Anti-Inflammatory and Cytoprotective Effects of TMC-256C1 from Marine-Derived Fungus <i>Aspergillus</i> sp. SF-6354 via up-Regulation of Heme Oxygenase-1 in Murine Hippocampal and Microglial Cell Lines

Kim, Dong-Cheol,Cho, Kwang-Ho,Ko, Wonmin,Yoon, Chi-Su,Sohn, Jae Hak,Yim, Joung Han,Kim, Youn-Chul,Oh, Hyuncheol MDPI AG 2016 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.17 No.4

<P>In the course of searching for bioactive secondary metabolites from marine fungi, TMC-256C1 was isolated from an ethyl acetate extract of the marine-derived fungus <I>Aspergillus</I> sp. SF6354. TMC-256C1 displayed anti-neuroinflammatory effect in BV2 microglial cells induced by lipopolysaccharides (LPS) as well as neuroprotective effect against glutamate-stimulated neurotoxicity in mouse hippocampal HT22 cells. TMC-256C1 was shown to develop a cellular resistance to oxidative damage caused by glutamate-induced cytotoxicity and reactive oxygen species (ROS) generation in HT22 cells, and suppress the inflammation process in LPS-stimulated BV2 cells. Furthermore, the neuroprotective and anti-neuroinflammatory activities of TMC-256C1 were associated with upregulated expression of heme oxygenase (HO)-1 and nuclear translocation of nuclear factor-E2-related factor 2 (Nrf2) in HT22 and BV2 cells. We also found that TMC-256C1 activated p38 mitogen-activated protein kinases (MAPK) and phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathways in HT22 and BV2 cells. These results demonstrated that TMC-256C1 activates HO-1 protein expression, probably by increasing nuclear Nrf2 levels via the activation of the p38 MAPK and PI3K/Akt pathways.</P>

잔적토의 실내시험법 개발에 관한 연구

고호성,임종철 釜山大學校生産技術硏究所 1995 生産技術硏究所論文集 Vol.49 No.-

본 연구는 잔적토의 시료채취 방법을 개발하고 강도정수를 구하는 실내시험법을 개발하는 것이다. 새로이 설계된 시료채취법과 실험 장치로 강도정수를 구할 수 있다. 본 논문에서는 잔적토의 시료채취 방법과 실험 방법을 제안하였으며, 이 방법에 의한 시험 결과를 설명하였다. 시험은 사면 안정 해석에 강도정수를 사용할 수 있게 하기 위해 평면변형률 상태 하에서 수행되었다. This studies focuses on the development of sampling method and laboratory testing method of residual soil. Strength parameters are obtained by newly designed sampling and testing apparatus. In this paper, the sampling and testing method for the residual soil are proposed and some test results by this new method are described. Tests were made under plane state in order to be able to use the strength parameters for the slope stability analysis.

수용성 미셀용액에 가용화된 Acetanilide, p-diacetylbenzene 및 tetrabromo-p-quinone의 미세환경의 성질

高正秀,金信局,朴哲浩 木浦大學校 基礎科學硏究所 1994 基礎科學硏究誌 Vol.12 No.-

Solubilization of some carbonyl compounds such as acetanilide, p-diacetylbenzene and tetrabromo-p-quinone was investigated in a variety of aqueous micellar solutions by UV spectrophotometric method. The good linear relationship was obsorved between υ(n→π*)of these carbonyl compounds and solvent polarity parameter, ??, of some pure solvents. Themicroenvironmental polarity of these carbonyl compounds depended on the ionic properties of the surfactants, and decreased as cationic > anionic > nonionic.

[논문]다짐풍화토의 평면변형률 및 삼축압축시험의 강도정수에 관한 연구

고호성,임종철 釜山大學校生産技術硏究所 2004 生産技術硏究所論文集 Vol.63 No.-

본 연구에서는 다짐풍화토를 이용하여 축대칭 삼축시험과 평면변형률 압축시험을 행하였다. 전단저항각은 평면변형률 시험에서는 41.5°, 삼축압축시험에서는 38 .5°로 평면변형률압축시험의 경우가 삼축압축시험보다 3°정도 크게 나타났다. 동일한 시료를 사용한 불교란시료의 전단저항각은 다짐시료보다 6°정도 크게 나왔다. 응력경로가 일정한 상태로 접근하므로 수정 Cam-Clay 이론의 적용이 가능한 것으로 판단된다.

앵커테의 탄성계수(Ea)

임종철,홍석우,고호성 釜山大學校生産技術硏究所 1999 生産技術硏究所論文集 Vol.56 No.-

앵커는 흙막이 벽, 사면안정 등에서 사용되는 지반변형 억제공법이다. 앵커가 지중에서 인발하중을 받으면 앵커체의 강성과 지반의 강성에 따라 각각 다른거동을 하게 된다. 본 논문에서는 인장형 및 압축형 앵커의 인발에 따른 표면에서의 응력거동을, 주로 탄성계수비에 따른 전단응력의 변화에 중점을 두고 수치해석 기법을 이용하여 분석하였다. 여기서, 탄성계수비(codfficient ratio of elasticity)란 지반탄성계수(Er)와 앵커체탄성계수(Ea)의 비(Ea/Er)를 말하는데, 이 탄성계수비에 의해 앵커의 진행성 파괴에 대한 영향을 평가할 수 있다. Anchor is used for a restraining of a ground deformation in the retaining wall, slope-stability et ctc. Whe n pullout load is applied to the anchor in the ground, the behavior of the anchor in the ground is differed by the rigdity of anchor body and ground. In this study, the stress-behavior is analyzed by the numerical a nalysis on the suface of an anchor body according to the pullout of an anchor. Mostly, The analysis is foc used on the change of a shear stress according to the coefficient ratio of elasticity. The coefficient ratio of elasticity(Ea/Er) si defined by the ratio between elastic modulus of ground(Er) and that of anchor body (Ea). By using this ratio, the progressive failure of anchor body can be analysed.

토사터널 보조공법 중 마이크로파일공법의 적용성에 관한 기초적 연구

임종철,고호성,홍석우 釜山大學校生産技術硏究所 1998 生産技術硏究所論文集 Vol.55 No.-

본 연구에서는 토사지반에 터널을 굴착할 경우 보조공법으로서 사용되는 마이크로파일의 적용성을 검토하기 위해 그 보강효과를 모형실험을 통하여 분석하였다. 특히, 보강방향, 보강형태, 보강범위의 영향에 연구의 초점을 맞추었다. 실험의 결과는 당므과 같다. ① 마이크로파일의 효과적인 설치방향은 dε₃방향이며, 이때의 설치각도는 수평과 60°각도를 이룬다. ② 마이크로 파일설치형태를 볼 때, 개방형보다는 폐쇄형이 더욱 효과적이다. In this study, the reinforcing effect of micro-pile for the soft ground tunnel is analysed by the laboratory model tests. Especially, the effects of diretions, types, and range of reinforcement are focused. The results of tests are as follows: ① The effective installation direction of micro-pile is dε₃ direction, and the most effective installation angle is 60 degree for the horizontal direction ② the closed type is more effective than the opened type of micro-pile installation.

실드터널 시공시의 지표 구조물의 침하 억제 대책에 관한 연구

임종철,윤이환,박이근,고호성,홍석우 釜山大學校生産技術硏究所 1999 生産技術硏究所論文集 Vol.56 No.-

연약지반 터널 굴차시 실드공법은 근접 구조물 안전에 유용한 공법이다. 하지만 실드 터널 공법은 터널 주변 지반의 변형을 최소화 할 수 있는 장점을 가지는 반면 테일 보이드(Tail Void)에 그라우트된 주입재가 경화되기 전에 발생하는 지반 변형은 피하기 어렵다. 본 연구에서는 테일 보이드로 인한 인접 구조물의 침하를 억제하는 방법중 하나인 마이크로파일(micropile)의 영향을 모형실험을 통하여 규명하였다. 기초적인 실험 결과로써 마이크로파일 보강시 마이크로파일의 효과적인 설치방향과 침하 억제비를 밝혔다. In soft ground tunneling, shield method is very good for safety of neighboring structures. Although shield tunnel method has the merits to minimize the deformation of ground around tunnel, ground deformations occurred until the material grouted in tail void hardens are inevitable. In this study, the effects of micropile used as one method to restrain the settlement of neighboring structures by the tail void are studied by laboratory model tests. As a basic test result, the effective direction of micropile and the restraint rate of settlement by micropile reinforcement are known.

기초주변지반의 마이크로 파일 보강에 의한 지지력 증가효과에 관한 연구

임종철,허진철,이태형,고호성 釜山大學校生産技術硏究所 2002 生産技術硏究所論文集 Vol.61 No.-

본 연구에서는 기초주변에 설치된 마이크로 파일의 길이와 보강범위에 따른 지반의 지지력 증가효과를 실내모형실험을 통하여 조사하였다. 실험 결과, 마이크로 파일의 최적 길이와 보강 범위가 제안되었다. 또한, 기초 직하에 설치된 마이크로 파일의 지지력과도 비교하였다. In this study, the increase in the bearing capacity of soil due to the variation of length and reinforcement scope of the micropiles installed near the foundation was investigated using model tests. From the test results, the length and the optimum reinforcement scope were proposed. In order to improve micropiles field application, it was compared with the increase in the bearing capacity for micropiles installed directly beneath the foundation.

초등학생의 1000m 달리기-걷기 평가방법에 관한 연구

박철호,박은경,고봉민,우상헌,안민호,차유림 東亞大學校附設스포츠科學硏究所 2002 스포츠科學硏究論文集 Vol.20 No.-

This research aims to develop a new evuluation method of endurance for elementary school students. The norm of the event of 1,000m running-walking was examined and reviewed. As a result, a new highly-valid norm for the present 1,000m running-walking was made. Among the 5th and 6th graders, 2,144 pupils were chosen. The subjects were given 1,000m running-walking and step test. The new norm led to the following results: 1. The frequency distribution of PEI according to Cajori's 5-stage evaluation method turned out to be normal for both 5th and 6th graders. In conclusion, this new norm of 1,000m running-walking is believed to provide more valid and credible scores for elementary school students. The 1,000m running-walking records and the PEI will be used as the basic data for foretelling one's endurance.

入力電流의 高調波 低減을 위한 새로운 다이리스터 整流回路의 개발

柳喆魯,金聖中,李公熙,李星龍,高榮浩 全北大學校 1987 論文集 Vol.29 No.-

The harmonics involved in input AC line currents of thyristor rectifier apparatus have recently been a serious problem in the cause of burning power condenser, mis-action of UFR(protective relay), and trouble of the automatic voltage controller, etc, in the sending or distribution electric power system. As an effective counter-measure for this, the method of having switching taps on the conventional interphase reactor and its artificial utilization have been adapted, as we know. The conventional 3 tap method, however, is not achieved an effect of reducing harmonics under firing angle 15˚. In this paper, a new method of reducing harmonics involved in input AC line currents or output DC voltage of rectifier circuit is presented, which is due mainly to the equipment of the 2-3 switching taps on interphase reactor. Thereofre, main contents of this study are the following three items; 1) optimal number of taps 2) optimal turn ratio of interphase reactor 3) optimal control angle of interphase reactor.