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주홍돈(Hong Don Joo),박상옥(Sang Wook Park),장직현(Jik Hyun Chang) 한국정보과학회 1993 한국정보과학회 학술발표논문집 Vol.20 No.2
본 논문에서는 변형된 정렬 문제로서, 정렬의 대상이 되는 원소와 각 원소에 주어진 왼쪽 한계값이 정렬된 후의 그 원소가 위치할 수 있는 자리를 제한하는 정렬 문제를 생각한다. Heap을 이용하여 문제를 해결하는 O(nlogn)의 시간복잡도를 가지는 순차 알고리즘은 이미 알려져있다. 여기에서는 주어진 문제를 해결하는 3가지의 병렬 알고리즘을 제시한다. 먼저 순차 알고리즘에서 Heap을 병렬화하여 O(logn)의 프로세서를 가지고 O(n)시간에 해결하는 병렬 알고리즘과 Heap을 이용하지 않는 알고리즘으로 O(n²/logn)의 프로세서를 가지고 O(logn)시간에 해결하는 병렬 알고리즘과 O(n)의 프로세서를 가지고 O(log²n) 시간에 해결하는 병렬 알고리즘을 제시한다.
In vitro and In vivo Anti-Helicobacter pylori Activities of Centella asiatica Leaf Extract
Hong-Mei Zheng,Myung-Joo Choi,Jae Min Kim,Kye Wan Lee,Yu Hwa Park,Don Haeng Lee 한국식품영양과학회 2016 Preventive Nutrition and Food Science Vol.21 No.3
Helicobacter pylori infection is associated with an increased risk of developing upper gastrointestinal tract diseases. However, treatment failure is a major cause of concern mainly due to possible recurrence of infection, the side effects, and resistance to antibiotics. The aim of this study was to investigate the activities of Centella asiatica leaf extract (CAE) against H. pylori both in vitro and in vivo. The minimum inhibitory concentrations (MICs) against 55 clinically isolated strains of H. pylori were tested using an agar dilution method. The MICs of CAE ranged from 0.125 mg/mL to 8 mg/mL, effectiveness in inhibiting H. pylori growth was 2 mg/mL. The anti-H. pylori effects of CAE in vivo were also examined in H. pylori-infected C57BL/6 mice. CAE was orally administrated once daily for 3 weeks at doses of 50 mg/kg and 250 mg/kg. CAE at the 50 mg/kg dose significantly reduced H. pylori colonization in mice gastric mucosa. Our study provides novel insights into the therapeutic effects of CAE against H. pylori infection, and it suggests that CAE may be useful as an alternative therapy.
In vitro and In vivo Anti-Helicobacter pylori Activities of Centella asiatica Leaf Extract
Zheng, Hong-Mei,Choi, Myung-Joo,Kim, Jae Min,Lee, Kye Wan,Park, Yu Hwa,Lee, Don Haeng The Korean Society of Food Science and Nutrition 2016 Preventive Nutrition and Food Science Vol.21 No.3
Helicobacter pylori infection is associated with an increased risk of developing upper gastrointestinal tract diseases. However, treatment failure is a major cause of concern mainly due to possible recurrence of infection, the side effects, and resistance to antibiotics. The aim of this study was to investigate the activities of Centella asiatica leaf extract (CAE) against H. pylori both in vitro and in vivo. The minimum inhibitory concentrations (MICs) against 55 clinically isolated strains of H. pylori were tested using an agar dilution method. The MICs of CAE ranged from 0.125 mg/mL to 8 mg/mL, effectiveness in inhibiting H. pylori growth was 2 mg/mL. The anti-H. pylori effects of CAE in vivo were also examined in H. pylori-infected C57BL/6 mice. CAE was orally administrated once daily for 3 weeks at doses of 50 mg/kg and 250 mg/kg. CAE at the 50 mg/kg dose significantly reduced H. pylori colonization in mice gastric mucosa. Our study provides novel insights into the therapeutic effects of CAE against H. pylori infection, and it suggests that CAE may be useful as an alternative therapy.
Jae Hong Yoo,Young Don Lee,Khalid A. Hussein,Jin Ho Joo 한국토양비료학회 2018 한국토양비료학회지 Vol.51 No.4
Composting of food waste might be effective way for food waste disposal which could be applied to improve soil properties in agricultural field. The purpose of this study is to evaluate the effect of food waste on two crops (Chinese cabbage, Tomato) compared to livestock manure. Seven different treatments (one livestock manure, two food wastes, one livestock manure + chemical fertilizer, two food waste + chemical fertilizer, and control) were applied to two crops . Treatment of livestock + chemical fertilizer and microorganism treated food waste +chemical fertilizer showed statistically significant differences on leaf width and root length of Chinese cabbage compared to other treatments. They showed highest values for these parameters. Value of four parameters (shoot length, total length, fresh weight and chlorophyll content) were highest with treatment of livestock + chemical fertilizer and microorganism treated food waste + chemical fertilizer for tomato growth.
돼지의 UCP3 유전자의 단일염기서열 변이와 경제형질과의 연관성 분석
Jae-Don Oh(오재돈),Kun-Woo Lee(오건우),Il-Jung Jung(정일정),Gwang-Joo Jeon(전광주),Hak-Kyo Lee(이학교),Hong-Sik Kong(공홍식) 한국생명과학회 2011 생명과학회지 Vol.21 No.1
Uncoupling protein (UCP) 3 유전자는 갈색지방세포의 미토콘드리아 내막에 존재하며 탈공역 산소(uncoupling oxygen)를 통해 ATP를 생산하는 것으로 알려져 있다. 이는 세포 내의 과다 에너지를 열로 발산시키는 기능을 하고 있다. 본 연구는 돼지의 UCP 3 유전자 내 missense mutation의 유전자형을 조사하고 경제형질과의 연관성을 분석하기 위하여 실시하였다. 돼지의 UCP3 유전자의 염기서열 분석을 통해 1405 bp 지역에서(accession number: AY739704) G염기가 A염기로 치환되는 변이를 확인하였다. 확인된 변이지역은 G가 A로 치환됨으로 인해 150번째 아미노산 서열이 glycine (GGG)에서 arginine (AGG)으로 바뀌는 missense mutation임을 확인하였다. 각 유전자형의 빈도는 0.164(GG), 0.587(GR) 그리고 0.249(RR)로 확인되었으며, 각 대립유전자의 빈도는 0.458(G)과 0.542(R)로 확인되었다. 돼지 UCP3의 G150R 유전자형과 경제형질 간의 연관성을 분석한 결과 등지방두께에 있어 유의적인 연관성이 검출되고 일당증체량과 90 kg 도달일령에서는 유의적인 값이 검출되지 않았다. Uncoupling protein (UCP) 3 has a number of proposed roles in the regulation of fatty acid metabolism. A number of polymorphisms in the human UCP3 gene have been identified, and the correlation with obesity related phenotypes evaluated. The objective of this study was to identify SNP in porcine UCP3 gene and to investigate the effect of the SNP on economic traits. The sequencing analysis method was used to identify nucleotide polymorphisms at position 1405 bp (Genebank accession No : AY739704) in porcine UCP3 gene. The SNP (G150R), located in the exon 3, changed the amino acid to glycine (GGG) from arginine (AGG). This G150R showed three genotypes - GG, GR and RR - by digestion with the restriction enzyme Sma Ⅰ using the PCR-RFLP method. The G150R showed significant effects only on back fat (P<0.05). Animals with the genotype GG had significantly higher back fat thickness (1.358 ㎝) than animals with the genotype GR (1.288 ㎝, P<0.05) and RR (1.286 ㎝, P<0.05). However, the genotypes had no significant association with ADG and days to 90㎏. According to results of this study, a G allele of the G150R was found to have a significant effect on back fat thickness. It will be possible to use SNP markers on selected pigs to improve backfat thickness, an important economic trait.
Enoxaparin Therapy for Arterial Thrombosis After Umbilical Cord Catheterization in Preterm Infants
Yoon-Joo Kim,Young Don Kim,Jae Hong Choi 대한신생아학회 2016 Neonatal medicine Vol.23 No.2
The incidence of symptomatic thrombosis of umbilical arterial catheterization is 1-3%. Therapeutic options may include: using heparin or low molecular weight heparin, using a thrombolytic agent, or surgical thrombectomy. However, there are insufficient data to recommend any one treatment over the others. Recently, enoxaparin, a low molecular weight heparin, has emerged as a drug of choice for the treatment of neonatal thrombosis due to pharmacologic stability over unfractionated heparin or thrombolytic agents. We report a case of successful treatment of aortic thrombosis after umbilical arterial catheterization with enoxaparin in preterm infants.
( Hyun Joo Jang ),( Jae Young Lee ),( Don Haeng Lee ),( Won Hong Kim ),( Joo Ha Hwang ) The Editorial Office of Gut and Liver 2010 Gut and Liver Vol.4 No.s1
High-intensity focused ultrasound (HIFU) is a novel therapeutic modality that permits noninvasive treatment of various benign and malignant solid tumors, including prostatic cancer, uterine fibroids, hepatic tumors, renal tumors, breast cancers, and pancreatic cancers. Several preclinical and clinical studies have investigated the safety and efficacy of HIFU for treating solid tumors, including pancreatic cancer. The results of nonrandomized studies of HIFU therapy in patients with pancreatic cancer have suggested that HIFU treatment can effectively alleviate cancer-related pain without any significant complications. This noninvasive method of delivering ultrasound energy into the body has recently been evolving from a method for purely thermal ablation to harnessing the mechanical effects of HIFU to induce a systemic immune response and to enhance targeted drug delivery. This review provides a brief overview of HIFU, describes current clinical applications of HIFU for pancreatic cancer, and discusses future applications and challenges. (Gut Liver 2010;4(Suppl. 1):S57-61)
The Effect of Food Waste Compost on Chinese Cabbage Growth and Change of Soil Properties
Jae Hong Yoo,Young Don Lee,Jin Ho Joo 한국토양비료학회 2019 한국토양비료학회지 Vol.52 No.4
The objective of this research is to evaluate the effect of food waste compost application on Chinese cabbage growth and soil chemical properties. For field experiment, seven different treatments (livestock compost (LC), livestock compost + chemical fertilizer (NPK), food waste compost (FWC), food waste compost + chemical fertilizer, food waste compost + livestock compost (FWC+LC), food waste compost + livestock compost + chemical fertilizer, and control) were applied to Chinese cabbage grown field. All the treatment were carried out in 3 replicates with completely randomized design. Treatment of FWC+LC+NPK showed highest values in all parameters (leaf length, leaf width, chlorophyll contents, fresh and dry weight) of Chinese cabbage. Especially fresh and dry weight of Chinese cabbage treated with FWC+LC+NPK showed two times higher values compared to control. The electrical conductivity, organic matter, and cation exchange capacity in soils treated with both FWC and LC showed significant increase compared to control, while pH, and available P₂O5 content did not.