관절을 Grade I이하에서보다 더 많이 침범하였다. 관절 주변 지방 침착역시 장골측과 관절 하부에 더 주로 침범하였고 Grade II 이상에서 약간 더 많았다. 관절 주변 골염은 Grade 0에서는 없었고, Grade I에서는 주로 장골측과 관절 하부에서 92%가 양성이었고, Grade II에서는 93%에서, Grade III에서는 64%에서 양성으로, 장골측을 주로 침범하였으나 관절 상하부의 구분은 없었다. 인대성 천장골 관절은 Grade I 이하에서 38%, II 이상에서는 94%에서 침범하였다. 관절 주변 골염과 지방 침착, 그리고 판누스의 관찰에는 MPGR보다 스핀에코 영상이 좋았고, 관절면의 불규칙성 또는 관절강의 확대와 관절 강직여부의 관찰에는 스핀에코에 비해 MPGR 영상이 좋았고, 연골하 경화는 비슷하였다. 천장골염의 정도와 ESR, CRP와의 연관성은 없었다. 걸론: 천장골 관절에서 염증의 시작은 주로 장골 측과 관절의 하부에서 먼저 시작되고, 관절이 진행될수록 장골측에서 천골측까지로 범위가 확대 되었다. MRI방법에 의한 차이로 초기단계에는 스핀에코 영상이 관절염을 확인하는데 도움이 되고 관절면이 불규칙하게 되고 경화가 되어 병이 진행된 상태에서는 MPGR영상이 진단에 더 도움이 되었다. 염증성 배부 동통이 있는 경우 단순 골반 검사에서 이상이 없는 환자인 경우에도 MRI 검사를 시행하여 천장골염의 유무를 확인하는 것이 중요하다. Objective: The early detection of sacroiliitis on X-ray is important to diagnose spondyloarthropathy(SpA). The conventional radiography, bone scan, and computer tomogram have the problems of sensitivity, specificity, and side effects. We examined sacroiliitis using MR imaging in patients who had inflammatory back pain, but no definite changes in conventional radiogrphy. Other radiologic techniques were compared in detection of early sacroillitis. Methods: Twenty six patients with SpA were examined. The MRI findings of both sacroiliac joints were evaluated in every patients, such as pannus, periarticular osteitis and fat accumulation, subchondral sclerosis, and joint space changes(irregularity, ankylosis). Also we analyzed the changes of sacroiliac joints in sacroiliitis. Results: The predominant sites of involvement were upper aspect and iliac surface of sacroiliac joint in subchondral sclerosis, lower and iliac in pannus, periarticular fat accumulation, and iliac in periarticular osteitis. The MPGR images were superior to spin echo images in evaluation of joint space changes(irregularity, and ankylosis). Conclusions: Sacroiliitis is initiated in iliac side and lower portion of sacroiliac joints. MRI can detect early changes of sacroiliitis in patients with no conventional radiographic changes. MRI seems to be needed in patients with inflammatory back pain.

단체놀이활동이 초등학생의 행동체력과 인성변화에 미치는 영향

장봉희,홍관이 강원대학교 체육과학연구소 2001 江原大學校附設體育科學硏究所論文集 Vol.- No.24

The purpose of this study was to examine in which way the active physical fitness and personality change of elementary school students were affected by programs constituted by group plays they contacted in daily living. The subjects in this study were 60 elementary school students in I-kun, K Province, who were divided into experimental and control groups. The 32-member experimental group were engaged in group play for 10 weeks, five times a week, 40 minutes each, and the 28-member control group was blocked from group play activities. The group play used in this study included snail house play, 8-shape play, the 38th-parallel play, turning round in triangular form, peanut play and squid play. To measure active physical fitness, speed, explosive muscular strength, muscular endurance, cardiorespiratory endurance, agility, balance and flexibility were tested. And the personality was tested by the Korea Psychological Advisory Research Institute's special personality inventory A. The pretest and posttest results were analyzed with SAS program, and t-test was conducted to test the research questions. The findings of this study were as below: 1.The group play activities served to develop the speed, explosive muscular strength, cardiorespiratory endurance, agility and balance of the boy students. 2.For the girl students, speed, muscular endurance, agility, balance and flexibility got better after engaged in group play activities. 3.The group play activities brought a positive change to the self- esteem and stress of the boy students. 4.The group play activities resulted in lowering the sex role security of the girl students, but their stress and deviant behavior control showed a positive change.

Gonadal Development, Spawning and Plasma Sex Steroid Levels of the Indoor Cultured Grunt, Hapalogenys nitens

Hee Woong Kang,Jae-Kwon Cho,Maeng-Hyun Son,Jong Youn Park,Chang Gi Hong,Jae Seung Chung,Ee-Yung Chung 한국발생생물학회 2015 발생과 생식 Vol.19 No.1

The gonadosomatic index (GSI), gonadal development and changes in hormones in plasma level of the indoor cultured grunt (Hapalogenys nitens) were investigated by histological study from August 2011 to October 2012. The GSI showed similar trends with gonad developmental stages during the culture periods. Changes in plasma level of estradiol-17β of female H. nitens reached the highest value before the spawning period, and seasonal changes in plasma level of estradiol-17β were similar in trends of oocyte developments and GSI changes. Testosterone levels of male H. nitens reached the highest value before and after the spent stage. Ovarian developmental stages of H. nitens could be classified into early growing stage, late growing stage, mature stage, ripe and spawning stage, recovery and resting stage. The testicular developmental stages could be divided into growing stage, mature stage, ripe and spent stage, and recovery and resting stage.

에이전트의 주의발생과 그에 따른 컨텍스트의 변화

홍창섭(Chang-Seob Hong),박종희(Jong-Hee Park) 한국콘텐츠학회 2007 한국콘텐츠학회 종합학술대회 논문집 Vol.5 No.2_2

에이전트의 사리에 맞는 행동과 그에 따라 다양한 사건, 행위를 하기 위해 필요한 주의는 크게 인식, 성향, 욕구에 따라 발생할 수 있고 이 주의가 변화함으로써 컨텍스트의 변화가 생긴다. 본 논문에서는 주의의 처리 방법에 대한 알고리즘과 그에 따른 컨텍스트의 변화에 대한 처리방법의 알고리즘을 제시한다. In order that An agent acts activity that makes sense corresponding to a variety of event and behavior, attention maybe occur according to perception, personality and desire. As a result contexts are switched while this attention is changed. In this paper. We propose the processing algorithm of the attention and corresponding contexts to it that are switched.

Gonadal Development, Spawning and Plasma Sex Steroid Levels of the Indoor Cultured Grunt, Hapalogenys nitens

Kang, Hee Woong,Cho, Jae-Kwon,Son, Maeng-Hyun,Park, Jong Youn,Hong, Chang Gi,Chung, Jae Seung,Chung, Ee-Yung The Korean Society of Developmental Biology 2015 발생과 생식 Vol.19 No.1

The gonadosomatic index (GSI), gonadal development and changes in hormones in plasma level of the indoor cultured grunt (Hapalogenys nitens) were investigated by histological study from August 2011 to October 2012. The GSI showed similar trends with gonad developmental stages during the culture periods. Changes in plasma level of estradiol-$17{\beta}$ of female H. nitens reached the highest value before the spawning period, and seasonal changes in plasma level of estradiol-$17{\beta}$ were similar in trends of oocyte developments and GSI changes. Testosterone levels of male H. nitens reached the highest value before and after the spent stage. Ovarian developmental stages of H. nitens could be classified into early growing stage, late growing stage, mature stage, ripe and spawning stage, recovery and resting stage. The testicular developmental stages could be divided into growing stage, mature stage, ripe and spent stage, and recovery and resting stage.

Giant hidroacanthoma simplex combined with variable eccrine tumors mimicking clonal seborrheic keratosis

( Jae Hong Oh ),( Byeong Chang Ko ),( Hee Jae Park ),( Seung Pil Ham ),( Mira Choi ),( Sik Haw ),( Hai-jin Park ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1

Hidrocanthoma simplex(HAS) is a rare benign intraepidermal neoplasm arising from eccrine duct. Clinically, it appears as brownish or verrucous plaque on the lower extremities. Histologically, HAS can exhibit intraepidermal cell nests which are called “Borst-Jadassohn phenomenon”. It could be observed in the HAS, clonal seborrheic keratosis (SK), Bowen’s disease and actinic keratosis. An 86-year-old female presented with several decades history of huge brown, verrucous plaque on the right buttock. At initial biopsy, intraepidermal clonal expansion of polygonal basaloid cells were observed within acanthotic epidermis. She was diagnosed as clonal SK, and was removed by CO2 laser ablation. After 3 months, she returned with polypoid grouped papules on the previously treated area. Histologic examination showed intraepidermal proliferation of small to medium-sized polygonal basaloid cells as well as large cells with abundant clear cytoplasm. Atypical cells with large, hyperchromatic nuclei were observed. There was a component of eccrine syringofibroadenoma which is characterized by thin, anastomosing cords of epithelial networks with duct formation extending from the base of the tumor. Tumor cells were stained with EMA and PAS. Final diagnosis was HAS combined with eccrine poroma, eccrine syringofibroadenoma and focal malignant changes. Herein we report a case showing natural history of eccrine tumor from HAS to malignant changes over time.

Auto Exposure Control을 사용하는 흉ㆍ복부 검사 시 Scan Projection Radiography의 획득방법에 따른 복부 CT의 DoseLength-Product 비교

김진희(Jin Hee Kim),이종민(Jong Min Lee),정용환(Young Hwan Chung),대창민(Chang Min Dae),민관홍(Kwan Hong Min) 대한CT영상기술학회 2015 대한CT영상기술학회지 Vol.17 No.1

목적 : Multi-scan 하는 흉부와 복부 CT 검사 시 SPR을 흉ㆍ복부 한 번에 획득한 경우와 각각 나누어서 획득한 경우 복부 CT의 DLP값을 분석하여 환자 선량을 비교하고자 했다. 대상 및 방법 : Phantom 연구에서 사용된 phantom은 whole body phantom(KUPBU -50 Kyoto kakaku Co,LTd)을 사용하였고 CT 장비는 Brilliance iCT(Philips healthcare, Cleveland, OH, USA, 이하 P사), Light Speed VCT(General Electric Medical System, Milwaukee, USA, 이하 G사), Somatom Definition Flash(Siemens Healthcare, Forchheim Germany, 이하 S사), Aquilion 64 (Toshiba medical system, Auklet Japan, 이하 T사)를 사용하였다. 각 장비 마다 흉ㆍ복부 한 번에 획득한 SPR(이하 W-SPR)과 흉부와 복부 각각 획득한 SPR(이하 S-SPR)을 이용하여 각 병원에서 사용하는 복부 protocol로 복부 scan을 하였고 장비에서 제공하는 DLP를 비교하였다. 임상연구는 2014년 5월부터 6월까지 내원한 환자 100명을 Group1로 분류하여 W-SPR로 복부 scan을 하였다. 2014년 7월부터 8월까지 내원한 환자 100명은 S-SPR로 복부 scan을 하였고 이를 Group 2라고 분류하였다. 각 Gruop간의 DLP의 차이는 Box-Whisker plot Chart를 이용하여 중앙값을 구했으며 DLP 증감률을 알아보았다. 결과 : Phantom을 이용한 실험에서 P사의 W-SPR로 검사한 복부 CT의 DLP가 367.1 mGyㆍcm, S-SPR의 복부 CT의 DLP는 398.1 mGyㆍcm로 측정되었다. 반면 S사, G사, T사는 흉 복부 포함하여 촬영한 SPR과 흉ㆍ복부 각각 촬영한 SPR에서의 복부 DLP는 거의 차이가 없는 것으로 나타났다. 임상 연구에서는 Group 1의 DLP의 중앙값이 442.7 mGyㆍcm, Group 2의 DLP의 중앙값이 494.2 mGyㆍcm 로 나타났다. 각 Group 간 DLP 증감률은 10.42%정도의 수치를 보였다. 결론 : 본 연구를 통해 각 제조사별로 ACE의 특징이 다르다는 것을 확인 할 수 있었으며, 특히 P사는 SPR의 Scan length에 영향을 받는 것으로 확인되므로, P사를 사용하는 검사자는 흉ㆍ복부 검사 시 SPR을 한 번에 획득하여 검사 하는 것이 환자 선량을 줄일 수 있다. Purpose : This study compare dose of patient by analyzing the DLP value of abdominal CT when the case of acquired SPR separately each of the chest and abdomen and when acquired SPR in chest-abdomen once in Multi-scan of Chest and Abdominal CT Scan. Materials and method : In phantom study, Whole body phantom (KUPBU -50 Kyoto kakaku Co,LTd) was used and CT scanners Brilliance iCT(Philips healthcare, Cleveland, OH, USA), Light Speed VCT(General Electric Medical System, Milwaukee, USA), Somatom Definition Flash(Siemens Healthcare, Forchheim Germany) and Aquilion 64 (Toshiba medical system, Auklet Japan) were used. Each of manufacture, we compared the DLP and compared the value of SPR when scanning chest and abdomen once(W-SPR) with scanning Chest and Abdomen separately (S-SPR). In Clinical study, 100 patients who visited the hospital May-June 2014 were classified into Group 1. And Scanned Abdomen using with W-SPR. 100 patients who visited July-August 2014 were classified as Group 2. And Scanned using the S-SPR. Using a Box-and- Whisker plot Chart, obtained the median value of differences between Gruop 1, 2 and DLP changes. Result : In phantom study, Philips result is 367.1 mGyㆍcm in DLP using a W-SPR and 398.1 mGyㆍcm in DLP of abdomen CT using a S-SPR. Otherwise, Siemens, GE, and Toshiba results are no difference between the DLP of abdomen CT using a W-SPR and S-SPR. In clinical study, the median DLP value percentage change was 10.42% decreased in Group 1. Median DLP values were 442.7mGyㆍcm in group 1 and 494.2mGyㆍcm in Group 2. Conclusion : According to the results, we once more confirm, each vendor’s AEC system applies different mechanism and characteristic. Especially, P vendor’s AEC system is influenced by SPR length, sensitively. Therefore, we recommend scanning chest and abdomen at once regarding the dose reduction for P machine users.